DOP2013000192A - Compuestos y composiciones como inhibidores de la trk - Google Patents
Compuestos y composiciones como inhibidores de la trkInfo
- Publication number
- DOP2013000192A DOP2013000192A DO2013000192A DO2013000192A DOP2013000192A DO P2013000192 A DOP2013000192 A DO P2013000192A DO 2013000192 A DO2013000192 A DO 2013000192A DO 2013000192 A DO2013000192 A DO 2013000192A DO P2013000192 A DOP2013000192 A DO P2013000192A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- trk
- compositions
- inhibitors
- abnormal
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000002074 deregulated effect Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161446572P | 2011-02-25 | 2011-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2013000192A true DOP2013000192A (es) | 2014-01-31 |
Family
ID=45815979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2013000192A DOP2013000192A (es) | 2011-02-25 | 2013-08-23 | Compuestos y composiciones como inhibidores de la trk |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9102671B2 (enExample) |
| EP (1) | EP2678338B1 (enExample) |
| JP (1) | JP5959541B2 (enExample) |
| KR (1) | KR20140014184A (enExample) |
| CN (1) | CN103492384B (enExample) |
| AP (1) | AP2013007103A0 (enExample) |
| AU (1) | AU2012220572A1 (enExample) |
| BR (1) | BR112013021638A2 (enExample) |
| CA (1) | CA2828219A1 (enExample) |
| CL (1) | CL2013002430A1 (enExample) |
| CO (1) | CO6751270A2 (enExample) |
| CR (1) | CR20130410A (enExample) |
| CU (1) | CU20130115A7 (enExample) |
| DO (1) | DOP2013000192A (enExample) |
| EA (1) | EA201391230A1 (enExample) |
| ES (1) | ES2551592T3 (enExample) |
| GE (1) | GEP20156285B (enExample) |
| GT (1) | GT201300209A (enExample) |
| IL (1) | IL227987A0 (enExample) |
| MA (1) | MA34969B1 (enExample) |
| MX (1) | MX2013009767A (enExample) |
| NI (1) | NI201300073A (enExample) |
| PE (1) | PE20140378A1 (enExample) |
| PH (1) | PH12013501758A1 (enExample) |
| SG (1) | SG192795A1 (enExample) |
| TN (1) | TN2013000348A1 (enExample) |
| WO (1) | WO2012116217A1 (enExample) |
| ZA (1) | ZA201306221B (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| BRPI0919873B8 (pt) | 2008-10-22 | 2021-05-25 | Array Biopharma Inc | compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| SMT201700372T1 (it) | 2010-05-20 | 2017-09-07 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| AU2012351748B2 (en) * | 2011-12-12 | 2016-04-14 | Dr. Reddy's Laboratories Ltd. | Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors |
| EP3628749A1 (en) | 2013-07-30 | 2020-04-01 | Blueprint Medicines Corporation | Ntrk2 fusions |
| JP2017500362A (ja) * | 2013-12-26 | 2017-01-05 | イグナイタ インコーポレイテッド | ピラゾロ［１，５−ａ］ピリジン誘導体およびその使用方法 |
| CA2934043C (en) * | 2014-02-05 | 2019-03-12 | VM Oncology LLC | Trka receptor tyrosine kinase antagonists and uses thereof |
| CN105524058B (zh) | 2014-10-21 | 2018-03-27 | 广州艾格生物科技有限公司 | 吡唑并[1,5‑a]吡啶类化合物及其应用 |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| CN104529815B (zh) * | 2014-12-04 | 2016-08-24 | 宁波欧迅化学新材料技术有限公司 | 合成2,4-二硝基苯氧胺的方法 |
| CA2987281A1 (en) * | 2015-05-29 | 2016-12-08 | Ignyta, Inc. | Compositions and methods for treating patients with rtk mutant cells |
