CN1800385B - 奈瑟球菌蛋白质的异源表达 - Google Patents

奈瑟球菌蛋白质的异源表达 Download PDF

Info

Publication number
CN1800385B
CN1800385B CN200510116305XA CN200510116305A CN1800385B CN 1800385 B CN1800385 B CN 1800385B CN 200510116305X A CN200510116305X A CN 200510116305XA CN 200510116305 A CN200510116305 A CN 200510116305A CN 1800385 B CN1800385 B CN 1800385B
Authority
CN
China
Prior art keywords
protein
expression
leading peptide
sequence
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200510116305XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1800385A (zh
Inventor
M·B·阿科
M·科曼杜西
C·加莱蒂
V·马斯格阿尼
M·M·朱利亚尼
M·皮扎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26243750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1800385(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0004695A external-priority patent/GB0004695D0/en
Priority claimed from GB0027675A external-priority patent/GB0027675D0/en
Application filed by Chiron SRL filed Critical Chiron SRL
Publication of CN1800385A publication Critical patent/CN1800385A/zh
Application granted granted Critical
Publication of CN1800385B publication Critical patent/CN1800385B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200510116305XA 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达 Expired - Fee Related CN1800385B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0004695A GB0004695D0 (en) 2000-02-28 2000-02-28 Protein expression
GB0004695.3 2000-02-28
GB0027675.8 2000-11-13
GB0027675A GB0027675D0 (en) 2000-11-13 2000-11-13 Protein Expression

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
CNB018087507A Division CN1201011C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达
CNB2003101028453A Division CN100473663C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达

Publications (2)

Publication Number Publication Date
CN1800385A CN1800385A (zh) 2006-07-12
CN1800385B true CN1800385B (zh) 2010-06-02

Family

ID=26243750

Family Applications (7)

Application Number Title Priority Date Filing Date
CN2010101656630A Pending CN101906413A (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达
CNB018087388A Expired - Fee Related CN100339482C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CN2007101391568A Expired - Fee Related CN101139590B (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CNB2003101036036A Expired - Fee Related CN100334214C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CNB2003101028453A Expired - Fee Related CN100473663C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达
CN200510116305XA Expired - Fee Related CN1800385B (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达
CNB018087507A Expired - Fee Related CN1201011C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达

Family Applications Before (5)

Application Number Title Priority Date Filing Date
CN2010101656630A Pending CN101906413A (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达
CNB018087388A Expired - Fee Related CN100339482C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CN2007101391568A Expired - Fee Related CN101139590B (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CNB2003101036036A Expired - Fee Related CN100334214C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的杂交表达
CNB2003101028453A Expired - Fee Related CN100473663C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB018087507A Expired - Fee Related CN1201011C (zh) 2000-02-28 2001-02-28 奈瑟球菌蛋白质的异源表达

Country Status (19)

