CN101480381B - 一种辅酶q10药物组合物 - Google Patents
一种辅酶q10药物组合物 Download PDFInfo
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- CN101480381B CN101480381B CN2009101031114A CN200910103111A CN101480381B CN 101480381 B CN101480381 B CN 101480381B CN 2009101031114 A CN2009101031114 A CN 2009101031114A CN 200910103111 A CN200910103111 A CN 200910103111A CN 101480381 B CN101480381 B CN 101480381B
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- coenzyme
- injection
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- solutol
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 148
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 97
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 97
- 229940110767 coenzyme Q10 Drugs 0.000 title claims abstract description 97
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 40
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- 239000007924 injection Substances 0.000 claims abstract description 78
- 239000002904 solvent Substances 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 17
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920001304 Solutol HS 15 Polymers 0.000 claims abstract description 13
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 10
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 24
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
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DE102009048974A1 (de) * | 2009-10-09 | 2011-04-14 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit Kombinationen aus öllöslichen kosmetischen oder dermatologischen Wirkstoffen und einem oder mehreren Sulfiten (Bisulfiten oder Disulfiten) |
RU2433820C2 (ru) * | 2009-12-30 | 2011-11-20 | Пация Мераби Георгиевич | Композиция с 6-декапренил-2,3-диметокси-5-метил-1,4-бензохиноном для парентерального введения и способ ее получения |
RU2445079C2 (ru) * | 2010-06-02 | 2012-03-20 | Общество С Ограниченной Ответственностью "Акцент" | Композиция на основе 6-декапренил-2,3-диметокси-5-метил-1,4-бензохинона и способ ее получения |
CN104415336B (zh) * | 2013-08-28 | 2019-05-03 | 沈阳药科大学 | 可消除泊洛沙姆起昙现象的组合物及其在药物制剂中的应用 |
CN105078993B (zh) * | 2015-08-26 | 2019-02-22 | 浙江大果生物医药科技有限公司 | 一种吲唑类化合物组合物及其制备方法和应用 |
CN106852908A (zh) * | 2015-12-03 | 2017-06-16 | 康普药业股份有限公司 | 一种辅酶q10葡萄糖注射液及制备方法 |
CN107929246B (zh) * | 2017-11-23 | 2020-10-27 | 广州领衔生物科技有限公司 | 抗氧化辅酶q10冻干粉及其生产工艺 |
CN111494225A (zh) * | 2020-03-04 | 2020-08-07 | 广州鸿懿实业发展有限公司 | 艾地苯醌冻干粉及其制备方法 |
CN111982763B (zh) * | 2020-08-17 | 2021-05-14 | 上海普康药业有限公司 | 一种辅酶 q10 的粒度及粒度分布测定方法 |
CN112370442B (zh) * | 2020-12-15 | 2022-03-01 | 浙江工业大学 | 一种辅酶q10药物递送系统及其制备方法 |
CN115487140B (zh) * | 2022-09-26 | 2023-08-29 | 马鞍山丰原制药有限公司 | 一种辅酶q10注射剂及制备方法 |
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CN1525850A (zh) * | 2001-04-12 | 2004-09-01 | ά���ѿ��ع�˾ | 含有辅酶q10的微乳剂预浓缩物和微乳剂 |
WO2006110924A2 (en) * | 2005-04-14 | 2006-10-19 | Jarrow Formulas, Inc. | Dietary supplement formulations for improved delivery of coenzyme q10 and methods of administration |
CN101278907A (zh) * | 2008-05-28 | 2008-10-08 | 喻文涛 | 一种辅酶q10注射液 |
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WO2006110924A2 (en) * | 2005-04-14 | 2006-10-19 | Jarrow Formulas, Inc. | Dietary supplement formulations for improved delivery of coenzyme q10 and methods of administration |
CN101278907A (zh) * | 2008-05-28 | 2008-10-08 | 喻文涛 | 一种辅酶q10注射液 |
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