CN108383837B - 一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用 - Google Patents
一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用 Download PDFInfo
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- CN108383837B CN108383837B CN201810134778.XA CN201810134778A CN108383837B CN 108383837 B CN108383837 B CN 108383837B CN 201810134778 A CN201810134778 A CN 201810134778A CN 108383837 B CN108383837 B CN 108383837B
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- methyl
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- tetrahydropyrido
- dihydronaphthyridin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810134778.XA CN108383837B (zh) | 2018-02-09 | 2018-02-09 | 一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用 |
Applications Claiming Priority (1)
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CN201810134778.XA CN108383837B (zh) | 2018-02-09 | 2018-02-09 | 一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用 |
Publications (2)
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CN108383837A CN108383837A (zh) | 2018-08-10 |
CN108383837B true CN108383837B (zh) | 2020-08-11 |
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CN201810134778.XA Active CN108383837B (zh) | 2018-02-09 | 2018-02-09 | 一种氨基取代四氢吡啶并嘧啶类化合物或其可用盐及其制备方法与应用 |
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CN (1) | CN108383837B (zh) |
Families Citing this family (1)
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CN112661702B (zh) * | 2020-12-23 | 2022-03-11 | 南京方生和医药科技有限公司 | 一种奥拉帕尼杂质及其制备方法 |
Family Cites Families (2)
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MX2010005070A (es) * | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
EP2686305B1 (en) * | 2011-03-14 | 2020-09-16 | Impact Therapeutics, Inc. | Quinazolinediones and their use |
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2018
- 2018-02-09 CN CN201810134778.XA patent/CN108383837B/zh active Active
Non-Patent Citations (1)
Title |
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Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening;Hao-Peng Sun等;《European Journal of Medicinal Chemistry》;20140321;第79卷;399-412 * |
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CN108383837A (zh) | 2018-08-10 |
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Inventor after: Liu Yang Inventor after: Wu Lixian Inventor after: Zhang Xiao Inventor after: Lin Shanshan Inventor after: Huang Xiuwang Inventor after: Xu Jianhua Inventor before: Wu Lixian Inventor before: Liu Yang Inventor before: Zhang Xiao Inventor before: Lin Shanshan Inventor before: Huang Xiuwang Inventor before: Xu Jianhua |
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