Country Link
US (9) US20040092711A1 (enExample)
EP (6) EP2270030B1 (enExample)
JP (8) JP4763210B2 (enExample)
CN (7) CN101906413A (enExample)
AT (3) ATE503837T1 (enExample)
AU (4) AU2001239478B2 (enExample)
BR (2) BR0108711A (enExample)
CA (5) CA2744921C (enExample)
CY (6) CY1106532T1 (enExample)
DE (3) DE60144353D1 (enExample)
DK (4) DK2270030T3 (enExample)
ES (5) ES2386534T3 (enExample)
LU (1) LU92240I2 (enExample)
MX (2) MXPA02008314A (enExample)
NL (1) NL300605I2 (enExample)
NZ (2) NZ521531A (enExample)
PT (4) PT1790660E (enExample)
RU (2) RU2299906C2 (enExample)
WO (2) WO2001064922A2 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0935659A1 (en) 1996-09-17 1999-08-18 Chiron Corporation Compositions and methods for treating intracellular diseases
BR9906927A (pt) * 1998-01-14 2001-11-20 Chiron Spa Proteìnas de neisseria meningitidis
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
WO2001031019A2 (en) 1999-10-29 2001-05-03 Chiron Spa Neisserial antigenic peptides
NZ532665A (en) 1998-05-01 2005-11-25 Inst Genomic Research Neisseria meningitidis antigens and compositions
JP4812942B2 (ja) * 1999-02-26 2011-11-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル CGモチーフを含むオリゴヌクレオチドを用いるNeisseria抗原殺菌活性の増強
DK1228217T3 (da) 1999-04-30 2013-02-25 Novartis Vaccines & Diagnostic Konserverede neisseria-antigener
CA2838395C (en) 1999-05-19 2016-07-19 Novartis Vaccines And Diagnostics S.R.L. Combination neisserial compositions
GB9911683D0 (en) * 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
CN102172398A (zh) * 2000-01-17 2011-09-07 诺华疫苗和诊断有限公司 含有脑膜炎奈瑟球菌b血清群外膜蛋白质的外膜囊(omv)疫苗
DE60144353D1 (de) 2000-02-28 2011-05-12 Novartis Vaccines & Diagnostic Hybride Expression Neisserscher Proteine
US7534444B2 (en) * 2001-04-17 2009-05-19 Novattis Vaccines And Diagnostics, Inc. Molecular mimetics of meningococcal B epitopes which elicit functionally active antibodies
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US6928463B1 (en) * 2001-07-06 2005-08-09 Nortel Networks Limited Broadband content delivery via personal content tunnel
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
PT2248822T (pt) 2001-07-27 2017-02-14 Glaxosmithkline Biologicals Sa Adesinas de meningococos
AU2014201962B2 (en) * 2001-09-06 2016-06-09 Glaxosmithkline Vaccines S.R.L. Hybrid and tandem expression of Neisserial proteins
EP1438323A4 (en) * 2001-10-03 2007-08-01 Novartis Vaccines & Diagnostic ADJUVOUS MENINGOCOCCUS COMPOSITIONS
US7838015B2 (en) 2001-10-03 2010-11-23 Novartis Vaccines And Diagnostics, Inc. Adjuvanted meningococcus compositions
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
AU2003260357B2 (en) 2002-08-02 2009-10-29 Glaxosmithkline Biologicals S.A. Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB- Neisseria minigitidis
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
HUE047780T2 (hu) * 2002-10-11 2020-05-28 Glaxosmithkline Biologicals Sa Polipeptid vakcinák hipervirulens meningokokkusz vonalak elleni széles-spektrumú védelemre
WO2004039399A1 (en) 2002-11-01 2004-05-13 Glaxosmithkline Biologicals S.A. Immunogenic composition
WO2004046177A2 (en) 2002-11-15 2004-06-03 Chiron Srl Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
ES2411080T3 (es) * 2003-01-30 2013-07-04 Novartis Ag Vacunas inyectables contra múltiples serogrupos de meningococos
WO2005019265A1 (en) 2003-08-13 2005-03-03 Chiron Corporation Improved method of purifying tfpi and tfpi analogs
EP1961426B1 (en) 2003-10-02 2011-04-27 Novartis Vaccines and Diagnostics S.r.l. Combined meningitis vaccines
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0409748D0 (en) 2004-04-30 2004-06-09 Chiron Srl Lactoferrin cleavage
GB0419408D0 (en) * 2004-09-01 2004-10-06 Chiron Srl 741 chimeric polypeptides
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
DK1858919T3 (da) 2005-02-18 2012-07-16 Novartis Vaccines & Diagnostic Immunogener fra uropathogen Escherichia coli
SI2351772T1 (sl) 2005-02-18 2016-11-30 Glaxosmithkline Biologicals Sa Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso
CN100475965C (zh) * 2005-07-22 2009-04-08 上海高科联合生物技术研发有限公司 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
US20110008279A1 (en) * 2005-12-06 2011-01-13 Vega Masignani Methods and Compositions Relating to Adhesins as Adjuvants
US20100166788A1 (en) 2006-08-16 2010-07-01 Novartis Vaccines And Diagnostics Immunogens from uropathogenic escherichia coli
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
GB0713880D0 (en) 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
PT2200642E (pt) 2007-10-19 2012-05-30 Novartis Ag Formulações de vacinas meningocócicas
