JP5667049B2 - 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置 - Google Patents

大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置 Download PDF

Info

Publication number
JP5667049B2
JP5667049B2 JP2011516300A JP2011516300A JP5667049B2 JP 5667049 B2 JP5667049 B2 JP 5667049B2 JP 2011516300 A JP2011516300 A JP 2011516300A JP 2011516300 A JP2011516300 A JP 2011516300A JP 5667049 B2 JP5667049 B2 JP 5667049B2
Authority
JP
Japan
Prior art keywords
array
chemfet
isfet
nucleic acid
reaction chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011516300A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011525810A (ja
JP2011525810A5 (cg-RX-API-DMAC7.html
Inventor
ロスバーグ，ジョナサン，エム．
ヒンズ，ウルフギャング
ジョンソン，キム，エル．
バスティロ，ジェームス，エム．
リーモン，ジョン，エイチ．
シュルツ，ジョナサン
Original Assignee
ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0811656A external-priority patent/GB2461127B/en
Priority claimed from GB0811657A external-priority patent/GB2461128B/en
Application filed by ライフ テクノロジーズ コーポレーション, ライフ テクノロジーズ コーポレーション filed Critical ライフ テクノロジーズ コーポレーション
Publication of JP2011525810A publication Critical patent/JP2011525810A/ja
Publication of JP2011525810A5 publication Critical patent/JP2011525810A5/ja
Application granted granted Critical
Publication of JP5667049B2 publication Critical patent/JP5667049B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2011516300A 2008-06-25 2009-06-25 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置 Active JP5667049B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0811656.8 2008-06-25
GB0811656A GB2461127B (en) 2008-06-25 2008-06-25 Methods and apparatus for measuring analytes using large scale FET arrays
GB0811657A GB2461128B (en) 2008-06-25 2008-06-25 ChemFET Arrays for Nucleic Acid Sequencing
GB0811657.6 2008-06-25
PCT/US2009/003766 WO2010008480A2 (en) 2008-06-25 2009-06-25 Methods and apparatus for measuring analytes using large scale fet arrays

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014250922A Division JP6088481B2 (ja) 2008-06-25 2014-12-11 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置

Publications (3)

Publication Number Publication Date
JP2011525810A JP2011525810A (ja) 2011-09-29
JP2011525810A5 JP2011525810A5 (cg-RX-API-DMAC7.html) 2013-09-19
JP5667049B2 true JP5667049B2 (ja) 2015-02-12

Family

ID=41550902

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011516300A Active JP5667049B2 (ja) 2008-06-25 2009-06-25 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
JP2014250922A Active JP6088481B2 (ja) 2008-06-25 2014-12-11 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
JP2017017569A Active JP6370938B2 (ja) 2008-06-25 2017-02-02 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014250922A Active JP6088481B2 (ja) 2008-06-25 2014-12-11 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
JP2017017569A Active JP6370938B2 (ja) 2008-06-25 2017-02-02 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置

Country Status (5)

