JP6342805B2 - 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途 - Google Patents

置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途 Download PDF

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Publication number
JP6342805B2
JP6342805B2 JP2014528675A JP2014528675A JP6342805B2 JP 6342805 B2 JP6342805 B2 JP 6342805B2 JP 2014528675 A JP2014528675 A JP 2014528675A JP 2014528675 A JP2014528675 A JP 2014528675A JP 6342805 B2 JP6342805 B2 JP 6342805B2
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cancer
substituted
unsubstituted
kinase
compound
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Expired - Fee Related
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JP2014528675A
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Japanese (ja)
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JP2014525464A (ja
JP2014525464A5 (enExample
Inventor
ダル，アルヴィン，シー．
ダス，ティルサ，ケー．
ソス，マーティン
ビヴォナ，トレヴァー，ジー．
ショカット，ケヴァン，エム．
カガン，ロス，エル．
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014528675A 2011-09-02 2012-08-31 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途 Expired - Fee Related JP6342805B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161530847P 2011-09-02 2011-09-02
US61/530,847 2011-09-02
US201261606296P 2012-03-02 2012-03-02
US61/606,296 2012-03-02
PCT/US2012/053542 WO2013077921A2 (en) 2011-09-02 2012-08-31 Substituted pyrazolo[3,4-d]pyrimidines and uses thereof

Publications (3)

Publication Number Publication Date
JP2014525464A JP2014525464A (ja) 2014-09-29
JP2014525464A5 JP2014525464A5 (enExample) 2015-10-29
JP6342805B2 true JP6342805B2 (ja) 2018-06-13

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JP2014528675A Expired - Fee Related JP6342805B2 (ja) 2011-09-02 2012-08-31 置換ピラゾロ［３，４−ｄ］ピリミジンおよびその用途

Country Status (7)

Country Link
US (2) US9321772B2 (enExample)
EP (1) EP2751112B1 (enExample)
JP (1) JP6342805B2 (enExample)
AU (1) AU2012341028C1 (enExample)
CA (1) CA2846496C (enExample)
MX (1) MX370814B (enExample)
WO (1) WO2013077921A2 (enExample)

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