RU2475496C2 (ru) 2008-02-21 2013-02-20 Новартис Аг МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP
PT2268618E (pt) 2008-03-03 2015-10-12 Novartis Ag Compostos e composições moduladores da actividade tlr
RU2360926C9 (ru) * 2008-03-17 2009-09-10 Всеволод Иванович Киселев ГИБРИДНЫЙ БЕЛОК CFP10-ESAT6, ИНДУЦИРУЮЩИЙ РЕАКЦИЮ ГИПЕРЧУВСТВИТЕЛЬНОСТИ ЗАМЕДЛЕННОГО ТИПА В ОТНОШЕНИИ M.Tuberculosis, КОДИРУЮЩАЯ ЕГО ХИМЕРНАЯ НУКЛЕИНОВАЯ КИСЛОТА И РЕКОМБИНАНТНЫЙ ПЛАЗМИДНЫЙ ЭКСПРЕССИРУЮЩИЙ ВЕКТОР, ЕЕ СОДЕРЖАЩИЙ, СПОСОБ ПОЛУЧЕНИЯ ГИБРИДНОГО БЕЛКА И ДОЗИРОВАННАЯ ЛЕКАРСТВЕННАЯ ФОРМА ДЛЯ ВНУТРИКОЖНОЙ ИНЪЕКЦИИ НА ЕГО ОСНОВЕ
CA2726512A1 (en) * 2008-06-09 2009-12-17 Novartis Ag Antibodies against neisserial factor h binding protein
JP5487463B2 (ja) 2008-08-08 2014-05-07 独立行政法人産業技術総合研究所 非拡散植物ウイルスベクター
CA2756522C (en) 2009-03-24 2018-06-26 Novartis Ag Adjuvanting meningococcal factor h binding protein
AU2010258677B2 (en) 2009-06-10 2016-10-06 Glaxosmithkline Biologicals S.A. Benzonaphthyridine-containing vaccines
ES2596653T3 (es) 2009-06-16 2017-01-11 Glaxosmithkline Biologicals Sa Ensayos bactericidas de opsonización y dependientes de anticuerpo mediado por el complemento de alto rendimiento
BR112012004275A2 (pt) 2009-08-27 2016-11-16 Novartis Ag polipeptídios híbridos incluindo sequências meningocócicas de fhbp
JP5988492B2 (ja) 2009-09-02 2016-09-07 ノバルティス アーゲー Tlr活性モジュレーターを含む免疫原性組成物
TWI445708B (zh) 2009-09-02 2014-07-21 Irm Llc 作為tlr活性調節劑之化合物及組合物
EP2483390A2 (en) 2009-09-30 2012-08-08 Novartis AG Expression of meningococcal fhbp polypeptides
CA2779816A1 (en) 2009-10-27 2011-05-05 Novartis Ag Modified meningococcal fhbp polypeptides
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
WO2011084549A1 (en) 2009-12-15 2011-07-14 Novartis Ag Homogeneous suspension of immunopotentiating compounds and uses thereof
EA031379B1 (ru) 2010-03-23 2018-12-28 Новартис Аг Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний
US10478483B2 (en) 2010-06-25 2019-11-19 Glaxosmithkline Biologicals Sa Combinations of meningococcal factor H binding proteins
SI3831406T1 (sl) 2010-08-23 2024-08-30 Wyeth Llc Stabilne formulacije antigenov neisseria meningitidis RLP2086
CA2810971C (en) 2010-09-10 2020-11-03 Novartis Ag Developments in meningococcal outer membrane vesicles
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
GB201102090D0 (en) * 2011-02-08 2011-03-23 Univ Sheffield Antigenic polypeptide
MX2014002375A (es) 2011-08-31 2014-09-15 Children S Hospital & Res Ct Oakland Secuencias diseñadas para facilitar la expresion de antigenos en neisseria y metodos de uso.
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
RU2665841C2 (ru) 2012-03-09 2018-09-04 Пфайзер Инк. Композиции neisseria meningitidis и способы их применения
EP2861247B1 (en) 2012-06-14 2020-12-09 GlaxoSmithKline Biologicals SA Vaccines for serogroup x meningococcus
EP2877492A1 (en) 2012-07-27 2015-06-03 Institut National de la Santé et de la Recherche Médicale (INSERM) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
WO2014084432A1 (ko) * 2012-11-30 2014-06-05 경상대학교 산학협력단 헬리코박터 파일로리 발현 벡터
EP2964665B1 (en) 2013-03-08 2018-08-01 Pfizer Inc Immunogenic fusion polypeptides
BR112016004463A2 (pt) 2013-09-08 2017-10-17 Pfizer composições de neisseria meningitidis e métodos das mesmas
SG10201907875TA (en) 2014-02-28 2019-09-27 Glaxosmithkline Biologicals Sa Modified meningococcal fhbp polypeptides
WO2016014719A1 (en) 2014-07-23 2016-01-28 Children's Hospital & Research Center Oakland Factor h binding protein variants and methods of use thereof
US10888611B2 (en) 2015-02-19 2021-01-12 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
GB201522153D0 (en) 2015-12-15 2016-01-27 Univ Southampton Meningococcal infection and modified neisseria lactamica
US12109259B2 (en) 2016-09-02 2024-10-08 Glaxosmithkline Biologicals Sa Vaccines for Neisseria gonorrhoeae
EP3312192B1 (en) * 2016-10-24 2023-02-22 BiOMVis Srl Immunogenic compositions containing bacterial outer membrane vesicles
CN118021947A (zh) 2017-01-31 2024-05-14 辉瑞大药厂 脑膜炎奈瑟菌组合物及其使用方法
CN110516550B (zh) * 2019-07-26 2022-07-05 电子科技大学 一种基于fpga的车道线实时检测方法
MX2022003682A (es) 2019-09-27 2022-04-25 Pfizer Composiciones de neisseria meningitidis y metodos de las mismas.
KR20220152402A (ko) * 2019-11-25 2022-11-15 그리피스 유니버시티 임균 감염에 대한 면역원성 단백질
AU2022223712A1 (en) 2021-02-19 2023-10-05 Sanofi Pasteur Inc. Meningococcal b recombinant vaccine
GB202208093D0 (en) 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
GB202208089D0 (en) 2022-06-01 2022-07-13 Glaxosmithkline Biologicals Sa Immunogenic composition
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1207773A (zh) * 1995-12-20 1999-02-10 诺沃挪第克公司 在酵母细胞中表达n-末端延伸蛋白质的载体

