JP4896735B2 - Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法 - Google Patents

Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法 Download PDF

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Publication number
JP4896735B2
JP4896735B2 JP2006546365A JP2006546365A JP4896735B2 JP 4896735 B2 JP4896735 B2 JP 4896735B2 JP 2006546365 A JP2006546365 A JP 2006546365A JP 2006546365 A JP2006546365 A JP 2006546365A JP 4896735 B2 JP4896735 B2 JP 4896735B2
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Japan
Prior art keywords
formula
acid
benzofuran
temperature
butyl
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Japanese (ja)
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JP2007517012A5 (enExample
JP2007517012A (ja
Inventor
シウトウエタン，アラン
ブレジエール，フランソワ
モルダク，フランソワーズ
ピロン，ジエローム
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クラリアント スペシャルティー ファイン ケミカルズ（フランス）
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006546365A 2003-12-24 2004-12-15 Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法 Expired - Fee Related JP4896735B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0315398A FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
FR0315398 2003-12-24
PCT/IB2004/004158 WO2005066149A1 (en) 2003-12-24 2004-12-15 Process for the preperation of n-alkyl-2(hydroxy-4 benzoyl)-3 benzofurans and its intermediates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011175599A Division JP5400840B2 (ja) 2003-12-24 2011-08-11 Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法

Publications (3)

Publication Number Publication Date
JP2007517012A JP2007517012A (ja) 2007-06-28
JP2007517012A5 JP2007517012A5 (enExample) 2008-01-17
JP4896735B2 true JP4896735B2 (ja) 2012-03-14

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ID=34639607

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006546365A Expired - Fee Related JP4896735B2 (ja) 2003-12-24 2004-12-15 Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法
JP2011175599A Expired - Fee Related JP5400840B2 (ja) 2003-12-24 2011-08-11 Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011175599A Expired - Fee Related JP5400840B2 (ja) 2003-12-24 2011-08-11 Ｎ−アルキル−２（ヒドロキシ−４ベンゾイル）−３ベンゾフラン及びその中間体の調製方法

Country Status (11)

Country Link
US (1) US7544817B2 (enExample)
EP (2) EP1699772B1 (enExample)
JP (2) JP4896735B2 (enExample)
KR (1) KR101150627B1 (enExample)
CN (2) CN100475801C (enExample)
DK (1) DK1699772T3 (enExample)
ES (1) ES2400943T3 (enExample)
FR (1) FR2864536B1 (enExample)
NO (1) NO20062936L (enExample)
TW (1) TWI365878B (enExample)
WO (1) WO2005066149A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
NZ588623A (en) 2008-04-17 2012-11-30 Sanofi Aventis Use of a medicament containing dronedarone with food for preventing cardiovascular hospitalization
EP2246341A1 (en) 2009-01-23 2010-11-03 Lonza Ltd. Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
CN103265513A (zh) * 2013-03-25 2013-08-28 德州学院 制备2-烷基-3-(4-羟基苯甲酰基)苯并呋喃的方法
EP4375276A4 (en) * 2021-07-21 2025-04-16 Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. COMPOUND FOR THE TREATMENT OF A DISEASE ASSOCIATED WITH ISCHEMIC BRAIN INJURY

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4969658A (enExample) * 1972-09-19 1974-07-05
JPS516958A (en) * 1974-06-06 1976-01-20 Labaz Benzo *b* chiofuenjudotainoseizoho
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
JPS5253851A (en) * 1975-10-28 1977-04-30 Lilly Co Eli Novel sterile agent
JPH0242073A (ja) * 1988-04-18 1990-02-13 Taro Pharmaceut Ind Ltd ２―アルキル―３―ベンゾイルベンゾフラン類及びそれらを含有する医薬組成物
JPH03169874A (ja) * 1989-10-23 1991-07-23 Sanofi Sa ３―ベンゾイルベンゾフラン誘導体の製造方法
JPH04316554A (ja) * 1990-08-06 1992-11-06 Sanofi Sa ベンゾフラン、ベンゾチオフェン、インドールおよびインドリジン誘導体、製法および組成物
JPH06184132A (ja) * 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
JP2001233870A (ja) * 2000-01-17 2001-08-28 Clariant France ３−（１−ヒドロキシ−ペンチリデン）−５−ニトロ−３ｈ−ベンゾフラン−２−オン、その製造方法及びその用途
JP2002514636A (ja) * 1998-05-12 2002-05-21 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性または高血糖症の治療に有用なフェニルオキソ−酢酸類

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4969658A (enExample) * 1972-09-19 1974-07-05
JPS516958A (en) * 1974-06-06 1976-01-20 Labaz Benzo *b* chiofuenjudotainoseizoho
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
JPS5253851A (en) * 1975-10-28 1977-04-30 Lilly Co Eli Novel sterile agent
JPH0242073A (ja) * 1988-04-18 1990-02-13 Taro Pharmaceut Ind Ltd ２―アルキル―３―ベンゾイルベンゾフラン類及びそれらを含有する医薬組成物
JPH03169874A (ja) * 1989-10-23 1991-07-23 Sanofi Sa ３―ベンゾイルベンゾフラン誘導体の製造方法
JPH04316554A (ja) * 1990-08-06 1992-11-06 Sanofi Sa ベンゾフラン、ベンゾチオフェン、インドールおよびインドリジン誘導体、製法および組成物
JPH06184132A (ja) * 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
JP2002514636A (ja) * 1998-05-12 2002-05-21 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性または高血糖症の治療に有用なフェニルオキソ−酢酸類
JP2001233870A (ja) * 2000-01-17 2001-08-28 Clariant France ３−（１−ヒドロキシ−ペンチリデン）−５−ニトロ−３ｈ−ベンゾフラン−２−オン、その製造方法及びその用途

Also Published As

Publication number Publication date
DK1699772T3 (da) 2013-05-27
EP2508517A1 (en) 2012-10-10
NO20062936L (no) 2006-09-22
KR101150627B1 (ko) 2012-06-01
CN1898226A (zh) 2007-01-17
CN101486698B (zh) 2011-07-27
US7544817B2 (en) 2009-06-09
CN101486698A (zh) 2009-07-22
US20070155831A1 (en) 2007-07-05
TWI365878B (en) 2012-06-11
TW200526616A (en) 2005-08-16
CN100475801C (zh) 2009-04-08
JP2007517012A (ja) 2007-06-28
HK1097835A1 (zh) 2007-07-06
KR20060111608A (ko) 2006-10-27
FR2864536B1 (fr) 2006-03-17
JP2012012400A (ja) 2012-01-19
EP1699772A1 (en) 2006-09-13
FR2864536A1 (fr) 2005-07-01
WO2005066149A1 (en) 2005-07-21
EP1699772B1 (en) 2013-02-20
JP5400840B2 (ja) 2014-01-29
ES2400943T3 (es) 2013-04-15

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