MX9802128A - Metodos mejorados para la produccion de vacunas de subunidades de proteosomas multivalentes y en la forma de complejos unidos no covalentemente. - Google Patents

Metodos mejorados para la produccion de vacunas de subunidades de proteosomas multivalentes y en la forma de complejos unidos no covalentemente.

Info

Publication number
MX9802128A
MX9802128A MX9802128A MX9802128A MX9802128A MX 9802128 A MX9802128 A MX 9802128A MX 9802128 A MX9802128 A MX 9802128A MX 9802128 A MX9802128 A MX 9802128A MX 9802128 A MX9802128 A MX 9802128A
Authority
MX
Mexico
Prior art keywords
diafiltration
proteosome
ultrafiltration
production
multivalent
Prior art date
Application number
MX9802128A
Other languages
English (en)
Inventor
George H Lowell
Wendell D Zollinger
James F Wood
Original Assignee
Us Army Medical Res Material
Command Usamrmc
George H Lowell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21707938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9802128(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Us Army Medical Res Material, Command Usamrmc, George H Lowell filed Critical Us Army Medical Res Material
Publication of MX9802128A publication Critical patent/MX9802128A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/008—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a un método para preparar vacunas de proteosomas-determinantes anfifílicos, multivalentes, adecuadas para la administracion parenteral o por las mucosas, que utiliza la tecnología de la diafiltracion o ultrafiltracion. Los determinantes anfifílicos incluye los lipopolisacáridos de las bacterias gram negativas, por ejemplo S. flexneri, P. shigelloides y S. sonnei. Los proteosomas son obtenidos de los meningococos del tipo 2b del grupo B. Los complejos de los proteosomas-determinates anfifílicos activos (complejos unidos no covalentemente) de la vacuna, son formados utilizando la diafiltracion o la ultrafiltracion para remover el detergente. El uso de la diafiltracion y ultrafiltracion reduce el tiempo de procesamiento y la oportunidad de la contaminacion y además permite el uso de la temperatura ambiente y una produccion a escala aumentada eficiente. Además, el proceso permite la verificacion confiable y continua del dializado, lo cual mejora la eficiencia del proceso completo. El tiempo de la diálisis para la produccion de un lote de vacunas es reducido desde > 7-10 días hasta menos de 72 horas y usualmente menos de 48 o 24 horas. El uso del proceso optimiza la presencia de cada componente antigénico en la preparacion de vacunas multivalentes.
MX9802128A 1995-09-18 1998-03-18 Metodos mejorados para la produccion de vacunas de subunidades de proteosomas multivalentes y en la forma de complejos unidos no covalentemente. MX9802128A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US385995P 1995-09-18 1995-09-18

Publications (1)

Publication Number Publication Date
MX9802128A true MX9802128A (es) 1998-11-29

Family

ID=21707938

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9802128A MX9802128A (es) 1995-09-18 1998-03-18 Metodos mejorados para la produccion de vacunas de subunidades de proteosomas multivalentes y en la forma de complejos unidos no covalentemente.

Country Status (20)