| EP3722441A1 (en) | 2015-06-01 | 2020-10-14 | Loxo Oncology Inc. | Method of diagnosing a cancer for a treatment with a trk inhibitor |
| HRP20210177T1 (hr) | 2015-07-16 | 2021-03-19 | Array Biopharma, Inc. | Supstituirani spojevi pirazolo[1,5-a]piridina kao inhibitori ret kinaze |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| BR112018070017A2 (pt) | 2016-04-04 | 2019-02-05 | Loxo Oncology Inc | métodos de tratamento de cânceres pediátricos |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PT3439662T (pt) | 2016-04-04 | 2024-09-30 | Loxo Oncology Inc | Formulações líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| PT3458456T (pt) | 2016-05-18 | 2020-12-07 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida |
| JP2019527233A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用 |
| EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
| EP3490974B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda receptor modulators and uses thereof |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| US10829492B2 (en) | 2016-10-28 | 2020-11-10 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor |
| CN108003161B (zh) * | 2016-10-28 | 2020-10-09 | 正大天晴药业集团股份有限公司 | 神经营养因子酪氨酸激酶受体抑制剂 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CN110267960B (zh) | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| PL3674307T3 (pl) | 2017-08-23 | 2023-11-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Związek makrocykliczny zawierający ugrupowanie aminopirazolu i pirymidyny oraz kompozycja farmaceutyczna i i ch zastosowanie |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| CA3080157A1 (en) | 2017-10-26 | 2019-05-02 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| WO2019191659A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| KR102612513B1 (ko) | 2018-07-31 | 2023-12-12 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제 |
| US11964988B2 (en) | 2018-09-10 | 2024-04-23 | Array Biopharma Inc. | Fused heterocyclic compounds as RET kinase inhibitors |
| CN111171019A (zh) * | 2018-11-13 | 2020-05-19 | 上海轶诺药业有限公司 | 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途 |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| JP7209415B2 (ja) | 2019-03-19 | 2023-01-20 | セントラル チャイナ ノーマル ユニバーシティ | ピラゾロピリミジン化合物、医薬組成物、及びその使用 |
| MX2021009863A (es) | 2019-03-21 | 2021-11-12 | Onxeo | Una molecula dbait en combinacion con inhibidor de quinasa para el tratamiento del cancer. |
| SG11202112381VA (en) | 2019-05-08 | 2021-12-30 | Tyk Medicines Inc | Compound used as kinase inhibitor and application thereof |
| CN110804059B (zh) * | 2019-09-30 | 2024-03-12 | 郑州泰基鸿诺医药股份有限公司 | 氨基甲酸酯类化合物、药物组合物及其应用 |
| CN110643672A (zh) * | 2019-10-15 | 2020-01-03 | 西安交通大学 | 高表达TrkB作为新型靶点在抑制胰腺癌转移方面的医药用途 |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| CN112979654B (zh) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | 杂芳基稠环化合物、其制备方法及应用 |
| WO2021148807A1 (en) * | 2020-01-22 | 2021-07-29 | Benevolentai Bio Limited | Pharmaceutical compositions and their uses |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN112779518B (zh) * | 2020-12-17 | 2022-07-22 | 东北师范大学 | 一种高发光强度的薄膜、制备方法及其用途 |
| CN112645955B (zh) * | 2020-12-24 | 2022-11-04 | 四川国康药业有限公司 | 一种[1,2,4]三唑并[4,3-b]哒嗪类化合物及其制备方法和用途 |