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239749A (en) * 1979-09-27 1980-12-16 United States Of America Neisseria gonorrhoeae vaccine
CA1282721C (en) 1984-06-04 1991-04-09 Bernard Roizman Herpes simplex virus as a vector
US5288641A (en) * 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
EP0273116A3 (en) 1986-10-09 1990-05-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Gonococcal and meningococcal polypeptides, vaccines and diagnostics
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
US5270176A (en) * 1987-11-20 1993-12-14 Hoechst Aktiengesellschaft Method for the selective cleavage of fusion proteins with lysostaphin
CA1340506C (en) * 1987-11-24 1999-04-20 Nicholas H. Carbonetti Production of gonorrheal pi proteins and vaccines
JPH03504079A (ja) 1988-03-21 1991-09-12 カイロン コーポレイション 組換えレトロウィルス
US5591624A (en) * 1988-03-21 1997-01-07 Chiron Viagene, Inc. Retroviral packaging cell lines
US5422120A (en) * 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
NL8803111A (nl) 1988-12-19 1990-07-16 Nederlanden Staat Multivalent meningococcen klasse i buitenmembraaneiwit vaccin.
ATE120093T1 (de) 1988-12-19 1995-04-15 Praxis Biolog Inc Meningococcales klasse i-aussenmembranprotein- vakzin.
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
CA2357538A1 (en) 1989-03-21 1990-10-04 Wisconsin Alumni Research Foundation Expression of exogenous polynucleotide sequences in a vertebrate
GB8919607D0 (en) 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
CU22302A1 (es) * 1990-09-07 1995-01-31 Cigb Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales
IE912559A1 (en) 1990-07-19 1992-01-29 Merck & Co Inc The class ii protein of the outer membrane of neisseria¹meningitidis, and vaccines containing same
WO1992005266A2 (en) 1990-09-21 1992-04-02 Viagene, Inc. Packaging cells
US5965424A (en) * 1991-01-11 1999-10-12 Boehringer Mannheim Gmbh Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases
ES2127217T3 (es) * 1991-03-14 1999-04-16 Imclone Systems Inc Epitopos de porina hibridos de recombinacion.
FR2681786A1 (fr) 1991-09-27 1993-04-02 Centre Nat Rech Scient Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires.
IL103059A0 (en) 1991-09-30 1993-02-21 Boehringer Ingelheim Int Conjugates for introducing nucleic acid into higher eucaryotic cells
NZ244306A (en) 1991-09-30 1995-07-26 Boehringer Ingelheim Int Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
US6100380A (en) * 1991-10-28 2000-08-08 Cytran, Inc. Immunomodulating peptides and methods of use
JPH07503372A (ja) 1992-01-23 1995-04-13 バイカル・インコーポレイテッド 生体外遺伝子導入
FR2692592B1 (fr) * 1992-06-19 1995-03-31 Pasteur Merieux Serums Vacc Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant.
JP2798499B2 (ja) * 1992-07-07 1998-09-17 扶桑薬品工業株式会社 感染症診断用プローブ
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
DE69415462T2 (de) * 1993-01-23 1999-07-15 Inmunologia Y Genetica Aplicada, S.A., Madrid Synthetischen peptiden und impfstoffe gegen parvovirus
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
CA2167938A1 (en) * 1993-07-30 1995-02-09 Christopher Elkins Production of gonorrheal pi proteins and vaccines in e. coli and salmonella
US5914254A (en) * 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
US5510264A (en) 1993-09-28 1996-04-23 Insight Biotech Inc. Antibodies which bind meningitis related homologous antigenic sequences
DK0729351T3 (da) 1993-11-16 2000-10-16 Skyepharma Inc Vesikler med reguleret afgivelse af aktivstoffer
DE69535669T2 (de) 1994-05-09 2008-12-04 Oxford Biomedica (Uk) Ltd. Retrovirale vektoren mit verminderter rekombinationsrate
FR2720408B1 (fr) * 1994-05-31 1996-08-14 Pasteur Merieux Serums Vacc Fragments Tbp2 de Neisseria meningitidis.
US6245337B1 (en) 1994-08-25 2001-06-12 Washington University Haemophilus adherence and penetration proteins
IL117483A (en) 1995-03-17 2008-03-20 Bernard Brodeur MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
US5646259A (en) * 1995-03-24 1997-07-08 St. Louis University DNA encoding haemophilus adhesion proteins
US6265567B1 (en) 1995-04-07 2001-07-24 University Of North Carolina At Chapel Hill Isolated FrpB nucleic acid molecule
DK0832093T3 (da) * 1995-06-07 2007-01-08 Sanofi Pasteur Inc Udtrykkelse af lipoproteiner
EA199800208A1 (ru) 1995-09-18 1998-10-29 Юнайтед Стэйтс Арми Медикал Ресерч Материэл Комманд (Юсамрмк) Усовершенствованные способы изготовления нековалентно комплексированных и поливалентных вакцин протеосомной подгруппы
