CR20130658A - Benzoxazepinonas fusionadas como moduladoras de canales iónicos - Google Patents

Benzoxazepinonas fusionadas como moduladoras de canales iónicos

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Publication number
CR20130658A
CR20130658A CR20130658A CR20130658A CR20130658A CR 20130658 A CR20130658 A CR 20130658A CR 20130658 A CR20130658 A CR 20130658A CR 20130658 A CR20130658 A CR 20130658A CR 20130658 A CR20130658 A CR 20130658A
Authority
CR
Costa Rica
Prior art keywords
benzoxazepinonas
fused
ion channel
channel modulators
compounds
Prior art date
Application number
CR20130658A
Other languages
English (en)
Inventor
Britton Kenneth Corkey
Elfatih Elzein
Robert H Jiang
Rao V Kalla
Dmitry Koltun
Xiaofen Li
Ruben Martinez
Eric Q Parkhill
Thao Perry
Jeff Zablocki
Chandrasekar Venkataramani
Michael Graupe
Juan Guerrero
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46513866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20130658(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CR20130658A publication Critical patent/CR20130658A/es

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Television Systems (AREA)
  • Luminescent Compositions (AREA)

Abstract

La presente invención se relaciona con compuestos que son inhibidores de los canales de sodio y a su uso en el tratamiento de diversos estados de enfermedad, que incluyen enfermedades cardiovasculares y diabetes. En formas de realización particulares, la estructura de los compuestos es dada por la Fórmula I: en donde Z1, Z2, Z3, Z4, X, Y, R2, R3 y R4 son como se describen en el presente documento, con métodos para la preparación y uso de los compuestos y con composiciones farmacéuticas que contienen los mismos.
CR20130658A 2011-07-01 2013-12-13 Benzoxazepinonas fusionadas como moduladoras de canales iónicos CR20130658A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161503980P 2011-07-01 2011-07-01
US201161582160P 2011-12-30 2011-12-30

Publications (1)

Publication Number Publication Date
CR20130658A true CR20130658A (es) 2014-04-15

Family

ID=46513866

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130658A CR20130658A (es) 2011-07-01 2013-12-13 Benzoxazepinonas fusionadas como moduladoras de canales iónicos

Country Status (37)

Country Link
US (5) US8586732B2 (es)
EP (6) EP3085694B1 (es)
JP (2) JP5889407B2 (es)
KR (2) KR20160040734A (es)
CN (2) CN103857659B (es)
AP (1) AP2013007300A0 (es)
AR (1) AR086828A1 (es)
AU (1) AU2012279236B2 (es)
BR (1) BR112013032361A2 (es)
CA (1) CA2838223A1 (es)
CL (1) CL2013003598A1 (es)
CO (1) CO6821960A2 (es)
CR (1) CR20130658A (es)
CY (1) CY1117915T1 (es)
DK (1) DK2726466T3 (es)
EA (2) EA201790417A3 (es)
EC (1) ECSP13013083A (es)
ES (6) ES2797128T3 (es)
HK (6) HK1196602A1 (es)
HR (1) HRP20160952T1 (es)
HU (1) HUE029398T2 (es)
IL (2) IL230022B (es)
MD (1) MD4371C1 (es)
ME (1) ME02546B (es)
MX (1) MX336810B (es)
NZ (2) NZ716245A (es)
PE (1) PE20140690A1 (es)
PL (1) PL2726466T3 (es)
PT (1) PT2726466T (es)
RS (1) RS55024B1 (es)
SI (1) SI2726466T1 (es)
SM (1) SMT201600271B (es)
TW (4) TWI622583B (es)
UA (1) UA115529C2 (es)
UY (1) UY34171A (es)
WO (1) WO2013006485A1 (es)
ZA (1) ZA201308981B (es)

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