CO6241110A2 - Analogos deamidas heteroarilicas como antagonistas del p2x7 - Google Patents

Analogos deamidas heteroarilicas como antagonistas del p2x7

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Publication number
CO6241110A2
CO6241110A2 CO09127786A CO09127786A CO6241110A2 CO 6241110 A2 CO6241110 A2 CO 6241110A2 CO 09127786 A CO09127786 A CO 09127786A CO 09127786 A CO09127786 A CO 09127786A CO 6241110 A2 CO6241110 A2 CO 6241110A2
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Colombia
Prior art keywords
alkyl
mono
cycloalkyl
aminosulfonyl
aminocarbonyl
Prior art date
Application number
CO09127786A
Other languages
English (en)
Inventor
David C Ihle
Qin Guo
Kevin Hodgetts
Jun Yuan
Original Assignee
Lundbeck & Co As H
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Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of CO6241110A2 publication Critical patent/CO6241110A2/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

o una sal farmacéuticamente aceptable del mismo, en donde: T, U y V se seleccionan independientemente entre CR3, CRA Y N, tal que (i) exactamente uno de T, U y V es CRA; y (ii) si X es CH2, Y es fenilo, y U y V son ambos carbonos sustituidos, entonces T no es N; W es -C(=O)NR4-, -NR4C(=O) o NR4-NR4-C(=O)-; X está ausente o es alquileno C1-C6 que es sustituido con de 0 a 4 sustituyentes elegidos independientemente entre: i) alquilo C1-C4, (cicloalquilo C1-C8)alquilo C0-C2 y fenilalquilo C0-C2;ii) sustituyentes que se toman conjuntamente para formar un anillo cicloalquilo o heterocicloalquilo de 3 a 7 miembros; y iii) sustituyentes que se toman conjuntamente con R4 para formar un heterocicloalquilo de 4- a 7- miembros; y es cicloalquilo C3-C16, heterocicloalquilo de 4- a 16- miembros, arilo de 6-a 16- miembros o heteroarilo de 5-a 16- miembros, cada uno de los cuales se sustituye con de 0 a 6 sustituyentes elegidos independientemente entre hidroxi, halógeno, ciano, amino, nitro, oxo, aminocarbonilo, aminosulfonilo, COOH, alquiloC1-C6, alquenilo C2-C6, alquinilo C2-C6a, haloalquilo C1-C6, hidroxialquiloC1-C6, aminoalquilo C1-C6, alcoxiC1-C6, haloalcoxiC1-C6, éter de alquilo C2-C6, alcanoilo C1-C6, alquilsulfoniloC1-C6, (cicloalquilo C3-C7) alquilo C0-C4, mono- o di-(alquilC1-C6)amino, alcanoilamino C1-C6, mono- o di-(alquilC1-C6)aminocarbonilo, mono o di (alquilC1-C6)aminosulfonilo y (alquilC1-C6)sulfonilamino; Z1 y Z3 son independientemente N o CR2; Z2 es N, CR2 o CRA; Cada R2 y cada R3 se elige independientemente entre hidrógeno, halógeno, ciano, amino, nitro, aminocarbonilo, aminosulfonilo, COOH, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, haloalquilo C1-C6, hidroxialquilo C1-C6, aminoalquilo C1-C6, alcoxi C1-C6, haloalcoxi C1-C6, alcanoilo C1-C6, alquil C2-C6 éter, (cicloalquilC3-C7)alquilo C0-C4, mono- o di-(alquilC1-C6)amino, alquilsulfonilo C1-C6, alcanoilamino C1-C6, mono- o di-(alquilC1-C6)aminocarbonilo, mono- o di-(alquilC1-C6)aminosulfonilo y (alquilC1-C6)sulfonilamino; Cada R4 es independientemente hidrógeno, alquilo C1-C6, (CicloalquilC3-C8)alquilo C0-C2 o ...
CO09127786A 2007-04-10 2009-11-10 Analogos deamidas heteroarilicas como antagonistas del p2x7 CO6241110A2 (es)

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US (2) US8580812B2 (es)
EP (2) EP2155744A1 (es)
JP (1) JP2010523668A (es)
KR (1) KR20090130109A (es)
CN (2) CN101772498A (es)
AU (1) AU2008236649B2 (es)
BR (1) BRPI0809567A2 (es)
CA (1) CA2682925A1 (es)
CO (1) CO6241110A2 (es)
EA (1) EA200970931A1 (es)
IL (1) IL201356A0 (es)
MX (1) MX2009010523A (es)
MY (1) MY148461A (es)
NZ (1) NZ580394A (es)
UA (1) UA99610C2 (es)
WO (1) WO2008124153A1 (es)

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US8580812B2 (en) 2013-11-12
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CA2682925A1 (en) 2008-10-16
US20100266509A1 (en) 2010-10-21
EP2592082A1 (en) 2013-05-15
KR20090130109A (ko) 2009-12-17
JP2010523668A (ja) 2010-07-15
AU2008236649B2 (en) 2013-05-02
EP2155744A1 (en) 2010-02-24
WO2008124153A1 (en) 2008-10-16
US20140038955A1 (en) 2014-02-06
MY148461A (en) 2013-04-30
BRPI0809567A2 (pt) 2014-09-23
AU2008236649A1 (en) 2008-10-16
CN101772498A (zh) 2010-07-07
MX2009010523A (es) 2009-12-15
EA200970931A1 (ru) 2010-04-30

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