JP2010533736A5 - - Google Patents
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- Publication number
- JP2010533736A5 JP2010533736A5 JP2010517200A JP2010517200A JP2010533736A5 JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5 JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- mono
- cycloalkyl
- aminosulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O Chemical compound CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O 0.000 description 17
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95062507P | 2007-07-19 | 2007-07-19 | |
| PCT/US2008/070613 WO2009012482A2 (en) | 2007-07-19 | 2008-07-21 | 5-membered heterocyclic amides and related compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Division JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533736A JP2010533736A (ja) | 2010-10-28 |
| JP2010533736A5 true JP2010533736A5 (enExample) | 2011-09-08 |
Family
ID=40260407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517200A Pending JP2010533736A (ja) | 2007-07-19 | 2008-07-21 | 5員複素環アミドおよび関連化合物 |
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20100292236A1 (enExample) |
| EP (1) | EP2178865B1 (enExample) |
| JP (2) | JP2010533736A (enExample) |
| KR (2) | KR20150118197A (enExample) |
| CN (2) | CN101711245B (enExample) |
| AU (1) | AU2008275891B2 (enExample) |
| BR (1) | BRPI0813426A2 (enExample) |
| CA (1) | CA2691507C (enExample) |
| CO (1) | CO6251318A2 (enExample) |
| CY (1) | CY1116809T1 (enExample) |
| DK (1) | DK2178865T3 (enExample) |
| EA (1) | EA017250B1 (enExample) |
| ES (1) | ES2551095T3 (enExample) |
| HK (1) | HK1213879A1 (enExample) |
| HR (1) | HRP20151052T1 (enExample) |
| HU (1) | HUE026446T2 (enExample) |
| IL (1) | IL202499A (enExample) |
| MX (1) | MX2009014159A (enExample) |
| MY (1) | MY154668A (enExample) |
| NZ (1) | NZ582057A (enExample) |
| PH (1) | PH12014501677A1 (enExample) |
| PL (1) | PL2178865T3 (enExample) |
| PT (1) | PT2178865E (enExample) |
| RS (1) | RS54303B1 (enExample) |
| SG (1) | SG187396A1 (enExample) |
| SI (1) | SI2178865T1 (enExample) |
| UA (1) | UA105758C2 (enExample) |
| WO (1) | WO2009012482A2 (enExample) |
| ZA (1) | ZA200908447B (enExample) |
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| AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| KR20100093129A (ko) | 2007-12-20 | 2010-08-24 | 노파르티스 아게 | Pi 3 키나제 억제제로서 사용되는 티아졸 유도체 |
| MX2010013705A (es) | 2008-06-13 | 2011-02-25 | Bayer Cropscience Ag | Nuevas amidas y tioamidas heteroaromaticas como plaguicidas. |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| JP5702293B2 (ja) | 2008-11-10 | 2015-04-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物 |
| BRPI0924084B1 (pt) | 2008-12-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina e composição farmacêutica que os compreende |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US9062008B2 (en) | 2010-05-12 | 2015-06-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2011143422A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | 2 -aminopyridine derivatives useful as inhibitors of atr kinase |
| JP2013526538A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| EP2569287B1 (en) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| AU2011253025A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2011163527A1 (en) | 2010-06-23 | 2011-12-29 | Vertex Pharmaceuticals Incorporated | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
| US8981116B2 (en) * | 2010-07-23 | 2015-03-17 | Solvay Sa | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids |
| CN101921268B (zh) * | 2010-08-27 | 2016-08-03 | 中山大学肿瘤防治中心 | 5-噻唑酰胺类化合物及生物学应用 |
| JP2013249256A (ja) * | 2010-09-15 | 2013-12-12 | Astellas Pharma Inc | 脂肪性肝疾患治療薬 |
| EP3061751A1 (en) | 2010-09-21 | 2016-08-31 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition |
| WO2012138938A1 (en) | 2011-04-05 | 2012-10-11 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of tra kinase |
| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| EP2723745A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| JP2014522818A (ja) | 2011-06-22 | 2014-09-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| KR20140048257A (ko) | 2011-07-15 | 2014-04-23 | 바스프 에스이 | 동물 해충을 퇴치하기 위해 치환된 3-피리딜 티아졸 화합물 및 유도체 i을 사용하는 살충 방법 |
