MXPA04009127A - Tratamiento de enfermedades mediadas por quimiocinas. - Google Patents
Tratamiento de enfermedades mediadas por quimiocinas.Info
- Publication number
- MXPA04009127A MXPA04009127A MXPA04009127A MXPA04009127A MXPA04009127A MX PA04009127 A MXPA04009127 A MX PA04009127A MX PA04009127 A MXPA04009127 A MX PA04009127A MX PA04009127 A MXPA04009127 A MX PA04009127A MX PA04009127 A MXPA04009127 A MX PA04009127A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- substituted
- compound
- unsubstituted
- formula
- Prior art date
Links
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| US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| KR20100008794A (ko) * | 2001-04-16 | 2010-01-26 | 쉐링 코포레이션 | Ｃｘｃ-케모카인 수용체 리간드로서의 3,4-이치환된 사이클로부텐-1,2-디온 |
| JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物 |
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| EP1551818B1 (en) * | 2002-10-09 | 2009-02-04 | Schering Corporation | Thiadiazoledioxides and thiadiazoleoxides as cxc- and cc-chemokine receptor ligands |
| US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
| US8221495B2 (en) * | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
| KR20050086430A (ko) * | 2002-11-07 | 2005-08-30 | 아보트 러보러터리즈 | 혼합되지 않은 개별 방울로서 다수의 약을 가진 보형물 |
| DE602004025458D1 (de) | 2003-04-18 | 2010-03-25 | Schering Corp | SYNTHESE VON 2-HYDROXY-N,N-DIMETHYL-3-ii2-i1(R)-(5-METHYL-2-FURANYL)PROPYL AMINO -3,4-DIOXO-1-CYCLOBUTEN-1-YL AMINO BENZAMID |
| US7338968B2 (en) * | 2003-12-19 | 2008-03-04 | Schering Corporation | Thiadiazoles AS CXC- and CC- chemokine receptor ligands |
| WO2005068460A1 (en) * | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
| CN1914187B (zh) | 2004-01-30 | 2012-01-25 | 先灵公司 | Cxc趋化因子受体配位体的结晶多晶型物 |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
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| CN1984899B (zh) * | 2004-05-12 | 2011-07-27 | 先灵公司 | Cxcr1和cxcr2趋化因子拮抗剂 |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| ATE486078T1 (de) * | 2005-06-29 | 2010-11-15 | Schering Corp | 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors |
| WO2007002764A2 (en) | 2005-06-29 | 2007-01-04 | Schering Corporation | Di-substituted oxadiazoles as cxc-chemokine receptor ligands |
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| JP2009542700A (ja) * | 2006-07-07 | 2009-12-03 | シェーリング コーポレイション | Ｃｘｃケモカイン受容体リガンドとしての３，４−ジ置換シクロブテン−１，２−ジオン |
| US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
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| EP2178826B1 (en) * | 2007-07-03 | 2017-05-17 | Merck Sharp & Dohme Corp. | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
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| WO2010131145A1 (en) * | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
| FR2961695B1 (fr) * | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
| US20140170112A1 (en) * | 2011-03-12 | 2014-06-19 | Vicus Therapeutics, Llc | Compositions for ameliorating systemic inflammation and methods for making and using them |
| WO2013030803A1 (en) | 2011-09-02 | 2013-03-07 | Novartis Ag | Choline salt of an anti - inflammatory substituted cyclobutenedione compound |
| FR2981934B1 (fr) * | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
| KR101306199B1 (ko) * | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 ｄ 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| KR20200037857A (ko) * | 2017-08-14 | 2020-04-09 | 알러간, 인코포레이티드 | 3,4-이치환된 3-시클로부텐-1,2-디온 및 그의 용도 |
