JPS56109590A - Production of clathrate compound of coenzyme q10 - Google Patents

Production of clathrate compound of coenzyme q10

Info

Publication number
JPS56109590A
JPS56109590A JP1258680A JP1258680A JPS56109590A JP S56109590 A JPS56109590 A JP S56109590A JP 1258680 A JP1258680 A JP 1258680A JP 1258680 A JP1258680 A JP 1258680A JP S56109590 A JPS56109590 A JP S56109590A
Authority
JP
Japan
Prior art keywords
coenzyme
cyclodextrin
clathrate
solution
1mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1258680A
Other languages
Japanese (ja)
Inventor
Yasuo Yonezawa
Kazuo Matsuda
Kaname Takagi
Hideo Tokugawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZERIA SHINYAKU KOGYO KK
Zeria Pharmaceutical Co Ltd
Original Assignee
ZERIA SHINYAKU KOGYO KK
Zeria Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZERIA SHINYAKU KOGYO KK, Zeria Pharmaceutical Co Ltd filed Critical ZERIA SHINYAKU KOGYO KK
Priority to JP1258680A priority Critical patent/JPS56109590A/en
Publication of JPS56109590A publication Critical patent/JPS56109590A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: One mole of coenzyme Q10 is incuded in 1mol of β- or γ-cyclodextrin to form a water-soluble clathrate, resulting in coenzyme Q10 with increased stability to light and oxygen in the air.
CONSTITUTION: To an aqueous saturated solution of β- or γ-cyclodextrin, is added a solution of 1mol of coenzyme Q10/mol of the cyclodextrin in ether, iso-octane or their mixture and they are stirred. Then, the solution is stood under cooling to 5°C. The precipitate is filtered and dried with air or under reduced pressure to give a powder, that is, the objective clathrate. the resultant clathrate is identified by differential thermal analysis and melting point. In the differential thermal analysis of coenzyme Q10, a sharp endothermal peak caused by melting is observed near to 50°C.
COPYRIGHT: (C)1981,JPO&Japio
JP1258680A 1980-02-05 1980-02-05 Production of clathrate compound of coenzyme q10 Pending JPS56109590A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1258680A JPS56109590A (en) 1980-02-05 1980-02-05 Production of clathrate compound of coenzyme q10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1258680A JPS56109590A (en) 1980-02-05 1980-02-05 Production of clathrate compound of coenzyme q10

Publications (1)

Publication Number Publication Date
JPS56109590A true JPS56109590A (en) 1981-08-31

Family

ID=11809452

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1258680A Pending JPS56109590A (en) 1980-02-05 1980-02-05 Production of clathrate compound of coenzyme q10

Country Status (1)

Country Link
JP (1) JPS56109590A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1174109A3 (en) * 2000-07-21 2004-01-07 Beiersdorf Aktiengesellschaft Combinations of active substances respectively adducts from cyclodextrins and at least a quinone and/or at least a hydroquinone and use of such combinations of active substances in cosmetic preparations
WO2005111224A3 (en) * 2004-05-18 2006-06-08 Kemijski Inst Water-soluble coenzyme q10 in inclusion complex with beta-cyclodextrin, process of preparing, and use thereof
JPWO2005041945A1 (en) * 2003-10-31 2007-04-26 株式会社カネカ Composition containing reduced coenzyme Q
WO2008007415A1 (en) * 2006-07-10 2008-01-17 Kanehide Bio Co., Ltd. Inclusion coenzyme q10 and method of producing inclusion coenzyme q10
WO2011112900A2 (en) 2010-03-12 2011-09-15 Cytotech Labs, Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1174109A3 (en) * 2000-07-21 2004-01-07 Beiersdorf Aktiengesellschaft Combinations of active substances respectively adducts from cyclodextrins and at least a quinone and/or at least a hydroquinone and use of such combinations of active substances in cosmetic preparations
US6825179B2 (en) 2000-07-21 2004-11-30 Beiersdorf Ag Active ingredient combinations or adducts of cyclodextrins and quinones
JPWO2005041945A1 (en) * 2003-10-31 2007-04-26 株式会社カネカ Composition containing reduced coenzyme Q
JP4732898B2 (en) * 2003-10-31 2011-07-27 株式会社カネカ Composition containing reduced coenzyme Q
WO2005111224A3 (en) * 2004-05-18 2006-06-08 Kemijski Inst Water-soluble coenzyme q10 in inclusion complex with beta-cyclodextrin, process of preparing, and use thereof
WO2008007415A1 (en) * 2006-07-10 2008-01-17 Kanehide Bio Co., Ltd. Inclusion coenzyme q10 and method of producing inclusion coenzyme q10
JPWO2008007415A1 (en) * 2006-07-10 2009-12-10 金秀バイオ株式会社 Inclusion Coenzyme Q10 and Method for Producing Inclusion Coenzyme Q10
WO2011112900A2 (en) 2010-03-12 2011-09-15 Cytotech Labs, Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
EP3366280A1 (en) 2010-03-12 2018-08-29 Berg LLC Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof

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