JP4846160B2 - ナイセリア属のタンパク質のハイブリッド発現 - Google Patents

ナイセリア属のタンパク質のハイブリッド発現 Download PDF

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Publication number
JP4846160B2
JP4846160B2 JP2001563609A JP2001563609A JP4846160B2 JP 4846160 B2 JP4846160 B2 JP 4846160B2 JP 2001563609 A JP2001563609 A JP 2001563609A JP 2001563609 A JP2001563609 A JP 2001563609A JP 4846160 B2 JP4846160 B2 JP 4846160B2
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protein
hybrid
proteins
buffer
strain
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JP2003525049A5 (enExample
JP2003525049A (ja
Inventor
マリーア ベアトリーチェ アリコ,
マウリツィオ コマンドゥッチ,
チェシーラ ガレオッティ,
ヴェーガ マシニャーニ,
マルツィア モーニカ ジュリアーニ,
マリアグラツィア ピッツァ,
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ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル
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Priority claimed from GB0004695A external-priority patent/GB0004695D0/en
Priority claimed from GB0027675A external-priority patent/GB0027675D0/en
Application filed by ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル filed Critical ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル
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Publication of JP2003525049A5 publication Critical patent/JP2003525049A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2001563609A 2000-02-28 2001-02-28 ナイセリア属のタンパク質のハイブリッド発現 Expired - Fee Related JP4846160B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0004695.3 2000-02-28
GB0004695A GB0004695D0 (en) 2000-02-28 2000-02-28 Protein expression
GB0027675.8 2000-11-13
GB0027675A GB0027675D0 (en) 2000-11-13 2000-11-13 Protein Expression
PCT/IB2001/000420 WO2001064920A2 (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010288968A Division JP5346004B2 (ja) 2000-02-28 2010-12-24 ナイセリア属のタンパク質のハイブリッド発現

Publications (3)

Publication Number Publication Date
JP2003525049A JP2003525049A (ja) 2003-08-26
JP2003525049A5 JP2003525049A5 (enExample) 2008-04-03
JP4846160B2 true JP4846160B2 (ja) 2011-12-28

Family

ID=26243750

Family Applications (8)

Application Number Title Priority Date Filing Date
JP2001563609A Expired - Fee Related JP4846160B2 (ja) 2000-02-28 2001-02-28 ナイセリア属のタンパク質のハイブリッド発現
JP2001563611A Expired - Fee Related JP4763210B2 (ja) 2000-02-28 2001-02-28 ナイセリアのタンパク質の異種発現
JP2010288968A Expired - Fee Related JP5346004B2 (ja) 2000-02-28 2010-12-24 ナイセリア属のタンパク質のハイブリッド発現
JP2011004414A Pending JP2011101657A (ja) 2000-02-28 2011-01-12 ナイセリアのタンパク質の異種発現
JP2012214120A Withdrawn JP2013005816A (ja) 2000-02-28 2012-09-27 ナイセリア属のタンパク質のハイブリッド発現
JP2013192617A Expired - Fee Related JP5941027B2 (ja) 2000-02-28 2013-09-18 ナイセリアのタンパク質の異種発現
JP2014054817A Pending JP2014121333A (ja) 2000-02-28 2014-03-18 ナイセリアのタンパク質の異種発現
JP2016078708A Pending JP2016128520A (ja) 2000-02-28 2016-04-11 ナイセリアのタンパク質の異種発現

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2001563611A Expired - Fee Related JP4763210B2 (ja) 2000-02-28 2001-02-28 ナイセリアのタンパク質の異種発現
JP2010288968A Expired - Fee Related JP5346004B2 (ja) 2000-02-28 2010-12-24 ナイセリア属のタンパク質のハイブリッド発現
JP2011004414A Pending JP2011101657A (ja) 2000-02-28 2011-01-12 ナイセリアのタンパク質の異種発現
JP2012214120A Withdrawn JP2013005816A (ja) 2000-02-28 2012-09-27 ナイセリア属のタンパク質のハイブリッド発現
JP2013192617A Expired - Fee Related JP5941027B2 (ja) 2000-02-28 2013-09-18 ナイセリアのタンパク質の異種発現
JP2014054817A Pending JP2014121333A (ja) 2000-02-28 2014-03-18 ナイセリアのタンパク質の異種発現
JP2016078708A Pending JP2016128520A (ja) 2000-02-28 2016-04-11 ナイセリアのタンパク質の異種発現

Country Status (19)

Country Link
US (9) US7803387B2 (enExample)
EP (6) EP1259627B1 (enExample)
JP (8) JP4846160B2 (enExample)
CN (7) CN101139590B (enExample)
AT (3) ATE387502T1 (enExample)
AU (4) AU2001239478B2 (enExample)
BR (2) BR0108713A (enExample)
CA (5) CA2689666C (enExample)
CY (6) CY1106532T1 (enExample)
DE (3) DE60144353D1 (enExample)
DK (4) DK1261723T3 (enExample)
ES (5) ES2360746T3 (enExample)
LU (1) LU92240I2 (enExample)
MX (2) MXPA02008314A (enExample)
NL (1) NL300605I2 (enExample)
NZ (2) NZ521531A (enExample)
PT (4) PT1261723E (enExample)
RU (2) RU2304617C2 (enExample)
WO (2) WO2001064922A2 (enExample)

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CA2400562A1 (en) 2001-09-07
CN100339482C (zh) 2007-09-26
CA2744921C (en) 2014-05-13
AU3947801A (en) 2001-09-12
JP2013005816A (ja) 2013-01-10
EP1947187B9 (en) 2011-09-21
EP2270030B1 (en) 2012-05-23
US20140363462A1 (en) 2014-12-11
JP2011101657A (ja) 2011-05-26
BR0108713A (pt) 2004-06-22
HK1055993A1 (zh) 2004-01-30
NZ521396A (en) 2004-06-25
JP2011083287A (ja) 2011-04-28
CA2689666C (en) 2015-02-24
CN1544462A (zh) 2004-11-10
CY2013025I1 (el) 2015-11-04
NZ521531A (en) 2005-12-23
DK1947187T3 (da) 2011-05-09
DK1790660T3 (da) 2012-09-17
AU3948801A (en) 2001-09-12
CA2744921A1 (en) 2001-09-07
DE60132978D1 (de) 2008-04-10
EP1947187A1 (en) 2008-07-23
CN100334214C (zh) 2007-08-29
HK1056197A1 (en) 2004-02-06
HK1064120A1 (zh) 2005-01-21
EP1261723B1 (en) 2008-02-27
CY2013025I2 (el) 2015-11-04
CN1508253A (zh) 2004-06-30
PT1790660E (pt) 2012-09-17
EP1947187B1 (en) 2011-03-30
CN1800385B (zh) 2010-06-02
CA2400570A1 (en) 2001-09-07
CN1426473A (zh) 2003-06-25
RU2002125882A (ru) 2004-03-10
ES2360746T9 (es) 2012-02-13
WO2001064920A3 (en) 2002-03-14
PT1947187E (pt) 2011-07-04
US20040110670A1 (en) 2004-06-10
ATE387502T1 (de) 2008-03-15
EP1261723A2 (en) 2002-12-04
AU2001239488B2 (en) 2006-01-19
CY1113477T1 (el) 2016-06-22
CY1113032T1 (el) 2016-04-13
US20040092711A1 (en) 2004-05-13
DK1947187T5 (da) 2011-10-24
EP2270031A2 (en) 2011-01-05

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