| KR101995088B1 (ko) | 2011-07-22 | 2019-07-02 | 이도르시아 파마슈티컬스 리미티드 | P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| WO2013049719A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| SG10201606774UA (en) | 2011-09-30 | 2016-10-28 | Vertex Pharma | Processes for making compounds useful as inhibitors of atr kinase |
| IN2014CN02501A (enExample) | 2011-09-30 | 2015-06-26 | Vertex Pharma | |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| MX2014003796A (es) | 2011-09-30 | 2015-01-16 | Vertex Pharma | Compuestos utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr). |
| WO2013071093A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2776422A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776421A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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| US9487508B2 (en) * | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| ES2651074T3 (es) | 2012-10-02 | 2018-01-24 | Bayer Cropscience Ag | Compuestos heterocíclicos como plaguicidas |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| US8912198B2 (en) | 2012-10-16 | 2014-12-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| SI2925757T1 (en) | 2012-11-19 | 2018-01-31 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| SMT202000713T1 (it) | 2012-12-07 | 2021-03-15 | Vertex Pharma | Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro |
| PL2931717T3 (pl) | 2012-12-12 | 2017-05-31 | Actelion Pharmaceuticals Ltd. | Pochodne indolokarboksyamidu jako antagoniści receptora p2x7 |
| US9556117B2 (en) | 2012-12-18 | 2017-01-31 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as P2X7 receptor antagonists |
| KR102222220B1 (ko) | 2013-01-22 | 2021-03-03 | 이도르시아 파마슈티컬스 리미티드 | P2x7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
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| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| HUE046727T2 (hu) | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
| JP6434048B2 (ja) | 2014-04-02 | 2018-12-05 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 農薬としてのヘテロ環式化合物 |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| CN107074863B (zh) | 2014-06-05 | 2019-12-03 | 沃泰克斯药物股份有限公司 | Atr激酶抑制剂的制备方法及其不同的固体形式 |
| PL3157566T3 (pl) | 2014-06-17 | 2019-10-31 | Vertex Pharma | Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr |
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| CN114929694B (zh) * | 2019-11-06 | 2025-02-07 | 拜耳公司 | 肾上腺素能受体adrac2拮抗剂 |
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| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
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| JP2010505957A (ja) * | 2006-10-10 | 2010-02-25 | アムゲン インコーポレイティッド | 糖尿病に対して使用されるn−アリールピラゾール化合物 |
| WO2008073825A1 (en) | 2006-12-08 | 2008-06-19 | Exelixis, Inc. | Lxr and fxr modulators |
| CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| WO2008138876A1 (en) | 2007-05-10 | 2008-11-20 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
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2008
- 2008-07-21 AU AU2008275891A patent/AU2008275891B2/en not_active Ceased
- 2008-07-21 MX MX2009014159A patent/MX2009014159A/es active IP Right Grant
- 2008-07-21 JP JP2010517200A patent/JP2010533736A/ja active Pending
- 2008-07-21 UA UAA200913338A patent/UA105758C2/uk unknown
- 2008-07-21 BR BRPI0813426-0A2A patent/BRPI0813426A2/pt not_active Application Discontinuation
- 2008-07-21 EP EP08796352.6A patent/EP2178865B1/en active Active
- 2008-07-21 ES ES08796352.6T patent/ES2551095T3/es active Active
- 2008-07-21 US US12/669,308 patent/US20100292236A1/en not_active Abandoned
- 2008-07-21 DK DK08796352.6T patent/DK2178865T3/en active
- 2008-07-21 HU HUE08796352A patent/HUE026446T2/en unknown
- 2008-07-21 PT PT87963526T patent/PT2178865E/pt unknown
- 2008-07-21 KR KR1020157026989A patent/KR20150118197A/ko not_active Ceased
- 2008-07-21 SG SG2012095287A patent/SG187396A1/en unknown
- 2008-07-21 CA CA2691507A patent/CA2691507C/en not_active Expired - Fee Related
- 2008-07-21 CN CN200880021346.2A patent/CN101711245B/zh not_active Expired - Fee Related
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- 2008-07-21 KR KR1020097026691A patent/KR101593237B1/ko not_active Expired - Fee Related
- 2008-07-21 CN CN201510081896.5A patent/CN104844578B/zh not_active Expired - Fee Related
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- 2008-07-21 HR HRP20151052TT patent/HRP20151052T1/hr unknown
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2014
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