SG11202012767UA - Inhibiting creb binding protein (cbp) - Google Patents
Inhibiting creb binding protein (cbp)Info
- Publication number
- SG11202012767UA SG11202012767UA SG11202012767UA SG11202012767UA SG11202012767UA SG 11202012767U A SG11202012767U A SG 11202012767UA SG 11202012767U A SG11202012767U A SG 11202012767UA SG 11202012767U A SG11202012767U A SG 11202012767UA SG 11202012767U A SG11202012767U A SG 11202012767UA
- Authority
- SG
- Singapore
- Prior art keywords
- cbp
- binding protein
- creb binding
- inhibiting
- inhibiting creb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862692593P | 2018-06-29 | 2018-06-29 | |
| PCT/US2018/051214 WO2019055869A1 (en) | 2017-09-15 | 2018-09-14 | Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors |
| PCT/US2018/051235 WO2019055877A1 (en) | 2017-09-15 | 2018-09-14 | Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors |
| US201962819490P | 2019-03-15 | 2019-03-15 | |
| PCT/US2019/039936 WO2020006483A1 (en) | 2018-06-29 | 2019-06-28 | Inhibiting creb binding protein (cbp) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202012767UA true SG11202012767UA (en) | 2021-01-28 |
Family
ID=68987627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202012767UA SG11202012767UA (en) | 2018-06-29 | 2019-06-28 | Inhibiting creb binding protein (cbp) |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10870648B2 (en) |
| EP (1) | EP3998266A1 (en) |
| JP (3) | JP6781806B2 (en) |
| KR (1) | KR20210025631A (en) |
| CN (2) | CN116178369A (en) |
| AU (2) | AU2019295790B2 (en) |
| BR (1) | BR112020026783A2 (en) |
| CA (1) | CA3105099A1 (en) |
| CY (1) | CY1124762T1 (en) |
| DK (1) | DK3587418T3 (en) |
| ES (1) | ES2900105T3 (en) |
| HR (1) | HRP20211698T1 (en) |
| HU (1) | HUE056885T2 (en) |
| IL (1) | IL279734A (en) |
| LT (1) | LT3587418T (en) |
| MA (1) | MA50675B1 (en) |
| MX (2) | MX2020014303A (en) |
| PL (1) | PL3587418T3 (en) |
| PT (1) | PT3587418T (en) |
| RS (1) | RS62732B1 (en) |
| SG (1) | SG11202012767UA (en) |
| SI (1) | SI3587418T1 (en) |
| WO (1) | WO2020006483A1 (en) |
| ZA (1) | ZA202100509B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020014303A (en) * | 2018-06-29 | 2021-03-25 | Forma Therapeutics Inc | Inhibiting creb binding protein (cbp). |
| BR112021018266A2 (en) * | 2019-03-15 | 2022-02-01 | Forma Therapeutics Inc | Compositions and methods for treating androgen receptor positive forms of cancer |
| US20230233558A1 (en) | 2020-06-25 | 2023-07-27 | Tolremo Therapeutics Ag | Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer |
| EP4171556A1 (en) | 2020-06-25 | 2023-05-03 | Tolremo Therapeutics AG | A combination of a cbp/p300 bromodomain inhibitor and an egfr inhibitor for use in treating egfr-mutant nsclc |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) * | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404207A (en) | 1981-11-06 | 1983-09-13 | Riker Laboratories, Inc. | Antimicrobial 8-substituted benzo [IJ]quinolizines |
| AU1868195A (en) | 1994-01-28 | 1995-08-15 | Cell Therapeutics, Inc. | Cell signaling inhibitors |
| US6011029A (en) | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| US6455564B1 (en) | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
| US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
| US7345051B2 (en) | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
| JP5355838B2 (en) | 2000-11-20 | 2013-11-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Chiral photoisomerizable compounds |
| WO2003033517A1 (en) | 2001-10-17 | 2003-04-24 | The University Of British Columbia | Ship 1 modulators |
| WO2003045929A1 (en) | 2001-11-26 | 2003-06-05 | Takeda Chemical Industries, Ltd. | Bicyclic derivative, process for producing the same, and use |
| HUP0203976A3 (en) | 2002-11-15 | 2004-08-30 | Sanofi Aventis | Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| IN2003CH00929A (en) | 2003-11-13 | 2008-10-06 | ||
| US20080188527A1 (en) | 2003-12-23 | 2008-08-07 | Cashman John R | Synthetic Compounds and Derivatives as Modulators of Smoking or Nicotine Ingestion and Lung Cancer |
