KR100849537B1 - 코엔자임 큐텐의 나노에멀젼 조성물 - Google Patents
코엔자임 큐텐의 나노에멀젼 조성물 Download PDFInfo
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- KR100849537B1 KR100849537B1 KR1020070067217A KR20070067217A KR100849537B1 KR 100849537 B1 KR100849537 B1 KR 100849537B1 KR 1020070067217 A KR1020070067217 A KR 1020070067217A KR 20070067217 A KR20070067217 A KR 20070067217A KR 100849537 B1 KR100849537 B1 KR 100849537B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
Abstract
Description
성상 | 안정성(코엔자임큐텐 함량%) | |||||||
상온 | 고온(45℃) | |||||||
층분리 | 석출 | 초기 | 1년 | 2년 | 초기 | 1년 | 2년 | |
실시예 1 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 2 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 3 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 4 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 5 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 6 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
실시예 7 | 양호 | 양호 | 100 | 100 | 100 | 100 | 100 | 100 |
Claims (7)
- 코엔자임 큐텐(Coenzyme Q10) 5-20중량%, 에탄올 1-5중량%, 레시틴 1-5중량%, 카프릴릭/카프릭글리세라이드 20-30중량%, 글리세린 10-20중량%, 보조유화제 1-15중량%, 및 물(balance)을 포함하는 코엔자임큐텐의 나노에멀젼 조성물.
- 제 1 항에 있어서,상기 보조유화제는 폴리솔베이트 20(Polyoxyethylene(20) sorbitan monolaurate), 폴리솔베이트 80(Polyoxyethylene(20) sorbitan monooleate), 음이온성 아미노산계열의 유화제, 슈가에스테르, 콜레스테롤 및 소듐라우릴설페이트(sodium lauryl sulfate)로 이루어진 군에서 선택되는 1 이상의 물질인 코엔자임큐텐의 나노에멀젼 조성물.
- 제 2 항에 있어서,상기 음이온성 아미노산계열의 유화제는 티이에이 코코일글루타메이트(TEA cocoyl glutamate), 소듐글루타메이트(sodium glutamate), 소듐코코일글루타메이트(sodium cocoyl glutamate), 마그네슘 코코일글루타메이트, 및 소듐라우로일글루 타메이트(sodium lauroyl glutamate)로 이루어진 군에서 선택되는 1 이상의 물질인 코엔자임큐텐의 나노에멀젼 조성물.
- 코엔자임 큐텐(Coenzyme Q10) 5-20중량%, 에탄올 1-5중량%, 카프릴릭/카프릭글리세라이드(Caprylic/Capric Glyceride) 20-30중량%, 유화제 1-25중량%, 글리세린 10-20중량% 및 물(balance)을 포함하는 코엔자임큐텐의 나노에멀젼 조성물.
- 제 4 항에 있어서,상기 유화제는 폴리솔베이트 20(Polyoxyethylene(20) sorbitan monolaurate), 폴리솔베이트 80(Polyoxyethylene(20) sorbitan monooleate), 음이온성 아미노산계열의 유화제, 슈가에스테르, 콜레스테롤 및 소듐라우릴설페이트(sodium lauryl sulfate)로 이루어진 군에서 선택되는 1 이상의 물질인 코엔자임큐텐의 나노에멀젼 조성물.
- 제 5 항에 있어서,상기 음이온성 아미노산계열의 유화제는 티이에이 코코일글루타메이트(TEA cocoyl glutamate), 소듐글루타메이트(sodium glutamate), 소듐코코일글루타메이트(sodium cocoyl glutamate), 마그네슘 코코일글루타메이트, 및 소듐라우로일글루타메이트(sodium lauroyl glutamate)로 이루어진 군에서 선택되는 1 이상의 물질인 코엔자임 큐텐의 나노에멀젼 조성물.
- 제 1 항 내지 제 6 항 중 어느 한 항에 있어서,점도가 1.0 내지 15cPs(센티포아즈)인 코엔자임 큐텐의 나노에멀젼 조성물.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070067217A KR100849537B1 (ko) | 2007-07-04 | 2007-07-04 | 코엔자임 큐텐의 나노에멀젼 조성물 |
US12/666,330 US8372395B2 (en) | 2007-07-04 | 2008-04-24 | Nano-emulsion composition of coenzyme Q10 |
CN200880022497XA CN101686924B (zh) | 2007-07-04 | 2008-04-24 | 辅酶q10的纳米乳液组合物 |
EP08753148.9A EP2160180B1 (en) | 2007-07-04 | 2008-04-24 | Nano-emulsion composition of coenzyme q10 |
PCT/KR2008/002311 WO2009005215A1 (en) | 2007-07-04 | 2008-04-24 | Nano-emulsion composition of coenzyme q10 |
JP2010514592A JP5171947B2 (ja) | 2007-07-04 | 2008-04-24 | コエンザイムq10のナノ−エマルジョン組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020070067217A KR100849537B1 (ko) | 2007-07-04 | 2007-07-04 | 코엔자임 큐텐의 나노에멀젼 조성물 |
Publications (1)
Publication Number | Publication Date |
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KR100849537B1 true KR100849537B1 (ko) | 2008-07-31 |
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Application Number | Title | Priority Date | Filing Date |
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KR1020070067217A KR100849537B1 (ko) | 2007-07-04 | 2007-07-04 | 코엔자임 큐텐의 나노에멀젼 조성물 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8372395B2 (ko) |
EP (1) | EP2160180B1 (ko) |
JP (1) | JP5171947B2 (ko) |
KR (1) | KR100849537B1 (ko) |
CN (1) | CN101686924B (ko) |
WO (1) | WO2009005215A1 (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010016686A2 (ko) * | 2008-08-06 | 2010-02-11 | 주식회사 에델프라우 | 국소 투여용 나노에멀젼 |
KR20140021467A (ko) * | 2010-03-12 | 2014-02-20 | 베르그 엘엘씨 | 코엔자임 Q10(CoQ10)의 정맥내 제형 및 이의 사용 방법 |
WO2017030409A1 (ko) * | 2015-08-20 | 2017-02-23 | 코스맥스 주식회사 | 레시틴 및 소듐디라우라미도글루타미이드라이신을 함유하는 블루에멀젼 조성물 |
KR20230158671A (ko) | 2022-05-11 | 2023-11-21 | 주식회사 보고신약 | 수용성 코엔자임큐텐 및 이의 제조방법 |
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DK2548456T3 (en) | 2008-03-20 | 2015-09-28 | Virun Inc | Emulsions including (comprising) a PEG derivative of tocopherol |
BRPI0909185A2 (pt) * | 2008-03-20 | 2015-08-25 | Virun Inc | Derivado de vitamina e e seus usos |
WO2010008475A2 (en) * | 2008-06-23 | 2010-01-21 | Virun, Inc. | Compositions containing nono-polar compounds |
EP2309879B1 (en) * | 2008-07-15 | 2016-03-30 | Comstock, Robert Lawrence | Improved emulsifying system for nutraceutical composition |
KR100913689B1 (ko) * | 2009-02-20 | 2009-08-24 | 화일약품주식회사 | 공액리놀레산 함유 수성 나노에멀젼 조성물 |
CA2761717A1 (en) | 2009-05-11 | 2010-11-18 | Berg Biosystems, Llc | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
RU2411027C1 (ru) * | 2009-06-24 | 2011-02-10 | Пация Мераби Георгиевич | Нанодисперсная композиция с коэнзимом q10 и способ ее получения |
US9320295B2 (en) * | 2010-03-23 | 2016-04-26 | Virun, Inc. | Compositions containing non-polar compounds |
WO2011162802A1 (en) | 2010-06-21 | 2011-12-29 | Virun, Inc. | Compositions containing non-polar compounds |
JP6189749B2 (ja) * | 2010-06-23 | 2017-08-30 | ブライトサイド イノベーションズ,インコーポレイティド | レシチン担体小胞とその作製方法 |
CN102293753B (zh) * | 2010-06-25 | 2014-03-12 | 沈阳药科大学 | 辅酶q10纳米混悬剂冻干组合物及其制备方法和应用 |
BRPI1002486B1 (pt) * | 2010-07-22 | 2017-07-18 | Evidence Soluções Farmacêuticas Ltda Epp | Stabilized topical composition and process of obtaining composition stable topic |
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US10973763B2 (en) | 2011-06-17 | 2021-04-13 | Berg Llc | Inhalable pharmaceutical compositions |
JP2014520541A (ja) * | 2011-07-15 | 2014-08-25 | プレイオン | 透明な栄養マイクロエマルジョンの配合物 |
WO2013120025A1 (en) | 2012-02-10 | 2013-08-15 | Virun, Inc. | Beverage compositions containing non-polar compounds |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
MX2015014097A (es) | 2013-04-08 | 2016-06-07 | Berg Llc | Tratamiento de cancer empleando terapias combinadas de coenzima q10. |
WO2014188861A1 (ja) | 2013-05-20 | 2014-11-27 | ユーハ味覚糖株式会社 | ユビキノール高含有ゲル状組成物 |
IL276423B2 (en) | 2013-09-04 | 2024-05-01 | Berg Llc | Pharmaceutical preparations containing coenzyme Q10 for use in cancer treatment |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
WO2017182264A1 (en) | 2016-04-21 | 2017-10-26 | Unilever Plc | Novel nanoemulsions comprising fatty acid and n-acyl derivatives of amino acid salt |
EP3290026A1 (en) | 2016-09-06 | 2018-03-07 | Athenion AG | Method for solubilizing poorly water-soluble dietary supplements and pharmaceutically active agents |
CN108175746A (zh) * | 2016-12-08 | 2018-06-19 | 江苏金甙生物技术有限公司 | 一种n-乙酰半胱氨酸纳米乳液药物制剂及其制备方法 |
CN107693397A (zh) * | 2017-09-15 | 2018-02-16 | 成都迷艾化妆品有限公司 | 一种隔离遮瑕bb霜及其制备方法 |
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Also Published As
Publication number | Publication date |
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EP2160180A1 (en) | 2010-03-10 |
EP2160180A4 (en) | 2013-08-07 |
WO2009005215A1 (en) | 2009-01-08 |
US8372395B2 (en) | 2013-02-12 |
US20110008305A1 (en) | 2011-01-13 |
CN101686924A (zh) | 2010-03-31 |
EP2160180B1 (en) | 2016-11-09 |
CN101686924B (zh) | 2013-01-23 |
JP5171947B2 (ja) | 2013-03-27 |
JP2010530904A (ja) | 2010-09-16 |
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