CN109010292A - 一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 - Google Patents
一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 Download PDFInfo
- Publication number
- CN109010292A CN109010292A CN201811091550.3A CN201811091550A CN109010292A CN 109010292 A CN109010292 A CN 109010292A CN 201811091550 A CN201811091550 A CN 201811091550A CN 109010292 A CN109010292 A CN 109010292A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- water
- parenteral nutrition
- nutrition agent
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
时间(min) | 流动相A% | 流动相B% |
0 | 90.0 | 10.0 |
5 | 90.0 | 10.0 |
20 | 80.0 | 20.0 |
25 | 80.0 | 20.0 |
30 | 90.0 | 10.0 |
时间(min) | 流动相A% | 流动相B% | 流动相C% | 流动相D% |
0 | 5 | 50 | 25 | 20 |
10 | 5 | 50 | 25 | 20 |
20 | 15 | 50 | 25 | 0 |
30 | 15 | 50 | 25 | 0 |
35 | 5 | 50 | 25 | 20 |
40 | 5 | 50 | 25 | 20 |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811091550.3A CN109010292B (zh) | 2018-09-19 | 2018-09-19 | 一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811091550.3A CN109010292B (zh) | 2018-09-19 | 2018-09-19 | 一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109010292A true CN109010292A (zh) | 2018-12-18 |
CN109010292B CN109010292B (zh) | 2020-03-17 |
Family
ID=64617191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811091550.3A Active CN109010292B (zh) | 2018-09-19 | 2018-09-19 | 一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109010292B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10656059B2 (en) | 2018-03-07 | 2020-05-19 | Alcala Pharmaceutical, Inc. | Method for qualitative and quantitative multiplexing of drug analytes from biological samples |
CN111505184A (zh) * | 2020-05-26 | 2020-08-07 | 费森尤斯卡比华瑞制药有限公司 | 一种含有多种维生素的冻干粉针剂成分测定方法 |
CN112336870A (zh) * | 2020-12-03 | 2021-02-09 | 温州医科大学 | 一种眼部各类维生素协同起效的缓释体系及其制备方法 |
EP3973949A1 (en) | 2020-09-25 | 2022-03-30 | Baxter International Inc | Stabilization of vitamin a in a nutritional solution |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104337829A (zh) * | 2014-05-29 | 2015-02-11 | 西安力邦肇新生物科技有限公司 | 一瓶装脂微乳复合13种维生素冻干制剂 |
CN104706643A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种脂溶性维生素注射浓缩液(ⅰ)、其制备方法及用途 |
-
2018
- 2018-09-19 CN CN201811091550.3A patent/CN109010292B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104706643A (zh) * | 2013-12-16 | 2015-06-17 | 天津迈迪瑞康生物医药科技有限公司 | 一种脂溶性维生素注射浓缩液(ⅰ)、其制备方法及用途 |
CN104337829A (zh) * | 2014-05-29 | 2015-02-11 | 西安力邦肇新生物科技有限公司 | 一瓶装脂微乳复合13种维生素冻干制剂 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10656059B2 (en) | 2018-03-07 | 2020-05-19 | Alcala Pharmaceutical, Inc. | Method for qualitative and quantitative multiplexing of drug analytes from biological samples |
US11054349B2 (en) | 2018-03-07 | 2021-07-06 | Alcala Pharmaceutical, Inc. | Method for preparation of dried blood sample for multiplexing of analytes |
CN111505184A (zh) * | 2020-05-26 | 2020-08-07 | 费森尤斯卡比华瑞制药有限公司 | 一种含有多种维生素的冻干粉针剂成分测定方法 |
EP3973949A1 (en) | 2020-09-25 | 2022-03-30 | Baxter International Inc | Stabilization of vitamin a in a nutritional solution |
WO2022063956A1 (en) | 2020-09-25 | 2022-03-31 | Baxter International Inc. | Stabilization of vitamin a in a nutritional solution |
CN112336870A (zh) * | 2020-12-03 | 2021-02-09 | 温州医科大学 | 一种眼部各类维生素协同起效的缓释体系及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN109010292B (zh) | 2020-03-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109010292A (zh) | 一种多种维生素肠外营养剂毫微球冻干注射剂及其制备方法 | |
US6528067B1 (en) | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof | |
CN103961364A (zh) | 含有多种维生素的药物组合物及其制备方法和检测方法 | |
CN102068453B (zh) | 一种稳定的复合维生素组合物及其制备方法 | |
CN102805728B (zh) | 一种丙泊酚脂肪乳注射液及其制备方法 | |
CN101480381B (zh) | 一种辅酶q10药物组合物 | |
JP2002502811A (ja) | 亜硫酸塩を含有するプロポフォール組成物 | |
EP1332755A1 (en) | Taxol liposome composition for treatment of cancer and preparation thereof | |
WO2022160971A1 (zh) | 一种含有难溶性药物的浓缩液以及由其制备的乳剂 | |
CN104940939B (zh) | 大剂量甘油在可耐受冻融脂肪乳剂中的应用 | |
WO2016177346A1 (zh) | 一种卡巴他赛脂肪乳注射剂及其制备方法和用途 | |
CN101897668A (zh) | 一种奥沙利铂脂质体及其制备方法和用途 | |
CN115105472A (zh) | 一种用于口腔粘膜给药的纳米混悬剂及其制造方法 | |
CN107441044A (zh) | 一种纳米脂肪乳剂 | |
CN101708156B (zh) | 一种喜树碱类药物注射溶液及其注射剂和制备方法 | |
CN103816120B (zh) | 含有维生素k1的脂肪乳剂 | |
CN103735514A (zh) | 一种聚乙二醇维生素e琥珀酸酯和钙网蛋白修饰的纳米粒及其制备方法 | |
CN105287406A (zh) | 一种丙泊酚脂质体冻干制剂及其制备方法 | |
CN113350312B (zh) | 一种辅酶q10纳米胶囊及其制备方法与应用 | |
CN110721155A (zh) | 一种长效载药脂肪乳制剂及其制备方法 | |
CN114869904B (zh) | 复方维生素自乳化给药系统及其制备方法 | |
JP3155312B2 (ja) | 安定な静脈注射用総合ビタミン剤 | |
CN103385851B (zh) | 用于抗癌的可注射用药物组合物 | |
CN107519187B (zh) | 一种脂溶性维生素冻干乳的制备方法 | |
RU2370258C2 (ru) | Фармацевтическая композиция для парентеральной доставки в форме лиофилизата и способ ее получения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20181218 Assignee: Jiangxi Yiyao Pharmaceutical Co.,Ltd. Assignor: GUANGZHOU HANGUANG PHARMACEUTICAL CO.,LTD. Contract record no.: X2022440000225 Denomination of invention: A multi vitamin parenteral nutrition nanospheres freeze-dried injection and its preparation method Granted publication date: 20200317 License type: Common License Record date: 20221012 |
|
EE01 | Entry into force of recordation of patent licensing contract | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A multi vitamin parenteral nutrition nano microsphere freeze-dried injection and its preparation method Effective date of registration: 20230621 Granted publication date: 20200317 Pledgee: Development Zone sub branch of Bank of Guangzhou Co.,Ltd. Pledgor: GUANGZHOU HANGUANG PHARMACEUTICAL CO.,LTD. Registration number: Y2023980045134 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |