JP5813321B2 - 体細胞の再プログラム化 - Google Patents
体細胞の再プログラム化 Download PDFInfo
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- JP5813321B2 JP5813321B2 JP2010501136A JP2010501136A JP5813321B2 JP 5813321 B2 JP5813321 B2 JP 5813321B2 JP 2010501136 A JP2010501136 A JP 2010501136A JP 2010501136 A JP2010501136 A JP 2010501136A JP 5813321 B2 JP5813321 B2 JP 5813321B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C12N2501/604—Klf-4
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- C12N2501/608—Lin28
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- C12N2510/00—Genetically modified cells
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91968707P | 2007-03-23 | 2007-03-23 | |
| US60/919,687 | 2007-03-23 | ||
| US97498007P | 2007-09-25 | 2007-09-25 | |
| US60/974,980 | 2007-09-25 | ||
| US98905807P | 2007-11-19 | 2007-11-19 | |
| US60/989,058 | 2007-11-19 | ||
| PCT/US2008/057924 WO2008118820A2 (en) | 2007-03-23 | 2008-03-21 | Somatic cell reprogramming |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094203A Division JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521990A JP2010521990A (ja) | 2010-07-01 |
| JP2010521990A5 JP2010521990A5 (cg-RX-API-DMAC7.html) | 2011-04-14 |
| JP5813321B2 true JP5813321B2 (ja) | 2015-11-17 |
Family
ID=39708430
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010501136A Active JP5813321B2 (ja) | 2007-03-23 | 2008-03-21 | 体細胞の再プログラム化 |
| JP2015094203A Active JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
| JP2018147683A Active JP6924732B2 (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2018147684A Pending JP2018183183A (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2021126772A Pending JP2021176331A (ja) | 2007-03-23 | 2021-08-02 | 体細胞の再プログラム化 |
| JP2024010931A Pending JP2024038501A (ja) | 2007-03-23 | 2024-01-29 | 体細胞の再プログラム化 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094203A Active JP6788329B2 (ja) | 2007-03-23 | 2015-05-01 | 体細胞の再プログラム化 |
| JP2018147683A Active JP6924732B2 (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2018147684A Pending JP2018183183A (ja) | 2007-03-23 | 2018-08-06 | 体細胞の再プログラム化 |
| JP2021126772A Pending JP2021176331A (ja) | 2007-03-23 | 2021-08-02 | 体細胞の再プログラム化 |
| JP2024010931A Pending JP2024038501A (ja) | 2007-03-23 | 2024-01-29 | 体細胞の再プログラム化 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US8440461B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3399025B1 (cg-RX-API-DMAC7.html) |
| JP (6) | JP5813321B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101516833B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101743306A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008231020B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2684242C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3399025T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL200982A (cg-RX-API-DMAC7.html) |
| SG (2) | SG193653A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008118820A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| EP1885845A2 (en) | 2005-06-01 | 2008-02-13 | Wisconsin Alumni Research Foundation | Method of forming dendritic cells from embryonic stem cells |
| US8034613B2 (en) | 2005-06-01 | 2011-10-11 | Wisconsin Alumni Research Foundation | Multipotent lymphohematopoietic progenitor cells |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| CN101864392B (zh) | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| WO2007095064A2 (en) | 2006-02-09 | 2007-08-23 | Wisconsin Alumni Research Foundation | ERYTHROID CELLS PRODUCING ADULT-TYPE β-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS |
| CA2684242C (en) | 2007-03-23 | 2019-11-12 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| MX352541B (es) * | 2007-04-07 | 2017-11-29 | Whitehead Inst Biomedical Res | Reprogramación de células somáticas. |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US20110236971A2 (en) * | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| AU2008297024B2 (en) * | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| AU2008286249B2 (en) | 2007-12-10 | 2013-10-10 | Kyoto University | Efficient method for nuclear reprogramming |
| SG10201400329YA (en) | 2008-05-02 | 2014-05-29 | Univ Kyoto | Method of nuclear reprogramming |
| WO2009137844A2 (en) * | 2008-05-09 | 2009-11-12 | Vistagen Therapeutics, Inc. | Pancreatic endocrine progenitor cells derived from pluripotent stem cells |
| CA2954948A1 (en) * | 2008-06-04 | 2009-12-10 | Cellular Dynamics International, Inc. | Methods for the production of ips cells using non-viral approach |
| CA2969377C (en) | 2008-06-13 | 2019-12-03 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
| CA2695590C (en) | 2008-06-27 | 2018-01-09 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| KR101685209B1 (ko) * | 2008-07-30 | 2016-12-09 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| KR101773345B1 (ko) * | 2008-08-12 | 2017-08-31 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | iPS 세포의 생산 방법 |
| WO2010033906A2 (en) * | 2008-09-19 | 2010-03-25 | President And Fellows Of Harvard College | Efficient induction of pluripotent stem cells using small molecule compounds |
| WO2010042800A1 (en) * | 2008-10-10 | 2010-04-15 | Nevada Cancer Institute | Methods of reprogramming somatic cells and methods of use for such cells |
| US8268620B2 (en) * | 2008-10-24 | 2012-09-18 | Wisconsin Alumni Research Foundation | OCT4 and SOX2 with SV40 T antigen produce pluripotent stem cells from primate somatic cells |
| EP2342333A4 (en) * | 2008-10-30 | 2013-05-08 | Univ Kyoto | Method for producing induced pluripotent stem cells |
| WO2010056808A2 (en) * | 2008-11-12 | 2010-05-20 | The Regents Of The University Of California | Compositions and methods for re-programming and re-differentiating cells |
| US9045737B2 (en) * | 2008-12-13 | 2015-06-02 | Dnamicroarray, Inc. | Artificial three-dimensional microenvironment niche culture |
| US20110300627A1 (en) * | 2009-01-20 | 2011-12-08 | Sing George L | Dedifferentiation and reprogramming of cells |
| CA2753208C (en) | 2009-02-20 | 2018-08-21 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| EP2401372A4 (en) * | 2009-02-27 | 2012-09-19 | Univ Kyoto | NEW NUCLEAR REPROGRAMMING SUBSTANCE |
| US9487756B2 (en) | 2009-03-20 | 2016-11-08 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| EP2421957B1 (en) | 2009-04-22 | 2020-11-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| JP5777113B2 (ja) | 2009-05-29 | 2015-09-09 | 学校法人慶應義塾 | 人工多能性幹細胞のクローンの選択方法 |
| DK2548950T3 (en) | 2009-06-05 | 2017-12-11 | Cellular Dynamics Int Inc | Reprogramming of T cells and hematopoietic cells |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| JP5645197B2 (ja) * | 2009-06-23 | 2014-12-24 | 学校法人日本大学 | 幹細胞の未分化状態を維持する新規方法 |
| KR101774206B1 (ko) | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| JP5751548B2 (ja) | 2009-08-07 | 2015-07-22 | 国立大学法人京都大学 | イヌiPS細胞及びその製造方法 |
| JP5709015B2 (ja) | 2009-08-19 | 2015-04-30 | 国立大学法人大阪大学 | 角膜移植用シート |
| US8993329B2 (en) | 2009-09-24 | 2015-03-31 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| GB2474492B (en) * | 2009-10-19 | 2014-05-21 | Tristem Trading Cyprus Ltd | Treatment using reprogrammed mature adult cells |
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