IN2003CH00929A - - Google Patents

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Publication number
IN2003CH00929A
IN2003CH00929A IN929CH2003A IN2003CH00929A IN 2003CH00929 A IN2003CH00929 A IN 2003CH00929A IN 929CH2003 A IN929CH2003 A IN 929CH2003A IN 2003CH00929 A IN2003CH00929 A IN 2003CH00929A
Authority
IN
India
Prior art keywords
sub
pcaf
mum
compounds
useful
Prior art date
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to IN929CH2003 priority Critical patent/IN2003CH00929A/en
Priority to PCT/IB2004/052294 priority patent/WO2005047457A2/en
Priority to US10/579,219 priority patent/US7402706B2/en
Priority to EP04799059A priority patent/EP1694622B1/en
Priority to AT04799059T priority patent/ATE549309T1/en
Publication of IN2003CH00929A publication Critical patent/IN2003CH00929A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Abstract

In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC<SUB>50</SUB>-1 muM) and pCAF (IC<SUB>50</SUB>-15 muM). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.
IN929CH2003 2003-11-13 2003-11-13 IN2003CH00929A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IN929CH2003 IN2003CH00929A (en) 2003-11-13 2003-11-13
PCT/IB2004/052294 WO2005047457A2 (en) 2003-11-13 2004-11-04 Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof
US10/579,219 US7402706B2 (en) 2003-11-13 2004-11-04 Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof
EP04799059A EP1694622B1 (en) 2003-11-13 2004-11-04 Polyisoprenyl benzophenones as inhibitors of histone acetyl transferases and uses thereof
AT04799059T ATE549309T1 (en) 2003-11-13 2004-11-04 POLYISOPREVONL BENZOPHENONE AS INHIBITORS OF HISTONE ACETYLTRANSDFERASES AND APPLICATIONS THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN929CH2003 IN2003CH00929A (en) 2003-11-13 2003-11-13

Publications (1)

Publication Number Publication Date
IN2003CH00929A true IN2003CH00929A (en) 2008-10-06

Family

ID=34586954

Family Applications (1)

Application Number Title Priority Date Filing Date
IN929CH2003 IN2003CH00929A (en) 2003-11-13 2003-11-13

Country Status (5)

Country Link
US (1) US7402706B2 (en)
EP (1) EP1694622B1 (en)
AT (1) ATE549309T1 (en)
IN (1) IN2003CH00929A (en)
WO (1) WO2005047457A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022254465A1 (en) * 2021-06-02 2022-12-08 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
AR057579A1 (en) * 2005-11-23 2007-12-05 Merck & Co Inc SPIROCICLICAL COMPOUNDS AS INHIBITORS OF ACETYLASE HISTONE (HDAC)
KR101005173B1 (en) * 2008-02-18 2011-01-04 인제대학교 산학협력단 Fraction from stem bark of Vietnamese medicinal plant Garcinia oblongifoliaClusiaceae and compounds isolated therefrom having antioxidant and cytotoxic activities
CN102575236B (en) * 2009-09-07 2014-10-01 贾瓦哈拉尔尼赫鲁高级科学研究中心 Inhibition of histone acetyltransferases by CTK7A and methods thereof
EP2649035B1 (en) 2010-12-09 2020-05-13 Indus Biotech Private Limited A complex of garcinol, cyclodextrin and preparation method thereof
WO2013148114A1 (en) * 2012-03-30 2013-10-03 University Of Florida Research Foundation, Inc. P300/cbp inhibitors and methods of use
GB201215942D0 (en) * 2012-09-06 2012-10-24 Glaxo Group Ltd Method of treatent
EP3614846A4 (en) * 2017-06-22 2021-01-13 Sami Labs Limited Garcinol compositions for therapeutic management of endoplasmic reticulum stress
AU2018334272B2 (en) 2017-09-15 2023-06-15 Forma Therapeutics, Inc. Tetrahydro-imidazo quinoline compositions as CBP/p300 inhibitors
MX2020014303A (en) 2018-06-29 2021-03-25 Forma Therapeutics Inc Inhibiting creb binding protein (cbp).
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08259493A (en) * 1995-03-20 1996-10-08 Sugimoto Masami Anti-mrsa active substance

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022254465A1 (en) * 2021-06-02 2022-12-08 Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) Small molecule modulator targeting a rare histone modification regulating adipogenesis and pharmaceutical formulation thereof

Also Published As

Publication number Publication date
EP1694622B1 (en) 2012-03-14
EP1694622A2 (en) 2006-08-30
US7402706B2 (en) 2008-07-22
WO2005047457B1 (en) 2005-12-01
ATE549309T1 (en) 2012-03-15
WO2005047457A3 (en) 2005-08-04
WO2005047457A2 (en) 2005-05-26
US20070254961A1 (en) 2007-11-01

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