WO2012115402A3 - Crystalline form of docetaxel and process for preparation thereof - Google Patents

Crystalline form of docetaxel and process for preparation thereof Download PDF

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Publication number
WO2012115402A3
WO2012115402A3 PCT/KR2012/001238 KR2012001238W WO2012115402A3 WO 2012115402 A3 WO2012115402 A3 WO 2012115402A3 KR 2012001238 W KR2012001238 W KR 2012001238W WO 2012115402 A3 WO2012115402 A3 WO 2012115402A3
Authority
WO
WIPO (PCT)
Prior art keywords
docetaxel
crystalline form
present
preparing
anhydrous crystalline
Prior art date
Application number
PCT/KR2012/001238
Other languages
French (fr)
Other versions
WO2012115402A2 (en
Inventor
Si-Young Sung
Byoung-Hwa Son
Ki-Moon Ryu
Moon-Sung Kim
Dong-Sung Kim
Soon-Hoe Kim
Original Assignee
Dong-A Pharm.Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong-A Pharm.Co.,Ltd. filed Critical Dong-A Pharm.Co.,Ltd.
Publication of WO2012115402A2 publication Critical patent/WO2012115402A2/en
Publication of WO2012115402A3 publication Critical patent/WO2012115402A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel anhydrous crystalline form of docetaxel. The novel anhydrous crystalline form of docetaxel according to the present invention is significant since it solves drawbacks the prior art such as stability and accompanying its relative substances increase. Moreover, the present invention provides a process for preparing the anhydrous crystalline form of docetaxel, which can solve the problems such as low yield, long processing time and low purity of the prior art. Also, the present invention provides a process for preparing the crystalline form of docetaxel trihydrates, which can solve the problems such as low yield, difficult reaction condition, long reaction time and time of drying. Therefore the crystalline form of docetaxel trihydrates is produced with the high yield in the mild condition by the process for preparing it.
PCT/KR2012/001238 2011-02-22 2012-02-20 Crystalline form of docetaxel and process for preparation thereof WO2012115402A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110015463A KR20120096200A (en) 2011-02-22 2011-02-22 Crystalline form of docetaxel and process for preparation thereof
KR10-2011-0015463 2011-02-22

Publications (2)

Publication Number Publication Date
WO2012115402A2 WO2012115402A2 (en) 2012-08-30
WO2012115402A3 true WO2012115402A3 (en) 2012-10-18

Family

ID=46721312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/001238 WO2012115402A2 (en) 2011-02-22 2012-02-20 Crystalline form of docetaxel and process for preparation thereof

Country Status (2)

Country Link
KR (1) KR20120096200A (en)
WO (1) WO2012115402A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018527287A (en) 2015-05-15 2018-09-20 アルブヴェックス エルエルシー Complex of docetaxel and human serum albumin
CN106674156A (en) * 2015-11-09 2017-05-17 上海贝美医药科技有限公司 New crystalline form of docetaxel and preparation method thereof
US11419842B2 (en) 2016-10-27 2022-08-23 Zhuhai Beihai Biotech Co., Ltd. Neutral pH compositions of Docetaxel and human serum albumin

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044950A2 (en) * 2005-10-12 2007-04-19 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
WO2008051465A2 (en) * 2006-10-20 2008-05-02 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
JP2010138084A (en) * 2008-12-10 2010-06-24 Mercian Corp Manufacturing method of crystalline docetaxel trihydrate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007044950A2 (en) * 2005-10-12 2007-04-19 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
WO2008051465A2 (en) * 2006-10-20 2008-05-02 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
JP2010138084A (en) * 2008-12-10 2010-06-24 Mercian Corp Manufacturing method of crystalline docetaxel trihydrate

Also Published As

Publication number Publication date
WO2012115402A2 (en) 2012-08-30
KR20120096200A (en) 2012-08-30

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