TW200808314A - Treatment of chemokine mediated diseases - Google Patents

Treatment of chemokine mediated diseases Download PDF

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Publication number
TW200808314A
TW200808314A TW096114061A TW96114061A TW200808314A TW 200808314 A TW200808314 A TW 200808314A TW 096114061 A TW096114061 A TW 096114061A TW 96114061 A TW96114061 A TW 96114061A TW 200808314 A TW200808314 A TW 200808314A
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Taiwan
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group
doc
substituted
compound
unsubstituted
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TW096114061A
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English (en)
Chinese (zh)
Inventor
G Taveras Arthur
Billah Motasim
Lundell Daniel
Kreutner William
Jakway James
S Fine Jay
A Bober Loretta
Chao Jianhua
Biju Purakkattle
Yu Younong
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Schering Corp
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Publication of TW200808314A publication Critical patent/TW200808314A/zh

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TW096114061A 2002-03-18 2003-03-18 Treatment of chemokine mediated diseases TW200808314A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36531402P 2002-03-18 2002-03-18

Publications (1)

Publication Number Publication Date
TW200808314A true TW200808314A (en) 2008-02-16

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ID=28454639

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TW096114061A TW200808314A (en) 2002-03-18 2003-03-18 Treatment of chemokine mediated diseases
TW092105892A TW200304811A (en) 2002-03-18 2003-03-18 Treatment of chemokine mediated diseases

Family Applications After (1)

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TW092105892A TW200304811A (en) 2002-03-18 2003-03-18 Treatment of chemokine mediated diseases

Country Status (14)

