WO2008099887A1 - メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩 - Google Patents

メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩 Download PDF

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Publication number
WO2008099887A1
WO2008099887A1 PCT/JP2008/052448 JP2008052448W WO2008099887A1 WO 2008099887 A1 WO2008099887 A1 WO 2008099887A1 JP 2008052448 W JP2008052448 W JP 2008052448W WO 2008099887 A1 WO2008099887 A1 WO 2008099887A1
Authority
WO
WIPO (PCT)
Prior art keywords
salt
methylaminoquinazolin
dimethoxy
phenyl
methyl
Prior art date
Application number
PCT/JP2008/052448
Other languages
English (en)
French (fr)
Inventor
Eiichi Yamamoto
Osamu Asano
Jun Niijima
Kazumasa Nara
Kazuki Miyazaki
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41429385&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008099887(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from TW096105966A external-priority patent/TWI404709B/zh
Priority claimed from TH701000756A external-priority patent/TH101413B/th
Priority claimed from PCT/JP2007/053066 external-priority patent/WO2007097317A1/ja
Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to JP2008558123A priority Critical patent/JP5102230B2/ja
Priority to AU2008215411A priority patent/AU2008215411B2/en
Priority to EP08711290A priority patent/EP2123641A4/en
Priority to CN2008800052028A priority patent/CN101687818B/zh
Priority to CA002678477A priority patent/CA2678477A1/en
Publication of WO2008099887A1 publication Critical patent/WO2008099887A1/ja
Priority to IL199760A priority patent/IL199760A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Abstract

メチル　Ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質、塩および塩の水和物は、ＰＤＥ４阻害作用を有し、アトピー性皮膚炎などのアレルギー性疾患の治療に有用である。
PCT/JP2008/052448 2007-02-16 2008-02-14 メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩 WO2008099887A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008558123A JP5102230B2 (ja) 2007-02-16 2008-02-14 メチルｎ−［３−（６，７−ジメトキシ−２−メチルアミノキナゾリン−４−イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩
AU2008215411A AU2008215411B2 (en) 2007-02-16 2008-02-14 Crystal, amorphous form and salt of methyl N-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
EP08711290A EP2123641A4 (en) 2007-02-16 2008-02-14 CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
CN2008800052028A CN101687818B (zh) 2007-02-19 2008-02-14 甲基n-[3-(6,7-二甲氧基-2-甲氨基喹唑啉-4-基)苯基]对氨羰基苯甲酸的结晶、无定形物或盐
CA002678477A CA2678477A1 (en) 2007-02-16 2008-02-14 Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
IL199760A IL199760A0 (en) 2007-02-16 2009-07-08 Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
TW096105966A TWI404709B (zh) 2006-02-21 2007-02-16 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
TW096105966 2007-02-16
PK16507 2007-02-19
PK165/2007 2007-02-19
TH0701000756 2007-02-19
TH701000756A TH101413B (th) 2007-02-19 อนุพันธ์ 4-(3-เบนโซอิลอะมิโนเฟนิล)-6,7-ไดเมทธอกซี-2-เมทธิลอะมิโนควินาโซลีน
JPPCT/JP2007/053066 2007-02-20
PCT/JP2007/053066 WO2007097317A1 (ja) 2006-02-21 2007-02-20 ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体
US11/707904 2007-02-20
US11/707,904 US7939540B2 (en) 2006-02-21 2007-02-20 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
US95659807P 2007-08-17 2007-08-17
JP2007212910 2007-08-17
US60/956598 2007-08-17
JP2007-212910 2007-08-17

Publications (1)

Publication Number Publication Date
WO2008099887A1 true WO2008099887A1 (ja) 2008-08-21

Family

ID=41429385

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052448 WO2008099887A1 (ja) 2007-02-16 2008-02-14 メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩

Country Status (5)

Country Link
US (1) US8530654B2 (ja)
EP (1) EP2123641A4 (ja)
AU (1) AU2008215411B2 (ja)
CA (1) CA2678477A1 (ja)
WO (1) WO2008099887A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992622A1 (en) * 2006-02-21 2008-11-19 Eisai R&D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
US8492543B2 (en) 2007-08-17 2013-07-23 Eisai R&D Management Co., Ltd. Method for producing quinazoline derivative
US8513269B2 (en) 2007-08-17 2013-08-20 Eisai R&D Management Co., Ltd. Preparation for external use
US8530654B2 (en) 2007-02-16 2013-09-10 Eisai R&D Management Co., Ltd. Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid
CN110446705A (zh) * 2017-03-30 2019-11-12 默克专利股份公司 (s)-[2-氯-4-氟-5-(7-吗啉-4-基喹唑啉-4-基)苯基]-(6-甲氧基-哒嗪-3-基)甲醇的固体形式