Country Link
US (6) US8470164B2 (cg-RX-API-DMAC7.html)
EP (2) EP2307577B1 (cg-RX-API-DMAC7.html)
JP (3) JP5667049B2 (cg-RX-API-DMAC7.html)
CN (1) CN102203282B (cg-RX-API-DMAC7.html)
WO (1) WO2010008480A2 (cg-RX-API-DMAC7.html)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP4134667B1 (en) 2006-12-14 2025-11-12 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
EP2307577B1 (en) * 2008-06-25 2015-06-03 Life Technologies Corporation Methods for measuring analytes using large scale fet arrays
JP2011525990A (ja) * 2008-06-26 2011-09-29 ライフ テクノロジーズ コーポレーション Ｆｅｔアレイを用いて分子相互作用を検出するための方法および装置
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010047804A1 (en) * 2008-10-22 2010-04-29 Ion Torrent Systems Incorporated Integrated sensor arrays for biological and chemical analysis
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
CN102712950B (zh) * 2009-07-29 2015-05-20 皮罗比特私人有限公司 用于实施测定法的方法和装置
US8962279B2 (en) * 2009-12-30 2015-02-24 Intel Corporation Solid-phase chelators and electronic biosensors
TWI539172B (zh) 2010-06-30 2016-06-21 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
WO2012006222A1 (en) 2010-07-03 2012-01-12 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US8986525B2 (en) 2010-08-06 2015-03-24 Dna Electronics Limited Method and apparatus for sensing a property of a fluid
US8715932B2 (en) 2010-08-20 2014-05-06 Intel Corporation Nucleic acid sequencing
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
AU2011226766A1 (en) 2010-09-24 2012-04-12 Life Technologies Corporation Matched pair transistor circuits
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9399217B2 (en) * 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
AU2011312218B2 (en) 2010-10-04 2015-11-05 Sequencing Health, Inc. Systems and methods for automated reusable parallel biological reactions
EP2438860A1 (de) * 2010-10-07 2012-04-11 BIOTRONIK SE & Co. KG Medizinisches Sensorsystem
CN103201392A (zh) * 2010-10-08 2013-07-10 Dna电子有限公司 离子信号增强
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
DK2729580T3 (en) 2011-07-08 2015-12-14 Keygene Nv SEQUENCE BASED genotyping BASED ON OLIGONUKLEOTIDLIGERINGSASSAYS
GB201112140D0 (en) 2011-07-14 2011-08-31 Dna Electronics Nucleic acid amplification
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
CN104105797B (zh) 2011-12-01 2016-08-31 吉纳普赛斯股份有限公司 用于高效电子测序与检测的系统和方法
US9322798B2 (en) 2011-12-15 2016-04-26 Intel Corporation Diamond electrode nanogap transducers
KR101754859B1 (ko) 2011-12-28 2017-07-06 인텔 코포레이션 선택적 표면 고정화 부위를 갖는 나노갭 트랜스듀서
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
KR20140140080A (ko) * 2012-03-16 2014-12-08 라이프 테크놀로지스 코포레이션 생물학적 샘플을 포함하기 위한 시스템 및 방법
EP2653562A1 (en) 2012-04-20 2013-10-23 Institut Pasteur Anellovirus genome quantification as a biomarker of immune suppression
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
DE102012210183B4 (de) * 2012-06-18 2017-03-23 Siemens Healthcare Gmbh Anordnung und Verfahren zur Analyse von Nukleinsäuresequenzen
GB201212775D0 (en) 2012-07-18 2012-08-29 Dna Electronics Ltd Sensing apparatus and method
US20140052381A1 (en) * 2012-08-14 2014-02-20 Life Technologies Corporation Systems and Methods for Detecting Homopolymer Insertions/Deletions
US9034606B2 (en) * 2012-08-23 2015-05-19 New England Biolabs, Inc. Detection of an amplification reaction product using pH-sensitive dyes
CN108229104B (zh) * 2012-09-14 2022-06-10 生命技术公司 为数字pcr实验设计者所用的方法和系统
WO2014060542A1 (en) 2012-10-17 2014-04-24 Institut National De La Recherche Agronomique Determination of a tendency to gain weight
BR112015008619A2 (pt) 2012-10-17 2017-12-19 Institut De Rech Pour Le Developpement Ird prognóstico do impacto de dieta sobre comorbidades relacionadas à obesidade
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US10066260B2 (en) * 2013-03-14 2018-09-04 Life Technologies Corporation Matrix arrays and methods for making same
WO2014149779A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical device with thin conductive element
EP2972279B1 (en) 2013-03-15 2021-10-06 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
WO2014152625A1 (en) 2013-03-15 2014-09-25 Genapsys, Inc. Systems and methods for biological analysis
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
WO2015038954A1 (en) 2013-09-13 2015-03-19 Life Technologies Corporation Device preparation using condensed nucleic acid particles
EP3058359B1 (en) * 2013-09-18 2021-01-27 Suprasensor Technologies, LLC Method for securing a membrane material to the gate of a molecular receptor-based field-effect transistor (chemfet)
US20160252517A1 (en) * 2013-10-11 2016-09-01 The Regents Of The University Of California Biomolecular interaction detection devices and methods
DE102013220848A1 (de) 2013-10-15 2015-04-16 Robert Bosch Gmbh Verfahren zum Betreiben eines chemisch sensitiven Feldeffekttransistors
CN103602726B (zh) * 2013-10-21 2015-06-03 田埂 同时对多种核酸样本进行测序的方法
EP2873739B1 (en) 2013-11-13 2017-04-12 Centre National de la Recherche Scientifique (CNRS) Diagnosis of syndromic obesity
CN104055526A (zh) * 2013-12-05 2014-09-24 庞德兴 一种无源微创皮下生化参数检测芯片
US9797976B2 (en) * 2013-12-11 2017-10-24 Taiwan Semiconductor Manufacturing Company Biosensor calibration system and related method
EP3080300B1 (en) 2013-12-11 2020-09-02 Genapsys Inc. Systems and methods for biological analysis and computation
US9822401B2 (en) 2014-04-18 2017-11-21 Genapsys, Inc. Methods and systems for nucleic acid amplification
TWI535199B (zh) * 2014-05-15 2016-05-21 聯詠科技股份有限公司 運算放大器
US9710592B2 (en) 2014-05-23 2017-07-18 International Business Machines Corporation Multiple-depth trench interconnect technology at advanced semiconductor nodes
US9454631B2 (en) 2014-05-23 2016-09-27 International Business Machines Corporation Stitch-derived via structures and methods of generating the same
CN106536037B (zh) 2014-06-19 2019-10-25 生命技术公司 掺入固体缓冲剂的系统和方法
JP6851305B2 (ja) * 2014-07-02 2021-03-31 ライフ テクノロジーズ コーポレーション センサー基質を装填するための方法
KR20170097712A (ko) 2014-12-18 2017-08-28 라이프 테크놀로지스 코포레이션 대형 fet 어레이를 사용한 분석물 측정을 위한 방법과 장치
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
TWI794007B (zh) 2014-12-18 2023-02-21 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
EP3766991B1 (en) * 2015-03-05 2022-07-20 Life Technologies Corporation Surface stabilization of biosensors
JP6692831B2 (ja) * 2015-05-12 2020-05-13 イラミーナ インコーポレーテッド 核酸をシーケンシングするための電界効果装置および方法
ES2597129B1 (es) * 2015-07-13 2017-11-08 Consejo Superior De Investigaciones Científicas (Csic) Sensor de iones de medida diferencial
CN105301079B (zh) * 2015-10-13 2019-10-15 上海小海龟科技有限公司 用于待测物离子活度检测的半导体器件及其检测方法
US20190024164A1 (en) * 2016-01-11 2019-01-24 Stc.Unm Electric-field-assisted nucleotide sequencing methods
EP3445870B1 (en) 2016-04-22 2022-09-07 Pacific Biosciences of California, Inc. Nucleic acid sequencing method and system employing enhanced detection of nucleotide-specific ternary complex formation
JP6821947B2 (ja) * 2016-04-28 2021-01-27 凸版印刷株式会社 粒子の収容方法、及び、粒子の封入方法
CN107460233A (zh) * 2016-06-06 2017-12-12 张家港万众芯生物科技有限公司 一种通过检测焦磷酸电荷的基因测序方法
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US12188893B2 (en) 2016-08-30 2025-01-07 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10611994B2 (en) 2016-08-30 2020-04-07 International Business Machines Corporation Electrochemical sensors for cell culture monitoring
US11684640B2 (en) 2016-12-22 2023-06-27 Institut Gustave Roussy Microbiota composition, as a marker of responsiveness to anti-PD1/PD-L1/PD-L2 antibodies and use of microbial modulators for improving the efficacy of an anti-PD1/PD-L1/PD-L2 ab-based
CN110312936B (zh) * 2017-02-22 2025-06-10 豪夫迈·罗氏有限公司 用于传感器装置的电极的聚合物覆层
JP2018151324A (ja) * 2017-03-14 2018-09-27 東芝テック株式会社 イオンセンサチップ
CN107164466B (zh) * 2017-05-11 2019-03-26 京东方科技集团股份有限公司 芯片基板及其制作工艺、基因测序芯片及基因测序方法
US10163781B1 (en) * 2017-05-31 2018-12-25 Taiwan Semiconductor Manufacturing Co., Ltd. Semiconductor devices and methods of forming the same
CN109212001B (zh) * 2017-06-30 2021-02-05 中国科学院微电子研究所 检测装置及方法
JP2020529865A (ja) * 2017-07-26 2020-10-15 モハメド アデル エル−ソッカリー，モハメド 濃度に基づくｄｎａシーケンシングマシン
MX2020003113A (es) 2017-09-21 2020-09-07 Genapsys Inc Sistemas y metodos para secuenciar acido nucleico.
CN108225621B (zh) * 2018-01-03 2020-05-22 电子科技大学 一种基于有机场效应管压力传感器及其制备方法
CN108220412B (zh) * 2018-01-03 2021-10-01 京东方科技集团股份有限公司 一种基因测序基板及其制备方法、基因测序装置
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
CN110184325A (zh) * 2018-02-22 2019-08-30 张家港万众一芯生物科技有限公司 基于微孔阵列芯片的单分子文库pcr扩增的基因测序方法
US10153317B1 (en) * 2018-04-26 2018-12-11 Alentic Microscience Inc. Image sensors comprising a chamber to confine a sample at a sensor surface of successive light sensitive subareas and non-light sensitive areas
JP7701265B2 (ja) * 2018-09-13 2025-07-01 ライフ テクノロジーズ コーポレーション Ｃｈｅｍｆｅｔセンサーアレイベースのシステムを用いた細胞分析
US11768188B2 (en) * 2018-10-24 2023-09-26 Climate Llc Cartridge-based sensor system for monitoring properties of field soils and wastewater
CN111349555B (zh) * 2018-12-21 2023-07-18 成都万众壹芯生物科技有限公司 一种基于微孔阵列芯片的数字pcr扩增装置及其使用方法
WO2020167447A2 (en) * 2019-02-15 2020-08-20 Illumina, Inc. Sensing systems
EP3931353A4 (en) * 2019-03-01 2022-11-16 Revere Biosensors, LLC Systems and methods for separating decoded arrays
WO2020210981A1 (en) 2019-04-16 2020-10-22 Boe Technology Group Co., Ltd. Micro-channel device and manufacturing method thereof and micro-fluidic system
SG11202012811RA (en) 2019-05-31 2021-01-28 Illumina Inc Flow cell with one or more barrier features
WO2020258037A1 (en) * 2019-06-25 2020-12-30 Ardent Biomed Guangdong Co., Ltd Apparatus and method for high throughput parallel nucleic acid sequencing on surfaces of microbeads
US12485415B2 (en) * 2019-11-13 2025-12-02 Beijing Boe Technology Development Co., Ltd. Detection chip, method for manufacturing detection chip, method for operating detection chip, and reaction system
EP3895716A1 (en) 2020-04-17 2021-10-20 Maat Pharma Fmt performance prediction test to guide and optimize therapeutic management of gvhd patients
US11610999B2 (en) * 2020-06-10 2023-03-21 Globalfoundries Dresden Module One Limited Liability Company & Co. Kg Floating-gate devices in high voltage applications
EP3978630A1 (en) 2020-10-05 2022-04-06 Commissariat à l'Energie Atomique et aux Energies Alternatives Method for predicting the efficiency of a treatment stimulating an ifn-beta dependent adaptive immune response via detection of a single nucleotide polymorphism
DE102020132756B3 (de) * 2020-12-09 2022-03-24 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Körperschaft des öffentlichen Rechts Ferroelektrischer Biochip
FR3115795A1 (fr) 2020-11-04 2022-05-06 Biomerieux Utilisation du virus torque teno (ttv) en tant que marqueur pour determiner la capacite de proliferation des lymphocytes t
KR20220132855A (ko) * 2021-03-24 2022-10-04 삼성전자주식회사 유전자 증폭 칩, 유전자 증폭 장치, 및 유전자 증폭 칩의 제조방법
US20240165619A1 (en) * 2021-05-31 2024-05-23 Beijing Boe Technology Development Co., Ltd. Detection chip, and fabrication method and sample introduction method thereof
FR3125300A1 (fr) 2021-07-19 2023-01-20 Biomerieux Utilisation du virus torque teno (ttv) en tant que marqueurs pour determiner le risque de complication chez un patient admis au sein d’un etablissement de sante
JP7513577B2 (ja) * 2021-09-02 2024-07-09 株式会社東芝 ケミカルセンサ装置
CN115409174B (zh) * 2022-11-01 2023-03-31 之江实验室 一种基于dram存内计算的碱基序列过滤方法与装置
EP4495261A1 (en) 2023-07-20 2025-01-22 Université de Versailles Saint-Quentin-en-Yvelines Detection of corticosteroid efficiency by analysing the rs37973 and rs28362491 polymorphisms
KR102748674B1 (ko) * 2024-04-22 2024-12-31 순천향대학교 산학협력단 센싱 장치 및 이를 이용한 표적 핵산 검출 방법

