JP4738696B2 - Ａβペプチドを隔離するヒト化抗体 - Google Patents

Ａβペプチドを隔離するヒト化抗体 Download PDF

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Publication number
JP4738696B2
JP4738696B2 JP2001562582A JP2001562582A JP4738696B2 JP 4738696 B2 JP4738696 B2 JP 4738696B2 JP 2001562582 A JP2001562582 A JP 2001562582A JP 2001562582 A JP2001562582 A JP 2001562582A JP 4738696 B2 JP4738696 B2 JP 4738696B2
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antibody
xaa
fragment
human
peptide
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JP2003523764A5 (enExample
JP2003523764A (ja
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デイビッド・エム・ホルツマン
ロナルド・デマットス
ケリー・アール・ベイルズ
スティーブン・エム・ポール
直也 鶴下
マキシミリアノ・バスケス
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Washington University in St Louis WUSTL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2001562582A 2000-02-24 2001-02-26 Ａβペプチドを隔離するヒト化抗体 Expired - Lifetime JP4738696B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18460100P 2000-02-24 2000-02-24
US60/184,601 2000-02-24
US25449800P 2000-12-08 2000-12-08
US25446500P 2000-12-08 2000-12-08
US60/254,498 2000-12-08
US60/254,465 2000-12-08
PCT/US2001/006191 WO2001062801A2 (en) 2000-02-24 2001-02-26 Humanized antibodies that sequester amyloid beta peptide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008240971A Division JP4914412B2 (ja) 2000-02-24 2008-09-19 Ａβペプチドを隔離するヒト化抗体

Publications (3)

Publication Number Publication Date
JP2003523764A JP2003523764A (ja) 2003-08-12
JP2003523764A5 JP2003523764A5 (enExample) 2008-04-10
JP4738696B2 true JP4738696B2 (ja) 2011-08-03

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JP2001562582A Expired - Lifetime JP4738696B2 (ja) 2000-02-24 2001-02-26 Ａβペプチドを隔離するヒト化抗体
JP2008240971A Expired - Lifetime JP4914412B2 (ja) 2000-02-24 2008-09-19 Ａβペプチドを隔離するヒト化抗体

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JP2008240971A Expired - Lifetime JP4914412B2 (ja) 2000-02-24 2008-09-19 Ａβペプチドを隔離するヒト化抗体

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US (4) US7195761B2 (enExample)
EP (4) EP3070100B1 (enExample)
JP (2) JP4738696B2 (enExample)
KR (1) KR100767146B1 (enExample)
CN (3) CN104341500A (enExample)
AT (1) ATE279442T1 (enExample)
AU (1) AU4178601A (enExample)
BR (1) BRPI0108676B8 (enExample)
CA (1) CA2400559C (enExample)
CY (1) CY1118381T1 (enExample)
CZ (2) CZ306683B6 (enExample)
DE (2) DE60106394T3 (enExample)
DK (2) DK1257584T4 (enExample)
DZ (1) DZ3295A1 (enExample)
EA (1) EA006606B1 (enExample)
ES (2) ES2184660T5 (enExample)
HR (2) HRP20020693B1 (enExample)
HU (2) HUP0204074A3 (enExample)
IL (3) IL151378A0 (enExample)
LT (1) LT1481992T (enExample)
MX (1) MXPA02008145A (enExample)
NO (2) NO329840B1 (enExample)
NZ (1) NZ520800A (enExample)
PL (2) PL218883B1 (enExample)
PT (2) PT1257584E (enExample)
SI (2) SI1257584T2 (enExample)
SK (2) SK288711B6 (enExample)
TR (1) TR200202799T3 (enExample)
UA (1) UA75881C2 (enExample)
WO (1) WO2001062801A2 (enExample)
ZA (1) ZA200206712B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022023050A (ja) * 2016-08-09 2022-02-07 イーライ リリー アンド カンパニー 併用療法

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NO20023957L (no) 2002-10-22
DK1257584T4 (da) 2013-03-25
CN1426423B (zh) 2010-05-12
IL193631A (en) 2010-11-30
US7195761B2 (en) 2007-03-27
EP1257584B9 (en) 2004-12-01
IL193631A0 (en) 2009-02-11
US8591894B2 (en) 2013-11-26
SI1257584T1 (en) 2005-04-30
US20090238821A1 (en) 2009-09-24
HRP20080430A2 (en) 2008-11-30
CA2400559C (en) 2012-05-01
HUP0204074A3 (en) 2004-07-28
DE60106394D1 (de) 2004-11-18
EP3150633A1 (en) 2017-04-05
NO329840B1 (no) 2011-01-10
JP4914412B2 (ja) 2012-04-11
ZA200206712B (en) 2003-11-21
HRP20020693A2 (en) 2004-12-31
EP3070100B1 (en) 2021-07-07
EP1481992A2 (en) 2004-12-01
AU4178601A (en) 2001-09-03
NO20083805L (no) 2002-10-22
CZ306683B6 (cs) 2017-05-03
KR100767146B1 (ko) 2007-10-15
LT1481992T (lt) 2017-02-10
HRP20020693B1 (hr) 2012-01-31
EP1481992A3 (en) 2004-12-08
HUP0204074A2 (hu) 2003-03-28
HUP0800571A2 (en) 2003-03-28
US7892545B2 (en) 2011-02-22
JP2003523764A (ja) 2003-08-12
NO337363B1 (no) 2016-03-29
MXPA02008145A (es) 2004-04-05
EP1257584B1 (en) 2004-10-13
CN1426423A (zh) 2003-06-25

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