BR112012017448A2 - método para a preparação de sais de ácido metanossulfônico de tetrazol, e novo composto empregado no mesmo - Google Patents
método para a preparação de sais de ácido metanossulfônico de tetrazol, e novo composto empregado no mesmoInfo
- Publication number
- BR112012017448A2 BR112012017448A2 BR112012017448A BR112012017448A BR112012017448A2 BR 112012017448 A2 BR112012017448 A2 BR 112012017448A2 BR 112012017448 A BR112012017448 A BR 112012017448A BR 112012017448 A BR112012017448 A BR 112012017448A BR 112012017448 A2 BR112012017448 A2 BR 112012017448A2
- Authority
- BR
- Brazil
- Prior art keywords
- methanesulfonic acid
- acid salts
- preparation
- compound employed
- new compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
método para a preparação de sais de ácido metanossulfônico de tetrazol, e novo composto empregado no mesmo. de acordo com a presente invenção, um método para a preparação de sais de ácido metanossulfônico de tetrazol compreende uma reação de acilação empregado um novo éster de s-benzotiazol-2-il de ácido 4-iodo-4h-cromeno-2-carbônico. o método da presente invenção pode encurtar um tempo de reação e melhorar a segurança quando comparado aos métodos convencionais, e pode preparar sais de ácido metanossulfônico de tetrazol de elevada pureza em uma elevada taxa de produção sem o emprego de um método de cromatografia de coluna.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2010-0003835 | 2010-01-15 | ||
| KR1020100003835A KR101466245B1 (ko) | 2010-01-15 | 2010-01-15 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
| PCT/KR2011/000291 WO2011087316A2 (ko) | 2010-01-15 | 2011-01-14 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012017448A2 true BR112012017448A2 (pt) | 2016-08-09 |
| BR112012017448B1 BR112012017448B1 (pt) | 2021-05-25 |
Family
ID=44304835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012017448-7A BR112012017448B1 (pt) | 2010-01-15 | 2011-01-14 | método para a preparação de sais de ácido metanossulfônico de tetrazol, e novo composto empregado no mesmo |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8680277B2 (pt) |
| EP (1) | EP2524916B1 (pt) |
| JP (1) | JP5575921B2 (pt) |
| KR (1) | KR101466245B1 (pt) |
| CN (1) | CN102812020B (pt) |
| AU (1) | AU2011205891B2 (pt) |
| BR (1) | BR112012017448B1 (pt) |
| CA (1) | CA2786434C (pt) |
| DK (1) | DK2524916T3 (pt) |
| ES (1) | ES2514340T3 (pt) |
| HK (1) | HK1177211A1 (pt) |
| IL (1) | IL220851A (pt) |
| MX (1) | MX2012007868A (pt) |
| NO (1) | NO342589B1 (pt) |
| NZ (1) | NZ601805A (pt) |
| PL (1) | PL2524916T3 (pt) |
| RU (1) | RU2509769C1 (pt) |
| SG (1) | SG182430A1 (pt) |
| WO (1) | WO2011087316A2 (pt) |
| ZA (1) | ZA201206084B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101986683B1 (ko) | 2012-12-13 | 2019-06-10 | 한미약품 주식회사 | 테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체 |
| CN103804352B (zh) * | 2014-01-23 | 2017-06-13 | 中国药科大学 | 三氮唑苯乙基四氢异喹啉类化合物及其制备方法和应用 |
| JO3737B1 (ar) * | 2015-07-21 | 2021-01-31 | Athenex Therapeutics Ltd | تركيبات علاجية من باكليتاكسيل تعطى عن طريق الفم ومثبط P-gp لعلاج السرطان |
| US11165722B2 (en) | 2016-06-29 | 2021-11-02 | International Business Machines Corporation | Cognitive messaging with dynamically changing inputs |