Family Cites Families (384)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6019A (en) * 1849-01-09 Cast-iron car-wheel
JPS5530312B2 (cg-RX-API-DMAC7.html) 1975-01-16 1980-08-09
GB2096824A (en) 1981-04-09 1982-10-20 Sibbald Alastair Chemically sensitive field effect transistor
EP0065202B1 (de) 1981-05-15 1986-03-12 Licentia Patent-Verwaltungs-GmbH Verfahren zur Messung von Ionenkonzentrationen
JPS5870155U (ja) 1981-11-06 1983-05-12 ヤマハ株式会社 電子機器用収納家具
US4411741A (en) 1982-01-12 1983-10-25 University Of Utah Apparatus and method for measuring the concentration of components in fluids
NL8302964A (nl) 1983-08-24 1985-03-18 Cordis Europ Inrichting voor het bepalen van de aktiviteit van een ion (pion) in een vloeistof.
NL8303792A (nl) 1983-11-03 1985-06-03 Cordis Europ Inrichting voorzien van een op een isfet gebaseerd meetcircuit; voor toepassing in het meetcircuit geschikte isfet en werkwijze ter vervaardiging van een in het meetcircuit toe te passen isfet.
JPS60128345A (ja) 1983-12-15 1985-07-09 Olympus Optical Co Ltd イオン濃度測定装置
US4660063A (en) 1985-03-18 1987-04-21 General Electric Company Immersion type ISFET
DE3513168A1 (de) 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US4743954A (en) 1985-06-07 1988-05-10 University Of Utah Integrated circuit for a chemical-selective sensor with voltage output
US4863849A (en) 1985-07-18 1989-09-05 New York Medical College Automatable process for sequencing nucleotide
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
GB8522785D0 (en) 1985-09-14 1985-10-16 Emi Plc Thorn Chemical-sensitive semiconductor device
US4822566A (en) 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
DE3605178A1 (de) 1986-02-19 1987-08-20 Standard Elektrik Lorenz Ag Bewegungssensor
US4864229A (en) 1986-05-03 1989-09-05 Integrated Ionics, Inc. Method and apparatus for testing chemical and ionic sensors
US4722830A (en) 1986-05-05 1988-02-02 General Electric Company Automated multiple stream analysis system
US5113870A (en) 1987-05-01 1992-05-19 Rossenfeld Joel P Method and apparatus for the analysis, display and classification of event related potentials by interpretation of P3 responses
JP2825206B2 (ja) 1988-02-08 1998-11-18 アイースタット コーポレーション 金属酸化物電極
WO1989009238A1 (fr) 1988-03-25 1989-10-05 Jps Chimie, Jenneret, Pousaz Et Soerensen & Cie Resines chelatantes et procede d'utilisation dans l'extraction d'ions metalliques
US4971903A (en) 1988-03-25 1990-11-20 Edward Hyman Pyrophosphate-based method and apparatus for sequencing nucleic acids
US4874499A (en) 1988-05-23 1989-10-17 Massachusetts Institute Of Technology Electrochemical microsensors and method of making such sensors
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US4990974A (en) 1989-03-02 1991-02-05 Thunderbird Technologies, Inc. Fermi threshold field effect transistor
DE68925897T2 (de) 1989-04-28 1996-10-02 Ibm Gate-Array-Zelle, bestehend aus FET's von verschiedener und optimierter Grösse
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
JP3001104B2 (ja) * 1989-10-04 2000-01-24 オリンパス光学工業株式会社 センサー構造体及びその製造法
US5110441A (en) 1989-12-14 1992-05-05 Monsanto Company Solid state ph sensor
US5317407A (en) 1991-03-11 1994-05-31 General Electric Company Fixed-pattern noise correction circuitry for solid-state imager
KR940010562B1 (ko) 1991-09-06 1994-10-24 손병기 Ta_2O_5수소이온 감지막을 갖는 감이온 전계효과 트랜지스터의 제조방법
GB2278235B (en) 1991-10-21 1996-05-08 Holm Kennedy James W Method and device for biochemical sensing
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5284566A (en) 1993-01-04 1994-02-08 Bacharach, Inc. Electrochemical gas sensor with wraparound reference electrode
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
WO1994026029A1 (en) 1993-04-26 1994-11-10 Unifet Incorporated Method and apparatus for multiplexing devices having long thermal time constants
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
JP3413664B2 (ja) 1993-08-12 2003-06-03 ソニー株式会社 電荷転送装置
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US7375198B2 (en) 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5414284A (en) 1994-01-19 1995-05-09 Baxter; Ronald D. ESD Protection of ISFET sensors
JP3351088B2 (ja) 1994-03-28 2002-11-25 松下電工株式会社 電源装置
US5439839A (en) 1994-07-13 1995-08-08 Winbond Electronics Corporation Self-aligned source/drain MOS process
DE4430811C1 (de) 1994-08-30 1995-09-07 Fraunhofer Ges Forschung Verfahren zum Herstellen eines integrierten ionensensitiven Feldeffekttransistors in CMOS-Silizium-Planartechnologie
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US5631704A (en) 1994-10-14 1997-05-20 Lucent Technologies, Inc. Active pixel sensor and imaging system having differential mode
US5490971A (en) 1994-10-25 1996-02-13 Sippican, Inc. Chemical detector
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
DE19512117A1 (de) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Meßeinrichtung
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5702964A (en) 1995-10-17 1997-12-30 Lg Semicon, Co., Ltd. Method for forming a semiconductor device having a floating gate
AU4081297A (en) 1996-08-21 1998-03-06 Smithkline Beecham Corporation Rapid process for arraying and synthesizing bead-based combinatorial libraries
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US5958703A (en) 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
IL129767A0 (en) 1996-12-12 2000-02-29 Prolume Ltd Apparatus and method for detecting and identifying infectious agents
US20030215857A1 (en) 1996-12-20 2003-11-20 Roche Diagnostics Gmbh Method for the direct, exponential amplification and sequencing of DNA molecules and its application
US6605428B2 (en) 1996-12-20 2003-08-12 Roche Diagnostics Gmbh Method for the direct, exponential amplification and sequencing of DNA molecules and its application
DE19653439A1 (de) 1996-12-20 1998-07-02 Svante Dr Paeaebo Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung
US5912560A (en) 1997-02-25 1999-06-15 Waferscale Integration Inc. Charge pump circuit for voltage boosting in integrated semiconductor circuits
US5793230A (en) 1997-02-26 1998-08-11 Sandia Corporation Sensor readout detector circuit
US6197557B1 (en) 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
JP3666604B2 (ja) 1997-04-16 2005-06-29 アプレラ コーポレーション 核酸アーカイビング
US6872527B2 (en) 1997-04-16 2005-03-29 Xtrana, Inc. Nucleic acid archiving
US5911873A (en) 1997-05-02 1999-06-15 Rosemount Analytical Inc. Apparatus and method for operating an ISFET at multiple drain currents and gate-source voltages allowing for diagnostics and control of isopotential points
US7220550B2 (en) 1997-05-14 2007-05-22 Keensense, Inc. Molecular wire injection sensors
EP0985142A4 (en) 1997-05-23 2006-09-13 Lynx Therapeutics Inc SYSTEM AND APPARATUS FOR THE SEQUENTIAL TREATMENT OF ANALYTES
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
JP4231560B2 (ja) 1997-05-29 2009-03-04 株式会社堀場製作所 化学量の分布の電気化学的測定方法および装置
US6002299A (en) 1997-06-10 1999-12-14 Cirrus Logic, Inc. High-order multipath operational amplifier with dynamic offset reduction, controlled saturation current limiting, and current feedback for enhanced conditional stability
FR2764702B1 (fr) 1997-06-11 1999-09-03 Lyon Ecole Centrale Procede d'identification et/ou de dosage de substances biologiques, presentes dans un liquide conducteur, dispositif et capteur d'affinite utiles pour la mise en oeuvre de ce procede
US5923421A (en) 1997-07-24 1999-07-13 Lockheed Martin Energy Research Corporation Chemical detection using calorimetric spectroscopy
