CN102068453B - 一种稳定的复合维生素组合物及其制备方法 - Google Patents
一种稳定的复合维生素组合物及其制备方法 Download PDFInfo
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含量 | 实施例18 | 实施例19 | 实施例20 | 实施例2 | 施尼维他 |
维生素A棕榈酸酯 | 97.9% | 97.8% | 97.5% | 97.9% | 97.8% |
维生素D3 | 79.1% | 85.4% | 97.3% | 96.8% | 82.9% |
消旋α-生育酚 | 83.9% | 90.8% | 96.7% | 97.0% | 91.8% |
维生素C | 88.7% | 94.7% | 95.7% | 95.3% | 90.9% |
烟酰胺 | 98.2% | 98.8% | 98.5% | 98.3% | 97.5% |
右泛醇 | 98.6% | 98.1% | 98.4% | 98.3% | 96.9% |
维生素B6 | 97.2% | 97.1% | 96.8% | 97.0% | 94.6% |
核黄素磷酸钠 | 97.4% | 97.1% | 97.9% | 97.8% | 92.7% |
四水合辅羧酶 | 97.6% | 97.2% | 96.8% | 96.6% | 92.9% |
叶酸 | 95.0% | 96.0% | 94.8% | 94.1% | 92.6% |
生物素 | 98.8% | 98.7% | 98.5% | 98.7% | 95.7% |
维生素B12 | 80.6% | 83.2% | 86.4% | 85.3% | 80.6% |
含量 | 实施例21 | 实施例22 | 实施例23 | 实施例24 |
维生素A棕榈酸酯 | 98.1% | 97.4% | 97.5% | 97.8% |
维生素D3 | 96.0% | 96.8% | 95.9% | 61.3% |
消旋α-生育酚 | 94.6% | 95.3% | 96.1% | 48.9% |
维生素C | 94.7% | 95.6% | 95.6% | 76.4% |
烟酰胺 | 97.2% | 98.0% | 98.4% | 99.6% |
右泛醇 | 99.0% | 99.2% | 98.6% | 98.7% |
维生素B6 | 97.5% | 95.8% | 96.8% | 98.5% |
核黄素磷酸钠 | 96.6% | 96.1% | 97.5% | 96.4% |
四水合辅羧酶 | 97.5% | 96.3% | 96.7% | 98.0% |
叶酸 | 92.8% | 94.2% | 95.4% | 94.5% |
生物素 | 98.4% | 97.9% | 98.4% | 93.9% |
维生素B12 | 85.2% | 86.0% | 87.1% | 75.5% |
指标 | 实施例1 | 实施例2 | 实施例3 | 施尼维他 |
维生素D3 | 99.7 | 98.6 | 97.1 | 82.1 |
消旋α-生育酚 | 98.4 | 98.7 | 98.8 | 94.1 |
维生素A棕榈酸酯 | 99.5 | 99.7 | 100.2 | 99.4 |
维生素C | 93.5 | 96.1 | 96.5 | 89.6 |
烟酰胺 | 99.4 | 99.2 | 98.6 | 98.4 |
维生素B6 | 98.6 | 98.1 | 99.1 | 94.6 |
右泛醇 | 99.7 | 101.7 | 98.2 | 97.8 |
维生素B1 | 98.6 | 99.8 | 99.6 | 94.3 |
核黄素磷酸钠 | 98.3 | 96.4 | 97.0 | 91.2 |
叶酸 | 98.5 | 98.0 | 99.5 | 89.0 |
生物素 | 98.6 | 99.7 | 99.1 | 96.5 |
维生素B12 | 89.7 | 87.7 | 90.8 | 80.2 |
指标 | 实施例1 | 实施例2 | 实施例3 |
维生素D3 | 98.7 | 99.3 | 99.2 |
消旋α-生育酚 | 98.2 | 98.1 | 98.7 |
维生素A棕榈酸酯 | 99.7 | 99.8 | 98.6 |
维生素C | 98.3 | 98.4 | 99.9 |
烟酰胺 | 99.5 | 99.2 | 98.3 |
维生素B6 | 99.1 | 98.6 | 99.2 |
右泛醇 | 100.4 | 101.3 | 99.5 |
维生素B1 | 99.2 | 99.4 | 99.2 |
核黄素磷酸钠 | 98.0 | 99.5 | 97.3 |
叶酸 | 98.7 | 99.0 | 98.1 |
生物素 | 101.8 | 99.7 | 98.6 |
维生素B12 | 92.8 | 93.4 | 97.1 |
1 | 2 | 3 | 4 | 5 | 6 | 对照 | |
供试品(ml) | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | ||
生理盐水(ml) | 2.4 | 2.3 | 2.2 | 2.1 | 2.0 | 2.5 | 蒸馏水 |
2%细胞悬液(ml) | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
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CN2010102739791A CN102068453B (zh) | 2009-11-23 | 2010-09-07 | 一种稳定的复合维生素组合物及其制备方法 |
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CN200910238023A CN101711769A (zh) | 2009-11-23 | 2009-11-23 | 一种稳定的注射用12种复合维生素组合物及其制备方法 |
CN2010102739791A CN102068453B (zh) | 2009-11-23 | 2010-09-07 | 一种稳定的复合维生素组合物及其制备方法 |
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Cited By (1)
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WO2014016277A3 (de) * | 2012-07-24 | 2014-04-10 | Azoba Health Care Ag | Vitaminzubereitung |
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CN102526075B (zh) * | 2010-12-07 | 2014-04-30 | 西藏海思科药业集团股份有限公司 | 一种脂溶性维生素冻干针剂及其制备方法 |
CN102657662B (zh) * | 2012-04-18 | 2013-05-08 | 宁辉 | 脂溶性复合维生素ⅱ组合物、冻干粉针剂及其制备方法 |
CN103006683A (zh) * | 2013-01-11 | 2013-04-03 | 山西普德药业股份有限公司 | 注射用12种复合维生素药物组合物及制备方法 |
CN103536528B (zh) * | 2013-10-25 | 2015-04-01 | 江西国药有限责任公司 | 一种核黄素磷酸钠注射液及其制备工艺 |
CN106153796A (zh) * | 2015-04-17 | 2016-11-23 | 西藏卫信康医药股份有限公司 | 注射用12种复合维生素的含量分析检测方法 |
CN108420797B (zh) * | 2018-05-09 | 2022-05-03 | 南京海融制药有限公司 | 维生素d类似物制剂及其制备方法 |
JP2020196672A (ja) * | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンb12類含有組成物 |
CN113016875B (zh) * | 2021-02-09 | 2021-11-19 | 赣州市全标生物科技有限公司 | 一种氮气介导三级稳态保护的婴幼儿辅食营养包与其制备方法 |
CN112841319B (zh) * | 2021-02-09 | 2021-11-19 | 赣州市全标生物科技有限公司 | 一种全程氮气介导下的婴幼儿辅食营养包与其制备方法 |
CN113368064B (zh) * | 2021-06-08 | 2022-06-28 | 吉林津升制药有限公司 | 一种烟酸冻干粉及其制备方法 |
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US3914419A (en) * | 1973-08-02 | 1975-10-21 | American Cyanamid Co | Two compartment one unit consecutively injectable liquid vitamin package |
JPS6238A (ja) * | 1985-03-12 | 1987-01-06 | Sankyo Co Ltd | 混合ビタミン凍結乾燥製剤の製法 |
JPH062664B2 (ja) * | 1987-11-17 | 1994-01-12 | 日本化薬株式会社 | 安定な総合ビタミン凍結乾燥製剤 |
CN1879648A (zh) * | 2005-06-19 | 2006-12-20 | 青岛众智医药科技有限公司 | 一种多种维生素冻干制剂及其制备方法 |
CN101537012B (zh) * | 2009-04-24 | 2010-07-21 | 武汉普生制药有限公司 | 一种复合维生素冻干粉针及其制备方法 |
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