JP5968231B2 - コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法 - Google Patents

コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法 Download PDF

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JP5968231B2
JP5968231B2 JP2012557270A JP2012557270A JP5968231B2 JP 5968231 B2 JP5968231 B2 JP 5968231B2 JP 2012557270 A JP2012557270 A JP 2012557270A JP 2012557270 A JP2012557270 A JP 2012557270A JP 5968231 B2 JP5968231 B2 JP 5968231B2
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coq10
formulation
active agent
poloxamer
dmpc
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JP2013522233A5 (https=
JP2013522233A (ja
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ナレイン，ニーブン，ラジン
マックック，ジョン，パトリック
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バーグ エルエルシー
バーグ エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012557270A 2010-03-12 2011-03-11 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法 Active JP5968231B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31363210P 2010-03-12 2010-03-12
US61/313,632 2010-03-12
US38510710P 2010-09-21 2010-09-21
US61/385,107 2010-09-21
PCT/US2011/028042 WO2011112900A2 (en) 2010-03-12 2011-03-11 Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof

Related Child Applications (1)

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JP2016132936A Division JP6431003B2 (ja) 2010-03-12 2016-07-05 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法

Publications (3)

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JP2013522233A JP2013522233A (ja) 2013-06-13
JP2013522233A5 JP2013522233A5 (https=) 2014-05-01
JP5968231B2 true JP5968231B2 (ja) 2016-08-10

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JP2012557270A Active JP5968231B2 (ja) 2010-03-12 2011-03-11 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法
JP2016132936A Active JP6431003B2 (ja) 2010-03-12 2016-07-05 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法
JP2018206201A Active JP6861682B2 (ja) 2010-03-12 2018-11-01 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法
JP2020201909A Pending JP2021050221A (ja) 2010-03-12 2020-12-04 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法

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JP2016132936A Active JP6431003B2 (ja) 2010-03-12 2016-07-05 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法
JP2018206201A Active JP6861682B2 (ja) 2010-03-12 2018-11-01 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法
JP2020201909A Pending JP2021050221A (ja) 2010-03-12 2020-12-04 コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法

Country Status (27)

Country Link
US (2) US11400058B2 (https=)
EP (2) EP3366280A1 (https=)
JP (4) JP5968231B2 (https=)
KR (2) KR101907411B1 (https=)
CN (2) CN105168135A (https=)
AU (4) AU2011224207B2 (https=)
BR (1) BR112012022916B1 (https=)
CA (2) CA2791693C (https=)
CL (1) CL2012002507A1 (https=)
CO (1) CO6620033A2 (https=)
CR (1) CR20120507A (https=)
CY (1) CY1120290T1 (https=)
DK (1) DK2544663T3 (https=)
EA (1) EA032941B1 (https=)
ES (1) ES2664793T3 (https=)
HK (1) HK1219055A1 (https=)
IL (1) IL221675B (https=)
MX (2) MX344078B (https=)
MY (1) MY163995A (https=)
NZ (3) NZ701451A (https=)
PE (1) PE20130045A1 (https=)
PH (1) PH12012501806B1 (https=)
PL (1) PL2544663T3 (https=)
PT (1) PT2544663T (https=)
SG (3) SG10202010355PA (https=)
TW (2) TWI602562B (https=)
WO (1) WO2011112900A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016199573A (ja) * 2010-03-12 2016-12-01 バーグ エルエルシー コエンザイムＱ１０（ＣｏＱ１０）の静脈内投与用製剤およびその使用方法

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CN102481271A (zh) 2009-05-11 2012-05-30 博格生物系统有限责任公司 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法
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EP2720680B1 (en) 2011-06-17 2020-02-12 Berg LLC Inhalable pharmaceutical compositions
EA032345B1 (ru) * 2012-06-01 2019-05-31 Берг Ллк Способ лечения рака с использованием кофермента q10
NZ713868A (en) * 2013-04-08 2021-12-24 Berg Llc Treatment of cancer using coenzyme q10 combination therapies
KR102370843B1 (ko) * 2013-09-04 2022-03-04 버그 엘엘씨 코엔자임 q10의 연속주입에 의한 암치료 방법
US11458096B2 (en) * 2014-04-09 2022-10-04 Pulse Pharmaceuticals Pvt. Ltd. Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base
US9895446B2 (en) 2015-07-14 2018-02-20 Professional Compounding Centers Of America Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
ES3017696T3 (en) 2017-05-17 2025-05-13 Bpgbio Inc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
WO2019148282A1 (en) 2018-02-01 2019-08-08 The Royal Institution For The Advancement Of Learning/Mcgill University Formulations for improving the delivery of hydrophobic agents
EP3773520A4 (en) * 2018-04-09 2021-12-22 Orgenesis Inc. BIOXOMES AND REDOXOMES PARTICLES, PROCESS AND COMPOSITION
US20200138744A1 (en) * 2018-10-15 2020-05-07 Berg Llc Methods of treating pancreatic cancer using coenzyme q10
IL268457B (en) * 2019-08-04 2022-05-01 Omega 3 Galilee Ltd Oil- suspension of edible solids and methods of preparing the same
WO2021102356A1 (en) 2019-11-20 2021-05-27 Berg Llc Combination therapy of a coenzyme q10 compound and radiation therapy for treatment of glioma
JPWO2023120553A1 (https=) * 2021-12-24 2023-06-29
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer
US20250262169A1 (en) * 2024-02-16 2025-08-21 Bpgbio, Inc. Methods of treating coenzyme q10 deficiency
WO2025199182A1 (en) * 2024-03-19 2025-09-25 New York University Treatment with 4-hydroxybenzoic acid to augment coq10 production

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