BR9610484A - Processo para produção de vacinas de sub-unidades de proteosoma, não covalentemente complexadas e multivalentes - Google Patents
Processo para produção de vacinas de sub-unidades de proteosoma, não covalentemente complexadas e multivalentesInfo
- Publication number
- BR9610484A BR9610484A BR9610484-8A BR9610484A BR9610484A BR 9610484 A BR9610484 A BR 9610484A BR 9610484 A BR9610484 A BR 9610484A BR 9610484 A BR9610484 A BR 9610484A
- Authority
- BR
- Brazil
- Prior art keywords
- vaccines
- multivalent
- ultrafiltration
- amphiphilic
- proteasome
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 title 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 title 1
- 238000000108 ultra-filtration Methods 0.000 abstract 3
- 238000011026 diafiltration Methods 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000606999 Plesiomonas shigelloides Species 0.000 abstract 1
- 241000607762 Shigella flexneri Species 0.000 abstract 1
- 241000607760 Shigella sonnei Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 229940031348 multivalent vaccine Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/008—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/25—Shigella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"MéTODOS APERFEIçOADOS PARA A PRODUçãO DE VACINAS DE SUBUNIDADES PROTEOSSÈMICAS EM COMPLEXO NãO-COVALENTE DE MULTIVALENTES"<D>. Um processo para preparar vacinas de determinante proteossomo-anfifílico, multivalentes, adequadas para administração parenteral ou mucosal utilizando a tecnologia de diafiltração ou ultrafiltração. Os determinantes anfifílicos incluem lipopolissacarídios procedentes de bactéria gram-negativa, por exemplo, S. flexneri, P. shigelloides e S. sonnei. Proteossomos são obtidos de meningococci tipo 2b grupo B. Complexos de determinante proteossomo-anfifílico ativos (complexos não covalentes) da vacina são formados usando-se deafiltração ou ultrafiltração para remover o detergente. O uso de diafiltração ou ultrafiltração diminui o tempo de processamento e a oportunidade de contaminação e ainda permite o uso de temperatura ambiente e aumento eficiente. Além disso, o processo permite monitoração segura e contínua do dialisado que acentua a eficiência de todo o processo. O tempo de diálise para produção de um lote de vacina é reduzido de > 7-10 dias para menos de 72 horas e normalmente menos de 48 ou 24 horas. O uso do processo otimiza a presença de cada componente antigênico na preparação de vacinas multivalentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US385995P | 1995-09-18 | 1995-09-18 | |
PCT/US1996/015002 WO1997010844A1 (en) | 1995-09-18 | 1996-09-18 | Improved methods for the production of non-covalently complexed and multivalent proteosome sub-unit vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9610484A true BR9610484A (pt) | 2001-09-11 |
Family
ID=21707938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9610484-8A BR9610484A (pt) | 1995-09-18 | 1996-09-18 | Processo para produção de vacinas de sub-unidades de proteosoma, não covalentemente complexadas e multivalentes |
Country Status (20)
Country | Link |
---|---|
US (1) | US6476201B1 (pt) |
EP (1) | EP0854729B2 (pt) |
JP (2) | JP4033489B2 (pt) |
KR (1) | KR19990045763A (pt) |
CN (1) | CN1211192A (pt) |
AT (1) | ATE261313T1 (pt) |
BR (1) | BR9610484A (pt) |
CA (1) | CA2232410C (pt) |
CZ (1) | CZ298460B6 (pt) |
DE (1) | DE69631835T3 (pt) |
DK (1) | DK0854729T3 (pt) |
EA (1) | EA199800208A1 (pt) |
ES (1) | ES2217325T5 (pt) |
HU (1) | HUP9901577A3 (pt) |
IL (1) | IL123720A (pt) |
MX (1) | MX9802128A (pt) |
NO (1) | NO320074B1 (pt) |
PL (1) | PL325604A1 (pt) |