Country Link
US (2) US20040053953A1 (enExample)
EP (1) EP1485089B1 (enExample)
JP (1) JP4733350B2 (enExample)
CN (1) CN100444839C (enExample)
AR (1) AR040400A1 (enExample)
AU (1) AU2003220384B2 (enExample)
BR (1) BR0308739A (enExample)
CA (1) CA2479126C (enExample)
MX (1) MXPA04009127A (enExample)
NO (1) NO20044402L (enExample)
NZ (1) NZ535314A (enExample)
TW (2) TW200808314A (enExample)
WO (1) WO2003080053A1 (enExample)
ZA (1) ZA200407339B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
NZ529551A (en) * 2001-04-16 2006-02-24 Schering Corp 3,4-DI-substituted cyclobutene-1,2-diones as CXC- chemokine receptor ligands
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
MXPA04003439A (es) 2001-10-12 2004-07-08 Schering Corp Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc.
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
ATE422203T1 (de) * 2002-10-09 2009-02-15 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
US8221495B2 (en) * 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
US7208190B2 (en) * 2002-11-07 2007-04-24 Abbott Laboratories Method of loading beneficial agent to a prosthesis by fluid-jet application
US8524148B2 (en) * 2002-11-07 2013-09-03 Abbott Laboratories Method of integrating therapeutic agent into a bioerodible medical device
ES2338657T3 (es) * 2003-04-18 2010-05-11 Schering Corporation Sintesis de 2-hydroxi-n,n-dimetil-3-((2-((1(r)-(5-metil-2-furanil)propil)amino)-3,4-dioxo-1-ciclobuten-1-il)amino)benzamida.
JP4939229B2 (ja) * 2003-12-19 2012-05-23 シェーリング コーポレイション Cxc−ケモカインレセプターリガンドおよびcc−ケモカインレセプターリガンドとしてのチアジアゾール
TW200530231A (en) 2003-12-22 2005-09-16 Schering Corp Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
KR100883476B1 (ko) 2004-01-30 2009-02-16 쉐링 코포레이션 Cxc-케모킨 수용체 리간드의 결정성 다형체
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
KR20070012826A (ko) * 2004-04-16 2007-01-29 제넨테크, 인크. 항체에 대한 분석법
CN1984899B (zh) 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
AR049384A1 (es) * 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
JP2009500328A (ja) * 2005-06-29 2009-01-08 シェーリング コーポレイション Cxc−ケモカインレセプターリガンドとしての5,6−ジ−置換オキサジアゾロピラジンおよびチアジアゾロピラジン
EP1912971A2 (en) 2005-06-29 2008-04-23 Shering Corporation Di-substituted oxadiazoles as cxc-chemokine receptor ligands
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
WO2007146296A1 (en) * 2006-06-12 2007-12-21 Schering Corporation Pharmaceutical formulations and compositions of a selective antagonist of either cxcr2 or both cxcr1 and cxcr2 and methods of using the same for treating inflammatory disorders
JP2009542700A (ja) * 2006-07-07 2009-12-03 シェーリング コーポレイション Cxcケモカイン受容体リガンドとしての3,4−ジ置換シクロブテン−1,2−ジオン
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
MX2009013276A (es) 2007-06-06 2010-01-25 Novartis Ag Compuestos anti-inflamatorios de ciclobutenodiona sustituida.
EP2178826B1 (en) * 2007-07-03 2017-05-17 Merck Sharp & Dohme Corp. Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
WO2010131147A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
FR2961695B1 (fr) * 2010-06-29 2012-07-06 Galderma Res & Dev Utilisation de composes dans le traitement ou la prevention de troubles cutanes
US20140170112A1 (en) * 2011-03-12 2014-06-19 Vicus Therapeutics, Llc Compositions for ameliorating systemic inflammation and methods for making and using them
CA2846510C (en) 2011-09-02 2019-10-22 Novartis Ag Choline salt of an anti - inflammatory substituted cyclobutenedione compound
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
KR101306199B1 (ko) * 2012-01-31 2013-09-09 부산대학교 산학협력단 포스포리파아제 d 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Cxcr2抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
WO2019036374A1 (en) * 2017-08-14 2019-02-21 Allergan, Inc. 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND THEIR USE
SG11202002322TA (en) * 2017-09-14 2020-04-29 Daiichi Sankyo Co Ltd Compound having cyclic structure
CN111867579B (zh) 2018-01-08 2023-11-24 凯莫森特里克斯股份有限公司 Ccr6或cxcr2拮抗剂治疗泛发性脓疱型银屑病的方法
CU20210016A7 (es) 2018-09-21 2021-10-12 Pfizer Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas útiles como inhibidores de ccr6
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物
EP3868368A1 (en) * 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof
WO2025092968A1 (zh) * 2023-11-03 2025-05-08 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1669798A1 (de) 1966-07-28 1971-08-26 Huels Chemische Werke Ag Verfahren zum Stabilisieren markomolekularer Polyacetale
FR1531943A (fr) 1966-07-28 1968-07-05 Huels Chemische Werke Ag Procédé pour stabiliser des poly-acétals macromoléculaires
DE2638855C3 (de) 1976-08-28 1980-04-24 Chemische Werke Huels Ag, 4370 Marl Verwendung von Quadratsäureamiden als Stabilisierungsmittel für geformte oder nicht geformte Kunststoffe
CS214745B2 (en) * 1976-08-28 1982-05-28 Huels Chemische Werke Ag Shaped and non-shaped products from plastic materials
DE3309655A1 (de) 1983-03-17 1984-09-20 Bayer Ag, 5090 Leverkusen 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
US4978665A (en) 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
JPH02256668A (ja) 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
GB9312210D0 (en) 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds
US5506252A (en) * 1993-11-17 1996-04-09 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5466712A (en) * 1994-11-04 1995-11-14 American Home Products Corporation Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
WO1996015103A1 (en) 1994-11-16 1996-05-23 American Home Products Corporation Diaminocyclobutene-3,4-diones
KR20000070368A (ko) * 1997-01-23 2000-11-25 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 인터루킨-8 수용체 길항제
US5840764A (en) * 1997-01-30 1998-11-24 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
WO1998033763A1 (en) 1997-01-30 1998-08-06 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
AR015425A1 (es) * 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
JP2002526522A (ja) 1998-10-02 2002-08-20 ニューロサーチ、アクティーゼルスカブ ジアミノシクロブテン−3,4−ジオン誘導体、その製造方法及びその使用方法
DE69922526T2 (de) 1998-10-08 2005-06-02 Smithkline Beecham Plc, Brentford 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3)
US6376555B1 (en) * 1998-12-04 2002-04-23 American Home Products Corporation 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
JP2002532457A (ja) 1998-12-14 2002-10-02 アメリカン・ホーム・プロダクツ・コーポレイション Vla−4により仲介される白血球接着を阻害する3,4−ジアミノ−3−シクロブテン−1,2−ジオン誘導体
ES2249059T3 (es) 1998-12-16 2006-03-16 Bayer Healthcare Ag Nuevos compuestos de bifenilo y analogos de bifenilo como antagonista de integrina.
US6420396B1 (en) * 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
CA2386049A1 (en) 1999-10-15 2001-04-26 Daniel S. Gardner Bicyclic and tricyclic amines as modulators of chemokine receptor activity
AR033803A1 (es) * 2000-03-01 2004-01-07 Smithkline Beecham Corp Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas
AU2001243351A1 (en) 2000-03-01 2001-09-12 Smith Kline Beecham Corporation Il-8 receptor antagonists
WO2001068569A2 (en) 2000-03-14 2001-09-20 Smithkline Beecham Corporation Il-8 receptor antagonists
AR035642A1 (es) * 2000-05-26 2004-06-23 Pharmacia Corp Uso de una composicion de celecoxib para el alivio rapido del dolor
WO2001092202A1 (en) * 2000-05-30 2001-12-06 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2002057230A1 (en) * 2001-01-16 2002-07-25 Smithkline Beecham Corporation Il-8 receptor antagonists
DE60230722D1 (de) * 2001-01-16 2009-02-26 Smithkline Beecham Corp Il-8-rezeptor-antagonisten
PL367534A1 (en) * 2001-02-02 2005-02-21 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20030204085A1 (en) 2001-02-02 2003-10-30 Taveras Arthur G. 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
NZ529551A (en) * 2001-04-16 2006-02-24 Schering Corp 3,4-DI-substituted cyclobutene-1,2-diones as CXC- chemokine receptor ligands
MXPA04003439A (es) 2001-10-12 2004-07-08 Schering Corp Compuestos de maleimida 3,4 disustituidos como antagonistas de receptor de quimiocina cxc.
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
JP4836388B2 (ja) 2002-03-22 2011-12-14 第一三共株式会社 eNOS発現に起因する疾患の予防または治療薬
ATE422203T1 (de) 2002-10-09 2009-02-15 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden

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US7960433B2 (en) 2011-06-14
AU2003220384A1 (en) 2003-10-08
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CA2479126A1 (en) 2003-10-02
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US20070155756A1 (en) 2007-07-05
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CA2479126C (en) 2011-11-15
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AU2003220384B2 (en) 2007-05-10

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