CN100444839C - 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 - Google Patents
式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 Download PDFInfo
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- CN100444839C CN100444839C CNB038106183A CN03810618A CN100444839C CN 100444839 C CN100444839 C CN 100444839C CN B038106183 A CNB038106183 A CN B038106183A CN 03810618 A CN03810618 A CN 03810618A CN 100444839 C CN100444839 C CN 100444839C
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36531402P | 2002-03-18 | 2002-03-18 | |
| US60/365,314 | 2002-03-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1652779A CN1652779A (zh) | 2005-08-10 |
| CN100444839C true CN100444839C (zh) | 2008-12-24 |
Family
ID=28454639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038106183A Expired - Fee Related CN100444839C (zh) | 2002-03-18 | 2003-03-17 | 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040053953A1 (enExample) |
| EP (1) | EP1485089B1 (enExample) |
| JP (1) | JP4733350B2 (enExample) |
| CN (1) | CN100444839C (enExample) |
| AR (1) | AR040400A1 (enExample) |
| AU (1) | AU2003220384B2 (enExample) |
| BR (1) | BR0308739A (enExample) |
| CA (1) | CA2479126C (enExample) |
| MX (1) | MXPA04009127A (enExample) |
| NO (1) | NO20044402L (enExample) |
| NZ (1) | NZ535314A (enExample) |
| TW (2) | TW200304811A (enExample) |
| WO (1) | WO2003080053A1 (enExample) |
| ZA (1) | ZA200407339B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| PT1818325E (pt) * | 2001-04-16 | 2010-05-12 | Schering Corp | Ciclobuteno-1,2-dionas 3,4-di-substituídas como ligandos de receptor de quimoquina cxc |
| EP1434775A1 (en) | 2001-10-12 | 2004-07-07 | Schering Corporation | 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists |
| US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
| US20040186142A1 (en) * | 2002-10-09 | 2004-09-23 | Schering Corporation Pharmacopeia, Inc. | Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC- chemokine receptor ligands |
| US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
| US8221495B2 (en) * | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
| ATE461673T1 (de) * | 2002-11-07 | 2010-04-15 | Abbott Lab | Verfahren zum anbringen eines medikaments auf eine prothese mittels eines flüssigstrahls |
| MXPA05011183A (es) | 2003-04-18 | 2005-12-14 | Schering Corp | Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida. |
| EP1694659B8 (en) * | 2003-12-19 | 2008-10-08 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
| US7671212B2 (en) * | 2003-12-22 | 2010-03-02 | Schering Corporation | Isothiazole dioxides as CXC- and CC-chemokine receptor ligands |
| DE602005022986D1 (de) * | 2004-01-30 | 2010-09-30 | Schering Corp | Kristalline polymorphe eines cxc-chemokinrezeptorliganden |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| BRPI0509419A (pt) * | 2004-04-16 | 2007-09-04 | Genentech Inc | método de ensaio imunossorvente ligado por enzimas, anticorpos, hibridoma e kit de imunoensaio |
| CA2565519A1 (en) | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| CN101253180B (zh) * | 2005-06-29 | 2011-08-03 | 先灵公司 | 作为cxc-化学活素受体配体的5,6-二取代的*二唑吡嗪和噻二唑吡嗪 |
| MX2008000366A (es) | 2005-06-29 | 2008-03-07 | Schering Corp | Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina. |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| CN101500544B (zh) * | 2006-06-12 | 2012-08-08 | 先灵公司 | Cxcr2或cxcr1与cxcr2两者的选择性拮抗剂的药物制剂和组合物及其用于治疗炎性疾病的使用方法 |
| KR20090028811A (ko) * | 2006-07-07 | 2009-03-19 | 쉐링 코포레이션 | Cxc-케모카인 수용체 리간드로서의 3,4-이치환된 사이클로부텐-1,2-디온 |
| US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
