WO2009025238A1 - キナゾリン誘導体の製造方法 - Google Patents
キナゾリン誘導体の製造方法 Download PDFInfo
- Publication number
- WO2009025238A1 WO2009025238A1 PCT/JP2008/064620 JP2008064620W WO2009025238A1 WO 2009025238 A1 WO2009025238 A1 WO 2009025238A1 JP 2008064620 W JP2008064620 W JP 2008064620W WO 2009025238 A1 WO2009025238 A1 WO 2009025238A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- quinazoline derivative
- producing quinazoline
- methylamine
- formula
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009529018A JP5043945B2 (ja) | 2007-08-17 | 2008-08-15 | キナゾリン誘導体の製造方法 |
EP08827791A EP2189450B1 (en) | 2007-08-17 | 2008-08-15 | Method for producing quinazoline derivative |
CA2696727A CA2696727A1 (en) | 2007-08-17 | 2008-08-15 | Method for producing quinazoline derivative |
CN2008800220818A CN101687820B (zh) | 2007-08-17 | 2008-08-15 | 喹唑啉衍生物的制造方法 |
US12/733,169 US8492543B2 (en) | 2007-08-17 | 2008-08-15 | Method for producing quinazoline derivative |
AT08827791T ATE538102T1 (de) | 2007-08-17 | 2008-08-15 | Verfahren zur herstellung eines chinazolinderivats |
AU2008290000A AU2008290000B2 (en) | 2007-08-17 | 2008-08-15 | Method for producing quinazoline derivative |
IL204017A IL204017A (en) | 2007-08-17 | 2010-02-17 | A method for the derivative production of quinazoline |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-212921 | 2007-08-17 | ||
JP2007212921 | 2007-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009025238A1 true WO2009025238A1 (ja) | 2009-02-26 |
Family
ID=40378143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/064620 WO2009025238A1 (ja) | 2007-08-17 | 2008-08-15 | キナゾリン誘導体の製造方法 |
Country Status (10)
Country | Link |
---|---|
US (1) | US8492543B2 (ja) |
EP (1) | EP2189450B1 (ja) |
JP (1) | JP5043945B2 (ja) |
KR (1) | KR20100042245A (ja) |
CN (3) | CN102532041A (ja) |
AT (1) | ATE538102T1 (ja) |
AU (1) | AU2008290000B2 (ja) |
CA (1) | CA2696727A1 (ja) |
IL (1) | IL204017A (ja) |
WO (1) | WO2009025238A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014133020A1 (ja) * | 2013-02-28 | 2014-09-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE538102T1 (de) | 2007-08-17 | 2012-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung eines chinazolinderivats |
BR112018075202A2 (pt) * | 2016-06-07 | 2019-03-19 | Dermavant Sciences GmbH | formulação tópica e método de tratamento de uma condição dermatológica em um sujeito |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999037622A1 (fr) * | 1998-01-26 | 1999-07-29 | Eisai Co., Ltd. | Derives heterocycliques azotes et medicaments produits a partir de ces derives |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE150304T1 (de) | 1990-09-04 | 1997-04-15 | Fujisawa Pharmaceutical Co | Tricyclische verbindungen enthaltende salben |
JP3466305B2 (ja) | 1994-12-12 | 2003-11-10 | 久光製薬株式会社 | 溶解剤および該溶解剤を含有する外用製剤 |
WO1998010767A2 (en) | 1996-09-13 | 1998-03-19 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
JP3373838B2 (ja) | 1999-10-25 | 2003-02-04 | 山之内製薬株式会社 | ナフチリジン誘導体 |
AR029185A1 (es) * | 1999-10-25 | 2003-06-18 | Yamanouchi Pharma Co Ltd | Derivado de naftiridina |
NZ553731A (en) | 2002-05-28 | 2007-07-27 | Altana Pharma Ag | Topically applicable pharmaceutical preparation of roflumilast and liquid paraffin |
US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
JP4387717B2 (ja) | 2003-07-11 | 2009-12-24 | 株式会社資生堂 | 油中水型皮膚外用医薬品製剤 |
JP2005047909A (ja) | 2003-07-17 | 2005-02-24 | Santen Pharmaceut Co Ltd | ピペリジン誘導体を有効成分とする掻痒治療剤 |