| US20220135548A1 (en) | 2019-02-14 | 2022-05-05 | Teva Pharmaceuticals International Gmbh | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5- dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide and of its mesylate salt |
| US20220169637A1 (en) * | 2019-03-25 | 2022-06-02 | Dr. Reddy's Laboratories Limited | Solid forms of encequidar mesylate and processes thereof |
| WO2020230037A1 (en) * | 2019-05-13 | 2020-11-19 | Dr. Reddy's Laboratories Limited | Alternate process for the preparation of encequidar |
| WO2021044350A1 (en) * | 2019-09-04 | 2021-03-11 | Dr. Reddy’S Laboratories Limited | Solid forms of encequidar mesylate and processes thereof |
| US20230278990A1 (en) | 2020-07-10 | 2023-09-07 | Teva Czech Industries S.R.O | Solid state forms of n-[2-(2-{4-[2-(6,7-dimethoxy-3,4-dihydro-2(1h)-isoquinolinyl)ethyl]phenyl}-2h-tetrazol-5-yl)-4,5-dimethoxyphenyl]-4-oxo-4h-chromene-2-carboxamide mesylate salt |
| CA3194694A1 (en) | 2020-10-07 | 2022-04-14 | Sameer Urgaonkar | Acetamido-phenyltetrazole derivatives and methods of using the same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| KR100508019B1 (ko) * | 2003-07-19 | 2005-08-17 | 한미약품 주식회사 | 고순도 1-안드로스텐 유도체의 제조 방법 |
| KR100557093B1 (ko) | 2003-10-07 | 2006-03-03 | 한미약품 주식회사 | 다약제 내성 저해 활성을 갖는 테트라졸 유도체 및 그의제조방법 |
| US7279471B2 (en) * | 2004-04-15 | 2007-10-09 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
| KR100686695B1 (ko) * | 2005-06-11 | 2007-02-26 | 주식회사 에스텍파마 | 프란루카스트 또는 그의 수화물의 제조방법 및 그의 합성중간체 |
| US20070161791A1 (en) * | 2006-01-09 | 2007-07-12 | Narsimha Reddy Penthala | Process for the preparation of terazosin hydrocloride dihydrate |
-
2010
- 2010-01-15 KR KR1020100003835A patent/KR101466245B1/ko active IP Right Grant
-
2011
- 2011-01-14 PL PL11733103T patent/PL2524916T3/pl unknown
- 2011-01-14 CN CN201180005610.5A patent/CN102812020B/zh active Active
- 2011-01-14 AU AU2011205891A patent/AU2011205891B2/en active Active
- 2011-01-14 BR BR112012017448-7A patent/BR112012017448B1/pt active IP Right Grant
- 2011-01-14 CA CA2786434A patent/CA2786434C/en active Active
- 2011-01-14 DK DK11733103.3T patent/DK2524916T3/da active
- 2011-01-14 EP EP11733103.3A patent/EP2524916B1/en active Active
- 2011-01-14 RU RU2012134783/04A patent/RU2509769C1/ru active
- 2011-01-14 MX MX2012007868A patent/MX2012007868A/es active IP Right Grant
- 2011-01-14 WO PCT/KR2011/000291 patent/WO2011087316A2/ko active Application Filing
- 2011-01-14 ES ES11733103.3T patent/ES2514340T3/es active Active
- 2011-01-14 US US13/522,272 patent/US8680277B2/en active Active
- 2011-01-14 JP JP2012548895A patent/JP5575921B2/ja active Active
- 2011-01-14 SG SG2012050472A patent/SG182430A1/en unknown
- 2011-01-14 NZ NZ601805A patent/NZ601805A/en unknown
-
2012
- 2012-07-10 IL IL220851A patent/IL220851A/en active IP Right Grant
- 2012-07-20 NO NO20120841A patent/NO342589B1/no unknown
- 2012-08-14 ZA ZA2012/06084A patent/ZA201206084B/en unknown
-
2013
- 2013-04-18 HK HK13104698.2A patent/HK1177211A1/xx unknown
-
2014
- 2014-02-03 US US14/171,318 patent/US8940908B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 405/14 , C07D 403/02 , C07D 417/12 Ipc: C07D 405/14 (2006.01), C07D 403/02 (2006.01), C07D |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/01/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |