JP4472337B2 - アルキルアミノピリダジノン誘導体、この調製方法、およびこれを含む医薬組成物 - Google Patents

アルキルアミノピリダジノン誘導体、この調製方法、およびこれを含む医薬組成物 Download PDF

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Publication number
JP4472337B2
JP4472337B2 JP2003530685A JP2003530685A JP4472337B2 JP 4472337 B2 JP4472337 B2 JP 4472337B2 JP 2003530685 A JP2003530685 A JP 2003530685A JP 2003530685 A JP2003530685 A JP 2003530685A JP 4472337 B2 JP4472337 B2 JP 4472337B2
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general formula
carbon atoms
formula
group
hydrogen atom
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JP2003530685A
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Japanese (ja)
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JP2005503437A (ja
JP2005503437A5 (enExample
Inventor
バルコーツイ ヨージェフ
シミグ ヂュラ
コータイ ナヂ ペーター
レーヴァイ ヂェルヂィ
ガチャーリュイ イシュトヴァーン
マルトンネー マルコー ベルナデット
シュミット エーヴァ
エヂエド アンドラーシュ
コムパグネ ハユナルカ
レヴェレキ チシッラ
ミクローシュネー コヴァーチュ アニコー
セーナーシュイ ガーボル
ウェルマン ヤーノシュ
ラースロー ハールシュイング ガーボル
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Egis Gyógyszergyár Zrt
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Egis Gyógyszergyár Zrt
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Publication of JP2005503437A publication Critical patent/JP2005503437A/ja
Publication of JP2005503437A5 publication Critical patent/JP2005503437A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2003530685A 2001-09-27 2002-09-26 アルキルアミノピリダジノン誘導体、この調製方法、およびこれを含む医薬組成物 Expired - Lifetime JP4472337B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
PCT/HU2002/000096 WO2003027097A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (3)

Publication Number Publication Date
JP2005503437A JP2005503437A (ja) 2005-02-03
JP2005503437A5 JP2005503437A5 (enExample) 2006-01-05
JP4472337B2 true JP4472337B2 (ja) 2010-06-02

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003530685A Expired - Lifetime JP4472337B2 (ja) 2001-09-27 2002-09-26 アルキルアミノピリダジノン誘導体、この調製方法、およびこれを含む医薬組成物
JP2003530669A Pending JP2005508914A (ja) 2001-09-27 2002-09-26 置換アルキルアミノピリダジノン誘導体、その製法及び該誘導体を含有する医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2003530669A Pending JP2005508914A (ja) 2001-09-27 2002-09-26 置換アルキルアミノピリダジノン誘導体、その製法及び該誘導体を含有する医薬組成物

Country Status (25)

Country Link
US (2) US20050043314A1 (enExample)
EP (2) EP1430034B1 (enExample)
JP (2) JP4472337B2 (enExample)
KR (2) KR100911069B1 (enExample)
CN (3) CN1325489C (enExample)
AT (2) ATE288910T1 (enExample)
AU (2) AU2002330656B9 (enExample)
BR (2) BR0212932A (enExample)
CA (2) CA2461467A1 (enExample)
CZ (2) CZ2004528A3 (enExample)
DE (2) DE60202969T2 (enExample)
DK (2) DK1430034T3 (enExample)
EA (2) EA006942B1 (enExample)
ES (2) ES2237696T3 (enExample)
HU (1) HU227237B1 (enExample)
MA (2) MA27137A1 (enExample)
MX (2) MXPA04002836A (enExample)
NO (2) NO326370B1 (enExample)
NZ (2) NZ532104A (enExample)
PL (2) PL369256A1 (enExample)
PT (2) PT1430047E (enExample)
SI (2) SI1430034T1 (enExample)
SK (2) SK1892004A3 (enExample)
WO (2) WO2003027078A1 (enExample)
ZA (2) ZA200402545B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
JP5147866B2 (ja) * 2007-03-15 2013-02-20 メルク・シャープ・アンド・ドーム・コーポレーション グルカン合成酵素阻害剤として有用であるピリダジノン誘導体
BR112020022006A2 (pt) * 2018-04-30 2021-01-26 Ribon Therapeutics Inc. piridazinonas como inibidores de parp7
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
WO2020223229A1 (en) 2019-04-29 2020-11-05 Ribon Therapeutics, Inc. Solid forms of a parp7 inhibitor
TWI902715B (zh) 2019-10-30 2025-11-01 美商律幫治療股份有限公司 作為ｐａｒｐ７抑制劑的嗒酮
WO2022188889A1 (zh) * 2021-03-12 2022-09-15 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法
CN118388414A (zh) * 2023-01-17 2024-07-26 中国药科大学 哒嗪酮类化合物及其制备方法、药物组合物和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
JP2004500314A (ja) 1998-06-05 2004-01-08 エギシュ　ヂョヂセルヂャール　エルテー ３（２ｈ）−ピリダジノン−４−置換アミノ−５−クロロ−誘導体の製法