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
WO1999019341A1 (en) 1997-10-10 1999-04-22 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
KR100251528B1 (ko) 1997-10-22 2000-04-15 김덕중 복수개의 센스 소오스 패드를 구비한 센스 전계효과 트랜지스터
US6369737B1 (en) 1997-10-30 2002-04-09 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for converting a low dynamic range analog signal to a large dynamic range floating-point digital representation
US6050719A (en) 1998-01-30 2000-04-18 Affymetrix, Inc. Rotational mixing method using a cartridge having a narrow interior
US7090975B2 (en) 1998-03-13 2006-08-15 Promega Corporation Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
CA2325886C (en) 1998-04-09 2009-07-21 California Institute Of Technology Electronic techniques for analyte detection
WO1999057321A1 (en) 1998-05-01 1999-11-11 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
US6195585B1 (en) 1998-06-26 2001-02-27 Advanced Bionics Corporation Remote monitoring of implantable cochlear stimulator
JP4137239B2 (ja) 1998-08-03 2008-08-20 株式会社堀場製作所 Ｉｓｆｅｔアレイ
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6191444B1 (en) 1998-09-03 2001-02-20 Micron Technology, Inc. Mini flash process and circuit
CA2317743A1 (en) 1998-12-11 2000-06-22 Paul Mansky Sensor array-based system and method for rapid materials characterization
ATE319857T1 (de) 1998-12-14 2006-03-15 Li Cor Inc Kit und methode zur nukleinsäuresequenzierung einzelner moleküle durch polymerase synthese
DE19857953C2 (de) 1998-12-16 2001-02-15 Conducta Endress & Hauser Vorrichtung zum Messen der Konzentration von Ionen in einer Meßflüssigkeit
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6361671B1 (en) 1999-01-11 2002-03-26 The Regents Of The University Of California Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels
GB9901475D0 (en) 1999-01-22 1999-03-17 Pyrosequencing Ab A method of DNA sequencing
US20020150909A1 (en) 1999-02-09 2002-10-17 Stuelpnagel John R. Automated information processing in randomly ordered arrays
WO2000051191A1 (en) 1999-02-22 2000-08-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem A hybrid electrical device with biological components
AU3498900A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Sequencing by incorporation
US20050244870A1 (en) 1999-04-20 2005-11-03 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6620584B1 (en) 1999-05-20 2003-09-16 Illumina Combinatorial decoding of random nucleic acid arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7097973B1 (en) 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
WO2001006244A2 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System General signaling protocols for chemical receptors in immobilized matrices
US6459398B1 (en) 1999-07-20 2002-10-01 D.S.P.C. Technologies Ltd. Pulse modulated digital to analog converter (DAC)
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
US7604996B1 (en) 1999-08-18 2009-10-20 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
EP1212599A2 (en) 1999-08-30 2002-06-12 Illumina, Inc. Methods for improving signal detection from an array
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7124221B1 (en) 1999-10-19 2006-10-17 Rambus Inc. Low latency multi-level communication interface
GB9926956D0 (en) 1999-11-13 2000-01-12 Koninkl Philips Electronics Nv Amplifier
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
US20030148301A1 (en) 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
JP2001175340A (ja) 1999-12-14 2001-06-29 Matsushita Electric Ind Co Ltd 電位発生回路
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
AU2001238068A1 (en) 2000-02-07 2001-08-14 Illumina, Inc. Nucleic acid detection methods using universal priming
WO2001061865A1 (en) 2000-02-14 2001-08-23 Koninklijke Philips Electronics N.V. Current-to-voltage converter with controllable gain, and signal processing circuit comprising such converter
CA2388738A1 (en) 2000-02-15 2001-08-23 Lynx Therapeutics, Inc. Data analysis and display system for ligation-based dna sequencing
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
US6649416B1 (en) 2000-02-18 2003-11-18 Trustees Of Tufts College Intelligent electro-optical sensor array and method for analyte detection
FR2805826B1 (fr) * 2000-03-01 2002-09-20 Nucleica Nouvelles puces a adn
DE60144142D1 (de) 2000-03-02 2011-04-14 Microchips Inc Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
JP3442338B2 (ja) 2000-03-17 2003-09-02 株式会社日立製作所 Ｄｎａ分析装置、ｄｎａ塩基配列決定装置、ｄｎａ塩基配列決定方法、および反応モジュール
EP1272860B1 (de) 2000-03-30 2005-08-10 Infineon Technologies AG Sensor-anordnung und verfahren zum erfassen eines zustands eines transistors einer sensor-anordnung
EP1285252A1 (en) 2000-04-24 2003-02-26 Eagle Research & Development, LLC An ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8232582B2 (en) 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
US20020042388A1 (en) 2001-05-01 2002-04-11 Cooper Mark J. Lyophilizable and enhanced compacted nucleic acids
US20020168678A1 (en) 2000-06-07 2002-11-14 Li-Cor, Inc. Flowcell system for nucleic acid sequencing
US6482639B2 (en) 2000-06-23 2002-11-19 The United States Of America As Represented By The Secretary Of The Navy Microelectronic device and method for label-free detection and quantification of biological and chemical molecules
EP2100971A3 (en) 2000-07-07 2009-11-25 Visigen Biotechnologies, Inc. Real-time sequence determination
US20070119711A1 (en) 2000-08-02 2007-05-31 Caliper Life Sciences, Inc. High throughput separations based analysis systems and methods
US6611037B1 (en) 2000-08-28 2003-08-26 Micron Technology, Inc. Multi-trench region for accumulation of photo-generated charge in a CMOS imager
US6939451B2 (en) 2000-09-19 2005-09-06 Aclara Biosciences, Inc. Microfluidic chip having integrated electrodes
AU2001296809A1 (en) 2000-10-10 2002-04-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US6537881B1 (en) 2000-10-16 2003-03-25 Advanced Micro Devices, Inc. Process for fabricating a non-volatile memory device
US6558626B1 (en) 2000-10-17 2003-05-06 Nomadics, Inc. Vapor sensing instrument for ultra trace chemical detection
WO2002047266A2 (en) 2000-10-20 2002-06-13 The Board Of Trustees Of The Leland Stanford Junior University Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
US6770472B2 (en) 2000-11-17 2004-08-03 The Board Of Trustees Of The Leland Stanford Junior University Direct DNA sequencing with a transcription protein and a nanometer scale electrometer
WO2002048701A2 (en) 2000-12-11 2002-06-20 President And Fellows Of Harvard College Nanosensors
GB2370410A (en) 2000-12-22 2002-06-26 Seiko Epson Corp Thin film transistor sensor
US6958216B2 (en) 2001-01-10 2005-10-25 The Trustees Of Boston College DNA-bridged carbon nanotube arrays
JP4809983B2 (ja) 2001-02-14 2011-11-09 明彦 谷岡 生体高分子とリガンドとの相互作用を検出する装置及びその方法
EP1236804A1 (en) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
GB0105831D0 (en) * 2001-03-09 2001-04-25 Toumaz Technology Ltd Method for dna sequencing utilising enzyme linked field effect transistors
DE10111458B4 (de) 2001-03-09 2008-09-11 Siemens Ag Analyseeinrichtung
US8114591B2 (en) 2001-03-09 2012-02-14 Dna Electronics Ltd. Sensing apparatus and method
WO2002072892A1 (en) 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
JP2002272463A (ja) 2001-03-22 2002-09-24 Olympus Optical Co Ltd 一塩基多型の型を判定する方法
US20040146849A1 (en) 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050058990A1 (en) 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
