WO2011087316A3 - 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 - Google Patents

테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 Download PDF

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Publication number
WO2011087316A3
WO2011087316A3 PCT/KR2011/000291 KR2011000291W WO2011087316A3 WO 2011087316 A3 WO2011087316 A3 WO 2011087316A3 KR 2011000291 W KR2011000291 W KR 2011000291W WO 2011087316 A3 WO2011087316 A3 WO 2011087316A3
Authority
WO
WIPO (PCT)
Prior art keywords
methanesulfonic acid
acid salts
same
compound used
novel compound
Prior art date
Application number
PCT/KR2011/000291
Other languages
English (en)
French (fr)
Other versions
WO2011087316A2 (ko
Inventor
방극찬
박범우
최종원
이재철
안용훈
안영길
김맹섭
Original Assignee
한미홀딩스 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US13/522,272 priority Critical patent/US8680277B2/en
Priority to EP11733103.3A priority patent/EP2524916B1/en
Priority to CN201180005610.5A priority patent/CN102812020B/zh
Priority to MX2012007868A priority patent/MX2012007868A/es
Priority to PL11733103T priority patent/PL2524916T3/pl
Priority to SG2012050472A priority patent/SG182430A1/en
Priority to DK11733103.3T priority patent/DK2524916T3/da
Priority to CA2786434A priority patent/CA2786434C/en
Priority to JP2012548895A priority patent/JP5575921B2/ja
Priority to NZ601805A priority patent/NZ601805A/en
Application filed by 한미홀딩스 주식회사 filed Critical 한미홀딩스 주식회사
Priority to BR112012017448-7A priority patent/BR112012017448B1/pt
Priority to RU2012134783/04A priority patent/RU2509769C1/ru
Priority to AU2011205891A priority patent/AU2011205891B2/en
Priority to ES11733103.3T priority patent/ES2514340T3/es
Publication of WO2011087316A2 publication Critical patent/WO2011087316A2/ko
Publication of WO2011087316A3 publication Critical patent/WO2011087316A3/ko
Priority to IL220851A priority patent/IL220851A/en
Priority to NO20120841A priority patent/NO342589B1/no
Priority to ZA2012/06084A priority patent/ZA201206084B/en
Priority to HK13104698.2A priority patent/HK1177211A1/xx
Priority to US14/171,318 priority patent/US8940908B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

신규한 4-옥소-4H-크로멘-2-카르보티온산 S-벤조티아졸-2-일 에스터를 사용한 아실화 반응을 포함하는 본 발명의 테트라졸 메탄설폰산 염의 제조방법은, 종래의 방법에 비해 반응시간을 단축시킬 수 있고, 안전성을 개선시킬 수 있으며, 컬럼 크로마토그래피 방법을 통하지 않고도 테트라졸 메탄설폰산 염을 고순도 및 고수율로 제조할 수 있다.
PCT/KR2011/000291 2010-01-15 2011-01-14 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 WO2011087316A2 (ko)

Priority Applications (19)

Application Number Priority Date Filing Date Title
BR112012017448-7A BR112012017448B1 (pt) 2010-01-15 2011-01-14 método para a preparação de sais de ácido metanossulfônico de tetrazol, e novo composto empregado no mesmo
EP11733103.3A EP2524916B1 (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
MX2012007868A MX2012007868A (es) 2010-01-15 2011-01-14 Metodo para preparar sales de acido tetrazol-mentasulfonico, y un nuevo compuesto utilizado en las mismas.
PL11733103T PL2524916T3 (pl) 2010-01-15 2011-01-14 Sposób wytwarzania soli kwasu tetrazolometanosulfonowego oraz nowy związek stosowny w tym sposobie
SG2012050472A SG182430A1 (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
DK11733103.3T DK2524916T3 (da) 2010-01-15 2011-01-14 Fremgangsmåde til fremstilling af tetrazolmethansulfonsyresalte og en ny forbindelse, der anvendes i samme
CA2786434A CA2786434C (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
RU2012134783/04A RU2509769C1 (ru) 2010-01-15 2011-01-14 Способ получения солей тетразолметансульфоновой кислоты и новое соединение, используемое в нем
NZ601805A NZ601805A (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
US13/522,272 US8680277B2 (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
CN201180005610.5A CN102812020B (zh) 2010-01-15 2011-01-14 用于制备四唑甲磺酸盐的方法及其使用的新化合物
JP2012548895A JP5575921B2 (ja) 2010-01-15 2011-01-14 テトラゾールメタンスルホン酸塩の製造方法及びそれに用いられる新規化合物
AU2011205891A AU2011205891B2 (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
ES11733103.3T ES2514340T3 (es) 2010-01-15 2011-01-14 Procedimiento para preparar sales de ácido tetrazol metanosulfónico y compuestos novedosos usados en el mismo
IL220851A IL220851A (en) 2010-01-15 2012-07-10 Process for the preparation of n - (2 - (2 - (4 - (2 - (7,6-dimethoxy-4,3-dihydro-iso-quinoline-2 - (1 h))) ethyl) phenyl) - h2 - tetrazole - 5-ram (5,4-dimethoxyphenyl) -4-oxo-h4-chromium-2-carboxamide methane-sulfonate, its intermediate and intermediate preparation process
NO20120841A NO342589B1 (no) 2010-01-15 2012-07-20 Fremgangsmåte for fremstilling av tetrazol-metansulfonsyresalter og ny forbindelse som anvendes i denne
ZA2012/06084A ZA201206084B (en) 2010-01-15 2012-08-14 Method for preparing tetrazole methanesulfonic acid salts,and novel compound used in same
HK13104698.2A HK1177211A1 (en) 2010-01-15 2013-04-18 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
US14/171,318 US8940908B2 (en) 2010-01-15 2014-02-03 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100003835A KR101466245B1 (ko) 2010-01-15 2010-01-15 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물
KR10-2010-0003835 2010-01-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/522,272 A-371-Of-International US8680277B2 (en) 2010-01-15 2011-01-14 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same
US14/171,318 Division US8940908B2 (en) 2010-01-15 2014-02-03 Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same