DE19534579C2 (de) 1995-09-18 2000-06-08 Max Planck Gesellschaft Nucleinsäure-Moleküle codierend Proteine, die die Adhäsion von Neisseria-Zellen an humane Zellen vermitteln
FR2739624B1 (fr) * 1995-10-10 1997-12-05 Pasteur Merieux Serums Vacc Nouvelle sous-unite tbp2 de neisseria meningitidis
AU2115897A (en) * 1996-02-01 1997-08-22 North American Vaccine, Inc. Expression of group b neisseria meningitidis outer membrane (mb3) protein from yeast and vaccines
US6083499A (en) * 1996-04-19 2000-07-04 Mycogen Corporation Pesticidal toxins
AU5426098A (en) 1996-10-24 1998-05-15 Emory University Invasion associated genes from (neisseria meningitidis) serogroup
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
CA2274495C (en) 1996-12-20 2009-06-02 Board Of Regents, The University Of Texas System Uspa1 and uspa2 antigens of moraxella catarrhalis
US6017531A (en) 1997-06-02 2000-01-25 W. R. Grace & Co. Hydrophilic composition containing protease produced by Vibrio
US6583275B1 (en) * 1997-07-02 2003-06-24 Genome Therapeutics Corporation Nucleic acid sequences and expression system relating to Enterococcus faecium for diagnostics and therapeutics
US6914131B1 (en) * 1998-10-09 2005-07-05 Chiron S.R.L. Neisserial antigens
CA2671261A1 (en) * 1997-11-06 1999-05-20 Novartis Vaccines And Diagnostics S.R.L. Neisserial antigens
GB9726398D0 (en) 1997-12-12 1998-02-11 Isis Innovation Polypeptide and coding sequences
BR9906927A (pt) * 1998-01-14 2001-11-20 Chiron Spa Proteìnas de neisseria meningitidis
WO1999040200A1 (en) * 1998-02-03 1999-08-12 Center For Disease Control And Prevention RECOMBINANT LIPIDATED PsaA PROTEIN, METHODS OF PREPARATION AND USE
JP2002503648A (ja) * 1998-02-11 2002-02-05 イーライ・リリー・アンド・カンパニー 葉酸拮抗薬を製造するのに有用な方法および中間体
GB9808734D0 (en) 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
GB9808866D0 (en) 1998-04-24 1998-06-24 Smithkline Beecham Biolog Novel compounds
US6150502A (en) * 1998-04-29 2000-11-21 Genesis Research & Development Corporation Limited Polypeptides expressed in skin cells
WO2001031019A2 (en) * 1999-10-29 2001-05-03 Chiron Spa Neisserial antigenic peptides
US6615024B1 (en) * 1998-05-01 2003-09-02 Arraycomm, Inc. Method and apparatus for determining signatures for calibrating a communication station having an antenna array
NZ532665A (en) 1998-05-01 2005-11-25 Inst Genomic Research Neisseria meningitidis antigens and compositions
US20070026021A1 (en) * 1998-05-01 2007-02-01 Chiron S.R.I. Neisseria meningitidis antigens and compositions
US5990085A (en) * 1998-05-04 1999-11-23 Michigan State University Inhibin-HBc fusion protein
GB9810276D0 (en) 1998-05-13 1998-07-15 Smithkline Beecham Biolog Novel compounds
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
AU1202200A (en) 1998-10-09 2000-05-01 Chiron Corporation Neisseria genomic sequences and methods of their use
CN1350585A (zh) 1999-01-15 2002-05-22 史密丝克莱恩比彻姆生物有限公司 脑膜炎奈瑟氏菌多肽basb052
CA2360658A1 (en) 1999-01-22 2000-07-27 Smithkline Beecham Biologicals S.A. Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies
GB9902084D0 (en) 1999-01-29 1999-03-24 Smithkline Beecham Biolog Novel compounds
JP4812942B2 (ja) * 1999-02-26 2011-11-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル CGモチーフを含むオリゴヌクレオチドを用いるNeisseria抗原殺菌活性の増強
BR0010361A (pt) 1999-04-30 2003-06-10 Chiron Corp Seq ências genÈmicas de neisseria e uso destas
DK1228217T3 (da) 1999-04-30 2013-02-25 Novartis Vaccines & Diagnostic Konserverede neisseria-antigener
GB9911683D0 (en) * 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
CA2838395C (en) 1999-05-19 2016-07-19 Novartis Vaccines And Diagnostics S.R.L. Combination neisserial compositions
GB9916529D0 (en) * 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
CN1433471A (zh) * 1999-11-29 2003-07-30 启龙股份公司 85kgDa奈瑟球菌的抗原
GB9928676D0 (en) 1999-12-03 2000-02-02 Provalis Uk Ltd Pseudomonas aeruginosa antigens
US20010031268A1 (en) * 1999-12-17 2001-10-18 Baldwin Thomas John Antigen preparations
CN102172398A (zh) * 2000-01-17 2011-09-07 诺华疫苗和诊断有限公司 含有脑膜炎奈瑟球菌b血清群外膜蛋白质的外膜囊(omv)疫苗
BR0107857A (pt) 2000-01-25 2002-10-29 Univ Queensland Proteìnas compreendendo regiões conservadas de antìgeno nhha de superfìcie de neisseria meningitidis
DE60144353D1 (de) * 2000-02-28 2011-05-12 Novartis Vaccines & Diagnostic Hybride Expression Neisserscher Proteine
AU2001255524A1 (en) 2000-04-21 2001-11-07 Corixa Corporation Compositions and methods for the therapy and diagnosis of acne vulgaris
