WO2008108445A1 - ベンゾオキサゼピン誘導体およびその用途 - Google Patents

ベンゾオキサゼピン誘導体およびその用途 Download PDF

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Publication number
WO2008108445A1
WO2008108445A1 PCT/JP2008/054093 JP2008054093W WO2008108445A1 WO 2008108445 A1 WO2008108445 A1 WO 2008108445A1 JP 2008054093 W JP2008054093 W JP 2008054093W WO 2008108445 A1 WO2008108445 A1 WO 2008108445A1
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WIPO (PCT)
Prior art keywords
benz
tetrahydro
benzoxazepine derivatives
oxazepin
oxazepine
Prior art date
Application number
PCT/JP2008/054093
Other languages
English (en)
French (fr)
Inventor
Junya Shirai
Takahiro Matsumoto
Izumi Kamo
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to JP2009502625A priority Critical patent/JP5497429B2/ja
Priority to US12/449,975 priority patent/US8247403B2/en
Priority to EP08721512.5A priority patent/EP2123644B1/en
Publication of WO2008108445A1 publication Critical patent/WO2008108445A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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Abstract

　式（Ｉ）〔式中、各記号は明細書中と同義を示す。〕で表される化合物〔但し、９－クロロ－７－（１，１－ジメチルエチル）－２，３，４，５－テトラヒドロ－１，４－ベンゾオキサザピン及びＮ－［［（５Ｓ）－２－オキソ－３－（２，３，４，５－テトラヒドロ－１，４－ベンゾオキサゼピン－７－イル）－５－オキサゾリジニル］メチル］アセトアミドを除く。〕もしくはその塩またはそのプロドラッグは、セロトニン５－ＨＴ２Ｃ受容体を選択的に活性化する作用を有し、下部尿路症状、肥満及び／又は骨盤臓器脱の予防・治療剤として有用である。
PCT/JP2008/054093 2007-03-07 2008-03-06 ベンゾオキサゼピン誘導体およびその用途 WO2008108445A1 (ja)

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