| MY202326A (en) | 2017-09-14 | 2024-04-24 | Daiichi Sankyo Co Ltd | Compound having cyclic structure |
| ES3067325T3 (en) | 2018-01-08 | 2026-05-21 | Chemocentryx Inc | Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2 |
| PE20211070A1 (es) | 2018-09-21 | 2021-06-09 | Pfizer | Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6 |
| CN112851635B (zh) * | 2019-11-28 | 2022-09-16 | 中国医学科学院药物研究所 | 环状砜类化合物及其制备方法、用途和药物组合物 |
| EP3868368A1 (en) * | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
| CN121693497A (zh) * | 2023-11-03 | 2026-03-17 | 武汉朗来科技发展有限公司 | 作为ccr6拮抗剂的化合物、其药物组合物和用途 |
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| DE1669798A1 (de) | 1966-07-28 | 1971-08-26 | Huels Chemische Werke Ag | Verfahren zum Stabilisieren markomolekularer Polyacetale |
| FR1531943A (fr) | 1966-07-28 | 1968-07-05 | Huels Chemische Werke Ag | Procédé pour stabiliser des poly-acétals macromoléculaires |
| DE2638855C3 (de) | 1976-08-28 | 1980-04-24 | Chemische Werke Huels Ag, 4370 Marl | Verwendung von Quadratsäureamiden als Stabilisierungsmittel für geformte oder nicht geformte Kunststoffe |
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| DE3309655A1 (de) | 1983-03-17 | 1984-09-20 | Bayer Ag, 5090 Leverkusen | 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
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-
2003
- 2003-03-17 NZ NZ535314A patent/NZ535314A/en not_active IP Right Cessation
- 2003-03-17 WO PCT/US2003/008287 patent/WO2003080053A1/en not_active Ceased
- 2003-03-17 CA CA2479126A patent/CA2479126C/en not_active Expired - Fee Related
- 2003-03-17 BR BR0308739-5A patent/BR0308739A/pt not_active IP Right Cessation
- 2003-03-17 MX MXPA04009127A patent/MXPA04009127A/es unknown
- 2003-03-17 CN CNB038106183A patent/CN100444839C/zh not_active Expired - Fee Related
- 2003-03-17 JP JP2003577881A patent/JP4733350B2/ja not_active Expired - Fee Related
- 2003-03-17 EP EP03716685.7A patent/EP1485089B1/en not_active Expired - Lifetime
- 2003-03-17 US US10/390,078 patent/US20040053953A1/en not_active Abandoned
- 2003-03-17 AU AU2003220384A patent/AU2003220384B2/en not_active Ceased
- 2003-03-18 TW TW096114061A patent/TW200808314A/zh unknown
- 2003-03-18 AR AR20030100943A patent/AR040400A1/es not_active Application Discontinuation
- 2003-03-18 TW TW092105892A patent/TW200304811A/zh unknown
-
2004
- 2004-09-13 ZA ZA200407339A patent/ZA200407339B/en unknown
- 2004-10-15 NO NO20044402A patent/NO20044402L/no not_active Application Discontinuation
-
2007
- 2007-02-14 US US11/705,929 patent/US7960433B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR0308739A (pt) | 2005-01-11 |
| TW200808314A (en) | 2008-02-16 |
| TW200304811A (en) | 2003-10-16 |
| NZ535314A (en) | 2007-08-31 |
| ZA200407339B (en) | 2005-10-06 |
| CA2479126C (en) | 2011-11-15 |
| US7960433B2 (en) | 2011-06-14 |
| CN100444839C (zh) | 2008-12-24 |
| CA2479126A1 (en) | 2003-10-02 |
| EP1485089A1 (en) | 2004-12-15 |
| AU2003220384A1 (en) | 2003-10-08 |
| WO2003080053A1 (en) | 2003-10-02 |
| US20070155756A1 (en) | 2007-07-05 |
| JP2005533005A (ja) | 2005-11-04 |
| CN1652779A (zh) | 2005-08-10 |
| EP1485089B1 (en) | 2013-04-17 |
| AU2003220384B2 (en) | 2007-05-10 |
| NO20044402L (no) | 2004-12-17 |
| US20040053953A1 (en) | 2004-03-18 |
| AR040400A1 (es) | 2005-04-06 |
| JP4733350B2 (ja) | 2011-07-27 |
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