| CA2562244A1 (en) | 2004-04-07 | 2005-10-27 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| WO2007120339A1 (en) | 2005-12-19 | 2007-10-25 | Genentech, Inc. | Pyrimidine kinase inhibitors |
| US20070203236A1 (en) | 2006-01-11 | 2007-08-30 | Smith Jeffrey W | Novel antagonists of the human fatty acid synthase thioesterase |
| EA200802213A1 (en) | 2006-05-09 | 2009-10-30 | Химекуэст Фармасьютикалз, Инк. | METHODS OF TREATING BLOOD DISEASES |
| EP1878724A1 (en) | 2006-07-15 | 2008-01-16 | sanofi-aventis | A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| CA2574531C (en) | 2007-01-19 | 2016-10-25 | The University Of British Columbia | Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity |
| US8476458B2 (en) | 2007-06-21 | 2013-07-02 | The Wistar Institute | Methods and compositions for modulating P300/CBP activity |
| KR20100023907A (en) | 2007-06-26 | 2010-03-04 | 사노피-아벤티스 | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| WO2009001817A1 (en) | 2007-06-27 | 2008-12-31 | Taisho Pharmaceutical Co., Ltd. | COMPOUND HAVING 11β-HSD1 INHIBITORY ACTIVITY |
| TW200930369A (en) | 2007-11-15 | 2009-07-16 | Astrazeneca Ab | Bis-(sulfonylamino) derivatives in therapy |
| AR072008A1 (en) | 2008-06-13 | 2010-07-28 | Merck & Co Inc | HETEROBICICLIC COMPOUNDS AS QUINASA P38 INHIBITION AGENTS |
| PT3289876T (en) | 2008-06-16 | 2022-10-28 | Univ Tennessee Res Found | Compounds for treatment of cancer |
| EP2412710A4 (en) * | 2009-03-27 | 2012-08-08 | Kowa Co | Fused piperidine compound and pharmaceutical agent comprising same |
| US20100305093A1 (en) | 2009-04-09 | 2010-12-02 | Exelixis, Inc. | Inhibitors of mTOR and Methods of Making and Using |
| CA2758904C (en) | 2009-04-15 | 2017-04-04 | Jw Pharmaceutical Corporation | Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof |
| MX2011012584A (en) | 2009-05-26 | 2012-02-21 | Exelixis Inc | BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE. |
| WO2010138490A1 (en) | 2009-05-26 | 2010-12-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of mtor and methods of their use and manufacture |
| WO2011085039A2 (en) | 2010-01-05 | 2011-07-14 | The Johns Hopkins University | Use of histone acetyltransferase inhibitors as novel anti-cancer therapies |
| RU2581367C2 (en) | 2010-03-01 | 2016-04-20 | Джи Ти Икс, ИНК. | Compounds for treating cancer |
| NZ705135A (en) * | 2010-05-26 | 2017-10-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| WO2012019093A1 (en) | 2010-08-05 | 2012-02-09 | Human Biomolecular Research Institute | Synthetic compounds and methods to decrease nicotine self-administration |
| ES2553610T3 (en) | 2010-12-14 | 2015-12-10 | Electrophoretics Limited | Casein kinase 1 delta inhibitors (CK1delta) |
| US8765978B2 (en) | 2010-12-16 | 2014-07-01 | Transitions Optical, Inc. | Method of making indeno-fused naphthol materials |
| WO2012116135A2 (en) | 2011-02-24 | 2012-08-30 | Emory University | Noggin blocking compositions for ossification and methods related thereto |
| UY34171A (en) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | FUSIONED HETEROCYCLIC COMPOUNDS AS IONIC CHANNEL MODULATORS |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| WO2013148114A1 (en) | 2012-03-30 | 2013-10-03 | University Of Florida Research Foundation, Inc. | P300/cbp inhibitors and methods of use |
| US9211333B2 (en) | 2012-06-05 | 2015-12-15 | Hong Kong Baptist University | Anti-cancer agents synthesized based on miliusane compounds |
| EP2897962A1 (en) | 2012-09-21 | 2015-07-29 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
| RU2543485C2 (en) | 2013-02-26 | 2015-03-10 | Андрей Александрович Иващенко | Heterocyclic tgr5 bile acid receptor agonists, pharmaceutical composition, methods for preparing and using them |
| TWI527811B (en) | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | Benzimidazole derivatives as bromodomain inhibitors |
| EA035601B1 (en) | 2013-06-21 | 2020-07-14 | Зенит Эпидженетикс Лтд. | Bicyclic bromodomain inhibitors |
