JP5788316B2 - キナーゼインヒビターおよび使用方法 - Google Patents

キナーゼインヒビターおよび使用方法 Download PDF

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Publication number
JP5788316B2
JP5788316B2 JP2011517583A JP2011517583A JP5788316B2 JP 5788316 B2 JP5788316 B2 JP 5788316B2 JP 2011517583 A JP2011517583 A JP 2011517583A JP 2011517583 A JP2011517583 A JP 2011517583A JP 5788316 B2 JP5788316 B2 JP 5788316B2
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Japan
Prior art keywords
cycloalkyl
alkyl
heterocycloalkyl
compound
aryl
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JP2011517583A
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Japanese (ja)
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JP2011527692A (ja
JP2011527692A5 (OSRAM
Inventor
ピンダ レン，
ピンダ レン，
イー リュー，
イー リュー，
リャンシェン リー，
リャンシェン リー，
カトリーナ チャン，
カトリーナ チャン，
トロイ エドワード ウィルソン，
トロイ エドワード ウィルソン，
マイケル マーティン，
マイケル マーティン，
クリスティアン ロメル，
クリスティアン ロメル，
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インテリカイン， エルエルシー
インテリカイン， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
JP2011517583A 2008-07-08 2009-07-08 キナーゼインヒビターおよび使用方法 Expired - Fee Related JP5788316B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7912708P 2008-07-08 2008-07-08
US61/079,127 2008-07-08
PCT/US2009/049983 WO2010006086A2 (en) 2008-07-08 2009-07-08 Kinase inhibitors and methods of use

Related Child Applications (1)

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JP2015149598A Division JP6073994B2 (ja) 2008-07-08 2015-07-29 キナーゼインヒビターおよび使用方法

Publications (3)

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JP2011527692A JP2011527692A (ja) 2011-11-04
JP2011527692A5 JP2011527692A5 (OSRAM) 2012-09-13
JP5788316B2 true JP5788316B2 (ja) 2015-09-30

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JP2011517583A Expired - Fee Related JP5788316B2 (ja) 2008-07-08 2009-07-08 キナーゼインヒビターおよび使用方法
JP2015149598A Expired - Fee Related JP6073994B2 (ja) 2008-07-08 2015-07-29 キナーゼインヒビターおよび使用方法

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Country Status (13)

Country Link
US (2) US9096611B2 (OSRAM)
EP (2) EP3009436B1 (OSRAM)
JP (2) JP5788316B2 (OSRAM)
KR (1) KR20110039326A (OSRAM)
CN (1) CN102124009B (OSRAM)
AU (1) AU2009268611B2 (OSRAM)
BR (1) BRPI0915231A2 (OSRAM)
CA (1) CA2730106A1 (OSRAM)
IL (1) IL210363A (OSRAM)
MX (1) MX2011000216A (OSRAM)
NZ (1) NZ590258A (OSRAM)
WO (1) WO2010006086A2 (OSRAM)
ZA (1) ZA201100211B (OSRAM)

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AU2007347115A1 (en) 2006-04-04 2008-10-23 The Regents Of The University Of California PI3 kinase antagonists
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US8993580B2 (en) * 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
CA2740885C (en) 2008-10-16 2018-04-03 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
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