ATE538102T1 - Verfahren zur herstellung eines chinazolinderivats - Google Patents
Verfahren zur herstellung eines chinazolinderivatsInfo
- Publication number
- ATE538102T1 ATE538102T1 AT08827791T AT08827791T ATE538102T1 AT E538102 T1 ATE538102 T1 AT E538102T1 AT 08827791 T AT08827791 T AT 08827791T AT 08827791 T AT08827791 T AT 08827791T AT E538102 T1 ATE538102 T1 AT E538102T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- quinazoline derivative
- methylamine
- dimethoxyquinazolin
- aminophenyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- KMXOTNLMXAAOHE-UHFFFAOYSA-N 3-[2-(aminomethyl)-6,7-dimethoxyquinazolin-4-yl]aniline Chemical compound C=12C=C(OC)C(OC)=CC2=NC(CN)=NC=1C1=CC=CC(N)=C1 KMXOTNLMXAAOHE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007212921 | 2007-08-17 | ||
| PCT/JP2008/064620 WO2009025238A1 (ja) | 2007-08-17 | 2008-08-15 | キナゾリン誘導体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538102T1 true ATE538102T1 (de) | 2012-01-15 |
Family
ID=40378143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08827791T ATE538102T1 (de) | 2007-08-17 | 2008-08-15 | Verfahren zur herstellung eines chinazolinderivats |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8492543B2 (de) |
| EP (1) | EP2189450B1 (de) |
| JP (1) | JP5043945B2 (de) |
| KR (1) | KR20100042245A (de) |
| CN (3) | CN101687820B (de) |
| AT (1) | ATE538102T1 (de) |
| AU (1) | AU2008290000B2 (de) |
| CA (1) | CA2696727A1 (de) |
| IL (1) | IL204017A (de) |
| WO (1) | WO2009025238A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538102T1 (de) | 2007-08-17 | 2012-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung eines chinazolinderivats |
| JP6225161B2 (ja) * | 2013-02-28 | 2017-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 呼吸器疾患の予防治療剤 |
| AU2017277524B2 (en) * | 2016-06-07 | 2021-07-29 | Dermavant Sciences GmbH | Topical formulations of PDE-4 inhibitors and their methods of use |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2099112T3 (es) | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
| JP3466305B2 (ja) | 1994-12-12 | 2003-11-10 | 久光製薬株式会社 | 溶解剤および該溶解剤を含有する外用製剤 |
| WO1998010767A2 (en) | 1996-09-13 | 1998-03-19 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
| JPH11209350A (ja) * | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
| JP3373838B2 (ja) | 1999-10-25 | 2003-02-04 | 山之内製薬株式会社 | ナフチリジン誘導体 |
| TWI262919B (en) * | 1999-10-25 | 2006-10-01 | Yamanouchi Pharma Co Ltd | Naphthyridine derivative |
| US20060084684A1 (en) | 2002-05-28 | 2006-04-20 | Altana Pharma Ag | Topically applicable pharmaceutical preparation |
| US20040038958A1 (en) | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
| JP4387717B2 (ja) | 2003-07-11 | 2009-12-24 | 株式会社資生堂 | 油中水型皮膚外用医薬品製剤 |
| JP2005047909A (ja) | 2003-07-17 | 2005-02-24 | Santen Pharmaceut Co Ltd | ピペリジン誘導体を有効成分とする掻痒治療剤 |
| EP1647274A4 (de) * | 2003-07-17 | 2008-12-10 | Ono Pharmaceutical Co | Mittel zur behandlung von pruritus mit einem piperidin-derivat als wirkstoff |
| WO2005082865A1 (ja) | 2004-02-27 | 2005-09-09 | Astellas Pharma Inc. | 縮合二環性ピリミジン誘導体 |
| EP1855634A4 (de) | 2005-02-23 | 2012-07-11 | Stryker Canadian Man Inc | Diagnose- und kontrollsystem für eine patientenstütze |
| JP2008137892A (ja) | 2005-03-04 | 2008-06-19 | Eisai Co Ltd | 止痒剤 |
| TWI404709B (zh) | 2006-02-21 | 2013-08-11 | Eisai R&D Man Co Ltd | 4- (3-benzamidophenyl) -6,7-dimethoxy-2-methylamine quinazoline derivatives |
| EP1992622B1 (de) | 2006-02-21 | 2011-07-27 | Eisai R&D Management Co., Ltd. | 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminochinazolinderivat |
| CA2678477A1 (en) * | 2007-02-16 | 2008-08-21 | Eisai R&D Management Co., Ltd. | Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid |
| ATE538102T1 (de) | 2007-08-17 | 2012-01-15 | Eisai R&D Man Co Ltd | Verfahren zur herstellung eines chinazolinderivats |
| EP2202229B1 (de) | 2007-08-17 | 2012-03-14 | Eisai R&D Management Co., Ltd. | Neue zubereitung für die äusserliche anwendung |
-
2008
- 2008-08-15 AT AT08827791T patent/ATE538102T1/de active
- 2008-08-15 AU AU2008290000A patent/AU2008290000B2/en not_active Ceased
- 2008-08-15 JP JP2009529018A patent/JP5043945B2/ja not_active Expired - Fee Related
- 2008-08-15 KR KR1020097026235A patent/KR20100042245A/ko not_active Ceased
- 2008-08-15 WO PCT/JP2008/064620 patent/WO2009025238A1/ja not_active Ceased
- 2008-08-15 CN CN2008800220818A patent/CN101687820B/zh not_active Expired - Fee Related
- 2008-08-15 CN CN2011102772012A patent/CN102336717B/zh not_active Expired - Fee Related
- 2008-08-15 CA CA2696727A patent/CA2696727A1/en not_active Abandoned
- 2008-08-15 US US12/733,169 patent/US8492543B2/en not_active Expired - Fee Related
- 2008-08-15 CN CN2011103959045A patent/CN102532041A/zh active Pending
- 2008-08-15 EP EP08827791A patent/EP2189450B1/de active Active
-
2010
- 2010-02-17 IL IL204017A patent/IL204017A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102336717A (zh) | 2012-02-01 |
| CN102532041A (zh) | 2012-07-04 |
| EP2189450A4 (de) | 2010-10-20 |
| IL204017A (en) | 2013-01-31 |
| US20110152521A1 (en) | 2011-06-23 |
| JP5043945B2 (ja) | 2012-10-10 |
| CN101687820B (zh) | 2012-07-25 |
| WO2009025238A1 (ja) | 2009-02-26 |
| AU2008290000A1 (en) | 2009-02-26 |
| CN101687820A (zh) | 2010-03-31 |
| EP2189450B1 (de) | 2011-12-21 |
| JPWO2009025238A1 (ja) | 2010-11-25 |
| US8492543B2 (en) | 2013-07-23 |
| KR20100042245A (ko) | 2010-04-23 |
| CN102336717B (zh) | 2013-09-18 |
| EP2189450A1 (de) | 2010-05-26 |
| CA2696727A1 (en) | 2009-02-26 |
| AU2008290000B2 (en) | 2012-05-10 |
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