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130095772A (ko) 2010-10-05 2013-08-28 퍼듀 퍼머 엘피 나트륨 채널 차단제로서 퀴나졸린 화합물
RU2768826C2 (ru) * 2016-06-07 2022-03-24 Дермавант Саенсиз Гмбх Составы на основе ингибиторов pde-4 для местного применения и способы их применения
KR20200097297A (ko) 2017-12-07 2020-08-18 더마반트 사이언시즈 게엠베하 Pde-4 억제제의 국소 연고 제형 및 피부 병태 치료에서의 이의 용도

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1999037622A1 (fr) 1998-01-26 1999-07-29 Eisai Co., Ltd. Derives heterocycliques azotes et medicaments produits a partir de ces derives
WO2006093226A1 (ja) * 2005-03-04 2006-09-08 Eisai R & D Management Co., Ltd. 止痒剤

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JP3466305B2 (ja) 1994-12-12 2003-11-10 久光製薬株式会社 溶解剤および該溶解剤を含有する外用製剤
AU4342997A (en) 1996-09-13 1998-04-02 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders
AR015966A1 (es) 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
AR029185A1 (es) 1999-10-25 2003-06-18 Yamanouchi Pharma Co Ltd Derivado de naftiridina
JP3373838B2 (ja) 1999-10-25 2003-02-04 山之内製薬株式会社 ナフチリジン誘導体
UA88523C2 (ru) 2002-05-28 2009-10-26 Алтана Фарма Аг Фармацевтический препарат рофлумиласта для местного применения
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JP4387717B2 (ja) 2003-07-11 2009-12-24 株式会社資生堂 油中水型皮膚外用医薬品製剤
JP2005047909A (ja) 2003-07-17 2005-02-24 Santen Pharmaceut Co Ltd ピペリジン誘導体を有効成分とする掻痒治療剤
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TWI404709B (zh) 2006-02-21 2013-08-11 Eisai R&D Man Co Ltd 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
WO2007097317A1 (ja) * 2006-02-21 2007-08-30 Eisai R & D Management Co., Ltd. ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体
WO2008099887A1 (ja) 2007-02-16 2008-08-21 Eisai R & D Management Co., Ltd. メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩
US8513269B2 (en) 2007-08-17 2013-08-20 Eisai R&D Management Co., Ltd. Preparation for external use

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* Cited by examiner, † Cited by third party
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WO1999037622A1 (fr) 1998-01-26 1999-07-29 Eisai Co., Ltd. Derives heterocycliques azotes et medicaments produits a partir de ces derives
WO2006093226A1 (ja) * 2005-03-04 2006-09-08 Eisai R & D Management Co., Ltd. 止痒剤

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Title
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CSJ: THE CHEMICAL SOCIETY OF JAPAN: "Jikken Kagaku Koza 1, Kihon Sosa I", vol. 4TH ED., 5 November 1990, MARUZEN CO. LTD., pages: 184 - 186 *
LANCET, vol. 361, 2003, pages 151 - 160
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N. MIYAURA, A. SUZUKI, CHEM. REV., vol. 95, 1995, pages 2457
S. P. STANFORTH, TETRAHEDRON, vol. 54, 1998, pages 263
See also references of EP2123641A4 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992622A1 (en) * 2006-02-21 2008-11-19 Eisai R&D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
EP1992622A4 (en) * 2006-02-21 2009-05-06 Eisai R&D Man Co Ltd 4- (3-benzoylaminophenyl) -6,7-dimethoxy-2-METHYLAMINOCHINAZOLINDERIVAT
US7939540B2 (en) 2006-02-21 2011-05-10 Eisai R&D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
US8530654B2 (en) 2007-02-16 2013-09-10 Eisai R&D Management Co., Ltd. Crystals, amorphous substances or salts of methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl] terephthalamic acid
US8492543B2 (en) 2007-08-17 2013-07-23 Eisai R&D Management Co., Ltd. Method for producing quinazoline derivative
US8513269B2 (en) 2007-08-17 2013-08-20 Eisai R&D Management Co., Ltd. Preparation for external use
CN110446705A (zh) * 2017-03-30 2019-11-12 默克专利股份公司 (s)-[2-氯-4-氟-5-(7-吗啉-4-基喹唑啉-4-基)苯基]-(6-甲氧基-哒嗪-3-基)甲醇的固体形式
CN110446705B (zh) * 2017-03-30 2023-04-14 默克专利股份公司 (s)-[2-氯-4-氟-5-(7-吗啉-4-基喹唑啉-4-基)苯基]-(6-甲氧基-哒嗪-3-基)甲醇的固体形式

Also Published As

Publication number Publication date
US20090062539A1 (en) 2009-03-05
AU2008215411A1 (en) 2008-08-21
EP2123641A4 (en) 2011-06-22
CA2678477A1 (en) 2008-08-21
EP2123641A1 (en) 2009-11-25
AU2008215411B2 (en) 2012-11-22
US8530654B2 (en) 2013-09-10

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