CA2678477A1 - Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid - Google Patents

Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid Download PDF

Info

Publication number
CA2678477A1
CA2678477A1 CA002678477A CA2678477A CA2678477A1 CA 2678477 A1 CA2678477 A1 CA 2678477A1 CA 002678477 A CA002678477 A CA 002678477A CA 2678477 A CA2678477 A CA 2678477A CA 2678477 A1 CA2678477 A1 CA 2678477A1
Authority
CA
Canada
Prior art keywords
dimethoxy
methylaminoquinazolin
methyl
phenyl
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002678477A
Other languages
English (en)
French (fr)
Inventor
Eiichi Yamamoto
Osamu Asano
Jun Niijima
Kazumasa Nara
Kazuki Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co., Ltd.
Eiichi Yamamoto
Osamu Asano
Jun Niijima
Kazumasa Nara
Kazuki Miyazaki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41429385&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2678477(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from TW096105966A external-priority patent/TWI404709B/zh
Priority claimed from TH701000756A external-priority patent/TH101413B/th
Priority claimed from US11/707,904 external-priority patent/US7939540B2/en
Application filed by Eisai R&D Management Co., Ltd., Eiichi Yamamoto, Osamu Asano, Jun Niijima, Kazumasa Nara, Kazuki Miyazaki filed Critical Eisai R&D Management Co., Ltd.
Publication of CA2678477A1 publication Critical patent/CA2678477A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002678477A 2007-02-16 2008-02-14 Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid Abandoned CA2678477A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
TW096105966A TWI404709B (zh) 2006-02-21 2007-02-16 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
TW096105966 2007-02-16
PK16507 2007-02-19
PK165/2007 2007-02-19
TH701000756A TH101413B (th) 2007-02-19 อนุพันธ์ 4-(3-เบนโซอิลอะมิโนเฟนิล)-6,7-ไดเมทธอกซี-2-เมทธิลอะมิโนควินาโซลีน
TH0701000756 2007-02-19
US11/707,904 US7939540B2 (en) 2006-02-21 2007-02-20 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
US11/707904 2007-02-20
JPPCT/JP2007/053066 2007-02-20
PCT/JP2007/053066 WO2007097317A1 (ja) 2006-02-21 2007-02-20 ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体
US95659807P 2007-08-17 2007-08-17
US60/956598 2007-08-17
JP2007212910 2007-08-17
JP2007-212910 2007-08-17
PCT/JP2008/052448 WO2008099887A1 (ja) 2007-02-16 2008-02-14 メチル ｎ－［３－（６，７－ジメトキシ－２－メチルアミノキナゾリン－４－イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩

Publications (1)

Publication Number Publication Date
CA2678477A1 true CA2678477A1 (en) 2008-08-21

Family

ID=41429385

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002678477A Abandoned CA2678477A1 (en) 2007-02-16 2008-02-14 Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Country Status (5)