| CA2915561C (en) | 2013-06-21 | 2020-09-22 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| DE102013215912B3 (en) | 2013-08-12 | 2015-02-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Color-neutral coated copper-containing article, process for its preparation and use of a corresponding color-neutral coating |
| UY35834A (en) | 2013-11-14 | 2015-05-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | PIPERAZINAS DE PIRAZOLO REPLACED AS INHIBITORS OF CASEÍNA QUINASA 1 DELTA AND EPSILON |
| US9422281B2 (en) | 2013-11-18 | 2016-08-23 | Forma Therapeutics, Inc. | Benzopiperazine compositions as BET bromodomain inhibitors |
| AU2014348191B2 (en) | 2013-11-18 | 2019-03-28 | Forma Therapeutics Inc. | Tetrahydroquinoline compositions as BET bromodomain inhibitors |
| WO2016044694A1 (en) | 2014-09-19 | 2016-03-24 | Genentech, Inc. | Use of cbp/ep300 and bet inhibitors for treatment of cancer |
| JP6771464B2 (en) * | 2014-11-27 | 2020-10-21 | ジェネンテック， インコーポレイテッド | 4,5,6,7-Tetrahydro-1H-pyrazolo [4,3-C] Pyridine-3-amine compound as CBP and / or EP300 inhibitor |
| BR112017014770A2 (en) | 2015-01-08 | 2018-01-16 | Advinus Therapeutics Ltd | bicyclic compounds, compositions and medical applications thereof |
| WO2016128908A1 (en) | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| CA3024556A1 (en) | 2016-05-12 | 2017-11-16 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| WO2017205536A2 (en) | 2016-05-24 | 2017-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201617627D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| EP3612522A4 (en) * | 2017-04-18 | 2021-07-07 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| WO2019055877A1 (en) * | 2017-09-15 | 2019-03-21 | Forma Therapeutics, Inc. | Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors |
| MX2020014303A (en) * | 2018-06-29 | 2021-03-25 | Forma Therapeutics Inc | Inhibiting creb binding protein (cbp). |
-
2019
- 2019-06-28 MX MX2020014303A patent/MX2020014303A/en unknown
- 2019-06-28 KR KR1020217002866A patent/KR20210025631A/en active Search and Examination
- 2019-06-28 SG SG11202012767UA patent/SG11202012767UA/en unknown
- 2019-06-28 WO PCT/US2019/039936 patent/WO2020006483A1/en active Application Filing
- 2019-06-28 BR BR112020026783-0A patent/BR112020026783A2/en unknown
- 2019-06-28 US US16/457,596 patent/US10870648B2/en active Active
- 2019-06-28 CA CA3105099A patent/CA3105099A1/en active Pending
- 2019-06-28 AU AU2019295790A patent/AU2019295790B2/en active Active
- 2019-06-28 CN CN202211658329.8A patent/CN116178369A/en active Pending
- 2019-06-28 CN CN201980050022.XA patent/CN112513038B/en active Active
- 2019-07-01 ES ES19183741T patent/ES2900105T3/en active Active
- 2019-07-01 HU HUE19183741A patent/HUE056885T2/en unknown
- 2019-07-01 JP JP2019123100A patent/JP6781806B2/en active Active
- 2019-07-01 DK DK19183741.8T patent/DK3587418T3/en active
- 2019-07-01 EP EP21193994.7A patent/EP3998266A1/en active Pending
- 2019-07-01 LT LTEP19183741.8T patent/LT3587418T/en unknown
- 2019-07-01 PT PT191837418T patent/PT3587418T/en unknown
- 2019-07-01 HR HRP20211698TT patent/HRP20211698T1/en unknown
- 2019-07-01 MA MA50675A patent/MA50675B1/en unknown
- 2019-07-01 RS RS20211321A patent/RS62732B1/en unknown
- 2019-07-01 PL PL19183741T patent/PL3587418T3/en unknown
- 2019-07-01 SI SI201930136T patent/SI3587418T1/en unknown
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2020
- 2020-05-28 JP JP2020093126A patent/JP7017801B2/en active Active
- 2020-06-08 US US16/946,159 patent/US11254674B2/en active Active
- 2020-12-17 JP JP2020209005A patent/JP2021042255A/en active Pending
- 2020-12-18 MX MX2023013508A patent/MX2023013508A/en unknown
- 2020-12-23 IL IL279734A patent/IL279734A/en unknown
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2021
- 2021-01-25 ZA ZA2021/00509A patent/ZA202100509B/en unknown
- 2021-11-22 CY CY20211101010T patent/CY1124762T1/en unknown
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2022
- 2022-02-10 US US17/669,112 patent/US20220162207A1/en active Pending
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2023
- 2023-09-05 AU AU2023226653A patent/AU2023226653A1/en active Pending
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