EA199800208A1 - Усовершенствованные способы изготовления нековалентно комплексированных и поливалентных вакцин протеосомной подгруппы - Google Patents

Усовершенствованные способы изготовления нековалентно комплексированных и поливалентных вакцин протеосомной подгруппы

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Publication number
EA199800208A1
EA199800208A1 EA199800208A EA199800208A EA199800208A1 EA 199800208 A1 EA199800208 A1 EA 199800208A1 EA 199800208 A EA199800208 A EA 199800208A EA 199800208 A EA199800208 A EA 199800208A EA 199800208 A1 EA199800208 A1 EA 199800208A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ultrafiltration
production
amphiphilic
diafiltration
proteasome
Prior art date
Application number
EA199800208A
Other languages
English (en)
Inventor
Джордж Х. Лоувелл
Венделл Д. Золлингер
Джеймс Ф. Вудс
Original Assignee
Юнайтед Стэйтс Арми Медикал Ресерч Материэл Комманд (Юсамрмк)
Джордж Х. Лоувелл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21707938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199800208(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юнайтед Стэйтс Арми Медикал Ресерч Материэл Комманд (Юсамрмк), Джордж Х. Лоувелл filed Critical Юнайтед Стэйтс Арми Медикал Ресерч Материэл Комманд (Юсамрмк)
Publication of EA199800208A1 publication Critical patent/EA199800208A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/008—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Способ изготовления поливалентных вакцин с протеосом-амфифильной детерминантой, пригодных для применения парентерально или через слизистую оболочку, с использованием диафильтрационной или ультрафильтрационной технологии. Амфифильные детерминанты включают липополисахариды грамотрицательных бактерий, например S.flexneri, P.shigelloides и S.sonnei. Протеосомы получены из менингококков группы В типа 2b. Активные вакцинные комплексы (нековалентные комплексы) с протеосом-амфифильной детерминантой изготовлены с использованием диафильтрации или ультрафильтрации для удаления детергента. Применение диа- или ультрафильтрации сокращает время переработки и уменьшает возможность загрязнения, а также позволяет осуществлять процесс при комнатной температуре и эффективно повышать масштабы производства. К тому же способ дает возможность надежно и непрерывно контролировать диализат, что повышает эффективность процесса в целом. Время диализа при изготовлении вакцинной серии сокращено с 7-10 суток до 72 ч и менее, а на практике - менее чем до 48 или 24 ч. Использование способа позволяет оптимизировать содержание каждого антигенного компонента в препаратах поливалентных вакцин.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800208A 1995-09-18 1996-09-18 Усовершенствованные способы изготовления нековалентно комплексированных и поливалентных вакцин протеосомной подгруппы EA199800208A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US385995P 1995-09-18 1995-09-18
PCT/US1996/015002 WO1997010844A1 (en) 1995-09-18 1996-09-18 Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines

Publications (1)

Publication Number Publication Date
EA199800208A1 true EA199800208A1 (ru) 1998-10-29

Family

ID=21707938

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800208A EA199800208A1 (ru) 1995-09-18 1996-09-18 Усовершенствованные способы изготовления нековалентно комплексированных и поливалентных вакцин протеосомной подгруппы

Country Status (20)

Country Link
US (1) US6476201B1 (ru)
EP (1) EP0854729B2 (ru)
JP (2) JP4033489B2 (ru)
KR (1) KR19990045763A (ru)
CN (1) CN1211192A (ru)
AT (1) ATE261313T1 (ru)
BR (1) BR9610484A (ru)
CA (1) CA2232410C (ru)
CZ (1) CZ298460B6 (ru)
DE (1) DE69631835T3 (ru)
DK (1) DK0854729T3 (ru)
EA (1) EA199800208A1 (ru)
ES (1) ES2217325T5 (ru)
HU (1) HUP9901577A3 (ru)
IL (1) IL123720A (ru)
MX (1) MX9802128A (ru)
NO (1) NO320074B1 (ru)
PL (1) PL325604A1 (ru)
PT (1) PT854729E (ru)
WO (1) WO1997010844A1 (ru)

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US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
CA2332963C (en) * 1998-05-29 2013-07-23 Chiron Corporation Combination meningitidis b/c vaccines
NZ581940A (en) 1999-04-30 2011-07-29 Novartis Vaccines & Diagnostic Conserved neisserial antigens
EP1179072A2 (en) * 1999-05-19 2002-02-13 Chiron S.P.A. Combination neisserial compositions
EP1721618A3 (en) * 2000-02-15 2007-01-10 ID Biomedical Corporation of Quebec Proteosome influenza vaccine composition
EP1255561B1 (en) * 2000-02-15 2006-06-28 ID Biomedical Corporation of Quebec Proteosome influenza vaccine
PT1947187E (pt) 2000-02-28 2011-07-04 Novartis Vaccines & Diagnostic Expressões híbridas de proteínas de neisseria
WO2002072012A2 (en) * 2001-03-09 2002-09-19 Id Biomedical Corporation Of Quebec A novel proteosome-liposaccharide vaccine adjuvant
JP2006506467A (ja) * 2002-08-02 2006-02-23 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン組成物
SI2351579T1 (sl) 2002-10-11 2017-05-31 Glaxosmithkline Biologicals Sa Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
US7255867B2 (en) * 2002-11-15 2007-08-14 Id Biomedical Corporation Of Quebec Vaccine
GB0316560D0 (en) * 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
US7368537B2 (en) * 2003-07-15 2008-05-06 Id Biomedical Corporation Of Quebec Subunit vaccine against respiratory syncytial virus infection
JP2007505836A (ja) * 2003-09-15 2007-03-15 アイディー バイオメディカル コーポレイション オブ ケベック 麻疹サブユニットワクチン
US8173140B2 (en) 2003-10-22 2012-05-08 Id Biomedical Corporation Of Quebec Compositions and methods for activating innate and allergic immunity
CN101039691B (zh) 2004-06-25 2013-07-31 魁北克益得生物医学公司 用于治疗神经疾病的组合物和方法
RU2007103343A (ru) * 2004-06-30 2008-08-10 АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН ОФ КВЕБЕК (CA) Вакцинная композиция и способы лечения коронавирусной инфекции
US7552948B2 (en) 2006-03-29 2009-06-30 Tokai Rubber Industries, Ltd. Quick connector
ZA200900899B (en) * 2006-08-07 2010-07-28 Harvard College Protein matrix vaccines and methods of making and administering such vaccines
TWI565713B (zh) 2006-08-07 2017-01-11 哈佛大學校長及研究員協會 蛋白基質疫苗以及該疫苗的製造與使用方法
US20100288029A1 (en) * 2006-08-30 2010-11-18 Ge Healthcar Bio-Sciences Corp. System and method for characterizing membranes and membrane filtration devices
RU2477145C2 (ru) * 2008-05-30 2013-03-10 ДЗЕ Ю.Эс.Эй., ЭС РЕПРЕЗЕНТЕД БАЙ ДЗЕ СЕКРЕТАРИ ОФ ДЗЕ АРМИ, ОН БЕХАФ ОФ УОЛТЕР РИД АРМИ Мультивалентная вакцина из нативных везикул наружной мембраны менингококков, способы ее получения и применения
US20120231086A1 (en) * 2009-09-09 2012-09-13 Killen Kevin P Protein matrix vaccines of improved immunogenicity
AU2015321698B2 (en) * 2014-09-24 2018-06-28 The United States Of America As Represented By The Secretary Of The Navy Combined enterotoxigenic Escherichia coli and Campylobacter jejuni recombinant construct
US20220226465A1 (en) 2021-01-18 2022-07-21 ConserV Bioscience Coronavirus Immunogenic Compositions, Methods and Uses Thereof

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Also Published As

Publication number Publication date
KR19990045763A (ko) 1999-06-25
EP0854729A4 (en) 2000-02-02
ES2217325T3 (es) 2004-11-01
JP4033489B2 (ja) 2008-01-16
ATE261313T1 (de) 2004-03-15
US20020164357A1 (en) 2002-11-07
IL123720A (en) 2002-02-10
PL325604A1 (en) 1998-08-03
CZ81998A3 (cs) 1998-10-14
US6476201B1 (en) 2002-11-05
NO320074B1 (no) 2005-10-17
DK0854729T3 (da) 2004-07-12
IL123720A0 (en) 1998-10-30
EP0854729B2 (en) 2008-10-22
NO981189D0 (no) 1998-03-17
DE69631835T3 (de) 2009-03-05
CN1211192A (zh) 1999-03-17
PT854729E (pt) 2004-08-31
BR9610484A (pt) 2001-09-11
CA2232410C (en) 2003-06-17
ES2217325T5 (es) 2009-04-01
MX9802128A (es) 1998-11-29
EP0854729B1 (en) 2004-03-10
CZ298460B6 (cs) 2007-10-10
JP2000507913A (ja) 2000-06-27
DE69631835T2 (de) 2005-02-10
HUP9901577A2 (hu) 1999-08-30
HUP9901577A3 (en) 2000-03-28
JP2004099619A (ja) 2004-04-02
EP0854729A1 (en) 1998-07-29
WO1997010844A1 (en) 1997-03-27
DE69631835D1 (de) 2004-04-15
NO981189L (no) 1998-05-14
CA2232410A1 (en) 1997-03-27

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