Country Link
US (1) US8530654B2 (ja)
EP (1) EP2123641A4 (ja)
AU (1) AU2008215411B2 (ja)
CA (1) CA2678477A1 (ja)
WO (1) WO2008099887A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007218725B2 (en) * 2006-02-21 2011-12-01 Eisai R & D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
EP2123641A4 (en) 2007-02-16 2011-06-22 Eisai R&D Man Co Ltd CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
WO2009025239A1 (ja) 2007-08-17 2009-02-26 Eisai R & D Management Co., Ltd. 新規外用剤
WO2009025238A1 (ja) 2007-08-17 2009-02-26 Eisai R & D Management Co., Ltd. キナゾリン誘導体の製造方法
WO2012046132A1 (en) 2010-10-05 2012-04-12 Purdue Pharma L.P. Quinazoline compounds as sodium channel blockers
WO2017214289A1 (en) * 2016-06-07 2017-12-14 Dermavant Sciences GmbH Topical formulations of pde-4 inhibitors and their methods of use
US11053233B2 (en) * 2017-03-30 2021-07-06 Merck Patent Gmbh Solid form of (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-yl-quinazolin-4-yl)phenyl]-(6-methoxy-pyridazin-3-yl)-methanol
CN111683641A (zh) 2017-12-07 2020-09-18 德玛万科学有限公司 Pde-4抑制剂的局部用软膏剂制剂及其在治疗皮肤病况中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2099112T3 (es) * 1990-09-04 1997-05-16 Fujisawa Pharmaceutical Co Pomadas que contienen un compuesto triciclico.
JP3466305B2 (ja) 1994-12-12 2003-11-10 久光製薬株式会社 溶解剤および該溶解剤を含有する外用製剤
CA2265630A1 (en) 1996-09-13 1998-03-19 Gerald Mcmahon Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
AR015966A1 (es) 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
JPH11209350A (ja) 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
JP3373838B2 (ja) 1999-10-25 2003-02-04 山之内製薬株式会社 ナフチリジン誘導体
TWI262919B (en) * 1999-10-25 2006-10-01 Yamanouchi Pharma Co Ltd Naphthyridine derivative
NZ536920A (en) 2002-05-28 2007-04-27 Altana Pharma Ag Topically applicable pharmaceutical preparation
US20040038958A1 (en) 2002-07-11 2004-02-26 Chris Rundfeldt Topical treatment of skin diseases
JP4387717B2 (ja) 2003-07-11 2009-12-24 株式会社資生堂 油中水型皮膚外用医薬品製剤
US20060258703A1 (en) * 2003-07-17 2006-11-16 Ono Pharmaceutical Co., Ltd. Remedy for pruritus comprising piperidine derivative as the active ingredient
JP2005047909A (ja) 2003-07-17 2005-02-24 Santen Pharmaceut Co Ltd ピペリジン誘導体を有効成分とする掻痒治療剤
WO2005082865A1 (ja) 2004-02-27 2005-09-09 Astellas Pharma Inc. 縮合二環性ピリミジン誘導体
JP2008137892A (ja) * 2005-03-04 2008-06-19 Eisai Co Ltd 止痒剤
TWI404709B (zh) 2006-02-21 2013-08-11 Eisai R&D Man Co Ltd 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives
AU2007218725B2 (en) 2006-02-21 2011-12-01 Eisai R & D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
EP2123641A4 (en) 2007-02-16 2011-06-22 Eisai R&D Man Co Ltd CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
WO2009025239A1 (ja) 2007-08-17 2009-02-26 Eisai R & D Management Co., Ltd. 新規外用剤

Also Published As

Publication number Publication date
US20090062539A1 (en) 2009-03-05
AU2008215411A1 (en) 2008-08-21
EP2123641A4 (en) 2011-06-22
EP2123641A1 (en) 2009-11-25
US8530654B2 (en) 2013-09-10
WO2008099887A1 (ja) 2008-08-21
AU2008215411B2 (en) 2012-11-22

Similar Documents

Publication Publication Date Title
AU2008215411B2 (en) Crystal, amorphous form and salt of methyl N-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
EP4083042A1 (en) Spiro ring-containing quinazoline compound
CA3213029A1 (en) Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof
WO2017038838A1 (ja) 新規なピラゾロ［３，４－ｄ］ピリミジン化合物又はその塩
CA2574685A1 (en) Quinazolin-4-yl- piperidine and cinnolin-4-yl- piperidine derivatives as pde10 inhibitors for the treatment of cns disorders
JP6704422B2 (ja) キナゾリン誘導体の塩およびその製造方法
EP1992622B1 (en) 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2- methylaminoquinazoline derivative
JP4660045B2 (ja) ＮＦ−κＢ阻害剤を有効成分とする心筋炎、拡張型心筋症および心不全の予防または治療薬
AU2021221162A1 (en) Macrocyclic ULK1/2 inhibitors
US20060111368A1 (en) Phosphodiesterase inhibitor
EP2057148B1 (en) Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents
DK2624833T3 (en) 4- (Methylaminophenoxy) pyridin-3-yl-benzamide derivatives for the treatment of cancer
IL193322A (en) Derivatives of 4– (3 – benzoylaminophenyl) –7,6 – domethoxy – 2– methylaminoquinazoline
CN108383837B (zh) 一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用
JP5102230B2 (ja) メチルｎ−［３−（６，７−ジメトキシ−２−メチルアミノキナゾリン−４−イル）フェニル］テレフタラミックアシッドの結晶、非晶質体または塩
CA2907921C (en) Inhibition of il-2 production
KR20090118025A (ko) 메틸 ｎ-[3-(6,7-디메톡시-2-메틸아미노퀴나졸린-4-일)페닐]테레프탈람산의 결정, 비정질체 또는 염
CN114685519B (zh) 一类吡喃并咔唑生物碱衍生物及其治疗阿尔茨海默症的用途
CN114957252B (zh) 一种化合物及其制备方法以及药物组合物和在制备eed抑制剂中的应用
CN103910736B (zh) 一类二氢吡喃并嘧啶衍生物及其医药应用
CN117946164A (zh) 一种新型结构化合物st3gal4抑制剂及其应用
JP2020189788A (ja) 睡眠誘導剤である複素環化合物

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20150216