PE20200729A1 - Inhibidores de quinasa y usos de los mismos - Google Patents
Inhibidores de quinasa y usos de los mismosInfo
- Publication number
- PE20200729A1 PE20200729A1 PE2019002424A PE2019002424A PE20200729A1 PE 20200729 A1 PE20200729 A1 PE 20200729A1 PE 2019002424 A PE2019002424 A PE 2019002424A PE 2019002424 A PE2019002424 A PE 2019002424A PE 20200729 A1 PE20200729 A1 PE 20200729A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- independently
- kinase inhibitors
- alkyl
- protein kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 abstract 1
- 206010051606 Necrotising colitis Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 208000001163 Tangier disease Diseases 0.000 abstract 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 abstract 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 208000009999 tuberous sclerosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/04—Seven-membered rings having the hetero atoms in positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Referido a un compuesto de formula I; en donde W1, W3, y W4 son CR7; W2 es N o CR7; R7 es H, halogeno, -CN, entre otros; R1a, R1b y R1c son independientemente H, halogeno, -CN, -N3, entre otros; R2a y R2b son independientemente H, halogeno, alquilo C1-C8, haloalquilo C1-C8, entre otros; R3a y R3b son independientemente H, halogeno, alquilo C1-C8, alquenilo C2-C8, entre otros; Y es O, C(O), S, S(O), entre otros; Z es C(R9)2, C(O), O, S, entre otros. Tambien se refiere a composiciones farmaceutica y un metodo para inhibir la proteina quinasa 1, que interactua con el receptor, y en el tratamiento de una enfermedad o trastorno mediado por la proteina quinasa, tales como enterocolitis necrotizante, esclerosis tuberosa, enfermedad de Tangier, entre otros.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507698P | 2017-05-17 | 2017-05-17 | |
| US201862664895P | 2018-04-30 | 2018-04-30 | |
| PCT/US2018/033266 WO2018213632A1 (en) | 2017-05-17 | 2018-05-17 | Kinase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20200729A1 true PE20200729A1 (es) | 2020-07-23 |
Family
ID=64274744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019002424A PE20200729A1 (es) | 2017-05-17 | 2018-05-17 | Inhibidores de quinasa y usos de los mismos |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11203600B2 (es) |
| EP (1) | EP3624797A4 (es) |
| JP (2) | JP7064512B2 (es) |
| KR (1) | KR102638151B1 (es) |
| CN (1) | CN110913858A (es) |
| AU (1) | AU2018269743B2 (es) |
| BR (1) | BR112019023918A2 (es) |
| CA (1) | CA3063934A1 (es) |
| CL (1) | CL2019003263A1 (es) |
| CO (1) | CO2019012957A2 (es) |
| CR (1) | CR20190566A (es) |
| DO (1) | DOP2019000290A (es) |
| EC (1) | ECSP19089214A (es) |
| IL (1) | IL270648B2 (es) |
| MX (2) | MX2019013645A (es) |
| PE (1) | PE20200729A1 (es) |
| PH (1) | PH12019550235A1 (es) |
| SG (1) | SG10201913927VA (es) |
| TW (1) | TWI794232B (es) |
| WO (1) | WO2018213632A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220072019A1 (en) * | 2018-10-19 | 2022-03-10 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with nad+ or a nad+ precursor |
| WO2021187605A1 (ja) * | 2020-03-19 | 2021-09-23 | 田辺三菱製薬株式会社 | 含窒素複素環αシアノカルボニル化合物 |
| TW202214617A (zh) | 2020-06-02 | 2022-04-16 | 法商賽諾菲公司 | 作為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途 |