CA2414884A1 (en) 2000-07-03 2002-01-10 Chiron S.P.A. Immunisation against chlamydia pneumoniae
GB0017149D0 (en) 2000-07-12 2000-08-30 Chiron Spa Helicobacter pylori mutants
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
GB0103424D0 (en) * 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
AU2002330681C1 (en) 2001-07-26 2015-04-02 Glaxosmithkline Biologicals S.A. Vaccines comprising aluminium adjuvants and histidine
GB0118249D0 (en) * 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
PT2248822T (pt) * 2001-07-27 2017-02-14 Glaxosmithkline Biologicals Sa Adesinas de meningococos
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
GB0129007D0 (en) * 2001-12-04 2002-01-23 Chiron Spa Adjuvanted antigenic meningococcal compositions
AU2003260357B2 (en) * 2002-08-02 2009-10-29 Glaxosmithkline Biologicals S.A. Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB- Neisseria minigitidis
US7785608B2 (en) * 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
HUE047780T2 (hu) * 2002-10-11 2020-05-28 Glaxosmithkline Biologicals Sa Polipeptid vakcinák hipervirulens meningokokkusz vonalak elleni széles-spektrumú védelemre
GB0227346D0 (en) * 2002-11-22 2002-12-31 Chiron Spa 741
EP1590459A2 (en) 2003-01-15 2005-11-02 Wyeth Holdings Corporation Methods for increasing neisseria protein expression and compositions thereof
ES2411080T3 (es) * 2003-01-30 2013-07-04 Novartis Ag Vacunas inyectables contra múltiples serogrupos de meningococos
JP2006525330A (ja) 2003-04-16 2006-11-09 ワイエス・ホールディングス・コーポレーション 髄膜炎菌性疾患の予防および処置のための新規免疫原性組成物
GB0315021D0 (en) * 2003-06-26 2003-07-30 Chiron Srl Immunogenic gonococcal compositions
EP1961426B1 (en) * 2003-10-02 2011-04-27 Novartis Vaccines and Diagnostics S.r.l. Combined meningitis vaccines
GB0323103D0 (en) * 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
GB0408977D0 (en) * 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0409748D0 (en) * 2004-04-30 2004-06-09 Chiron Srl Lactoferrin cleavage
GB0410866D0 (en) * 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
GB0419408D0 (en) 2004-09-01 2004-10-06 Chiron Srl 741 chimeric polypeptides
JP4993750B2 (ja) 2005-01-27 2012-08-08 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド 髄膜炎菌に起因する疾患に対する広域防御のための、gna1870を基にした小胞ワクチン
GB0524066D0 (en) * 2005-11-25 2006-01-04 Chiron Srl 741 ii
ES2670231T3 (es) 2006-03-22 2018-05-29 Glaxosmithkline Biologicals S.A. Regímenes para inmunización con conjugados meningocócicos
TW200806315A (en) 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
AU2007263531B2 (en) * 2006-06-29 2012-03-15 J. Craig Venter Institute, Inc. Polypeptides from neisseria meningitidis
AR064642A1 (es) * 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
WO2008125985A2 (en) 2007-04-11 2008-10-23 Novartis Ag Blocking interaction between pathogen factors and factor h to inhibit hemorrhagic syndromes
IN2009KN04098A (enExample) 2007-06-04 2015-08-28 Novartis Ag
RU2475496C2 (ru) 2008-02-21 2013-02-20 Новартис Аг МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHBP
PT2268618E (pt) * 2008-03-03 2015-10-12 Novartis Ag Compostos e composições moduladores da actividade tlr
CA2717870A1 (en) 2008-03-10 2009-09-17 Children's Hospital & Research Center At Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
CA2733943A1 (en) 2008-09-03 2010-03-11 Children's Hospital & Research Center At Oakland Peptides presenting an epitope of an a domain of factor h binding protein and methods of use
IT1394288B1 (it) 2008-09-12 2012-06-06 Novartis Vaccines & Diagnostic Immunogeni di proteine che legano il fattore h.
GB0819633D0 (en) 2008-10-25 2008-12-03 Isis Innovation Composition
CA2756522C (en) * 2009-03-24 2018-06-26 Novartis Ag Adjuvanting meningococcal factor h binding protein
CN105999275A (zh) * 2010-09-01 2016-10-12 诺华有限公司 免疫增强剂吸附不溶性金属离子
EP2612148B1 (en) * 2010-09-04 2019-06-12 GlaxoSmithKline Biologicals SA Bactericidal antibody assays to assess immunogenicity and potency of meningococcal capsular saccharide vaccines
CA2810971C (en) * 2010-09-10 2020-11-03 Novartis Ag Developments in meningococcal outer membrane vesicles
ES2864764T3 (es) * 2011-05-11 2021-10-14 Childrens Medical Center Composición inmunogénica que presenta múltiples antígenos, y métodos y usos de la misma
US9184727B2 (en) * 2012-06-11 2015-11-10 Phonon Corporation SAW device and method for post-seal frequency trimming

