JP5889407B2 - イオンチャネルモジュレーターとしての縮合複素環式化合物 - Google Patents

イオンチャネルモジュレーターとしての縮合複素環式化合物 Download PDF

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JP5889407B2
JP5889407B2 JP2014519190A JP2014519190A JP5889407B2 JP 5889407 B2 JP5889407 B2 JP 5889407B2 JP 2014519190 A JP2014519190 A JP 2014519190A JP 2014519190 A JP2014519190 A JP 2014519190A JP 5889407 B2 JP5889407 B2 JP 5889407B2
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Japan
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dihydrobenzo
phenyl
alkyl
aryl
oxazepin
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JP2014522847A (ja
JP2014522847A5 (enExample
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ブリトン ケネス コーキー，
ブリトン ケネス コーキー，
エルファティー エルゼイン，
エルファティー エルゼイン，
ロバート エイチ． チアン，
ロバート エイチ． チアン，
ラオ ブイ． カーラ，
ラオ ブイ． カーラ，
ドミトリー コルタン，
ドミトリー コルタン，
シャオフェン リー，
シャオフェン リー，
ルーベン マルティネス，
ルーベン マルティネス，
エリック キュー． パークヒル，
エリック キュー． パークヒル，
タオ ペリー，
タオ ペリー，
ジェフ ザブロッキ，
ジェフ ザブロッキ，
チャンドラセカール ベンカタラマニ，
チャンドラセカール ベンカタラマニ，
ミカエル グラウプ，
ミカエル グラウプ，
フアン ゲレロ，
フアン ゲレロ，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
ギリアード サイエンシーズ， インコーポレイテッド
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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JP2014519190A 2011-07-01 2012-06-29 イオンチャネルモジュレーターとしての縮合複素環式化合物 Expired - Fee Related JP5889407B2 (ja)

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US201161503980P 2011-07-01 2011-07-01
US61/503,980 2011-07-01
US201161582160P 2011-12-30 2011-12-30
US61/582,160 2011-12-30
PCT/US2012/045086 WO2013006485A1 (en) 2011-07-01 2012-06-29 Fused benzoxazepinones as ion channel modulators

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