JP5959541B2 - Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン - Google Patents

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Publication number

JP5959541B2

JP5959541B2 JP2013555571A JP2013555571A JP5959541B2 JP 5959541 B2 JP5959541 B2 JP 5959541B2 JP 2013555571 A JP2013555571 A JP 2013555571A JP 2013555571 A JP2013555571 A JP 2013555571A JP 5959541 B2 JP5959541 B2 JP 5959541B2

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JP

Japan

Prior art keywords

formula

compound

fluorophenyl

cancer

independently selected

Prior art date

2011-02-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 101000850794 Homo sapiens Tropomyosin alpha-3 chain Proteins 0.000 title description 7
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• 125000005843 halogen group Chemical group 0.000 claims description 61
• RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 59
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• MYBGMWWPJXLDCY-MAUKXSAKSA-N 5-[(2r,4s)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]-n-(2-hydroxyethyl)pyrazolo[1,5-a]pyridine-3-carboxamide Chemical compound C1([C@H]2C[C@H](F)CN2C=2C=CN3N=CC(=C3C=2)C(=O)NCCO)=CC=CC(F)=C1 MYBGMWWPJXLDCY-MAUKXSAKSA-N 0.000 claims description 2
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• VTNKTKYDHACWHN-XJKSGUPXSA-N 5-[(2r,4s)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyridine-3-carboxylic acid Chemical compound C1([C@H]2C[C@H](F)CN2C=2C=CN3N=CC(=C3C=2)C(=O)O)=CC=CC(F)=C1 VTNKTKYDHACWHN-XJKSGUPXSA-N 0.000 claims description 2
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• SDPMFLLMNLIZHR-XJKSGUPXSA-N [5-[(2r,4s)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyridin-3-yl]urea Chemical compound C1([C@H]2C[C@H](F)CN2C=2C=CN3N=CC(=C3C=2)NC(=O)N)=CC=CC(F)=C1 SDPMFLLMNLIZHR-XJKSGUPXSA-N 0.000 claims description 2
• LIGKFGZCIYEDDJ-NZQKXSOJSA-N benzyl n-[5-[(2r,4s)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyridin-3-yl]carbamate Chemical compound N1([C@H](C[C@@H](C1)F)C=1C=C(F)C=CC=1)C(=CC1=2)C=CN1N=CC=2NC(=O)OCC1=CC=CC=C1 LIGKFGZCIYEDDJ-NZQKXSOJSA-N 0.000 claims description 2
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