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1207773A (zh) * 1995-12-20 1999-02-10 诺沃挪第克公司 在酵母细胞中表达n-末端延伸蛋白质的载体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
高长寿等.人α降钙素基因相关肽基因在酵母细胞中的分泌表达与产物的分离纯化.生物工程学报11 4.1995,11(4),366-371页全文.
高长寿等.人α降钙素基因相关肽基因在酵母细胞中的分泌表达与产物的分离纯化.生物工程学报11 4.1995,11(4),366-371页全文. *

Also Published As

Publication number Publication date
US20140363462A1 (en) 2014-12-11
ES2299476T3 (es) 2008-06-01
CN101139590B (zh) 2012-07-18
EP2270031A3 (en) 2011-02-16
CN100339482C (zh) 2007-09-26
NZ521531A (en) 2005-12-23
EP1790660B1 (en) 2012-06-20
DK1947187T5 (da) 2011-10-24
US20170080077A1 (en) 2017-03-23
CA2689666A1 (en) 2001-09-07
EP1261723A2 (en) 2002-12-04
CY1106532T1 (el) 2012-01-25
JP5941027B2 (ja) 2016-06-29
CN1508253A (zh) 2004-06-30
EP2270031A2 (en) 2011-01-05
JP2016128520A (ja) 2016-07-14
ES2360746T9 (es) 2012-02-13
AU3947801A (en) 2001-09-12
CY1113032T1 (el) 2016-04-13
DE60132978T2 (de) 2009-02-26
EP2270030A3 (en) 2011-02-02
HK1071147A1 (zh) 2005-07-08
AU2001239478B2 (en) 2007-05-17
US9150898B2 (en) 2015-10-06
DK1947187T3 (da) 2011-05-09
HK1064120A1 (zh) 2005-01-21
EP1790660A2 (en) 2007-05-30
JP2014000092A (ja) 2014-01-09
RU2304617C2 (ru) 2007-08-20
JP2014121333A (ja) 2014-07-03
NL300605I2 (enExample) 2016-09-22
ATE503837T1 (de) 2011-04-15
US20060051840A1 (en) 2006-03-09
EP2270030A2 (en) 2011-01-05
JP4846160B2 (ja) 2011-12-28
JP5346004B2 (ja) 2013-11-20
JP4763210B2 (ja) 2011-08-31
ES2360746T3 (es) 2011-06-08
US20140294885A1 (en) 2014-10-02
ES2391153T3 (es) 2012-11-22
RU2002125880A (ru) 2004-03-10
PT2270030E (pt) 2012-07-24
US7803387B2 (en) 2010-09-28
WO2001064920A2 (en) 2001-09-07
CA2400570A1 (en) 2001-09-07
ATE387502T1 (de) 2008-03-15
CN100473663C (zh) 2009-04-01
RU2299906C2 (ru) 2007-05-27
CA2875231A1 (en) 2001-09-07
CA2400570C (en) 2010-04-27
EP1790660A3 (en) 2007-10-31
CY2013025I2 (el) 2015-11-04
WO2001064920A3 (en) 2002-03-14
US9267163B2 (en) 2016-02-23
EP1947187A1 (en) 2008-07-23
US20170080076A1 (en) 2017-03-23
BR0108711A (pt) 2004-06-22
CY2013025I1 (el) 2015-11-04
US20040110670A1 (en) 2004-06-10
PT1261723E (pt) 2008-06-05
CN101139590A (zh) 2008-03-12
HK1055993A1 (zh) 2004-01-30
CN1201011C (zh) 2005-05-11
CA2689666C (en) 2015-02-24
EP1947187B9 (en) 2011-09-21
DK2270030T3 (da) 2012-08-13
PT1790660E (pt) 2012-09-17
CN1800385A (zh) 2006-07-12
US8703914B2 (en) 2014-04-22
DE60126249T2 (de) 2008-05-29
NZ521396A (en) 2004-06-25
CN1544462A (zh) 2004-11-10
CA2400562C (en) 2011-09-20
US20040092711A1 (en) 2004-05-13
US20100267931A1 (en) 2010-10-21
CN1426471A (zh) 2003-06-25
JP2003525049A (ja) 2003-08-26
