EA201790417A2 - Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов - Google Patents

Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов

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Publication number
EA201790417A2
EA201790417A2 EA201790417A EA201790417A EA201790417A2 EA 201790417 A2 EA201790417 A2 EA 201790417A2 EA 201790417 A EA201790417 A EA 201790417A EA 201790417 A EA201790417 A EA 201790417A EA 201790417 A2 EA201790417 A2 EA 201790417A2
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Eurasian Patent Office
Prior art keywords
modulators
heterocyclic compounds
ion channels
condensed heterocyclic
compounds
Prior art date
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EA201790417A
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English (en)
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EA201790417A3 (ru
Inventor
Бриттон Кеннет Корки
Эльфатих Эльзейн
Роберт Х. Цзян
Рао В. Калла
Дмитрий Колтун
Сяофэнь Ли
Рубен Мартинес
Эрик К. Паркхилл
Тао Перри
Джефф Заблокки
Чандрасекар Венкатарамани
Майкл Грауп
Хуан Герреро
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Джилид Сайэнс, Инк.
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Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201790417A2 publication Critical patent/EA201790417A2/ru
Publication of EA201790417A3 publication Critical patent/EA201790417A3/ru

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Abstract

Настоящее изобретение относится к соединениям, представляющим собой ингибиторы натриевого канала, и к их применению в лечении различных болезненных состояний, включая сердечно-сосудистые заболевания и диабет. Согласно конкретным вариантам реализации структура соединений согласно настоящему изобретению представлена формулой Iгде Z, Z, Z, Z, X, Y, R, Rи Rтакие, как описано в описании изобретения, а также к способам получения и применения соединений согласно настоящему изобретению и к фармацевтическим композициям, содержащим указанные соединения.
EA201790417A 2011-07-01 2012-06-29 Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов EA201790417A3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161503980P 2011-07-01 2011-07-01
US201161582160P 2011-12-30 2011-12-30

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EA201790417A2 true EA201790417A2 (ru) 2017-07-31
EA201790417A3 EA201790417A3 (ru) 2017-11-30

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EA201391639A EA027356B1 (ru) 2011-07-01 2012-06-29 Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов
EA201790417A EA201790417A3 (ru) 2011-07-01 2012-06-29 Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов

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