Country Link
US (1) US6476201B1 (es)
EP (1) EP0854729B2 (es)
JP (2) JP4033489B2 (es)
KR (1) KR19990045763A (es)
CN (1) CN1211192A (es)
AT (1) ATE261313T1 (es)
BR (1) BR9610484A (es)
CA (1) CA2232410C (es)
CZ (1) CZ298460B6 (es)
DE (1) DE69631835T3 (es)
DK (1) DK0854729T3 (es)
EA (1) EA199800208A1 (es)
ES (1) ES2217325T5 (es)
HU (1) HUP9901577A3 (es)
IL (1) IL123720A (es)
MX (1) MX9802128A (es)
NO (1) NO320074B1 (es)
PL (1) PL325604A1 (es)
PT (1) PT854729E (es)
WO (1) WO1997010844A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5961970A (en) 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
US8007815B1 (en) * 1998-05-29 2011-08-30 Novartis Ag Combination meningitidis B/C vaccines
CN100392082C (zh) 1999-04-30 2008-06-04 启龙股份公司 保守的奈瑟球菌抗原
DK2270173T3 (en) * 1999-05-19 2016-03-07 Glaxosmithkline Biolog Sa Neisserial combination compositions
US6743900B2 (en) 2000-02-15 2004-06-01 Id Biomedical Corporation Of Quebec Proteosome influenza vaccine
EP1721618A3 (en) * 2000-02-15 2007-01-10 ID Biomedical Corporation of Quebec Proteosome influenza vaccine composition
MXPA02008314A (es) 2000-02-28 2002-12-09 Chiron Spa Expresion heterologa de proteinas de neisseria.
MXPA03008154A (es) * 2001-03-09 2004-11-12 Id Biomedical Corp Quebec Novedoso adyuvante de vacuna de proteosoma-liposacarido.
WO2004015099A2 (en) * 2002-08-02 2004-02-19 Glaxosmithkline Biologicals Sa Vaccine composition comprising lipooligosaccharide with reduced phase variability
CA2501812C (en) 2002-10-11 2012-07-10 Mariagrazia Pizza Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
US7255867B2 (en) * 2002-11-15 2007-08-14 Id Biomedical Corporation Of Quebec Vaccine
GB0316560D0 (en) * 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
US7368537B2 (en) * 2003-07-15 2008-05-06 Id Biomedical Corporation Of Quebec Subunit vaccine against respiratory syncytial virus infection
JP2007505836A (ja) * 2003-09-15 2007-03-15 アイディー バイオメディカル コーポレイション オブ ケベック 麻疹サブユニットワクチン
ES2615169T3 (es) * 2003-10-22 2017-06-05 Id Biomedical Corporation Of Quebec Composiciones y procedimientos de activación de la inmunidad innata y alérgica
RU2387453C2 (ru) 2004-06-25 2010-04-27 АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН ОФ КВЕБЕК Композиции и способы лечения неврологических нарушений
JP2008505114A (ja) * 2004-06-30 2008-02-21 アイディー バイオメディカル コーポレイション オブ ケベック コロナウイルス感染を処置するためのワクチン組成物
US7552948B2 (en) 2006-03-29 2009-06-30 Tokai Rubber Industries, Ltd. Quick connector
CN110064053A (zh) * 2006-08-07 2019-07-30 哈佛大学校长及研究员协会 蛋白质基质疫苗及这种疫苗的制备和给药方法
MX2009001412A (es) 2006-08-07 2009-04-24 Harvard College Vacunas de matriz de proteinas y metodos de hacer y administrar tales vacunas.
JP2010502425A (ja) * 2006-08-30 2010-01-28 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 膜を評価するシステム及び方法並びに膜濾過装置
AU2009262893B2 (en) * 2008-05-30 2015-05-21 The U.S.A., as represented by The Secretary of the Army, on behalf of Walter Reed Army Institute Of Research Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
US20120231086A1 (en) * 2009-09-09 2012-09-13 Killen Kevin P Protein matrix vaccines of improved immunogenicity
EP4183408A1 (en) * 2014-09-24 2023-05-24 The United States of America as Represented by The Secretary of the Navy Combined enterotoxigenic escherichia coli and shigella recombinant
EP4277654A1 (en) 2021-01-18 2023-11-22 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines
RU1522494C (ru) * 1987-06-16 1994-11-15 Научно-производственное объединение "Иммунопрепарат" Способ получения инактивированной вакцины гриппа
RU2023448C1 (ru) * 1987-07-30 1994-11-30 Сентро Насьональ Де Биопрепарадос Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
US5145702A (en) * 1988-09-19 1992-09-08 Opta Food Ingredients, Inc. Hydrophobic protein microparticles and preparation thereof
ES2070312T5 (es) * 1988-12-19 2003-05-16 American Cyanamid Co Vacuna de proteina de membrana exterior meningococica de clase 1.
US5102989A (en) * 1991-03-15 1992-04-07 Merck & Co., Inc. Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells
CA2139517A1 (en) * 1992-07-20 1994-02-03 Paul M. Keller Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
AU5543294A (en) * 1993-10-29 1995-05-22 Pharmos Corp. Submicron emulsions as vaccine adjuvants
US6743900B2 (en) * 2000-02-15 2004-06-01 Id Biomedical Corporation Of Quebec Proteosome influenza vaccine