CY1111591T1 (el) 2015-10-07
ES2281409T3 (es) 2007-10-01
JP2003525050A (ja) 2003-08-26
CY1113477T1 (el) 2016-06-22
AU3948801A (en) 2001-09-12
CA2744921A1 (en) 2001-09-07
US8114960B2 (en) 2012-02-14
WO2001064922A3 (en) 2001-12-06
JP2013005816A (ja) 2013-01-10
RU2002125882A (ru) 2004-03-10
ATE352631T1 (de) 2007-02-15
EP2270030B1 (en) 2012-05-23
JP2011083287A (ja) 2011-04-28
JP2011101657A (ja) 2011-05-26
DE60144353D1 (de) 2011-05-12
EP1259627A2 (en) 2002-11-27
MXPA02008313A (es) 2002-12-09
CN100334214C (zh) 2007-08-29
DK1261723T3 (da) 2008-06-23
US20130005667A1 (en) 2013-01-03
MXPA02008314A (es) 2002-12-09
DK1790660T3 (da) 2012-09-17
AU2001239488B2 (en) 2006-01-19
WO2001064922A2 (en) 2001-09-07
DE60132978D1 (de) 2008-04-10
CN1426473A (zh) 2003-06-25
HK1056197A1 (en) 2004-02-06
EP1947187B1 (en) 2011-03-30
CN101906413A (zh) 2010-12-08
PT1947187E (pt) 2011-07-04
CY1107447T1 (el) 2012-12-19
CA2744921C (en) 2014-05-13
ES2386534T3 (es) 2012-08-22
EP1261723B1 (en) 2008-02-27
CA2400562A1 (en) 2001-09-07
EP1259627B1 (en) 2007-01-24
BR0108713A (pt) 2004-06-22
DE60126249D1 (de) 2007-03-15
LU92240I2 (fr) 2013-09-04

Similar Documents

Publication Publication Date Title
CN1800385B (zh) 奈瑟球菌蛋白质的异源表达
AU2001239488A1 (en) Heterologous expression of neisserial proteins
US20020164603A1 (en) DNAs and proteins or peptides specific to bacteria of the species Neisseria meningitidis, processes for obtaining them and their biological uses
IL154853A (en) Nucleic acids and proteins from Streptococcus A and B, preparations containing them, their use and methods for their preparation
AU2007268172A1 (en) Real-time multiplex detection of three bacterial species responsible for sexually-transmitted diseases
HK1071147B (en) Heterologous expression of neisserial proteins
HK1056197B (en) Heterologous expression of neisserial proteins
AU2014274586A1 (en) Nucleic acids and proteins from streptococcus groups A & B

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: NOVARTIS VACCINES + DIAGNOSTIC

Free format text: FORMER NAME: CHIRON S.P.A.

CP01 Change in the name or title of a patent holder

Address after: Italy Siena

Patentee after: Novartis Vaccines & Diagnostic

Address before: Italy Siena

Patentee before: Chiron S. P. A.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20170728

Address after: Belgium Sutter Rixon

Patentee after: Glazo Smithkline Beecham Biologicals S. A.

Address before: Italy Siena

Patentee before: Novartis Vaccines & Diagnostic

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100602

Termination date: 20180228