Also Published As

Publication number Publication date
HU0103912D0 (en) 2001-12-28
JP2005508914A (ja) 2005-04-07
HU227237B1 (en) 2010-12-28
AU2002330656A2 (en) 2003-04-07
AU2002330656B2 (en) 2009-04-09
HK1069817A1 (en) 2005-06-03
PT1430034E (pt) 2005-06-30
BR0212839A (pt) 2004-10-13
KR100890667B1 (ko) 2009-03-26
NO20041704L (no) 2004-04-26
JP2005503437A (ja) 2005-02-03
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
ZA200402544B (en) 2005-04-26
SK1902004A3 (en) 2004-10-05
EP1430047A1 (en) 2004-06-23
NZ532104A (en) 2005-10-28
EP1430034A1 (en) 2004-06-23
ZA200402545B (en) 2005-04-26
CA2461510C (en) 2009-07-07
ATE288899T1 (de) 2005-02-15
CN1325489C (zh) 2007-07-11
CN101099740A (zh) 2008-01-09
EP1430047B1 (en) 2005-02-09
MA27068A1 (fr) 2004-12-20
US20040242873A1 (en) 2004-12-02
WO2003027097A1 (en) 2003-04-03
SK1892004A3 (en) 2004-10-05
CA2461467A1 (en) 2003-04-03
SI1430034T1 (en) 2005-08-31
ATE288910T1 (de) 2005-02-15
DE60202969T2 (de) 2006-01-19
NZ532103A (en) 2005-08-26
WO2003027078A1 (en) 2003-04-03
SI1430047T1 (en) 2005-08-31
CZ2004528A3 (cs) 2004-08-18
ES2237690T3 (es) 2005-08-01
HK1115728A1 (en) 2008-12-05
PL369107A1 (en) 2005-04-18
ES2237696T3 (es) 2005-08-01
BR0212932A (pt) 2004-10-13
EA200400469A1 (ru) 2004-08-26
NO326370B1 (no) 2008-11-17
US20050043314A1 (en) 2005-02-24
CN1571783A (zh) 2005-01-26
DK1430034T3 (da) 2005-05-30
DE60202970D1 (de) 2005-03-17
HUP0103912A3 (en) 2004-03-01
DE60202969D1 (de) 2005-03-17
KR100911069B1 (ko) 2009-08-06
NO20041551L (no) 2004-06-10
CN100368404C (zh) 2008-02-13
KR20040039446A (ko) 2004-05-10
US6930110B2 (en) 2005-08-16
HK1069816A1 (en) 2005-06-03
CZ2004532A3 (cs) 2004-08-18
CA2461510A1 (en) 2003-04-03
NO325080B1 (no) 2008-01-28
AU2002328166B2 (en) 2008-04-17
MA27137A1 (fr) 2005-01-03
MXPA04002836A (es) 2004-07-05
PL369256A1 (en) 2005-04-18
DE60202970T2 (de) 2006-02-16
EA200400470A1 (ru) 2004-08-26
EA006392B1 (ru) 2005-12-29
MXPA04002838A (es) 2004-07-05
HUP0103912A2 (hu) 2003-07-28
EP1430034B1 (en) 2005-02-09
PT1430047E (pt) 2005-06-30
KR20040039445A (ko) 2004-05-10
DK1430047T3 (da) 2005-06-06
CN101099740B (zh) 2010-09-08
EA006942B1 (ru) 2006-06-30
AU2002330656B9 (en) 2009-09-03

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