BR0212932A - Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos - Google Patents

Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos

Info

Publication number
BR0212932A
BR0212932A BR0212932-9A BR0212932A BR0212932A BR 0212932 A BR0212932 A BR 0212932A BR 0212932 A BR0212932 A BR 0212932A BR 0212932 A BR0212932 A BR 0212932A
Authority
BR
Brazil
Prior art keywords
hydrogen
alkyl
carbon atoms
pharmaceutical composition
composition containing
Prior art date
Application number
BR0212932-9A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Gyula Simig
Peter Kotay Nagy
Gy Rgy Levay
Istvan Gacsalyi
Bernadett Martonne Marko
Eva Schmidt
Andras Egyed
Hajnalka Kompagne
Csilla Leveleki
Aniko Miklosne Kovacs
Janos Wellmann
Laszlo Gabor Harsing
Gabor Szenasi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of BR0212932A publication Critical patent/BR0212932A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE ALQUILAMINOPIRIDAZINONA SUBSTITUìDOS, PROCESSO PARA A PREPARAçãO DESTES, COMPOSIçãO FARMACêUTICA CONTENDO OS MESMOS E SEUS USOS". A invenção se relaciona a novos derivados de alquilaminopiridazinona substituídos da Fórmula geral (I), (onde R~ 1~ é hidrogênio ou alquil tendo de 1-4 átomos de carbono; um entre X e Y representa hidrogênio ou halogênio e o outro representa um grupo da Fórmula geral (II) , R~ 2~ é hidrogênio ou alquil tendo de 1-4 átomos de carbono; n é 1, 2 ou 3; R~ 3~ representa hidrogênio, alquil tendo de 1-4 átomos de carbono ou aril-(C~ 1-4~ alquil); Z representa oxigênio; ou R~ 3~ e Z juntamente com os grupos colocados entre eles formam um anel de piperazina; e R~ 4~ representa hidrogênio, halogênio, triflúormetil ou alcoxi tendo de 1-4 átomos de carbono) e sais de adição ácida farmaceuticamente aceitáveis destes. Os compostos da invenção são úteis no tratamento de condições ansiolíticas e distúrbios cognitivos.
BR0212932-9A 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos BR0212932A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
PCT/HU2002/000096 WO2003027097A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
BR0212932A true BR0212932A (pt) 2004-10-13

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0212839-0A BR0212839A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos
BR0212932-9A BR0212932A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes, composição farmacêutica contendo os mesmos e seus usos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0212839-0A BR0212839A (pt) 2001-09-27 2002-09-26 Derivados de alquilaminopiridazinona substituìdos, processo para a preparação destes e composição farmacêutica contendo os mesmos

Country Status (26)

Country Link
US (2) US6930110B2 (pt)
EP (2) EP1430047B1 (pt)
JP (2) JP4472337B2 (pt)
KR (2) KR100911069B1 (pt)
CN (3) CN1325489C (pt)
AT (2) ATE288910T1 (pt)
AU (2) AU2002330656B9 (pt)
BR (2) BR0212839A (pt)
CA (2) CA2461467A1 (pt)
CZ (2) CZ2004528A3 (pt)
DE (2) DE60202969T2 (pt)
DK (2) DK1430047T3 (pt)
EA (2) EA006392B1 (pt)
ES (2) ES2237690T3 (pt)
HK (3) HK1069817A1 (pt)
HU (1) HU227237B1 (pt)
MA (2) MA27137A1 (pt)
MX (2) MXPA04002838A (pt)
NO (2) NO326370B1 (pt)
NZ (2) NZ532104A (pt)
PL (2) PL369256A1 (pt)
PT (2) PT1430047E (pt)
SI (2) SI1430047T1 (pt)
SK (2) SK1902004A3 (pt)
WO (2) WO2003027078A1 (pt)
ZA (2) ZA200402544B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
AU2008227100B2 (en) * 2007-03-15 2014-01-09 Albany Molecular Research, Inc. Pyridazinone derivatives useful as glucan synthase inhibitors
KR20210014108A (ko) * 2018-04-30 2021-02-08 리본 테라퓨틱스 인코포레이티드 Parp7 억제제로서의 피리다지논
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
CN117425648A (zh) * 2021-03-12 2024-01-19 杭州英创医药科技有限公司 作为parp7抑制剂的化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) * 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
SK18492000A3 (sk) * 1998-06-05 2001-06-11 Egis Gy�Gyszergy�R Rt. Spôsob prípravy 3(2h)-pyridazinón-4-substituovaných amino-5-chlórderivátov

Also Published As

Publication number Publication date
EA200400470A1 (ru) 2004-08-26
KR100890667B1 (ko) 2009-03-26
JP2005503437A (ja) 2005-02-03
DK1430047T3 (da) 2005-06-06
EP1430034A1 (en) 2004-06-23
WO2003027078A1 (en) 2003-04-03
MXPA04002838A (es) 2004-07-05
PL369256A1 (en) 2005-04-18
HK1069817A1 (en) 2005-06-03
EP1430047A1 (en) 2004-06-23
NZ532104A (en) 2005-10-28
CZ2004532A3 (cs) 2004-08-18
BR0212839A (pt) 2004-10-13
US20040242873A1 (en) 2004-12-02
WO2003027097A1 (en) 2003-04-03
CN1325489C (zh) 2007-07-11
MA27068A1 (fr) 2004-12-20
NO325080B1 (no) 2008-01-28
ZA200402544B (en) 2005-04-26
AU2002330656A2 (en) 2003-04-07
PT1430047E (pt) 2005-06-30
ES2237696T3 (es) 2005-08-01
HK1115728A1 (en) 2008-12-05
SK1902004A3 (en) 2004-10-05
HU0103912D0 (en) 2001-12-28
HUP0103912A2 (hu) 2003-07-28
DE60202969D1 (de) 2005-03-17
PL369107A1 (en) 2005-04-18
HU227237B1 (en) 2010-12-28
KR20040039445A (ko) 2004-05-10
CZ2004528A3 (cs) 2004-08-18
CA2461510A1 (en) 2003-04-03
SI1430047T1 (en) 2005-08-31
EP1430034B1 (en) 2005-02-09
MXPA04002836A (es) 2004-07-05
NO20041551L (no) 2004-06-10
KR100911069B1 (ko) 2009-08-06
NO20041704L (no) 2004-04-26
EA200400469A1 (ru) 2004-08-26
EA006392B1 (ru) 2005-12-29
JP2005508914A (ja) 2005-04-07
KR20040039446A (ko) 2004-05-10
US6930110B2 (en) 2005-08-16
AU2002330656B2 (en) 2009-04-09
CA2461467A1 (en) 2003-04-03
MA27137A1 (fr) 2005-01-03
ES2237690T3 (es) 2005-08-01
NO326370B1 (no) 2008-11-17
CN100368404C (zh) 2008-02-13
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
AU2002328166B2 (en) 2008-04-17
DE60202969T2 (de) 2006-01-19
SK1892004A3 (en) 2004-10-05
CA2461510C (en) 2009-07-07
US20050043314A1 (en) 2005-02-24
ZA200402545B (en) 2005-04-26
CN101099740A (zh) 2008-01-09
EA006942B1 (ru) 2006-06-30
AU2002330656B9 (en) 2009-09-03
HK1069816A1 (en) 2005-06-03
DE60202970D1 (de) 2005-03-17
CN101099740B (zh) 2010-09-08
HUP0103912A3 (en) 2004-03-01
SI1430034T1 (en) 2005-08-31
ATE288910T1 (de) 2005-02-15
ATE288899T1 (de) 2005-02-15
EP1430047B1 (en) 2005-02-09
JP4472337B2 (ja) 2010-06-02
CN1571783A (zh) 2005-01-26
DK1430034T3 (da) 2005-05-30
PT1430034E (pt) 2005-06-30
NZ532103A (en) 2005-08-26
DE60202970T2 (de) 2006-02-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.