JP4733350B2 - ケモカイン媒介疾患の併用治療 - Google Patents
ケモカイン媒介疾患の併用治療 Download PDFInfo
- Publication number
- JP4733350B2 JP4733350B2 JP2003577881A JP2003577881A JP4733350B2 JP 4733350 B2 JP4733350 B2 JP 4733350B2 JP 2003577881 A JP2003577881 A JP 2003577881A JP 2003577881 A JP2003577881 A JP 2003577881A JP 4733350 B2 JP4733350 B2 JP 4733350B2
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- Prior art keywords
- group
- formula
- compound
- alkyl
- inhibitor
- Prior art date
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- Expired - Fee Related
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- 0 *C(C(C(*)=C1*)=O)=C(*)N1O Chemical compound *C(C(C(*)=C1*)=O)=C(*)N1O 0.000 description 15
- HLPIHRDZBHXTFJ-UHFFFAOYSA-N CCc1ccc[o]1 Chemical compound CCc1ccc[o]1 HLPIHRDZBHXTFJ-UHFFFAOYSA-N 0.000 description 3
- JPBXKQARWDLKOL-HXUWFJFHSA-N CC(C)[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2ccccn2)=O)c1O Chemical compound CC(C)[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2ccccn2)=O)c1O JPBXKQARWDLKOL-HXUWFJFHSA-N 0.000 description 1
- OXZGQJVMTYTUMC-LJQANCHMSA-N CC(C)[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2n[o]c(C)c2)=O)c1O Chemical compound CC(C)[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2n[o]c(C)c2)=O)c1O OXZGQJVMTYTUMC-LJQANCHMSA-N 0.000 description 1
- GSTTYFZPWRSFNV-FQEVSTJZSA-N CC([C@H](c1cc(C)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)(F)F Chemical compound CC([C@H](c1cc(C)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)(F)F GSTTYFZPWRSFNV-FQEVSTJZSA-N 0.000 description 1
- RRRRXCOPMMELBR-RGUGMKFQSA-N CC([C@H](c1cc(C)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)F Chemical compound CC([C@H](c1cc(C)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)F RRRRXCOPMMELBR-RGUGMKFQSA-N 0.000 description 1
- MVRPGEKCCWFBCK-FQEVSTJZSA-N CC([C@H](c1ccc(C)[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)(F)F Chemical compound CC([C@H](c1ccc(C)[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O)(F)F MVRPGEKCCWFBCK-FQEVSTJZSA-N 0.000 description 1
- BGZSEAUPZCITOQ-UHFFFAOYSA-N CCC1=CC=C(C)C1 Chemical compound CCC1=CC=C(C)C1 BGZSEAUPZCITOQ-UHFFFAOYSA-N 0.000 description 1
- WCTGQSUIVKIRPT-OAHLLOKOSA-N CCN(CC)S(c([s]cc1NC(C(C2=O)=O)=C2N[C@H](C(C)C)c2ccc(C)[o]2)c1O)(=O)=O Chemical compound CCN(CC)S(c([s]cc1NC(C(C2=O)=O)=C2N[C@H](C(C)C)c2ccc(C)[o]2)c1O)(=O)=O WCTGQSUIVKIRPT-OAHLLOKOSA-N 0.000 description 1
- DOGFHWZRKIHCNP-MRXNPFEDSA-N CC[C@H](c1cc(CC)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O Chemical compound CC[C@H](c1cc(CC)c[o]1)N(C)C(C(C1=O)=O)=C1Nc1cccc(C(N(C)C)=O)c1O DOGFHWZRKIHCNP-MRXNPFEDSA-N 0.000 description 1
- OHMWIPJDIDNEDU-BZSJEYESSA-N CC[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C2=NOC(C)C#C2)=O)c1O Chemical compound CC[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)C2=NOC(C)C#C2)=O)c1O OHMWIPJDIDNEDU-BZSJEYESSA-N 0.000 description 1
- YXUIAEFAARSCMI-MRXNPFEDSA-N CC[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2ccccn2)=O)c1O Chemical compound CC[C@H](c1ccc(C)[o]1)NC(C(C1=O)=O)=C1Nc1cccc(C(N(C)c2ccccn2)=O)c1O YXUIAEFAARSCMI-MRXNPFEDSA-N 0.000 description 1
- NZHWONFZYMQAJN-UHFFFAOYSA-N CCc1cc(C(C)C)c[o]1 Chemical compound CCc1cc(C(C)C)c[o]1 NZHWONFZYMQAJN-UHFFFAOYSA-N 0.000 description 1
- SCHTWVSQHFFMTN-UHFFFAOYSA-N CCc1ccc(CSSc2ccccc2)[nH]1 Chemical compound CCc1ccc(CSSc2ccccc2)[nH]1 SCHTWVSQHFFMTN-UHFFFAOYSA-N 0.000 description 1
- XRPDDDRNQJNHLQ-UHFFFAOYSA-N CCc1ccc[nH]1 Chemical compound CCc1ccc[nH]1 XRPDDDRNQJNHLQ-UHFFFAOYSA-N 0.000 description 1
- FICAQKBMCKEFDI-UHFFFAOYSA-N Cc1n[o]c(C)c1 Chemical compound Cc1n[o]c(C)c1 FICAQKBMCKEFDI-UHFFFAOYSA-N 0.000 description 1
Classifications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36531402P | 2002-03-18 | 2002-03-18 | |
| US60/365,314 | 2002-03-18 | ||
| PCT/US2003/008287 WO2003080053A1 (en) | 2002-03-18 | 2003-03-17 | Combination treatments for chemokine-mediated diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533005A JP2005533005A (ja) | 2005-11-04 |