PT (1) | PT854729E (pt) |
WO (1) | WO1997010844A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
BR9910749A (pt) * | 1998-05-29 | 2001-02-13 | Chiron Corp | Composições e vacinas imunogênicas combinadas para meningites b e c e método de induzir uma resposta imune por administração da mesma |
RU2245366C2 (ru) | 1999-04-30 | 2005-01-27 | Чирон С.Р.Л. | Антиген neisseria, кодирующая его нуклеиновая кислота, их использование |
EP2270174A1 (en) | 1999-05-19 | 2011-01-05 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
EP1721618A3 (en) * | 2000-02-15 | 2007-01-10 | ID Biomedical Corporation of Quebec | Proteosome influenza vaccine composition |
DE60121136T2 (de) | 2000-02-15 | 2007-06-06 | Id Biomedical Corporation Of Quebec, Ville St. Laurent | Proteasom-influenzavirus-impfstoffzusammensetzung |
PT2270030E (pt) | 2000-02-28 | 2012-07-24 | Novartis Vaccines & Diagnostic | Expressão heteróloga de proteínas de neisseria |
EP1372706B1 (en) * | 2001-03-09 | 2010-12-01 | ID Biomedical Corporation of Quebec | Proteosome-liposaccharide vaccine adjuvant |
KR101239242B1 (ko) * | 2002-08-02 | 2013-03-11 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 항원 조합물을 포함하는 나이세리아 백신 조성물 |
WO2004032958A1 (en) | 2002-10-11 | 2004-04-22 | Chiron Srl | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
US7255867B2 (en) * | 2002-11-15 | 2007-08-14 | Id Biomedical Corporation Of Quebec | Vaccine |
GB0316560D0 (en) * | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
US7368537B2 (en) * | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
JP2007505836A (ja) * | 2003-09-15 | 2007-03-15 | アイディー バイオメディカル コーポレイション オブ ケベック | 麻疹サブユニットワクチン |
JP4966661B2 (ja) | 2003-10-22 | 2012-07-04 | アイディー バイオメディカル コーポレイション オブ ケベック | 生得的免疫およびアレルギー性免疫を活性化させるための組成物および方法 |
CA2571035A1 (en) * | 2004-06-25 | 2006-01-12 | Id Biomedical Corporation Of Quebec | Compositions and methods for treating neurological disorders |
AU2005319716A1 (en) * | 2004-06-30 | 2006-06-29 | Id Biomedical Corporation Of Quebec | Vaccine compositions for treating coronavirus infection |
US7552948B2 (en) | 2006-03-29 | 2009-06-30 | Tokai Rubber Industries, Ltd. | Quick connector |
CN101553246B (zh) * | 2006-08-07 | 2019-05-21 | 哈佛大学校长及研究员协会 | 蛋白质基质疫苗及这种疫苗的制备和给药方法 |
EP2056871B1 (en) * | 2006-08-07 | 2017-11-15 | President and Fellows of Harvard College | Protein matrix vaccines and methods of making and administering such vaccines |
WO2008027861A1 (en) * | 2006-08-30 | 2008-03-06 | Ge Healthcare Bio-Sciences Corp. | System and method for characterizing membranes and membrane filtration devices |
BRPI0913268A2 (pt) * | 2008-05-30 | 2016-03-15 | U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army | vacina de vesícula de membrana externa nativa multivalente meningocócica, métodos de fabricação e uso da mesma |
EP2473188A4 (en) * | 2009-09-09 | 2014-01-01 | Matrivax Res & Dev Corp | PROTEIN MATRIX VACCINES WITH IMPROVED IMMUNOGENICITY |
JP6590916B2 (ja) * | 2014-09-24 | 2019-10-16 | ザ ユナイテッド ステイツ オブ アメリカ アズ レプレゼンティッド バイ ザ セクレタリー オブ ザ ネイビーThe United States Of America As Represented By The Secretary Of The Navy | 毒素原性大腸菌およびジェジュニ菌の組合せの組換えコンストラクト |
CA3208643A1 (en) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
RU1522494C (ru) * | 1987-06-16 | 1994-11-15 | Научно-производственное объединение "Иммунопрепарат" | Способ получения инактивированной вакцины гриппа |
RU2023448C1 (ru) * | 1987-07-30 | 1994-11-30 | Сентро Насьональ Де Биопрепарадос | Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в |
US5145702A (en) * | 1988-09-19 | 1992-09-08 | Opta Food Ingredients, Inc. | Hydrophobic protein microparticles and preparation thereof |
