JP6129844B2 - 多量体オリゴヌクレオチド化合物 - Google Patents

多量体オリゴヌクレオチド化合物 Download PDF

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JP6129844B2
JP6129844B2 JP2014530879A JP2014530879A JP6129844B2 JP 6129844 B2 JP6129844 B2 JP 6129844B2 JP 2014530879 A JP2014530879 A JP 2014530879A JP 2014530879 A JP2014530879 A JP 2014530879A JP 6129844 B2 JP6129844 B2 JP 6129844B2
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oligonucleotide
linker
seq
compound
targeting
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JP2014527819A (ja
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オイゲン ウールマン，
オイゲン ウールマン，
マルクス ヴェバー，
マルクス ヴェバー，
ロメッシュ スブラマニアン，
ロメッシュ スブラマニアン，
トマス ディーノ ロッケル，
トマス ディーノ ロッケル，
アーサー エム． クレイグ，
アーサー エム． クレイグ，
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ラナ セラピューティクス インコーポレイテッド
ラナ セラピューティクス インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2014530879A 2011-09-14 2012-09-14 多量体オリゴヌクレオチド化合物 Active JP6129844B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161534561P 2011-09-14 2011-09-14
US61/534,561 2011-09-14
PCT/US2012/055535 WO2013040429A1 (en) 2011-09-14 2012-09-14 Multimeric oligonucleotide compounds

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US (5) US9580708B2 (enExample)
EP (2) EP3533873A1 (enExample)
JP (2) JP6129844B2 (enExample)
AU (2) AU2012308320C1 (enExample)
CA (1) CA2848753C (enExample)
DK (1) DK2756080T3 (enExample)
HK (1) HK1200484A1 (enExample)
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US12458604B2 (en) 2020-10-14 2025-11-04 The Trustees Of The University Of Pennsylvania Methods of lipid nanoparticle manufacture and compositions derived therefrom

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US12576040B2 (en) 2020-10-14 2026-03-17 The Trustees Of The University Of Pennsylvania Ionizable lipids and methods of manufacture and use thereof

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