| JP2005533005A5 JP2005533005A5 (enExample) | 2010-05-27 |
| JP4733350B2 true JP4733350B2 (ja) | 2011-07-27 |
Family
ID=28454639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003577881A Expired - Fee Related JP4733350B2 (ja) | 2002-03-18 | 2003-03-17 | ケモカイン媒介疾患の併用治療 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040053953A1 (enExample) |
| EP (1) | EP1485089B1 (enExample) |
| JP (1) | JP4733350B2 (enExample) |
| CN (1) | CN100444839C (enExample) |
| AR (1) | AR040400A1 (enExample) |
| AU (1) | AU2003220384B2 (enExample) |
| BR (1) | BR0308739A (enExample) |
| CA (1) | CA2479126C (enExample) |
| MX (1) | MXPA04009127A (enExample) |
| NO (1) | NO20044402L (enExample) |
| NZ (1) | NZ535314A (enExample) |
| TW (2) | TW200808314A (enExample) |
| WO (1) | WO2003080053A1 (enExample) |
| ZA (1) | ZA200407339B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2344123C9 (ru) * | 2001-04-16 | 2009-05-20 | Шеринг Корпорейшн | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора |
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| MXPA04003439A (es) | 2001-10-12 | 2004-07-08 | Schering Corp | Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc. |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| PE20040570A1 (es) | 2002-10-09 | 2004-08-30 | Pharmacopeia Drug Discovery | Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina |
| US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
| KR20060037233A (ko) * | 2002-11-07 | 2006-05-03 | 아보트 러보러터리즈 | 농도 변화 유익제를 구비한 보형물 |
| US8221495B2 (en) * | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
| ATE457307T1 (de) | 2003-04-18 | 2010-02-15 | Schering Corp | Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)- (5-methyl-2-furanyl)propyl amino -3,4-dioxo-1- cyclobuten-1-yl amino benzamid |
| EP1694659B8 (en) | 2003-12-19 | 2008-10-08 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
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- 2003-03-17 BR BR0308739-5A patent/BR0308739A/pt not_active IP Right Cessation
- 2003-03-17 MX MXPA04009127A patent/MXPA04009127A/es unknown
- 2003-03-17 CN CNB038106183A patent/CN100444839C/zh not_active Expired - Fee Related
- 2003-03-17 WO PCT/US2003/008287 patent/WO2003080053A1/en not_active Ceased
- 2003-03-17 AU AU2003220384A patent/AU2003220384B2/en not_active Ceased
- 2003-03-17 NZ NZ535314A patent/NZ535314A/en not_active IP Right Cessation
- 2003-03-17 JP JP2003577881A patent/JP4733350B2/ja not_active Expired - Fee Related
- 2003-03-17 CA CA2479126A patent/CA2479126C/en not_active Expired - Fee Related
- 2003-03-17 US US10/390,078 patent/US20040053953A1/en not_active Abandoned
- 2003-03-18 AR AR20030100943A patent/AR040400A1/es not_active Application Discontinuation
- 2003-03-18 TW TW096114061A patent/TW200808314A/zh unknown
- 2003-03-18 TW TW092105892A patent/TW200304811A/zh unknown
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- 2004-09-13 ZA ZA200407339A patent/ZA200407339B/en unknown
- 2004-10-15 NO NO20044402A patent/NO20044402L/no not_active Application Discontinuation
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| AU2003220384A1 (en) | 2003-10-08 |
| TW200304811A (en) | 2003-10-16 |
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| NO20044402L (no) | 2004-12-17 |
| EP1485089A1 (en) | 2004-12-15 |
| MXPA04009127A (es) | 2005-01-25 |
| NZ535314A (en) | 2007-08-31 |
| CA2479126A1 (en) | 2003-10-02 |
| EP1485089B1 (en) | 2013-04-17 |
| BR0308739A (pt) | 2005-01-11 |
| CA2479126C (en) | 2011-11-15 |
| JP2005533005A (ja) | 2005-11-04 |
| AU2003220384B2 (en) | 2007-05-10 |
| CN1652779A (zh) | 2005-08-10 |
| ZA200407339B (en) | 2005-10-06 |
| TW200808314A (en) | 2008-02-16 |
| US7960433B2 (en) | 2011-06-14 |
| CN100444839C (zh) | 2008-12-24 |
| US20040053953A1 (en) | 2004-03-18 |
| US20070155756A1 (en) | 2007-07-05 |
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