BR112013018942A8 - Processo para o preparo de 4-amino-3-cloro-5-fluro-6(substituído)-picolinatos - Google Patents

Processo para o preparo de 4-amino-3-cloro-5-fluro-6(substituído)-picolinatos

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Publication number
BR112013018942A8
BR112013018942A8 BR112013018942A BR112013018942A BR112013018942A8 BR 112013018942 A8 BR112013018942 A8 BR 112013018942A8 BR 112013018942 A BR112013018942 A BR 112013018942A BR 112013018942 A BR112013018942 A BR 112013018942A BR 112013018942 A8 BR112013018942 A8 BR 112013018942A8
Authority
BR
Brazil
Prior art keywords
picolinates
preparation
chloro
amino
replaced
Prior art date
Application number
BR112013018942A
Other languages
English (en)
Other versions
BR112013018942A2 (pt
Inventor
Zhu Yuanming
T Whiteker Gregory
E Arndt Kim
M Renga James
D Frose Robert
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR112013018942A2 publication Critical patent/BR112013018942A2/pt
Publication of BR112013018942A8 publication Critical patent/BR112013018942A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSO PARA O PREPARO DE 4-AMIN0-3- CLOR0-5-FLUOR0-6-(SUBSTITUÍDO)PICOLINATOS. A presente invenção refere-se a um processo para o preparo de 4-amino-3-cloro-5-fluoro-6-(substituído)picolinatos que são convenientemente preparados a partir de 3,4,5,6-tetracloropicolinonitrilo por uma série de etapas envolvendo permuta de flúor, aminação, reação com hidrazina, halo-genação, hidrólise e esterificação e acoplamento auxiliado por metal de transição.
BR112013018942A 2011-01-25 2012-01-24 Processo para o preparo de 4-amino-3-cloro-5-fluro-6(substituído)-picolinatos BR112013018942A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161435974P 2011-01-25 2011-01-25
PCT/US2012/022288 WO2012103044A1 (en) 2011-01-25 2012-01-24 Process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates

Publications (2)

Publication Number Publication Date
BR112013018942A2 BR112013018942A2 (pt) 2018-05-22
BR112013018942A8 true BR112013018942A8 (pt) 2018-07-31

Family

ID=46544649

Family Applications (2)

Application Number Title Priority Date Filing Date
BR102012001638A BR102012001638A8 (pt) 2011-01-25 2012-01-24 Processo para preparação de 4-amino-3-cloro-5-fluoro-6(substituídos)picolinatos
BR112013018942A BR112013018942A8 (pt) 2011-01-25 2012-01-24 Processo para o preparo de 4-amino-3-cloro-5-fluro-6(substituído)-picolinatos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR102012001638A BR102012001638A8 (pt) 2011-01-25 2012-01-24 Processo para preparação de 4-amino-3-cloro-5-fluoro-6(substituídos)picolinatos

Country Status (20)

Country Link
US (2) US8609853B2 (pt)
EP (2) EP2901857B1 (pt)
JP (1) JP5739019B2 (pt)
KR (2) KR101517313B1 (pt)
CN (1) CN103429082B (pt)
AR (1) AR085023A1 (pt)
AU (1) AU2012209280B2 (pt)
BR (2) BR102012001638A8 (pt)
CA (1) CA2825389C (pt)
CO (1) CO6731128A2 (pt)
HK (2) HK1187493A1 (pt)
IL (1) IL227645B (pt)
MX (1) MX339636B (pt)
PL (2) PL2667713T3 (pt)
RU (1) RU2539578C1 (pt)
SG (2) SG192579A1 (pt)
TW (2) TWI547482B (pt)
UA (1) UA105610C2 (pt)
WO (1) WO2012103044A1 (pt)
ZA (1) ZA201305579B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609651A (zh) 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（一）
BR102014028162A2 (pt) 2013-11-12 2015-09-08 Dow Agrosciences Llc processo para fluoração de compostos
TW201524956A (zh) * 2013-11-12 2015-07-01 Dow Agrosciences Llc 用於氟化化合物之過程（二）
TWI726900B (zh) 2015-08-04 2021-05-11 美商陶氏農業科學公司 用於氟化化合物之過程
JP2019502729A (ja) * 2016-01-22 2019-01-31 ダウ アグロサイエンシィズ エルエルシー ４−アルコキシ−３−ヒドロキシピコリン酸を製造する方法
CN109415319A (zh) * 2016-05-19 2019-03-01 美国陶氏益农公司 通过直接苏楚基偶联合成芳基羧酸酯
WO2020061146A1 (en) 2018-09-19 2020-03-26 Dow Agrosciences Llc Preparation of halogen analogs of picloram
EP4121414A1 (en) 2020-03-18 2023-01-25 Corteva Agriscience LLC Improved synthesis of 4-amino-6-(heterocyclic)picolinates
US20230174490A1 (en) 2020-03-18 2023-06-08 Corteva Agriscience Llc Improved synthesis of 6-aryl-4-aminopicolinates

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US3755338A (en) * 1970-12-17 1973-08-28 Dow Chemical Co 4-amino-6-bromo-3,5-dichloropicolinic acid compounds
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Also Published As

Publication number Publication date
KR101542340B1 (ko) 2015-08-05
RU2539578C1 (ru) 2015-01-20
EP2901857A1 (en) 2015-08-05
WO2012103044A1 (en) 2012-08-02
ZA201305579B (en) 2014-09-25
AR085023A1 (es) 2013-08-07
CA2825389C (en) 2015-12-22
EP2901857B1 (en) 2017-03-01
PL2667713T3 (pl) 2017-08-31
SG192579A1 (en) 2013-09-30
IL227645A0 (en) 2013-09-30
CA2825389A1 (en) 2012-08-02
MX339636B (es) 2016-06-01
BR112013018942A2 (pt) 2018-05-22
EP2667713B1 (en) 2016-05-04
CO6731128A2 (es) 2013-08-15
JP2014511364A (ja) 2014-05-15
PL2901857T3 (pl) 2017-08-31
HK1206938A1 (en) 2016-01-22
KR20150006073A (ko) 2015-01-15
JP5739019B2 (ja) 2015-06-24
TW201307290A (zh) 2013-02-16
TW201600511A (zh) 2016-01-01
MX2013008604A (es) 2013-08-12
US8609853B2 (en) 2013-12-17
HK1187493A1 (en) 2014-04-11
CN103429082B (zh) 2015-05-06
CN103429082A (zh) 2013-12-04
US20140046070A1 (en) 2014-02-13
US9598368B2 (en) 2017-03-21
TWI520943B (zh) 2016-02-11
KR20130121951A (ko) 2013-11-06
US20120190858A1 (en) 2012-07-26
IL227645B (en) 2018-01-31
AU2012209280A1 (en) 2013-08-15
EP2667713A1 (en) 2013-12-04
EP2667713A4 (en) 2014-09-10
SG10201503717PA (en) 2015-06-29
BR102012001638A8 (pt) 2018-07-31
BR102012001638A2 (pt) 2015-07-28
TWI547482B (zh) 2016-09-01
UA105610C2 (uk) 2014-05-26
KR101517313B1 (ko) 2015-05-04
AU2012209280B2 (en) 2015-08-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A01N 43/40 (2006.01), C07D 213/72 (2006.01), C07D

B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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