US6418968B1 (en) 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
JP3883512B2 (ja) 2001-04-23 2007-02-21 三星電子株式会社 微細流路の側壁に形成されたｍｏｓｆｅｔよりなる物質検出用チップ、これを含む物質検出装置、及び物質検出装置を利用した物質検出方法
KR100442838B1 (ko) 2001-12-11 2004-08-02 삼성전자주식회사 프로브의 고정화 검출방법 및 상기 프로브와 표적시료의결합정도 검출방법
KR100455283B1 (ko) 2001-04-23 2004-11-08 삼성전자주식회사 물질 유로의 측벽에 형성된 ｍｏｓｆｅｔ으로 이루어진물질 검출용 칩, 이를 포함하는 물질 검출 장치, 이의제조 방법 및 물질 검출 장치를 이용한 물질 검출 방법
US6571189B2 (en) 2001-05-14 2003-05-27 Hewlett-Packard Company System and method for scanner calibration
US20040023253A1 (en) 2001-06-11 2004-02-05 Sandeep Kunwar Device structure for closely spaced electrodes
WO2003004690A2 (en) 2001-07-06 2003-01-16 454$m(3) CORPORATION Method for isolation of independent, parallel chemical micro-reactions using a porous filter
DE10133363A1 (de) 2001-07-10 2003-01-30 Infineon Technologies Ag Messzelle und Messfeld mit solchen Messzellen sowie Verwendung einer Messzelle und Verwendung eines Messfeldes
US7485443B2 (en) 2001-07-17 2009-02-03 Northwestern University Solid-phase reactions
JP2003032908A (ja) 2001-07-19 2003-01-31 Nisshinbo Ind Inc キャパシタ組電池、その制御方法、その制御装置及び自動車用蓄電システム
WO2003068947A1 (en) 2001-07-30 2003-08-21 Meso Scale Technologies, Llc. Assay electrodes having immobilized lipid/protein layers and methods of making and using the same
US6490220B1 (en) 2001-08-13 2002-12-03 Micron Technology, Inc. Method for reliably shutting off oscillator pulses to a charge-pump
US6929944B2 (en) 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US20030054396A1 (en) 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
DE10151020A1 (de) 2001-10-16 2003-04-30 Infineon Technologies Ag Schaltkreis-Anordnung, Sensor-Array und Biosensor-Array
DE10151021A1 (de) 2001-10-16 2003-04-30 Infineon Technologies Ag Sensor-Anordnung
US6795117B2 (en) 2001-11-06 2004-09-21 Candela Microsystems, Inc. CMOS image sensor with noise cancellation
US20030124599A1 (en) 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
CN100429509C (zh) 2001-11-16 2008-10-29 株式会社Bio-X Fet型传感器
CN1294260C (zh) 2001-12-19 2007-01-10 株式会社日立高新技术 电位滴定dna微阵列、其制造方法及核酸解析方法
US20050106587A1 (en) 2001-12-21 2005-05-19 Micronas Gmbh Method for determining of nucleic acid analytes
US6518146B1 (en) 2002-01-09 2003-02-11 Motorola, Inc. Semiconductor device structure and method for forming
US7772383B2 (en) 2002-01-25 2010-08-10 The Trustees Of Princeton University Chemical PCR: Compositions for enhancing polynucleotide amplification reactions
KR100403637B1 (ko) 2002-01-26 2003-10-30 삼성전자주식회사 출력 일그러짐을 최소화하는 파워 앰프 클리핑 회로
US6614301B2 (en) 2002-01-31 2003-09-02 Intel Corporation Differential amplifier offset adjustment
US7276749B2 (en) 2002-02-05 2007-10-02 E-Phocus, Inc. Image sensor with microcrystalline germanium photodiode layer
US6926865B2 (en) 2002-02-11 2005-08-09 Matsushita Electric Industrial Co., Ltd. Method and apparatus for detecting DNA hybridization
JP2003258128A (ja) 2002-02-27 2003-09-12 Nec Electronics Corp 不揮発性半導体記憶装置およびその製造方法ならびにその動作方法
US6953958B2 (en) 2002-03-19 2005-10-11 Cornell Research Foundation, Inc. Electronic gain cell based charge sensor
CA2382382A1 (fr) 2002-04-16 2003-10-16 Universite De Sherbrooke Moteur rotatif continu a combustion induite par onde de choc
US6828685B2 (en) 2002-06-14 2004-12-07 Hewlett-Packard Development Company, L.P. Memory device having a semiconducting polymer film
US6894930B2 (en) 2002-06-19 2005-05-17 Sandisk Corporation Deep wordline trench to shield cross coupling between adjacent cells for scaled NAND
US20040136866A1 (en) 2002-06-27 2004-07-15 Nanosys, Inc. Planar nanowire based sensor elements, devices, systems and methods for using and making same
US7092757B2 (en) 2002-07-12 2006-08-15 Cardiac Pacemakers, Inc. Minute ventilation sensor with dynamically adjusted excitation current
US6885827B2 (en) 2002-07-30 2005-04-26 Amplification Technologies, Inc. High sensitivity, high resolution detection of signals
EP1525470A2 (de) 2002-07-31 2005-04-27 Infineon Technologies AG Sensor-anordnung
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
CN100392097C (zh) 2002-08-12 2008-06-04 株式会社日立高新技术 使用dna微阵列的核酸检测方法以及核酸检测装置
US7267751B2 (en) 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
GB0219541D0 (en) 2002-08-22 2002-10-02 Secr Defence Method and apparatus for stand-off chemical detection
US8449824B2 (en) 2002-09-09 2013-05-28 Yizhong Sun Sensor instrument system including method for detecting analytes in fluids
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
EP1569510B1 (en) 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
SE0202867D0 (sv) 2002-09-27 2002-09-27 Pyrosequencing Ab New sequencing method
CN1500887A (zh) 2002-10-01 2004-06-02 ���µ�����ҵ��ʽ���� 引物伸长反应检测方法、碱基种类判别方法及其装置
AU2003282548A1 (en) 2002-10-10 2004-05-04 Nanosys, Inc. Nano-chem-fet based biosensors
DE10247889A1 (de) 2002-10-14 2004-04-22 Infineon Technologies Ag Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung
US20040079636A1 (en) 2002-10-25 2004-04-29 Chin Hsia Biomedical ion sensitive semiconductor sensor and sensor array
AU2003285092A1 (en) 2002-10-29 2004-05-25 Cornell Research Foundation, Inc. Chemical-sensitive floating gate field effect transistor
US6700814B1 (en) 2002-10-30 2004-03-02 Motorola, Inc. Sense amplifier bias circuit for a memory having at least two distinct resistance states
EP2228401A1 (en) 2002-11-01 2010-09-15 Georgia Tech Research Corporation Sacrificial compositions, methods of use thereof, and methods of decomposition thereof
DE10251757B4 (de) 2002-11-05 2006-03-09 Micronas Holding Gmbh Vorrichtung zur Bestimmung der Konzentration von in einer zu untersuchenden Probe enthaltenen Liganden
US7022288B1 (en) 2002-11-13 2006-04-04 The United States Of America As Represented By The Secretary Of The Navy Chemical detection sensor system
DE10255755B4 (de) 2002-11-28 2006-07-13 Schneider, Christian, Dr. Integrierte elektronische Schaltung mit Feldeffekt-Sensoren zum Nachweis von Biomolekülen
US20040197803A1 (en) 2002-12-06 2004-10-07 Hidenobu Yaku Method, primer and kit for determining base type
CN102212614B (zh) 2003-01-29 2013-12-25 454生命科学公司 核酸扩增和测序的方法
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US20050006234A1 (en) 2003-02-13 2005-01-13 Arjang Hassibi Semiconductor electrochemical bio-sensor array
US7317484B2 (en) 2003-02-26 2008-01-08 Digital Imaging Systems Gmbh CMOS APS readout scheme that combines reset drain current and the source follower output
US20070262363A1 (en) 2003-02-28 2007-11-15 Board Of Regents, University Of Texas System Low temperature fabrication of discrete silicon-containing substrates and devices
TWI235236B (en) 2003-05-09 2005-07-01 Univ Chung Yuan Christian Ion-sensitive circuit
WO2004106891A2 (en) 2003-05-22 2004-12-09 University Of Hawaii Ultrasensitive biochemical sensor
US7250115B2 (en) 2003-06-12 2007-07-31 Agilent Technologies, Inc Nanopore with resonant tunneling electrodes
WO2005015156A2 (en) 2003-08-04 2005-02-17 Idaho Research Foundation, Inc. Molecular detector
JP2005077210A (ja) 2003-08-29 2005-03-24 National Institute For Materials Science 生体分子検出素子及びそれを用いた核酸解析方法
GB0322010D0 (en) 2003-09-19 2003-10-22 Univ Cambridge Tech Detection of molecular interactions using field effect transistors
US7008550B2 (en) 2003-09-25 2006-03-07 Hitachi Global Storage Technologies Netherlands B.V. Method for forming a read transducer by ion milling and chemical mechanical polishing to eliminate nonuniformity near the MR sensor
