JP2010533736A5 - - Google Patents
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- JP2010533736A5 JP2010533736A5 JP2010517200A JP2010517200A JP2010533736A5 JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5 JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- mono
- cycloalkyl
- aminosulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O Chemical compound CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O 0.000 description 17
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95062507P | 2007-07-19 | 2007-07-19 | |
| PCT/US2008/070613 WO2009012482A2 (en) | 2007-07-19 | 2008-07-21 | 5-membered heterocyclic amides and related compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Division JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | ５員複素環アミドおよび関連化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533736A JP2010533736A (ja) | 2010-10-28 |
| JP2010533736A5 true JP2010533736A5 (enExample) | 2011-09-08 |
Family
ID=40260407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517200A Pending JP2010533736A (ja) | 2007-07-19 | 2008-07-21 | ５員複素環アミドおよび関連化合物 |
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | ５員複素環アミドおよび関連化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | ５員複素環アミドおよび関連化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20100292236A1 (enExample) |
| EP (1) | EP2178865B1 (enExample) |
| JP (2) | JP2010533736A (enExample) |
| KR (2) | KR101593237B1 (enExample) |
| CN (2) | CN104844578B (enExample) |
| AU (1) | AU2008275891B2 (enExample) |
| BR (1) | BRPI0813426A2 (enExample) |
| CA (1) | CA2691507C (enExample) |
| CO (1) | CO6251318A2 (enExample) |
| CY (1) | CY1116809T1 (enExample) |
| DK (1) | DK2178865T3 (enExample) |
| EA (1) | EA017250B1 (enExample) |
| ES (1) | ES2551095T3 (enExample) |
| HK (1) | HK1213879A1 (enExample) |
| HR (1) | HRP20151052T1 (enExample) |
| HU (1) | HUE026446T2 (enExample) |
| IL (1) | IL202499A (enExample) |
| MX (1) | MX2009014159A (enExample) |
| MY (1) | MY154668A (enExample) |
| NZ (1) | NZ582057A (enExample) |
| PH (1) | PH12014501677B1 (enExample) |
| PL (1) | PL2178865T3 (enExample) |
| PT (1) | PT2178865E (enExample) |
| RS (1) | RS54303B1 (enExample) |
| SG (1) | SG187396A1 (enExample) |
| SI (1) | SI2178865T1 (enExample) |
| UA (1) | UA105758C2 (enExample) |
| WO (1) | WO2009012482A2 (enExample) |
| ZA (1) | ZA200908447B (enExample) |
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| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| BRPI0820722A2 (pt) | 2007-12-20 | 2015-06-16 | Novartis Ag | Derivados de tiazol usados como inibidores de pi 3 cinases |
| US9428487B2 (en) * | 2008-06-13 | 2016-08-30 | Bayer Intellectual Property Gmbh | Heteroaromatic amides and thioamides as pesticides |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| MX2011004953A (es) | 2008-11-10 | 2011-12-14 | Vertex Pharma | Compuestos utiles como inhibidores de cinasa atr. |
| ES2921576T3 (es) | 2008-12-19 | 2022-08-29 | Vertex Pharma | Compuestos útiles como inhibidores de la quinasa ATR |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2745977C2 (ru) | 2010-04-22 | 2021-04-05 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US8969356B2 (en) | 2010-05-12 | 2015-03-03 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2011143419A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Pyrazines useful as inhibitors of atr kinase |
| EP2569313A1 (en) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| NZ603478A (en) | 2010-05-12 | 2014-09-26 | Vertex Pharma | 2 -aminopyridine derivatives useful as inhibitors of atr kinase |
| US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2569286B1 (en) | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| EP2585468A1 (en) | 2010-06-23 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
| EP2595962B1 (en) * | 2010-07-23 | 2018-07-11 | Solvay Sa | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids |
| CN101921268B (zh) * | 2010-08-27 | 2016-08-03 | 中山大学肿瘤防治中心 | 5-噻唑酰胺类化合物及生物学应用 |
| JP2013249256A (ja) * | 2010-09-15 | 2013-12-12 | Astellas Pharma Inc | 脂肪性肝疾患治療薬 |
| PH12013500467A1 (en) | 2010-09-21 | 2013-04-29 | Eisai R&D Man Co Ltd | Pharmaceutical composition |
| AU2012240030A1 (en) | 2011-04-05 | 2013-10-24 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of TRA kinase |
| WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| EP2723747A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| JP2014520835A (ja) | 2011-07-15 | 2014-08-25 | ビーエーエスエフ ソシエタス・ヨーロピア | 動物有害生物を駆除するための置換３−ピリジルチアゾール化合物および誘導体ｉを使用した有害生物防除方法 |
| KR101995088B1 (ko) | 2011-07-22 | 2019-07-02 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
| CA2850564A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US8765751B2 (en) | 2011-09-30 | 2014-07-01 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| RU2018108589A (ru) | 2011-09-30 | 2019-02-25 | Вертекс Фармасьютикалз Инкорпорейтед | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
| EP3878851A1 (en) | 2011-09-30 | 2021-09-15 | Vertex Pharmaceuticals Incorporated | Process for making compounds useful as inhibitors of atr kinase |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| JP2015502925A (ja) | 2011-11-09 | 2015-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用なピラジン化合物 |
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| EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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| PT2833973T (pt) | 2012-04-05 | 2017-12-21 | Vertex Pharma | Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos |
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| CA2885645A1 (en) * | 2012-09-19 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| RU2641916C2 (ru) | 2012-10-02 | 2018-01-23 | Байер Кропсайенс Аг | Гетероциклические соединения в качестве пестицидов |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2014078802A1 (en) | 2012-11-19 | 2014-05-22 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| WO2014089379A1 (en) | 2012-12-07 | 2014-06-12 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9718774B2 (en) | 2012-12-12 | 2017-08-01 | Idorsia Pharmaceuticals Ltd | Indole carboxamide derivatives as P2X7 receptor antagonist |
| AR094053A1 (es) | 2012-12-18 | 2015-07-08 | Actelion Pharmaceuticals Ltd | Derivados de indol carboxamida como antagonistas del receptor p2x₇ |
| KR102220847B1 (ko) * | 2013-01-22 | 2021-02-26 | 이도르시아 파마슈티컬스 리미티드 | Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체 |
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| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2015085132A1 (en) | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
| US9815792B2 (en) | 2014-04-02 | 2017-11-14 | Bayer Cropscience Aktiengesellschaft | Method for producing carboxamides |
| SG10201913575VA (en) | 2014-04-15 | 2020-02-27 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
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| CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| US20110046137A1 (en) | 2007-05-10 | 2011-02-24 | Glaxo Group Limited | Pyrazole Derivatives as P2X7 Modulators |
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