| KR200493347Y1 (ko) | 2020-07-06 | 2021-03-17 | 박혜진 | 휴대가 용이한 마스크 |
| WO2022175675A1 (en) * | 2021-02-19 | 2022-08-25 | Kalvista Pharmaceuticals Limited | Factor xiia inhibitors |
| TW202340182A (zh) | 2021-11-11 | 2023-10-16 | 美商健臻公司 | 做為ｒｉｐｋ１抑制劑之異㗁唑啶及其用途 |
| WO2024025817A1 (en) * | 2022-07-25 | 2024-02-01 | Denali Therapeutics Inc. | Solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5- dihydro-2h-pyrido[3,4-f][l,4]oxazepine-9-carbonitrile |
| US20240100065A1 (en) * | 2022-08-23 | 2024-03-28 | Genzyme Corporation | Methods for treating receptor-interacting protein kinase 1-mediated diseases |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3861187B2 (ja) * | 1996-08-02 | 2006-12-20 | 住友精化株式会社 | チアゼピン誘導体の製造方法 |
| MXPA03002649A (es) | 2000-09-27 | 2003-09-25 | Ajinomoto Kk | Derivado de benzodiazepina. |
| RU2456287C1 (ru) * | 2011-05-20 | 2012-07-20 | Николай Филиппович Савчук | Стимуляторы секреции инкретиновых гормонов, способы их получения и применения |
| TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
| TWI637951B (zh) * | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
| CN104059068B (zh) * | 2013-03-20 | 2017-02-08 | 中国科学院上海药物研究所 | β‑氨基羰基类化合物、其制备方法、药物组合物及其用途 |
| WO2016126721A1 (en) * | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | 3-aryl-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| TWI730959B (zh) * | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
| PL3307739T3 (pl) * | 2015-06-15 | 2021-05-31 | Glaxosmithkline Intellectual Property Development Limited | Regulatory nrf2 |
-
2018
- 2018-05-17 PE PE2019002424A patent/PE20200729A1/es unknown
- 2018-05-17 JP JP2019563596A patent/JP7064512B2/ja active Active
- 2018-05-17 TW TW107116834A patent/TWI794232B/zh active
- 2018-05-17 CA CA3063934A patent/CA3063934A1/en active Pending
- 2018-05-17 CN CN201880047293.5A patent/CN110913858A/zh active Pending
- 2018-05-17 WO PCT/US2018/033266 patent/WO2018213632A1/en unknown
- 2018-05-17 IL IL270648A patent/IL270648B2/en unknown
- 2018-05-17 EP EP18802127.3A patent/EP3624797A4/en active Pending
- 2018-05-17 SG SG10201913927VA patent/SG10201913927VA/en unknown
- 2018-05-17 KR KR1020197036911A patent/KR102638151B1/ko active IP Right Grant
- 2018-05-17 AU AU2018269743A patent/AU2018269743B2/en active Active
- 2018-05-17 MX MX2019013645A patent/MX2019013645A/es unknown
- 2018-05-17 BR BR112019023918-9A patent/BR112019023918A2/pt unknown
- 2018-05-17 CR CR20190566A patent/CR20190566A/es unknown
-
2019
- 2019-11-13 PH PH12019550235A patent/PH12019550235A1/en unknown
- 2019-11-14 US US16/684,340 patent/US11203600B2/en active Active
- 2019-11-14 DO DO2019000290A patent/DOP2019000290A/es unknown
- 2019-11-14 MX MX2022010755A patent/MX2022010755A/es unknown
- 2019-11-14 CL CL2019003263A patent/CL2019003263A1/es unknown
- 2019-11-19 CO CONC2019/0012957A patent/CO2019012957A2/es unknown
- 2019-12-16 EC ECSENADI201989214A patent/ECSP19089214A/es unknown
-
2021
- 2021-09-09 JP JP2021146775A patent/JP7241825B2/ja active Active
- 2021-10-26 US US17/511,193 patent/US20220041620A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7064512B2 (ja) | 2022-05-10 |
| TW201900618A (zh) | 2019-01-01 |
| PH12019550235A1 (en) | 2020-07-20 |
| IL270648B1 (en) | 2023-11-01 |
| KR102638151B1 (ko) | 2024-02-16 |
| WO2018213632A1 (en) | 2018-11-22 |