GB0323224D0 (en) 2003-10-03 2003-11-05 Rolls Royce Plc A module for a fuel cell stack
US20070087401A1 (en) 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
US7317216B2 (en) 2003-10-31 2008-01-08 University Of Hawaii Ultrasensitive biochemical sensing platform
US7067886B2 (en) 2003-11-04 2006-06-27 International Business Machines Corporation Method of assessing potential for charging damage in SOI designs and structures for eliminating potential for damage
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
DE10352917A1 (de) 2003-11-11 2005-06-16 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Sensoranordnung mit mehreren potentiometrischen Sensoren
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005054431A2 (en) 2003-12-01 2005-06-16 454 Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7279588B2 (en) 2003-12-02 2007-10-09 Seoul National University Foundation Dinuclear metal complex and pyrophosphate assay using the same
US8758688B2 (en) 2003-12-22 2014-06-24 Imec Microelectronic structures for patterned deposition of molecules onto surfaces
US7462512B2 (en) 2004-01-12 2008-12-09 Polytechnic University Floating gate field effect transistors for chemical and/or biological sensing
JP4065855B2 (ja) 2004-01-21 2008-03-26 株式会社日立製作所 生体および化学試料検査装置
EP1735458B1 (en) 2004-01-28 2013-07-24 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
JP3903183B2 (ja) 2004-02-03 2007-04-11 独立行政法人物質・材料研究機構 遺伝子検出電界効果デバイスおよびこれを用いた遺伝子多型解析方法
WO2005082098A2 (en) 2004-02-27 2005-09-09 President And Fellows Of Harvard College Polony fluorescent in situ sequencing beads
EP2436778A3 (en) 2004-03-03 2012-07-11 The Trustees of Columbia University in the City of New York Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
US20060057604A1 (en) 2004-03-15 2006-03-16 Thinkfar Nanotechnology Corporation Method for electrically detecting oligo-nucleotides with nano-particles
JP4127679B2 (ja) 2004-03-18 2008-07-30 株式会社東芝 核酸検出カセット及び核酸検出装置
DE102004014537A1 (de) 2004-03-23 2005-10-13 Fujitsu Ltd., Kawasaki Chipintegrierter Detektor zum Analysieren von Flüssigkeiten
JP4734234B2 (ja) 2004-03-24 2011-07-27 独立行政法人科学技術振興機構 生体分子に関する形態及び情報をｉｓ−ｆｅｔを利用して検出する測定法およびシステム
US20050221473A1 (en) 2004-03-30 2005-10-06 Intel Corporation Sensor array integrated circuits
WO2005095938A1 (en) 2004-04-01 2005-10-13 Nanyang Technological University Addressable transistor chip for conducting assays
US7117605B2 (en) 2004-04-13 2006-10-10 Gyrodata, Incorporated System and method for using microgyros to measure the orientation of a survey tool within a borehole
US7544979B2 (en) 2004-04-16 2009-06-09 Technion Research & Development Foundation Ltd. Ion concentration transistor and dual-mode sensors
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
TWI261801B (en) 2004-05-24 2006-09-11 Rohm Co Ltd Organic EL drive circuit and organic EL display device using the same organic EL drive circuit
US7264934B2 (en) 2004-06-10 2007-09-04 Ge Healthcare Bio-Sciences Corp. Rapid parallel nucleic acid analysis
US7361946B2 (en) 2004-06-28 2008-04-22 Nitronex Corporation Semiconductor device-based sensors
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
GB2416210B (en) 2004-07-13 2008-02-20 Christofer Toumazou Ion sensitive field effect transistors
JP3874772B2 (ja) 2004-07-21 2007-01-31 株式会社日立製作所 生体関連物質測定装置及び測定方法
JP4455215B2 (ja) 2004-08-06 2010-04-21 キヤノン株式会社 撮像装置
US7276453B2 (en) 2004-08-10 2007-10-02 E.I. Du Pont De Nemours And Company Methods for forming an undercut region and electronic devices incorporating the same
US7190026B2 (en) 2004-08-23 2007-03-13 Enpirion, Inc. Integrated circuit employable with a power converter
WO2006022370A1 (ja) 2004-08-27 2006-03-02 National Institute For Materials Science 電界効果デバイスを用いたdna塩基配列解析方法及び塩基配列解析装置
US20070212681A1 (en) 2004-08-30 2007-09-13 Benjamin Shapiro Cell canaries for biochemical pathogen detection
US7609303B1 (en) 2004-10-12 2009-10-27 Melexis Tessenderlo Nv Low noise active pixel image sensor using a modified reset value
JP2006138846A (ja) 2004-10-14 2006-06-01 Toshiba Corp 核酸検出センサ、核酸検出チップ及び核酸検出装置
US7534097B2 (en) 2004-10-15 2009-05-19 Nanyang Technological University Method and apparatus for controlling multi-fluid flow in a micro channel
US7381936B2 (en) 2004-10-29 2008-06-03 Ess Technology, Inc. Self-calibrating anti-blooming circuit for CMOS image sensor having a spillover protection performance in response to a spillover condition
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
CN101091100B (zh) 2004-11-18 2011-06-08 摩根研究股份有限公司 微型傅立叶变换分光光度计
US20060205061A1 (en) 2004-11-24 2006-09-14 California Institute Of Technology Biosensors based upon actuated desorption
KR100623177B1 (ko) 2005-01-25 2006-09-13 삼성전자주식회사 높은 유전율을 갖는 유전체 구조물, 이의 제조 방법, 이를포함하는 불휘발성 반도체 메모리 장치 및 그 제조 방법
EP1844328A4 (en) 2005-01-31 2009-09-16 Pacific Biosciences California USE OF REVERSIBLE EXTENSION TERMINATOR IN NUCLEIC ACID SEQUENCING
US20060199493A1 (en) 2005-02-04 2006-09-07 Hartmann Richard Jr Vent assembly
US20060182664A1 (en) 2005-02-14 2006-08-17 Peck Bill J Flow cell devices, systems and methods of using the same
US9040237B2 (en) * 2005-03-04 2015-05-26 Intel Corporation Sensor arrays and nucleic acid sequencing applications
KR101269508B1 (ko) 2005-03-11 2013-05-30 고꾸리쯔 다이가꾸 호우징 도요하시 기쥬쯔 가가꾸 다이가꾸 누적형 화학·물리현상 검출장치
US20060219558A1 (en) 2005-04-05 2006-10-05 Hafeman Dean G Improved Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
US20060228721A1 (en) 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
TWI287041B (en) 2005-04-27 2007-09-21 Jung-Tang Huang An ultra-rapid DNA sequencing method with nano-transistors array based devices
US20060269927A1 (en) 2005-05-25 2006-11-30 Lieber Charles M Nanoscale sensors
CN1881457A (zh) 2005-06-14 2006-12-20 松下电器产业株式会社 致动器控制方法和使用该方法的盘装置
CN101466847B (zh) 2005-06-15 2014-02-19 考利达基因组股份有限公司 用于遗传和化学分析的单分子阵列
US9169510B2 (en) 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
TW200701588A (en) 2005-06-29 2007-01-01 Leadtrend Tech Corp Dual loop voltage regulation circuit of power supply chip
US7890891B2 (en) 2005-07-11 2011-02-15 Peregrine Semiconductor Corporation Method and apparatus improving gate oxide reliability by controlling accumulated charge
JP2007035726A (ja) 2005-07-22 2007-02-08 Rohm Co Ltd 半導体装置、モジュールおよび電子機器
EP1913372A1 (de) 2005-08-08 2008-04-23 MicroGaN GmbH Halbleitersensor mit grosser bandlücke und isolierender deckschicht
US7365597B2 (en) 2005-08-19 2008-04-29 Micron Technology, Inc. Switched capacitor amplifier with higher gain and improved closed-loop gain accuracy
SG130066A1 (en) 2005-08-26 2007-03-20 Micron Technology Inc Microelectronic device packages, stacked microelectronic device packages, and methods for manufacturing microelectronic devices
JP4353958B2 (ja) 2005-09-15 2009-10-28 株式会社日立製作所 Ｄｎａ計測装置、及びｄｎａ計測方法
KR100984963B1 (ko) 2005-09-29 2010-10-05 지멘스 메디컬 솔루션즈 유에스에이, 인크. 양전자 방출 단층촬영에 의한 인체 영상화에 적합한 규모의방사성 표지 분자를 합성할 수 있는 마이크로유체 칩
US7466258B1 (en) 2005-10-07 2008-12-16 Cornell Research Foundation, Inc. Asynchronous analog-to-digital converter and method
US7794584B2 (en) 2005-10-12 2010-09-14 The Research Foundation Of State University Of New York pH-change sensor and method
US7335526B2 (en) 2005-10-31 2008-02-26 Hewlett-Packard Development Company, L.P. Sensing system
TWI295729B (en) 2005-11-01 2008-04-11 Univ Nat Yunlin Sci & Tech Preparation of a ph sensor, the prepared ph sensor, systems comprising the same, and measurement using the systems