Publications (2)

Publication Number Publication Date
WO2011087316A2 WO2011087316A2 (ko) 2011-07-21
WO2011087316A3 true WO2011087316A3 (ko) 2011-11-10

Family

ID=44304835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/000291 WO2011087316A2 (ko) 2010-01-15 2011-01-14 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물

Country Status (20)

Country Link
US (2) US8680277B2 (ko)
EP (1) EP2524916B1 (ko)
JP (1) JP5575921B2 (ko)
KR (1) KR101466245B1 (ko)
CN (1) CN102812020B (ko)
AU (1) AU2011205891B2 (ko)
BR (1) BR112012017448B1 (ko)
CA (1) CA2786434C (ko)
DK (1) DK2524916T3 (ko)
ES (1) ES2514340T3 (ko)
HK (1) HK1177211A1 (ko)
IL (1) IL220851A (ko)
MX (1) MX2012007868A (ko)
NO (1) NO342589B1 (ko)
NZ (1) NZ601805A (ko)
PL (1) PL2524916T3 (ko)
RU (1) RU2509769C1 (ko)
SG (1) SG182430A1 (ko)
WO (1) WO2011087316A2 (ko)
ZA (1) ZA201206084B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101986683B1 (ko) * 2012-12-13 2019-06-10 한미약품 주식회사 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
CN103804352B (zh) * 2014-01-23 2017-06-13 中国药科大学 三氮唑苯乙基四氢异喹啉类化合物及其制备方法和应用
JO3737B1 (ar) * 2015-07-21 2021-01-31 Athenex Therapeutics Ltd تركيبات علاجية من باكليتاكسيل تعطى عن طريق الفم ومثبط P-gp لعلاج السرطان
US11165722B2 (en) 2016-06-29 2021-11-02 International Business Machines Corporation Cognitive messaging with dynamically changing inputs
US20220135548A1 (en) 2019-02-14 2022-05-05 Teva Pharmaceuticals International Gmbh Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5- dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide and of its mesylate salt
US20220169637A1 (en) * 2019-03-25 2022-06-02 Dr. Reddy's Laboratories Limited Solid forms of encequidar mesylate and processes thereof
WO2020230037A1 (en) * 2019-05-13 2020-11-19 Dr. Reddy's Laboratories Limited Alternate process for the preparation of encequidar
WO2021044350A1 (en) * 2019-09-04 2021-03-11 Dr. Reddy’S Laboratories Limited Solid forms of encequidar mesylate and processes thereof
EP4178679A1 (en) 2020-07-10 2023-05-17 Teva Czech Industries s.r.o. Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide mesylate salt
WO2022076663A1 (en) 2020-10-07 2022-04-14 Athenex, Inc. Acetamido-phenyltetrazole derivatives and methods of using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050234054A1 (en) * 2004-04-15 2005-10-20 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US20070161791A1 (en) * 2006-01-09 2007-07-12 Narsimha Reddy Penthala Process for the preparation of terazosin hydrocloride dihydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
KR100508019B1 (ko) * 2003-07-19 2005-08-17 한미약품 주식회사 고순도 1-안드로스텐 유도체의 제조 방법
KR100557093B1 (ko) 2003-10-07 2006-03-03 한미약품 주식회사 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법
KR100686695B1 (ko) * 2005-06-11 2007-02-26 주식회사 에스텍파마 프란루카스트 또는 그의 수화물의 제조방법 및 그의 합성중간체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050234054A1 (en) * 2004-04-15 2005-10-20 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
US20070161791A1 (en) * 2006-01-09 2007-07-12 Narsimha Reddy Penthala Process for the preparation of terazosin hydrocloride dihydrate

Also Published As

Publication number Publication date
KR20110083870A (ko) 2011-07-21
MX2012007868A (es) 2012-08-03
DK2524916T3 (da) 2014-09-08
EP2524916B1 (en) 2014-07-23
NO342589B1 (no) 2018-06-18
EP2524916A4 (en) 2013-07-17
RU2012134783A (ru) 2014-02-20
AU2011205891B2 (en) 2013-09-05
ZA201206084B (en) 2013-10-30
HK1177211A1 (en) 2013-08-16
NO20120841A1 (no) 2012-07-20
BR112012017448B1 (pt) 2021-05-25
US20120330020A1 (en) 2012-12-27
NZ601805A (en) 2014-07-25
IL220851A0 (en) 2012-09-24
US8680277B2 (en) 2014-03-25
ES2514340T3 (es) 2014-10-28
PL2524916T3 (pl) 2015-01-30
CN102812020B (zh) 2015-03-18
EP2524916A2 (en) 2012-11-21
US8940908B2 (en) 2015-01-27
JP5575921B2 (ja) 2014-08-20
CA2786434A1 (en) 2011-07-21
CN102812020A (zh) 2012-12-05
SG182430A1 (en) 2012-08-30
JP2013517267A (ja) 2013-05-16
IL220851A (en) 2015-10-29
KR101466245B1 (ko) 2014-12-01
WO2011087316A2 (ko) 2011-07-21
CA2786434C (en) 2014-05-13
RU2509769C1 (ru) 2014-03-20
BR112012017448A2 (pt) 2016-08-09
AU2011205891A1 (en) 2012-09-06
US20140148602A1 (en) 2014-05-29

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