US20060258703A1 (en) * | 2003-07-17 | 2006-11-16 | Ono Pharmaceutical Co., Ltd. | Remedy for pruritus comprising piperidine derivative as the active ingredient |
WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
WO2006089398A1 (en) | 2005-02-23 | 2006-08-31 | Stryker Canadian Management Inc. | Diagnostic and control system for a patient support |
JP2008137892A (ja) | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | 止痒剤 |
PL1992622T3 (pl) | 2006-02-21 | 2012-01-31 | Eisai R&D Man Co Ltd | Pochodna 4-(3-benzoiloaminofenylo)-6,7-dimetoksy-2-metyloaminochinazoliny |
TWI404709B (zh) | 2006-02-21 | 2013-08-11 | Eisai R&D Man Co Ltd | 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives |
EP2123641A4 (en) | 2007-02-16 | 2011-06-22 | Eisai R&D Man Co Ltd | CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT |
WO2009025239A1 (ja) | 2007-08-17 | 2009-02-26 | Eisai R & D Management Co., Ltd. | 新規外用剤 |
ATE538102T1 (de) | 2007-08-17 | 2012-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung eines chinazolinderivats |
-
2008
- 2008-08-15 AT AT08827791T patent/ATE538102T1/de active
- 2008-08-15 JP JP2009529018A patent/JP5043945B2/ja not_active Expired - Fee Related
- 2008-08-15 CN CN2011103959045A patent/CN102532041A/zh active Pending
- 2008-08-15 US US12/733,169 patent/US8492543B2/en active Active
- 2008-08-15 CN CN2011102772012A patent/CN102336717B/zh not_active Expired - Fee Related
- 2008-08-15 CA CA2696727A patent/CA2696727A1/en not_active Abandoned
- 2008-08-15 AU AU2008290000A patent/AU2008290000B2/en not_active Ceased
- 2008-08-15 CN CN2008800220818A patent/CN101687820B/zh not_active Expired - Fee Related
- 2008-08-15 WO PCT/JP2008/064620 patent/WO2009025238A1/ja active Application Filing
- 2008-08-15 EP EP08827791A patent/EP2189450B1/en active Active
- 2008-08-15 KR KR1020097026235A patent/KR20100042245A/ko not_active Application Discontinuation
-
2010
- 2010-02-17 IL IL204017A patent/IL204017A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999037622A1 (fr) * | 1998-01-26 | 1999-07-29 | Eisai Co., Ltd. | Derives heterocycliques azotes et medicaments produits a partir de ces derives |
Non-Patent Citations (5)
Title |
---|
GREEN T.W. ET AL.: "Protective groups in organic synthesis, third edition", 1999, pages: 518-525, - 551-555, XP003022600 * |
J. AM. CHEM. SOC., 1958, pages 1154 |
J. ORG. CHEM., 1978, pages 4593 |
J. ORG. CHEM., 1979, pages 3748 |
SYNTHESIS, 1999, pages 66 - 68 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014133020A1 (ja) * | 2013-02-28 | 2014-09-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
JPWO2014133020A1 (ja) * | 2013-02-28 | 2017-02-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
Also Published As
Publication number | Publication date |
---|---|
KR20100042245A (ko) | 2010-04-23 |
JP5043945B2 (ja) | 2012-10-10 |
CN101687820B (zh) | 2012-07-25 |
US8492543B2 (en) | 2013-07-23 |
EP2189450B1 (en) | 2011-12-21 |
JPWO2009025238A1 (ja) | 2010-11-25 |
CN102532041A (zh) | 2012-07-04 |
CA2696727A1 (en) | 2009-02-26 |
EP2189450A1 (en) | 2010-05-26 |
AU2008290000B2 (en) | 2012-05-10 |
IL204017A (en) | 2013-01-31 |
ATE538102T1 (de) | 2012-01-15 |
EP2189450A4 (en) | 2010-10-20 |
CN102336717B (zh) | 2013-09-18 |
CN101687820A (zh) | 2010-03-31 |
US20110152521A1 (en) | 2011-06-23 |
AU2008290000A1 (en) | 2009-02-26 |
CN102336717A (zh) | 2012-02-01 |
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