US7538827B2 (en) 2005-11-17 2009-05-26 Chunghwa Picture Tubes, Ltd. Pixel structure
US7576037B2 (en) 2005-11-18 2009-08-18 Mei Technologies, Inc. Process and apparatus for combinatorial synthesis
US7566913B2 (en) 2005-12-02 2009-07-28 Nitronex Corporation Gallium nitride material devices including conductive regions and methods associated with the same
GB2436619B (en) 2005-12-19 2010-10-06 Toumaz Technology Ltd Sensor circuits
KR100718144B1 (ko) 2006-01-09 2007-05-14 삼성전자주식회사 이온 물질 검출용 ｆｅｔ 기반 센서, 그를 포함하는 이온물질 검출 장치 및 그를 이용한 이온 물질 검출 방법
CA2646465C (en) 2006-03-17 2015-06-16 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors
US20070233477A1 (en) 2006-03-30 2007-10-04 Infima Ltd. Lossless Data Compression Using Adaptive Context Modeling
US7923240B2 (en) 2006-03-31 2011-04-12 Intel Corporation Photo-activated field effect transistor for bioanalyte detection
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
KR100723426B1 (ko) 2006-04-26 2007-05-30 삼성전자주식회사 이온 물질 검출용 전계 효과 트랜지스터 및 그를 이용한이온 물질 검출 방법
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
JP4211805B2 (ja) 2006-06-01 2009-01-21 エプソンイメージングデバイス株式会社 電気光学装置および電子機器
WO2008007716A1 (fr) 2006-07-13 2008-01-17 National University Corporation Nagoya University Dispositif de détection de matériau
KR100799577B1 (ko) 2006-08-31 2008-01-30 한국전자통신연구원 가스 및 생화학물질 감지용 센서 제조 방법과 그 센서를포함하는 집적회로 및 그 제조 방법
US7960776B2 (en) 2006-09-27 2011-06-14 Cornell Research Foundation, Inc. Transistor with floating gate and electret
US8231831B2 (en) 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay structure
WO2008070375A2 (en) 2006-11-09 2008-06-12 Complete Genomics, Inc. Selection of dna adaptor orientation
DE102006052863B4 (de) 2006-11-09 2018-03-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Schutzstruktur für Halbleitersensoren und deren Verwendung
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP4134667B1 (en) 2006-12-14 2025-11-12 Life Technologies Corporation Apparatus for measuring analytes using fet arrays
US7972828B2 (en) 2006-12-19 2011-07-05 Sigma-Aldrich Co. Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
WO2008089282A2 (en) 2007-01-16 2008-07-24 Silver James H Sensors for detecting subtances indicative of stroke, ischemia, infection or inflammation
JP4325684B2 (ja) 2007-02-20 2009-09-02 株式会社デンソー センサ制御装置、及び印加電圧特性の調整方法
US8031809B2 (en) 2007-02-28 2011-10-04 Seiko Epson Corporation Template pulse generating circuit, communication device, and communication method
DE602007008953D1 (de) 2007-03-02 2010-10-14 Dna Electronics Ltd Qpcr unter verwendung eines ionen-sensitiven feldeffekt-transistors zur ph-messung
EP1975246A1 (de) * 2007-03-29 2008-10-01 Micronas Holding GmbH Markierungsfreie Sequenzierung auf einer Festphase mittels Feldeffekttransistoren
EP2173467B1 (en) 2007-07-13 2016-05-04 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
US7609093B2 (en) 2007-08-03 2009-10-27 Tower Semiconductor Ltd. Comparator with low supply current spike and input offset cancellation
EP2201021A4 (en) 2007-08-29 2012-01-25 Applied Biosystems Llc METHOD OF ALTERNATING NUCLEIC ACID SEQUENCING
WO2009041917A1 (en) 2007-09-28 2009-04-02 Agency For Science, Technology And Research Method of electrically detecting a nucleic acid molecule
KR100940415B1 (ko) 2007-12-03 2010-02-02 주식회사 동부하이텍 배면 드레인 구조 웨이퍼의 온저항 측정방법
CN101896624A (zh) 2007-12-13 2010-11-24 Nxp股份有限公司 对生物微粒进行测序的生物传感器装置和方法
US8124936B1 (en) 2007-12-13 2012-02-28 The United States Of America As Represented By The Secretary Of The Army Stand-off chemical detector
WO2009081890A1 (ja) 2007-12-20 2009-07-02 National University Corporation Toyohashi University Of Technology 複合検出装置
US20090194416A1 (en) 2008-01-31 2009-08-06 Chung Yuan Christian University Potentiometric biosensor for detection of creatinine and forming method thereof
DE102008012899A1 (de) 2008-03-06 2009-09-10 Robert Bosch Gmbh Verfahren zum Betreiben eines Gassensors
US8067731B2 (en) 2008-03-08 2011-11-29 Scott Technologies, Inc. Chemical detection method and system
US7885490B2 (en) 2008-03-10 2011-02-08 Octrolix Bv Optical chemical detector and method
US7667501B2 (en) 2008-03-19 2010-02-23 Texas Instruments Incorporated Correlated double sampling technique
JP5259219B2 (ja) 2008-03-19 2013-08-07 株式会社三社電機製作所 電源装置
US7821806B2 (en) 2008-06-18 2010-10-26 Nscore Inc. Nonvolatile semiconductor memory circuit utilizing a MIS transistor as a memory cell
EP2307577B1 (en) 2008-06-25 2015-06-03 Life Technologies Corporation Methods for measuring analytes using large scale fet arrays
GB2461127B (en) 2008-06-25 2010-07-14 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale FET arrays
JP2011525990A (ja) 2008-06-26 2011-09-29 ライフ テクノロジーズ コーポレーション Ｆｅｔアレイを用いて分子相互作用を検出するための方法および装置
KR101026468B1 (ko) 2008-09-10 2011-04-01 한국전자통신연구원 생분자 검출 장치 및 검출 방법
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010047804A1 (en) 2008-10-22 2010-04-29 Ion Torrent Systems Incorporated Integrated sensor arrays for biological and chemical analysis
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US7898277B2 (en) 2008-12-24 2011-03-01 Agere Systems Inc. Hot-electronic injection testing of transistors on a wafer
US8101479B2 (en) 2009-03-27 2012-01-24 National Semiconductor Corporation Fabrication of asymmetric field-effect transistors using L-shaped spacers
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US8080456B2 (en) 2009-05-20 2011-12-20 International Business Machines Corporation Robust top-down silicon nanowire structure using a conformal nitride
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20110037121A1 (en) 2009-08-16 2011-02-17 Tung-Hsing Lee Input/output electrostatic discharge device with reduced junction breakdown voltage
JP2011041205A (ja) 2009-08-18 2011-02-24 Panasonic Corp 電圧発生回路、デジタルアナログ変換器、ランプ波発生回路、アナログデジタル変換器、イメージセンサシステム及び電圧発生方法
SG188863A1 (en) 2009-09-11 2013-04-30 Agency Science Tech & Res Method of determining a sensitivity of a biosensor arrangement, and biosensor sensitivity determining system
US9018684B2 (en) 2009-11-23 2015-04-28 California Institute Of Technology Chemical sensing and/or measuring devices and methods
US8545248B2 (en) 2010-01-07 2013-10-01 Life Technologies Corporation System to control fluid flow based on a leak detected by a sensor
US9088208B2 (en) 2010-01-27 2015-07-21 Intersil Americas LLC System and method for high precision current sensing
WO2011106629A2 (en) 2010-02-26 2011-09-01 Life Technologies Corporation Modified proteins and methods of making and using same
US8878257B2 (en) 2010-06-04 2014-11-04 Freescale Semiconductor, Inc. Methods and apparatus for an ISFET
US8731847B2 (en) 2010-06-30 2014-05-20 Life Technologies Corporation Array configuration and readout scheme
TWI539172B (zh) 2010-06-30 2016-06-21 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
WO2012006222A1 (en) 2010-07-03 2012-01-12 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
EP2606343A4 (en) 2010-08-18 2017-08-16 Life Technologies Corporation Chemical coating of microwell for electrochemical detection device
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
AU2011226766A1 (en) 2010-09-24 2012-04-12 Life Technologies Corporation Matched pair transistor circuits
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
WO2012152308A1 (en) 2011-05-06 2012-11-15 X-Fab Semiconductor Foundries Ag Ion sensitive field effect transistor
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array