| KR20100031718A (ko) | 2007-06-06 | 2010-03-24 | 노파르티스 아게 | 항-염증성 치환된 시클로부텐디온 화합물 |
| WO2009005801A1 (en) * | 2007-07-03 | 2009-01-08 | Schering Corporation | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| WO2010131145A1 (en) * | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
| FR2961695B1 (fr) * | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
| WO2012125413A2 (en) * | 2011-03-12 | 2012-09-20 | Vicus Therapeutics, Llc | Compositions for ameliorating systemic inflammation and methods for making and using them |
| PT2760821T (pt) | 2011-09-02 | 2018-01-11 | Novartis Ag | Sal de colina de um composto anti-inflamatório de ciclobutenodiona substituída |
| FR2981934B1 (fr) * | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| KR101306199B1 (ko) * | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 d 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| EP3668832A1 (en) | 2017-08-14 | 2020-06-24 | Allergan, Inc. | 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof |
| EP3682881A4 (en) | 2017-09-14 | 2021-08-11 | Daiichi Sankyo Company, Limited | CONNECTION WITH CYCLICAL STRUCTURE |
| JP7322036B2 (ja) | 2018-01-08 | 2023-08-07 | ケモセントリックス,インコーポレイティド | Ccr6またはcxcr2のアンタゴニストを用いて汎発性膿疱性乾癬を治療する方法 |
| EP3852879A1 (en) | 2018-09-21 | 2021-07-28 | Pfizer Inc. | N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors |
| CN112851635B (zh) * | 2019-11-28 | 2022-09-16 | 中国医学科学院药物研究所 | 环状砜类化合物及其制备方法、用途和药物组合物 |
| EP3868368A1 (en) * | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
| WO2025092968A1 (zh) * | 2023-11-03 | 2025-05-08 | 武汉朗来科技发展有限公司 | 作为ccr6拮抗剂的化合物、其药物组合物和用途 |
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2003
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- 2003-03-17 CN CNB038106183A patent/CN100444839C/zh not_active Expired - Fee Related
- 2003-03-17 AU AU2003220384A patent/AU2003220384B2/en not_active Ceased
- 2003-03-17 WO PCT/US2003/008287 patent/WO2003080053A1/en not_active Ceased
- 2003-03-17 US US10/390,078 patent/US20040053953A1/en not_active Abandoned
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- 2003-03-17 JP JP2003577881A patent/JP4733350B2/ja not_active Expired - Fee Related
- 2003-03-17 CA CA2479126A patent/CA2479126C/en not_active Expired - Fee Related
- 2003-03-17 MX MXPA04009127A patent/MXPA04009127A/es unknown
- 2003-03-17 EP EP03716685.7A patent/EP1485089B1/en not_active Expired - Lifetime
- 2003-03-18 TW TW092105892A patent/TW200304811A/zh unknown
- 2003-03-18 AR AR20030100943A patent/AR040400A1/es not_active Application Discontinuation
- 2003-03-18 TW TW096114061A patent/TW200808314A/zh unknown
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| WO2001064208A1 (en) * | 2000-03-01 | 2001-09-07 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
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Also Published As
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| TW200808314A (en) | 2008-02-16 |
| AU2003220384B2 (en) | 2007-05-10 |
| CA2479126A1 (en) | 2003-10-02 |
| NO20044402L (no) | 2004-12-17 |
| US7960433B2 (en) | 2011-06-14 |
| ZA200407339B (en) | 2005-10-06 |
| BR0308739A (pt) | 2005-01-11 |
| EP1485089A1 (en) | 2004-12-15 |
| TW200304811A (en) | 2003-10-16 |
| US20070155756A1 (en) | 2007-07-05 |
| EP1485089B1 (en) | 2013-04-17 |
| CA2479126C (en) | 2011-11-15 |
| JP4733350B2 (ja) | 2011-07-27 |
| AU2003220384A1 (en) | 2003-10-08 |
| NZ535314A (en) | 2007-08-31 |
| US20040053953A1 (en) | 2004-03-18 |
| MXPA04009127A (es) | 2005-01-25 |
| CN1652779A (zh) | 2005-08-10 |
| JP2005533005A (ja) | 2005-11-04 |
| WO2003080053A1 (en) | 2003-10-02 |
| AR040400A1 (es) | 2005-04-06 |
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