| US11203600B2 (en) | 2021-12-21 |
| US20200087319A1 (en) | 2020-03-19 |
| EP3624797A4 (en) | 2021-07-21 |
| AU2018269743B2 (en) | 2024-01-11 |
| DOP2019000290A (es) | 2020-03-15 |
| CR20190566A (es) | 2020-06-14 |
| SG10201913927VA (en) | 2020-03-30 |
| JP2020520924A (ja) | 2020-07-16 |
| US20220041620A1 (en) | 2022-02-10 |
| BR112019023918A2 (pt) | 2020-06-02 |
| KR20200006125A (ko) | 2020-01-17 |
| MX2019013645A (es) | 2020-09-17 |
| IL270648A (es) | 2020-01-30 |
| MX2022010755A (es) | 2022-09-23 |
| JP2021193116A (ja) | 2021-12-23 |
| CA3063934A1 (en) | 2018-11-22 |
| TWI794232B (zh) | 2023-03-01 |
| ECSP19089214A (es) | 2020-05-29 |
| AU2018269743A1 (en) | 2020-01-16 |
| CO2019012957A2 (es) | 2020-05-29 |
| IL270648B2 (en) | 2024-03-01 |
| JP7241825B2 (ja) | 2023-03-17 |
| CN110913858A (zh) | 2020-03-24 |
| CL2019003263A1 (es) | 2020-04-17 |
| EP3624797A1 (en) | 2020-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20200729A1 (es) | Inhibidores de quinasa y usos de los mismos | |
| CO2019012998A2 (es) | Proteínas de unión a antígenos trem2 y usos de estas | |
| ECSP17085333A (es) | Anticuerpos anti-cd40 y sus usos. | |
| CL2018000422A1 (es) | Diacuerpos monovalentes biespecíficos que son capaces de unirse a b7-h3 y cd3, y usos de los mismos | |
| CO2017000399A2 (es) | Inhibidores de cinasa de interacción con proteína cinasa activada por mitógeno (mnk) y métodos relacionados con los mismos | |
| ECSP14003642A (es) | 4-fenil-piridinas sustituidas para el tratamiento de enfermedades relacionadas con el receptor de nk1 | |
| BR112017011920A2 (pt) | ?receptores de antígeno quimérico que direcionam receptor acoplado à proteína g e usos dos mesmos? | |
| ECSP16071151A (es) | Inhibidores de dihidropirrolopiridina de ror-gamma | |
| CL2016002573A1 (es) | Compuesto de ciclopropanamina y sus usos. | |
| PE20161251A1 (es) | Compuestos heteroarilo o arilo biciclicos fusionados y su uso como inhibidores de irak4 | |
| ECSP17038999A (es) | 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139 | |
| PE20190258A1 (es) | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos | |
| CL2015002121A1 (es) | Modulares de receptores nmda de espiro-lactama y sus usos. | |
| PE20141178A1 (es) | Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y uso del mismo | |
| CL2015002122A1 (es) | Moduladores de receptores nmda de espiro-lactama y sus usos. | |
| ECSP18010535A (es) | 2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1 | |
| ECSP13012724A (es) | Anticuerpos para el receptor de la barrera hematoencefálica de baja afinidad y sus usos | |
| CO6771450A2 (es) | Ureas asimétricas y usos médicos de las mismas | |
| BR112016024936A2 (pt) | moduladores de gpr40 à base de pirrolidina para tratamento de doenças como diabetes | |
| CO2018012077A2 (es) | Ésteres de oxaborol y sus usos | |
| CL2019000661A1 (es) | Inhibidores de dopamina–b–hidroxilasa penetrantes de la barrera hematoencefálica. | |
| CL2017001539A1 (es) | Compuestos indenil, composiciones farmacéuticas y sus usos médicos de los mismos | |
| CL2016002267A1 (es) | Ureas asimétricas p-sustituidas y usos médicos de las mismas | |
| BR112018000589A2 (pt) | composição de tratamento de cabelo, método para o tratamento de cabelo e utilização de uma composição | |
| CL2020001461A1 (es) | Inhibidores de dopamina–b–hidroxilasa. |