EP0449958B9 (en) * | 1988-12-19 | 2003-05-28 | American Cyanamid Company | Meningococcal class 1 outer-membrane protein vaccine |
US5102989A (en) * | 1991-03-15 | 1992-04-07 | Merck & Co., Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
CA2139517A1 (en) * | 1992-07-20 | 1994-02-03 | Paul M. Keller | Immunological conjugates of ompc and hiv-specific selected principal neutralization epitopes |
US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
AU5543294A (en) * | 1993-10-29 | 1995-05-22 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
DE60121136T2 (de) * | 2000-02-15 | 2007-06-06 | Id Biomedical Corporation Of Quebec, Ville St. Laurent | Proteasom-influenzavirus-impfstoffzusammensetzung |
-
1996
- 1996-09-18 EA EA199800208A patent/EA199800208A1/ru unknown
- 1996-09-18 HU HU9901577A patent/HUP9901577A3/hu unknown
- 1996-09-18 ES ES96932269T patent/ES2217325T5/es not_active Expired - Lifetime
- 1996-09-18 EP EP96932269A patent/EP0854729B2/en not_active Expired - Lifetime
- 1996-09-18 KR KR1019980702007A patent/KR19990045763A/ko not_active Application Discontinuation
- 1996-09-18 US US09/043,529 patent/US6476201B1/en not_active Expired - Lifetime
- 1996-09-18 CA CA002232410A patent/CA2232410C/en not_active Expired - Lifetime
- 1996-09-18 PL PL96325604A patent/PL325604A1/xx unknown
- 1996-09-18 JP JP51287597A patent/JP4033489B2/ja not_active Expired - Lifetime
- 1996-09-18 WO PCT/US1996/015002 patent/WO1997010844A1/en active IP Right Grant
- 1996-09-18 IL IL12372096A patent/IL123720A/en not_active IP Right Cessation
- 1996-09-18 CZ CZ0081998A patent/CZ298460B6/cs not_active IP Right Cessation
- 1996-09-18 CN CN96197616A patent/CN1211192A/zh active Pending
- 1996-09-18 DE DE69631835T patent/DE69631835T3/de not_active Expired - Lifetime
- 1996-09-18 BR BR9610484-8A patent/BR9610484A/pt not_active Application Discontinuation
- 1996-09-18 PT PT96932269T patent/PT854729E/pt unknown
- 1996-09-18 AT AT96932269T patent/ATE261313T1/de not_active IP Right Cessation
- 1996-09-18 DK DK96932269T patent/DK0854729T3/da active
-
1998
- 1998-03-17 NO NO19981189A patent/NO320074B1/no not_active IP Right Cessation
- 1998-03-18 MX MX9802128A patent/MX9802128A/es unknown
-
2003
- 2003-10-24 JP JP2003365270A patent/JP2004099619A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
IL123720A0 (en) | 1998-10-30 |
PL325604A1 (en) | 1998-08-03 |
MX9802128A (es) | 1998-11-29 |
ATE261313T1 (de) | 2004-03-15 |
HUP9901577A2 (hu) | 1999-08-30 |
CZ81998A3 (cs) | 1998-10-14 |
DE69631835D1 (de) | 2004-04-15 |
ES2217325T3 (es) | 2004-11-01 |
JP4033489B2 (ja) | 2008-01-16 |
CA2232410C (en) | 2003-06-17 |
EP0854729B2 (en) | 2008-10-22 |
HUP9901577A3 (en) | 2000-03-28 |
US20020164357A1 (en) | 2002-11-07 |
DE69631835T2 (de) | 2005-02-10 |
NO320074B1 (no) | 2005-10-17 |
EP0854729A1 (en) | 1998-07-29 |
EP0854729B1 (en) | 2004-03-10 |
US6476201B1 (en) | 2002-11-05 |
PT854729E (pt) | 2004-08-31 |
CN1211192A (zh) | 1999-03-17 |
EP0854729A4 (en) | 2000-02-02 |
JP2004099619A (ja) | 2004-04-02 |
DE69631835T3 (de) | 2009-03-05 |
CA2232410A1 (en) | 1997-03-27 |
DK0854729T3 (da) | 2004-07-12 |
WO1997010844A1 (en) | 1997-03-27 |
NO981189L (no) | 1998-05-14 |
JP2000507913A (ja) | 2000-06-27 |
EA199800208A1 (ru) | 1998-10-29 |
KR19990045763A (ko) | 1999-06-25 |
NO981189D0 (no) | 1998-03-17 |
IL123720A (en) | 2002-02-10 |
ES2217325T5 (es) | 2009-04-01 |
CZ298460B6 (cs) | 2007-10-10 |
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Legal Events
Date | Code | Title | Description |
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FA10 | Dismissal: dismissal - article 33 of industrial property law |