CO6251318A2 - Compuestos heterociclicos de 5 miembros como antagonistas p2x7 - Google Patents

Compuestos heterociclicos de 5 miembros como antagonistas p2x7

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Publication number
CO6251318A2
CO6251318A2 CO09146583A CO09146583A CO6251318A2 CO 6251318 A2 CO6251318 A2 CO 6251318A2 CO 09146583 A CO09146583 A CO 09146583A CO 09146583 A CO09146583 A CO 09146583A CO 6251318 A2 CO6251318 A2 CO 6251318A2
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Colombia
Prior art keywords
alkyl
mono
cycloalkyl
heterocycloalkyl
membered
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CO09146583A
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English (en)
Inventor
Hongbin Li
Jun Yuan
Rajagopal Bakthavatchalam
Kevin Hodgetts
Scott Michael Capitosti
Jianmin Mao
David J Wustrow
Qin Guo
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Lundbeck & Co As H
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Publication of CO6251318A2 publication Critical patent/CO6251318A2/es

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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

1.- Un compuesto de la fórmula:o una sal farmacéuticamente aceptable o hidrato del mismo, en donde: representa un anillo heteroarilo de 5 miembros; W es -C(=O)NR4-, NR4C(=O) o -NR4-NR4-C(=O)-;X está ausente o es alquileno C1-C6 que se sustituye con de 0 a 4 sustituyentes independientemente escogidos de: (i) hidroxi y -COOH; (ii) alquilo C1-C8, (cicloalquilo C3-C8) alquilo C0-C4, aminoalquilo C1-C6, alquil éter C2-C8, mono- o di-(alquilo C1-C6) aminoalquilo C0-C4, (heterocicloalquilo de 4 a 7 miembros) alquilo C0-C4 y fenilalquilo C0-C2;sustituyentes que se toman juntos, con cualesquier átomos de carbono que intervienen, para formar un cicloalquilo de 3 a 7 miembros o un heterocicloalquilo de 4 a 7 miembros; y(iv) sustituyentes que se toman junto con R4 y cualesquier átomos que intervienen para formar un heterocicloalquilo de a 4 a 7 miembros; cada uno de which (ii), (iii) y (iv) se sustituye con de 0 a 3 sustituyentes independientemente escogidos de hidroxi, halógeno, amino, oxo, aminocarbonilo, aminosulfonilo, -COOH, alquilo C1-C6, haloalquilo C1-C6, alcoxi C1-C6, (cicloalquilo C3-C7)alquilo C0-C4, mono- o di-(alquilo C1-C6)amino, mono- o di-(alquilo C1-C6)aminocarbonilo, mono- o di-(alquilo C1-C6)aminosulfonilo y heterocicloalquilo de 4 a 7 miembros;Y es cicloalquilo C4-C12 que se sustituye con de 0 a 6 sustituyentes independientemente escogidos de halógeno, hidroxi, ciano, amino, nitro, oxo, aminocarbonilo, aminosulfonilo, -COOH, alquilo C1-C6 alquenilo C2-C6, alquinilo C2-C6, haloalquilo C1-C6, hidroxialquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, (cicloalquilo C3-C7)alquilo C0-C4, (heterocicloalquilo de 4 a 7 miembros)alquilo C0-C4 y mono- o di- (alquilo C1-C6)aminoalquilo C0-C4; ...
CO09146583A 2007-07-19 2009-12-22 Compuestos heterociclicos de 5 miembros como antagonistas p2x7 CO6251318A2 (es)

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US8940771B2 (en) 2007-12-20 2015-01-27 Novartis Ag Organic compounds
EP2725021A1 (de) * 2008-06-13 2014-04-30 Bayer CropScience AG Neue heteroaromatische Thioamide als Schädlingsbekämpfungsmittel
UA104147C2 (uk) 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
MX2011004953A (es) 2008-11-10 2011-12-14 Vertex Pharma Compuestos utiles como inhibidores de cinasa atr.
CA2747252C (en) 2008-12-19 2018-09-18 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
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