Also Published As

Publication number Publication date
HUP9901577A3 (en) 2000-03-28
KR19990045763A (ko) 1999-06-25
EP0854729B2 (en) 2008-10-22
CA2232410C (en) 2003-06-17
DK0854729T3 (da) 2004-07-12
WO1997010844A1 (en) 1997-03-27
US6476201B1 (en) 2002-11-05
IL123720A (en) 2002-02-10
CA2232410A1 (en) 1997-03-27
EP0854729A4 (en) 2000-02-02
HUP9901577A2 (hu) 1999-08-30
EA199800208A1 (ru) 1998-10-29
CZ298460B6 (cs) 2007-10-10
JP4033489B2 (ja) 2008-01-16
ES2217325T3 (es) 2004-11-01
EP0854729A1 (en) 1998-07-29
DE69631835D1 (de) 2004-04-15
JP2004099619A (ja) 2004-04-02
ATE261313T1 (de) 2004-03-15
BR9610484A (pt) 2001-09-11
CN1211192A (zh) 1999-03-17
NO981189D0 (no) 1998-03-17
US20020164357A1 (en) 2002-11-07
NO981189L (no) 1998-05-14
IL123720A0 (en) 1998-10-30
EP0854729B1 (en) 2004-03-10
DE69631835T2 (de) 2005-02-10
PL325604A1 (en) 1998-08-03
NO320074B1 (no) 2005-10-17
CZ81998A3 (cs) 1998-10-14
PT854729E (pt) 2004-08-31
JP2000507913A (ja) 2000-06-27
ES2217325T5 (es) 2009-04-01
DE69631835T3 (de) 2009-03-05

Similar Documents

Publication Publication Date Title
MX9802128A (es) Metodos mejorados para la produccion de vacunas de subunidades de proteosomas multivalentes y en la forma de complejos unidos no covalentemente.
NO913518L (no) Vaksiner for ikke typebestembar haemophilus influenzae.
GR3033469T3 (en) Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci.
EP0639081B1 (en) Vaccine compositions for mucosal delivery
EP1297844A3 (en) Multicomponent meningococcal vaccine
CA2410652A1 (en) Outer membrane vesicle vaccine against disease caused by neisseria meningitidis serogroup a and process for the production thereof
CA2078359A1 (en) Protein-dimeric polysaccharide conjugate vaccine
HU185404B (en) Process for preparing pertussis toxoide
ES2560452T3 (es) Vacuna de IPV-DPT
JP2002537352A5 (es)
AU2027797A (en) Method of producing immunogenic products and vaccines
EP0082072B1 (fr) Procédé de production d'un vaccin biochimique contre les fièvres à salmonelles
Wolff et al. Recovery of soluble feline oncornavirus-associated cell membrane antigen from large volumes of tissue culture fluids
DE69329922D1 (de) Herstellung eines tetanusimpfstoffes
Rappaport et al. Development of a purified cholera toxoid. III. Refinements in purification of toxin and methods for the determination of residual somatic antigen
CA2133108A1 (en) Pasteurella haemolytica type a-1 bacterin-toxoid vaccine
IT1206250B (it) Stiche umane e relativi prodotti metodo per l'estrazione di antigeni di membrana aventi proprieta' immunogene a partire da cellule neopla-
RU93052669A (ru) Способ получения специфического лактоглобулина
Shewen et al. Process for the production of vaccine for prevention of Pasteurella haemolytica pneumonia in bovine
RU97115149A (ru) Способ вакцинации против вирусного гепатита в
Sansonetti 1 vol.(17× 26 cm) 476+ xix pages Savage DC, Fletcher M., Bacterial adhesion, mechanisms and physiological significance, Plenum Press, New York, London (1985)
Shewen The role of the Pasteurella haemolytica cytotoxin in bovine pneumonic pasteurellosis.
IT1246322B (it) Procedimento per la preparazione di farmaci per la cura dell'epatite bcaratterizzato dal fatto di identificare il recettore della transferrina come struttura di membrana responsabile dell'infezione; e farmaci cosi' ottenuti.
TH6095EX (th) วัคซีนและวิธีเตรียม
SU1815820A1 (ru) Способ получения иммуноглобулинового препарата