WO2009005024A1 - 光学活性アミンの製造方法 - Google Patents

光学活性アミンの製造方法 Download PDF

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Publication number
WO2009005024A1
WO2009005024A1 PCT/JP2008/061809 JP2008061809W WO2009005024A1 WO 2009005024 A1 WO2009005024 A1 WO 2009005024A1 JP 2008061809 W JP2008061809 W JP 2008061809W WO 2009005024 A1 WO2009005024 A1 WO 2009005024A1
Authority
WO
WIPO (PCT)
Prior art keywords
optically active
active amine
producing optically
producing
compound
Prior art date
Application number
PCT/JP2008/061809
Other languages
English (en)
French (fr)
Inventor
Sadayuki Maeda
Original Assignee
Hamari Chemicals, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamari Chemicals, Ltd. filed Critical Hamari Chemicals, Ltd.
Priority to US12/452,402 priority Critical patent/US8222452B2/en
Priority to JP2009521619A priority patent/JP5208934B2/ja
Priority to EP08790722A priority patent/EP2172443B1/en
Publication of WO2009005024A1 publication Critical patent/WO2009005024A1/ja
Priority to HK10103737.0A priority patent/HK1136274A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　本発明は、イミン化合物を、キラルなプロリンアミド類化合物を配位子とするイリジウム（ＩＩＩ）錯体および水素供与性化合物の存在下で水素移動型の不斉還元をすることを特徴とするキラルアミンの製造方法である。本発明は、光学収率および化学収率の両面において効率的にキラルアミンを製造するのに有用である。
PCT/JP2008/061809 2007-07-03 2008-06-30 光学活性アミンの製造方法 WO2009005024A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/452,402 US8222452B2 (en) 2007-07-03 2008-06-30 Method for producing optically active amines
JP2009521619A JP5208934B2 (ja) 2007-07-03 2008-06-30 光学活性アミンの製造方法
EP08790722A EP2172443B1 (en) 2007-07-03 2008-06-30 Method for producing optically active amine
HK10103737.0A HK1136274A1 (en) 2007-07-03 2010-04-16 Method for producing optically active amine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-175278 2007-07-03
JP2007175278 2007-07-03

Publications (1)

Publication Number Publication Date
WO2009005024A1 true WO2009005024A1 (ja) 2009-01-08

Family

ID=40226069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061809 WO2009005024A1 (ja) 2007-07-03 2008-06-30 光学活性アミンの製造方法

Country Status (5)

Country Link
US (1) US8222452B2 (ja)
EP (1) EP2172443B1 (ja)
JP (1) JP5208934B2 (ja)
HK (1) HK1136274A1 (ja)
WO (1) WO2009005024A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2228377A1 (en) * 2009-03-12 2010-09-15 Kanto Kagaku Kabushiki Kaisha Novel organometallic complex and process for preparing amine compound
US20120065426A1 (en) * 2010-09-15 2012-03-15 Kanto Kagaku Kabushiki Kaisha Process for preparing amine compound
WO2013011930A1 (ja) 2011-07-15 2013-01-24 浜理薬品工業株式会社 光学活性テトラヒドロキノリン類の製造方法
WO2013047738A1 (ja) * 2011-09-30 2013-04-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 グルホシネートｐ遊離酸の製造方法
CN114456078A (zh) * 2022-01-19 2022-05-10 汉瑞药业(荆门)有限公司 一种(r)-n-苄基-1-(4-甲氧基苯基)丙-2-胺的制备方法
CN114751852A (zh) * 2022-05-23 2022-07-15 山西库邦生物医药科技有限公司 一种西咯多辛关键中间体的制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103396352B (zh) * 2013-08-07 2015-04-08 苏州明锐医药科技有限公司 赛洛多辛的制备方法
CN104974073B (zh) * 2014-04-10 2017-11-03 江苏和成新材料有限公司 一种制备西洛多辛中间体的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6327471A (ja) * 1986-07-21 1988-02-05 Yamanouchi Pharmaceut Co Ltd 光学活性なベンゼンスルホンアミド誘導体の製造法
WO1997020789A1 (fr) 1995-12-06 1997-06-12 Japan Science And Technology Corporation Procede de preparation de composes optiquement actifs
WO2002010101A1 (fr) * 2000-08-01 2002-02-07 Shionogi & Co., Ltd. Procede de production d'un alcool en presence d'un complexe de metaux de transition contenant un compose amide en tant que liant
JP2004504371A (ja) * 2000-07-24 2004-02-12 カイロテック・テクノロジー・リミテッド ルテニウム錯体および不斉水素化におけるその使用
JP2004537588A (ja) 2001-08-09 2004-12-16 デグサ アクチエンゲゼルシャフト 移動水素化条件下でのカルボニル化合物の還元アミノ化による、アミンの製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2912572B2 (ja) * 1995-12-06 1999-06-28 科学技術振興事業団 光学活性アミン類の製造方法
CZ293922B6 (cs) * 2003-01-14 2004-08-18 Farmakźáa@Ás Způsob enantioselektivní redukce Q[@aza@Q@}@ethoxyfenoxyB@methylpent@enyl]@methoxybenzensulfonamidu pomocí chirálních acyloxyborohydridů

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6327471A (ja) * 1986-07-21 1988-02-05 Yamanouchi Pharmaceut Co Ltd 光学活性なベンゼンスルホンアミド誘導体の製造法
JPH066565B2 (ja) 1986-07-21 1994-01-26 山之内製薬株式会社 光学活性なベンゼンスルホンアミド誘導体の製造法
WO1997020789A1 (fr) 1995-12-06 1997-06-12 Japan Science And Technology Corporation Procede de preparation de composes optiquement actifs
EP0916637A1 (en) 1995-12-06 1999-05-19 Japan Science and Technology Corporation Process for preparating optically active compounds
JP2004504371A (ja) * 2000-07-24 2004-02-12 カイロテック・テクノロジー・リミテッド ルテニウム錯体および不斉水素化におけるその使用
WO2002010101A1 (fr) * 2000-08-01 2002-02-07 Shionogi & Co., Ltd. Procede de production d'un alcool en presence d'un complexe de metaux de transition contenant un compose amide en tant que liant
JP2004537588A (ja) 2001-08-09 2004-12-16 デグサ アクチエンゲゼルシャフト 移動水素化条件下でのカルボニル化合物の還元アミノ化による、アミンの製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANGEW. CHEM. INT. ED, vol. 40, 2001, pages 3425 - 3427
ANGEW. CHEM. INT. ED, vol. 42, 2003, pages 5472 - 5474

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481735B2 (en) 2009-03-12 2013-07-09 Kanto Kagaku Kabushiki Kaisha Organic metal complex and process for preparing amine compound
EP2228377A1 (en) * 2009-03-12 2010-09-15 Kanto Kagaku Kabushiki Kaisha Novel organometallic complex and process for preparing amine compound
US9211533B2 (en) 2009-03-12 2015-12-15 Kanto Kagaku Kabushiki Kaisha Organic metal complex and process for preparing amine compound
US20120065426A1 (en) * 2010-09-15 2012-03-15 Kanto Kagaku Kabushiki Kaisha Process for preparing amine compound
JP2012062270A (ja) * 2010-09-15 2012-03-29 Kanto Chem Co Inc アミン化合物の製造方法
WO2013011930A1 (ja) 2011-07-15 2013-01-24 浜理薬品工業株式会社 光学活性テトラヒドロキノリン類の製造方法
JPWO2013011930A1 (ja) * 2011-07-15 2015-02-23 浜理薬品工業株式会社 光学活性テトラヒドロキノリン類の製造方法
US9108986B2 (en) 2011-07-15 2015-08-18 Hamari Chemicals, Ltd. Method for producing optically active tetrahydroquinolines
JP2017095462A (ja) * 2011-07-15 2017-06-01 浜理薬品工業株式会社 光学活性テトラヒドロキノリン類の製造方法
JPWO2013047738A1 (ja) * 2011-09-30 2015-03-26 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 グルホシネートｐ遊離酸の製造方法
WO2013047738A1 (ja) * 2011-09-30 2013-04-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 グルホシネートｐ遊離酸の製造方法
US9255115B2 (en) 2011-09-30 2016-02-09 Meiji Seika Pharma Co. Ltd. Method for producing glufosinate P free acid
CN114456078A (zh) * 2022-01-19 2022-05-10 汉瑞药业(荆门)有限公司 一种(r)-n-苄基-1-(4-甲氧基苯基)丙-2-胺的制备方法
CN114751852A (zh) * 2022-05-23 2022-07-15 山西库邦生物医药科技有限公司 一种西咯多辛关键中间体的制备方法
CN114751852B (zh) * 2022-05-23 2023-09-15 山西库邦生物医药科技有限公司 一种西咯多辛关键中间体的制备方法

Also Published As

Publication number Publication date
EP2172443B1 (en) 2013-03-27
JPWO2009005024A1 (ja) 2010-08-26
EP2172443A4 (en) 2011-08-17
EP2172443A1 (en) 2010-04-07
JP5208934B2 (ja) 2013-06-12
US8222452B2 (en) 2012-07-17
HK1136274A1 (en) 2010-06-25
US20100160636A1 (en) 2010-06-24

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