CN100475801C - 制备2-正烷基-3-(4-羟基苯甲酰基)苯并呋喃及其中间体的方法 - Google Patents

制备2-正烷基-3-(4-羟基苯甲酰基)苯并呋喃及其中间体的方法 Download PDF

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Publication number
CN100475801C
CN100475801C CNB2004800382852A CN200480038285A CN100475801C CN 100475801 C CN100475801 C CN 100475801C CN B2004800382852 A CNB2004800382852 A CN B2004800382852A CN 200480038285 A CN200480038285 A CN 200480038285A CN 100475801 C CN100475801 C CN 100475801C
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CN
China
Prior art keywords
formula
alkyl
compound
phenyl ether
iii
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Expired - Fee Related
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CNB2004800382852A
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English (en)
Chinese (zh)
Other versions
CN1898226A (zh
Inventor
A·肖特滕
F·布勒热
F·莫尔达克
J·皮隆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Simple Chemical Co Ltd For Maxwell
Original Assignee
Clariant France SA
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Publication of CN1898226A publication Critical patent/CN1898226A/zh
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Publication of CN100475801C publication Critical patent/CN100475801C/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB2004800382852A 2003-12-24 2004-12-15 制备2-正烷基-3-(4-羟基苯甲酰基)苯并呋喃及其中间体的方法 Expired - Fee Related CN100475801C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0315398A FR2864536B1 (fr) 2003-12-24 2003-12-24 Procede de preparation de n-alkyl-2 (hydroxy-4-benzoyl)-3 benzofurannes et intermediaires pour sa mise en oeuvre
FR0315398 2003-12-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200910006741XA Division CN101486698B (zh) 2003-12-24 2004-12-15 取代的苯并呋喃及其制备方法

Publications (2)

Publication Number Publication Date
CN1898226A CN1898226A (zh) 2007-01-17
CN100475801C true CN100475801C (zh) 2009-04-08

Family

ID=34639607

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2004800382852A Expired - Fee Related CN100475801C (zh) 2003-12-24 2004-12-15 制备2-正烷基-3-(4-羟基苯甲酰基)苯并呋喃及其中间体的方法
CN200910006741XA Expired - Fee Related CN101486698B (zh) 2003-12-24 2004-12-15 取代的苯并呋喃及其制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200910006741XA Expired - Fee Related CN101486698B (zh) 2003-12-24 2004-12-15 取代的苯并呋喃及其制备方法

Country Status (11)

Country Link
US (1) US7544817B2 (enExample)
EP (2) EP2508517A1 (enExample)
JP (2) JP4896735B2 (enExample)
KR (1) KR101150627B1 (enExample)
CN (2) CN100475801C (enExample)
DK (1) DK1699772T3 (enExample)
ES (1) ES2400943T3 (enExample)
FR (1) FR2864536B1 (enExample)
NO (1) NO20062936L (enExample)
TW (1) TWI365878B (enExample)
WO (1) WO2005066149A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2914644B1 (fr) * 2007-04-06 2009-06-05 Finorga Soc Par Actions Simpli Procede de preparation de 2-(n-butyl)-3-(4-hydroxybenzoyl) -5-nitrobenzofurane
GB0719180D0 (en) * 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
CN102065855A (zh) 2008-04-17 2011-05-18 赛诺菲-安万特 决奈达隆在制备用于预防因心血管疾病住院或死亡的药物中的用途
EP2246341A1 (en) 2009-01-23 2010-11-03 Lonza Ltd. Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
US8602215B2 (en) 2010-06-30 2013-12-10 Sanofi Methods for reducing the risk of an adverse dronedarone/beta-blockers interaction in a patient suffering from atrial fibrillation
EP2452938A1 (en) 2010-11-12 2012-05-16 LEK Pharmaceuticals d.d. Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives
FR2973027A1 (fr) * 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
CN103265513A (zh) * 2013-03-25 2013-08-28 德州学院 制备2-烷基-3-(4-羟基苯甲酰基)苯并呋喃的方法
CA3232459A1 (en) * 2021-07-21 2023-01-26 Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd. Compound for treating diseases related to cerebral ischemic injury

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382742A (en) * 1972-09-19 1975-02-05 Labaz Benzofuran derivatives and process for preparing the same
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
FR2653431B1 (fr) * 1989-10-23 1994-05-27 Sanofi Sa Procede de preparation de derives de benzoyl-3 benzofuranne.
JP2873599B2 (ja) * 1990-03-09 1999-03-24 寿製薬株式会社 新規ベンゾフラン誘導体、尿酸排泄剤及びその製法
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JPH06184132A (ja) * 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
GB9416219D0 (en) * 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
EP1077965A1 (en) * 1998-05-12 2001-02-28 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
FR2803846B1 (fr) * 2000-01-17 2002-04-05 Clariant France Sa 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, son procede de preparation et son utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemistry and antibacterial activity of nitrobenzofurans. POWERS, LARRY J.:.JOURNAL OF MEDICINAL CHEMISTRY,Vol.19 No.1. 1976 *

Also Published As

Publication number Publication date
KR20060111608A (ko) 2006-10-27
TWI365878B (en) 2012-06-11
CN101486698A (zh) 2009-07-22
JP2012012400A (ja) 2012-01-19
TW200526616A (en) 2005-08-16
JP5400840B2 (ja) 2014-01-29
JP2007517012A (ja) 2007-06-28
EP1699772B1 (en) 2013-02-20
EP1699772A1 (en) 2006-09-13
HK1097835A1 (zh) 2007-07-06
CN1898226A (zh) 2007-01-17
NO20062936L (no) 2006-09-22
JP4896735B2 (ja) 2012-03-14
KR101150627B1 (ko) 2012-06-01
FR2864536B1 (fr) 2006-03-17
FR2864536A1 (fr) 2005-07-01
WO2005066149A1 (en) 2005-07-21
DK1699772T3 (da) 2013-05-27
US20070155831A1 (en) 2007-07-05
CN101486698B (zh) 2011-07-27
EP2508517A1 (en) 2012-10-10
US7544817B2 (en) 2009-06-09
ES2400943T3 (es) 2013-04-15

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