Also Published As

Publication number Publication date
JP6370938B2 (ja) 2018-08-08
US20120247977A1 (en) 2012-10-04
EP2307577B1 (en) 2015-06-03
US20150126378A1 (en) 2015-05-07
US9458502B2 (en) 2016-10-04
JP2011525810A (ja) 2011-09-29
EP2307577A4 (en) 2013-09-25
US11530444B2 (en) 2022-12-20
CN102203282B (zh) 2014-04-30
JP6088481B2 (ja) 2017-03-01
EP2982437A1 (en) 2016-02-10
WO2010008480A3 (en) 2010-06-03
CN102203282A (zh) 2011-09-28
US9194000B2 (en) 2015-11-24
EP2307577A2 (en) 2011-04-13
US20110217697A1 (en) 2011-09-08
US8524057B2 (en) 2013-09-03
WO2010008480A2 (en) 2010-01-21
US8470164B2 (en) 2013-06-25
US20170145497A1 (en) 2017-05-25
US20210047686A1 (en) 2021-02-18
EP2982437B1 (en) 2017-12-06
JP2015130858A (ja) 2015-07-23
JP2017136063A (ja) 2017-08-10
US20130324421A1 (en) 2013-12-05

Similar Documents

Publication Publication Date Title
JP6370938B2 (ja) 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
US20220259643A1 (en) Methods and apparatus for detecting molecular interactions using fet arrays
US8530941B2 (en) Methods and apparatus for measuring analytes using large scale FET arrays
JP2011525990A (ja) Ｆｅｔアレイを用いて分子相互作用を検出するための方法および装置
GB2461128A (en) Nucleic acid sequencing using chemically-sensitive field effect transistors (chemFETs)

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120330

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130401

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130806

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140414

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20141111

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141211

R150 Certificate of patent or registration of utility model

Ref document number: 5667049

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250