| CN112979646B (zh) * | 2021-03-08 | 2022-01-14 | 北京富龙康泰生物技术有限公司 | 一种咪唑并吡啶类衍生物 |
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-
2012
- 2012-02-23 CN CN201280019867.0A patent/CN103492384B/zh not_active Expired - Fee Related
- 2012-02-23 ES ES12708450.7T patent/ES2551592T3/es active Active
- 2012-02-23 GE GEAP201213241A patent/GEP20156285B/en unknown
- 2012-02-23 MX MX2013009767A patent/MX2013009767A/es not_active Application Discontinuation
- 2012-02-23 EP EP12708450.7A patent/EP2678338B1/en active Active
- 2012-02-23 MA MA36253A patent/MA34969B1/fr unknown
- 2012-02-23 AU AU2012220572A patent/AU2012220572A1/en not_active Abandoned
- 2012-02-23 US US14/000,578 patent/US9102671B2/en active Active
- 2012-02-23 KR KR1020137025068A patent/KR20140014184A/ko not_active Withdrawn
- 2012-02-23 EA EA201391230A patent/EA201391230A1/ru unknown
- 2012-02-23 WO PCT/US2012/026377 patent/WO2012116217A1/en not_active Ceased
- 2012-02-23 CA CA2828219A patent/CA2828219A1/en not_active Abandoned
- 2012-02-23 BR BR112013021638A patent/BR112013021638A2/pt not_active IP Right Cessation
- 2012-02-23 SG SG2013062179A patent/SG192795A1/en unknown
- 2012-02-23 JP JP2013555571A patent/JP5959541B2/ja not_active Expired - Fee Related
- 2012-02-23 PH PH1/2013/501758A patent/PH12013501758A1/en unknown
- 2012-02-23 AP AP2013007103A patent/AP2013007103A0/xx unknown
- 2012-02-23 PE PE2013001975A patent/PE20140378A1/es not_active Application Discontinuation
-
2013
- 2013-08-15 IL IL227987A patent/IL227987A0/en unknown
- 2013-08-19 TN TNP2013000348A patent/TN2013000348A1/fr unknown
- 2013-08-19 ZA ZA2013/06221A patent/ZA201306221B/en unknown
- 2013-08-22 CL CL2013002430A patent/CL2013002430A1/es unknown
- 2013-08-22 CO CO13199508A patent/CO6751270A2/es unknown
- 2013-08-23 DO DO2013000192A patent/DOP2013000192A/es unknown
- 2013-08-23 GT GT201300209A patent/GT201300209A/es unknown
- 2013-08-23 NI NI201300073A patent/NI201300073A/es unknown
- 2013-08-23 CU CU2013000115A patent/CU20130115A7/es unknown
- 2013-08-26 CR CR20130410A patent/CR20130410A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN103492384A (zh) | 2014-01-01 |
| MX2013009767A (es) | 2013-10-01 |
| TN2013000348A1 (en) | 2015-01-20 |
| AP2013007103A0 (en) | 2013-09-30 |
| PH12013501758A1 (en) | 2013-10-14 |
| JP2014506599A (ja) | 2014-03-17 |
| CL2013002430A1 (es) | 2013-11-29 |
| KR20140014184A (ko) | 2014-02-05 |
| CR20130410A (es) | 2013-10-17 |
| AU2012220572A1 (en) | 2013-08-29 |
| GT201300209A (es) | 2015-06-02 |
| EP2678338B1 (en) | 2015-09-09 |
| SG192795A1 (en) | 2013-09-30 |
| US9102671B2 (en) | 2015-08-11 |
| IL227987A0 (en) | 2013-09-30 |
| GEP20156285B (en) | 2015-05-11 |
| ZA201306221B (en) | 2014-04-30 |
| CA2828219A1 (en) | 2012-08-30 |
| CN103492384B (zh) | 2016-05-11 |
| US20130331397A1 (en) | 2013-12-12 |
| EP2678338A1 (en) | 2014-01-01 |
| EA201391230A1 (ru) | 2014-01-30 |
| PE20140378A1 (es) | 2014-03-28 |
| CO6751270A2 (es) | 2013-09-16 |
| NI201300073A (es) | 2013-12-17 |
| ES2551592T3 (es) | 2015-11-20 |
| CU20130115A7 (es) | 2013-12-27 |
| MA34969B1 (fr) | 2014-03-01 |
| BR112013021638A2 (pt) | 2016-08-02 |
| WO2012116217A1 (en) | 2012-08-30 |
| JP5959541B2 (ja) | 2016-08-02 |
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