TWI365878B - Process for the preparation of 2-(n-alkyl)-3(4-hydroxybenzoyl) benzofurans and its intermediates thereof - Google Patents

Process for the preparation of 2-(n-alkyl)-3(4-hydroxybenzoyl) benzofurans and its intermediates thereof

Info

Publication number
TWI365878B
TWI365878B TW093140136A TW93140136A TWI365878B TW I365878 B TWI365878 B TW I365878B TW 093140136 A TW093140136 A TW 093140136A TW 93140136 A TW93140136 A TW 93140136A TW I365878 B TWI365878 B TW I365878B
Authority
TW
Taiwan
Prior art keywords
benzofurans
hydroxybenzoyl
intermediates
alkyl
preparation
Prior art date
Application number
TW093140136A
Other languages
English (en)
Chinese (zh)
Other versions
TW200526616A (en
Inventor
Alain Shoutteeten
Francois Bleger
Francoise Mordacq
Jerome Piron
Original Assignee
Clariant Specialty Fine Chem F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Specialty Fine Chem F filed Critical Clariant Specialty Fine Chem F
Publication of TW200526616A publication Critical patent/TW200526616A/zh
Application granted granted Critical
Publication of TWI365878B publication Critical patent/TWI365878B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW093140136A 2003-12-24 2004-12-22 Process for the preparation of 2-(n-alkyl)-3(4-hydroxybenzoyl) benzofurans and its intermediates thereof TWI365878B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0315398A FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre

Publications (2)

Publication Number Publication Date
TW200526616A TW200526616A (en) 2005-08-16
TWI365878B true TWI365878B (en) 2012-06-11

Family

ID=34639607

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093140136A TWI365878B (en) 2003-12-24 2004-12-22 Process for the preparation of 2-(n-alkyl)-3(4-hydroxybenzoyl) benzofurans and its intermediates thereof

Country Status (11)

Country Link
US (1) US7544817B2 (enExample)
EP (2) EP2508517A1 (enExample)
JP (2) JP4896735B2 (enExample)
KR (1) KR101150627B1 (enExample)
CN (2) CN100475801C (enExample)
DK (1) DK1699772T3 (enExample)
ES (1) ES2400943T3 (enExample)
FR (1) FR2864536B1 (enExample)
NO (1) NO20062936L (enExample)
TW (1) TWI365878B (enExample)
WO (1) WO2005066149A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
CN102065855A (zh) 2008-04-17 2011-05-18 赛诺菲-安万特 决奈达隆在制备用于预防因心血管疾病住院或死亡的药物中的用途
EP2246341A1 (en) 2009-01-23 2010-11-03 Lonza Ltd. Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
CN103265513A (zh) * 2013-03-25 2013-08-28 德州学院 制备2-烷基-3-(4-羟基苯甲酰基)苯并呋喃的方法
CA3232459A1 (en) * 2021-07-21 2023-01-26 Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. Compound for treating diseases related to cerebral ischemic injury

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382742A (en) * 1972-09-19 1975-02-05 Labaz Benzofuran derivatives and process for preparing the same
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2653431B1 (fr) * 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JPH06184132A (ja) * 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
EP1077965A1 (en) * 1998-05-12 2001-02-28 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
FR2803846B1 (fr) * 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Also Published As

Publication number Publication date
KR20060111608A (ko) 2006-10-27
CN101486698A (zh) 2009-07-22
JP2012012400A (ja) 2012-01-19
TW200526616A (en) 2005-08-16
JP5400840B2 (ja) 2014-01-29
JP2007517012A (ja) 2007-06-28
EP1699772B1 (en) 2013-02-20
EP1699772A1 (en) 2006-09-13
HK1097835A1 (zh) 2007-07-06
CN1898226A (zh) 2007-01-17
NO20062936L (no) 2006-09-22
JP4896735B2 (ja) 2012-03-14
KR101150627B1 (ko) 2012-06-01
FR2864536B1 (fr) 2006-03-17
FR2864536A1 (fr) 2005-07-01
WO2005066149A1 (en) 2005-07-21
DK1699772T3 (da) 2013-05-27
CN100475801C (zh) 2009-04-08
US20070155831A1 (en) 2007-07-05
CN101486698B (zh) 2011-07-27
EP2508517A1 (en) 2012-10-10
US7544817B2 (en) 2009-06-09
ES2400943T3 (es) 2013-04-15

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees