ATE261313T1 - Verbesserte verfahren zur herstellung von nichtkovalent komplexierten und multivalenten impfstoffen gegen proteasomen-untereinheiten - Google Patents
Verbesserte verfahren zur herstellung von nichtkovalent komplexierten und multivalenten impfstoffen gegen proteasomen-untereinheitenInfo
- Publication number
- ATE261313T1 ATE261313T1 AT96932269T AT96932269T ATE261313T1 AT E261313 T1 ATE261313 T1 AT E261313T1 AT 96932269 T AT96932269 T AT 96932269T AT 96932269 T AT96932269 T AT 96932269T AT E261313 T1 ATE261313 T1 AT E261313T1
- Authority
- AT
- Austria
- Prior art keywords
- ultrafiltration
- producing
- proteosomeamphiphilic
- diafiltration
- vaccine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229940031348 multivalent vaccine Drugs 0.000 title abstract 2
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 title 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 title 1
- 238000000108 ultra-filtration Methods 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 3
- 238000011026 diafiltration Methods 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000606999 Plesiomonas shigelloides Species 0.000 abstract 1
- 241000607762 Shigella flexneri Species 0.000 abstract 1
- 241000607760 Shigella sonnei Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/008—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US385995P | 1995-09-18 | 1995-09-18 | |
| PCT/US1996/015002 WO1997010844A1 (en) | 1995-09-18 | 1996-09-18 | Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261313T1 true ATE261313T1 (de) | 2004-03-15 |
Family
ID=21707938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96932269T ATE261313T1 (de) | 1995-09-18 | 1996-09-18 | Verbesserte verfahren zur herstellung von nichtkovalent komplexierten und multivalenten impfstoffen gegen proteasomen-untereinheiten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6476201B1 (de) |
| EP (1) | EP0854729B2 (de) |
| JP (2) | JP4033489B2 (de) |
| KR (1) | KR19990045763A (de) |
| CN (1) | CN1211192A (de) |
| AT (1) | ATE261313T1 (de) |
| BR (1) | BR9610484A (de) |
| CA (1) | CA2232410C (de) |
| CZ (1) | CZ298460B6 (de) |
| DE (1) | DE69631835T3 (de) |
| DK (1) | DK0854729T3 (de) |
| EA (1) | EA199800208A1 (de) |
| ES (1) | ES2217325T5 (de) |
| HU (1) | HUP9901577A3 (de) |
| IL (1) | IL123720A (de) |
| MX (1) | MX9802128A (de) |
| NO (1) | NO320074B1 (de) |
| PL (1) | PL325604A1 (de) |
| PT (1) | PT854729E (de) |
| WO (1) | WO1997010844A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| US8007815B1 (en) * | 1998-05-29 | 2011-08-30 | Novartis Ag | Combination meningitidis B/C vaccines |
| CN100392082C (zh) | 1999-04-30 | 2008-06-04 | 启龙股份公司 | 保守的奈瑟球菌抗原 |
| DK2270173T3 (en) * | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
| US6743900B2 (en) | 2000-02-15 | 2004-06-01 | Id Biomedical Corporation Of Quebec | Proteosome influenza vaccine |
| EP1721618A3 (de) * | 2000-02-15 | 2007-01-10 | ID Biomedical Corporation of Quebec | Proteasom-influenzavirus-impfstoffzusammensetzung |
| MXPA02008314A (es) | 2000-02-28 | 2002-12-09 | Chiron Spa | Expresion heterologa de proteinas de neisseria. |
| MXPA03008154A (es) * | 2001-03-09 | 2004-11-12 | Id Biomedical Corp Quebec | Novedoso adyuvante de vacuna de proteosoma-liposacarido. |
| WO2004015099A2 (en) * | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine composition comprising lipooligosaccharide with reduced phase variability |
| CA2501812C (en) | 2002-10-11 | 2012-07-10 | Mariagrazia Pizza | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| US7255867B2 (en) * | 2002-11-15 | 2007-08-14 | Id Biomedical Corporation Of Quebec | Vaccine |
| GB0316560D0 (en) * | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| US7368537B2 (en) * | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| JP2007505836A (ja) * | 2003-09-15 | 2007-03-15 | アイディー バイオメディカル コーポレイション オブ ケベック | 麻疹サブユニットワクチン |
| ES2615169T3 (es) * | 2003-10-22 | 2017-06-05 | Id Biomedical Corporation Of Quebec | Composiciones y procedimientos de activación de la inmunidad innata y alérgica |
| RU2387453C2 (ru) | 2004-06-25 | 2010-04-27 | АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН ОФ КВЕБЕК | Композиции и способы лечения неврологических нарушений |
| JP2008505114A (ja) * | 2004-06-30 | 2008-02-21 | アイディー バイオメディカル コーポレイション オブ ケベック | コロナウイルス感染を処置するためのワクチン組成物 |
| US7552948B2 (en) | 2006-03-29 | 2009-06-30 | Tokai Rubber Industries, Ltd. | Quick connector |
| CN110064053A (zh) * | 2006-08-07 | 2019-07-30 | 哈佛大学校长及研究员协会 | 蛋白质基质疫苗及这种疫苗的制备和给药方法 |
| MX2009001412A (es) | 2006-08-07 | 2009-04-24 | Harvard College | Vacunas de matriz de proteinas y metodos de hacer y administrar tales vacunas. |
| JP2010502425A (ja) * | 2006-08-30 | 2010-01-28 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 膜を評価するシステム及び方法並びに膜濾過装置 |
| AU2009262893B2 (en) * | 2008-05-30 | 2015-05-21 | The U.S.A., as represented by The Secretary of the Army, on behalf of Walter Reed Army Institute Of Research | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
| US20120231086A1 (en) * | 2009-09-09 | 2012-09-13 | Killen Kevin P | Protein matrix vaccines of improved immunogenicity |
| EP4183408A1 (de) * | 2014-09-24 | 2023-05-24 | The United States of America as Represented by The Secretary of the Navy | Kombiniertes rekombinantes konstrukt aus enterotoxigenem escherichia coli und rekombinantes shigella |
| EP4277654A1 (de) | 2021-01-18 | 2023-11-22 | Conserv Bioscience Limited | Immunogene coronavirus-zusammensetzungen, verfahren und verwendungen davon |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| RU1522494C (ru) * | 1987-06-16 | 1994-11-15 | Научно-производственное объединение "Иммунопрепарат" | Способ получения инактивированной вакцины гриппа |
| RU2023448C1 (ru) * | 1987-07-30 | 1994-11-30 | Сентро Насьональ Де Биопрепарадос | Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в |
| US5145702A (en) * | 1988-09-19 | 1992-09-08 | Opta Food Ingredients, Inc. | Hydrophobic protein microparticles and preparation thereof |
| ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
| US5102989A (en) * | 1991-03-15 | 1992-04-07 | Merck & Co., Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
| CA2139517A1 (en) * | 1992-07-20 | 1994-02-03 | Paul M. Keller | Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes |
| US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| AU5543294A (en) * | 1993-10-29 | 1995-05-22 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US6743900B2 (en) * | 2000-02-15 | 2004-06-01 | Id Biomedical Corporation Of Quebec | Proteosome influenza vaccine |
-
1996
- 1996-09-18 BR BR9610484-8A patent/BR9610484A/pt not_active Application Discontinuation
- 1996-09-18 DK DK96932269T patent/DK0854729T3/da active
- 1996-09-18 EP EP96932269A patent/EP0854729B2/de not_active Expired - Lifetime
- 1996-09-18 ES ES96932269T patent/ES2217325T5/es not_active Expired - Lifetime
- 1996-09-18 PT PT96932269T patent/PT854729E/pt unknown
- 1996-09-18 IL IL12372096A patent/IL123720A/en not_active IP Right Cessation
- 1996-09-18 CA CA002232410A patent/CA2232410C/en not_active Expired - Lifetime
- 1996-09-18 US US09/043,529 patent/US6476201B1/en not_active Expired - Lifetime
- 1996-09-18 HU HU9901577A patent/HUP9901577A3/hu unknown
- 1996-09-18 WO PCT/US1996/015002 patent/WO1997010844A1/en active IP Right Grant
- 1996-09-18 DE DE69631835T patent/DE69631835T3/de not_active Expired - Lifetime
- 1996-09-18 AT AT96932269T patent/ATE261313T1/de not_active IP Right Cessation
- 1996-09-18 EA EA199800208A patent/EA199800208A1/ru unknown
- 1996-09-18 CZ CZ0081998A patent/CZ298460B6/cs not_active IP Right Cessation
- 1996-09-18 JP JP51287597A patent/JP4033489B2/ja not_active Expired - Lifetime
- 1996-09-18 KR KR1019980702007A patent/KR19990045763A/ko not_active Application Discontinuation
- 1996-09-18 CN CN96197616A patent/CN1211192A/zh active Pending
- 1996-09-18 PL PL96325604A patent/PL325604A1/xx unknown
-
1998
- 1998-03-17 NO NO19981189A patent/NO320074B1/no not_active IP Right Cessation
- 1998-03-18 MX MX9802128A patent/MX9802128A/es unknown
-
2003
- 2003-10-24 JP JP2003365270A patent/JP2004099619A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9901577A3 (en) | 2000-03-28 |
| KR19990045763A (ko) | 1999-06-25 |
| EP0854729B2 (de) | 2008-10-22 |
| CA2232410C (en) | 2003-06-17 |
| DK0854729T3 (da) | 2004-07-12 |
| WO1997010844A1 (en) | 1997-03-27 |
| US6476201B1 (en) | 2002-11-05 |
| IL123720A (en) | 2002-02-10 |
| CA2232410A1 (en) | 1997-03-27 |
| EP0854729A4 (de) | 2000-02-02 |
| HUP9901577A2 (hu) | 1999-08-30 |
| EA199800208A1 (ru) | 1998-10-29 |
| CZ298460B6 (cs) | 2007-10-10 |
| JP4033489B2 (ja) | 2008-01-16 |
| ES2217325T3 (es) | 2004-11-01 |
| EP0854729A1 (de) | 1998-07-29 |
| DE69631835D1 (de) | 2004-04-15 |
| JP2004099619A (ja) | 2004-04-02 |
| BR9610484A (pt) | 2001-09-11 |
| CN1211192A (zh) | 1999-03-17 |
| NO981189D0 (no) | 1998-03-17 |
| US20020164357A1 (en) | 2002-11-07 |
| NO981189L (no) | 1998-05-14 |
| IL123720A0 (en) | 1998-10-30 |
| EP0854729B1 (de) | 2004-03-10 |
| DE69631835T2 (de) | 2005-02-10 |
| PL325604A1 (en) | 1998-08-03 |
| NO320074B1 (no) | 2005-10-17 |
| CZ81998A3 (cs) | 1998-10-14 |
| PT854729E (pt) | 2004-08-31 |
| JP2000507913A (ja) | 2000-06-27 |
| ES2217325T5 (es) | 2009-04-01 |
| MX9802128A (es) | 1998-11-29 |
| DE69631835T3 (de) | 2009-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0854729 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |