JP4651714B2 - 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体 - Google Patents

糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体 Download PDF

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Publication number
JP4651714B2
JP4651714B2 JP2008520936A JP2008520936A JP4651714B2 JP 4651714 B2 JP4651714 B2 JP 4651714B2 JP 2008520936 A JP2008520936 A JP 2008520936A JP 2008520936 A JP2008520936 A JP 2008520936A JP 4651714 B2 JP4651714 B2 JP 4651714B2
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Prior art keywords
oxy
methyl
benzamide
ylcarbonyl
azetidin
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JP2009500443A5 (enExample
JP2009500443A (ja
Inventor
マッカーレッチャー，ダーレン
パイク，カート・ゴードン
ウェアリング，マイケル・ジェームズ
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AstraZeneca AB
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AstraZeneca AB
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Priority claimed from GB0514173A external-priority patent/GB0514173D0/en
Priority claimed from GB0516297A external-priority patent/GB0516297D0/en
Priority claimed from GB0523862A external-priority patent/GB0523862D0/en
Priority claimed from GB0524589A external-priority patent/GB0524589D0/en
Priority claimed from GB0607977A external-priority patent/GB0607977D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2009500443A publication Critical patent/JP2009500443A/ja
Publication of JP2009500443A5 publication Critical patent/JP2009500443A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008520936A 2005-07-09 2006-07-03 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体 Active JP4651714B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0514173A GB0514173D0 (en) 2005-07-09 2005-07-09 Chemical compounds
GB0516297A GB0516297D0 (en) 2005-08-09 2005-08-09 Chemical compounds
GB0523862A GB0523862D0 (en) 2005-11-24 2005-11-24 Chemical compounds
GB0524589A GB0524589D0 (en) 2005-12-02 2005-12-02 Chemical compounds
GB0607977A GB0607977D0 (en) 2006-04-22 2006-04-22 Chemical compounds
PCT/GB2006/002471 WO2007007041A1 (en) 2005-07-09 2006-07-03 Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2009157639A Division JP2009215320A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157686A Division JP2009263390A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157655A Division JP4651729B2 (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体

Publications (3)

Publication Number Publication Date
JP2009500443A JP2009500443A (ja) 2009-01-08
JP2009500443A5 JP2009500443A5 (enExample) 2010-08-19
JP4651714B2 true JP4651714B2 (ja) 2011-03-16

Family

ID=36809156

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2008520936A Active JP4651714B2 (ja) 2005-07-09 2006-07-03 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157639A Pending JP2009215320A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157655A Expired - Fee Related JP4651729B2 (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157686A Pending JP2009263390A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2009157639A Pending JP2009215320A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157655A Expired - Fee Related JP4651729B2 (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体
JP2009157686A Pending JP2009263390A (ja) 2005-07-09 2009-07-02 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体

Country Status (19)

Country Link
US (4) US7642259B2 (enExample)
EP (4) EP2305674A1 (enExample)
JP (4) JP4651714B2 (enExample)
KR (2) KR20110084339A (enExample)
AR (1) AR055074A1 (enExample)
AU (2) AU2006268406C1 (enExample)
BR (3) BRPI0613570B8 (enExample)
CA (1) CA2614746C (enExample)
EC (1) ECSP088164A (enExample)
ES (1) ES2397648T3 (enExample)
IL (2) IL188059A0 (enExample)
MX (1) MX2008000172A (enExample)
MY (1) MY147749A (enExample)
NO (1) NO20076658L (enExample)
NZ (4) NZ564608A (enExample)
SA (1) SA06270215B1 (enExample)
TW (1) TW200730174A (enExample)
UY (1) UY29656A1 (enExample)
WO (1) WO2007007041A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2009263390A (ja) * 2005-07-09 2009-11-12 Astrazeneca Ab 糖尿病の治療においてｇｌｋ活性化剤として使用するためのヘテロアリールベンズアミド誘導体

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TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
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TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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KR102513342B1 (ko) 2016-07-22 2023-03-22 브리스톨-마이어스 스큅 컴퍼니 글루코키나제 활성화제 및 그의 사용 방법
KR102836470B1 (ko) * 2021-09-02 2025-07-22 콘두이트 유케이 매니지먼트 엘티디 3-{[5-(아제티딘-1-일카르보닐)피라진-2-일]옥시}-5-{[(1s)-1-메틸-2-(메틸옥시)에틸]옥시)-n-(5-메틸피라진-2-일)벤즈아미드의치료 공결정

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NZ564608A (en) 2009-09-25
CA2614746A1 (en) 2007-01-18
JP2009500443A (ja) 2009-01-08
AU2010235903A1 (en) 2010-11-11
MX2008000172A (es) 2008-04-04
BRPI0613570A2 (pt) 2010-07-06
NZ575513A (en) 2009-11-27
EP1902052B1 (en) 2012-11-28
US20090118159A1 (en) 2009-05-07
MY147749A (en) 2013-01-15
JP2009215321A (ja) 2009-09-24
EP2301935A1 (en) 2011-03-30
BRPI0613570B1 (pt) 2020-02-18
IL188059A0 (en) 2008-03-20
HK1116769A1 (en) 2009-01-02
AU2006268406C1 (en) 2011-02-24
SA06270215B1 (ar) 2010-06-23
BRPI0622261A2 (pt) 2011-08-09
EP2301929A1 (en) 2011-03-30
JP2009215320A (ja) 2009-09-24
BRPI0613570A8 (pt) 2017-12-26
ES2397648T3 (es) 2013-03-08

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